NO20021118L - Fremgangsmåte for fremstilling av citalopram - Google Patents

Fremgangsmåte for fremstilling av citalopram

Info

Publication number
NO20021118L
NO20021118L NO20021118A NO20021118A NO20021118L NO 20021118 L NO20021118 L NO 20021118L NO 20021118 A NO20021118 A NO 20021118A NO 20021118 A NO20021118 A NO 20021118A NO 20021118 L NO20021118 L NO 20021118L
Authority
NO
Norway
Prior art keywords
citalopram
fluorophenyl
preparation
dimethylamine
rti
Prior art date
Application number
NO20021118A
Other languages
English (en)
Other versions
NO20021118D0 (no
Inventor
Eva Bolzonella
Andrea Castellin
Andrea Nicole
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/EP2000/006426 external-priority patent/WO2001002383A2/en
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of NO20021118D0 publication Critical patent/NO20021118D0/no
Publication of NO20021118L publication Critical patent/NO20021118L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

En fremgangsmåte for fremstilling av citalopram karakteri- sert ved (i) reaksjon av l-(4'-fluorfenyl)-l-(3-dimetyl- aminopropyl)-5-haloftalan med aktivert magnesium, for å danne Grignardreagensen [3-[l-(4-fluorfenyl)-l,3-dihydro- isobenzofuran-1-yl]propyl]dimetylamin 5-magnesiumhalid fulgt av (ii) reaksjon av [3-[l-(4-fluorfenyl)-l,3-dihyd- ro-isobenzofuran-1-yl]propyl]dimetylamin 5-magnesiumhalid med en forbindelse som inneholder en -CN gruppe bundet til en forlatende gruppe, for å danne citalopram.
NO20021118A 2000-07-06 2002-03-06 Fremgangsmåte for fremstilling av citalopram NO20021118L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/EP2000/006426 WO2001002383A2 (en) 1999-07-06 2000-07-06 Process for the synthesis of citalopram
PCT/DK2001/000481 WO2002004435A1 (en) 2000-07-06 2001-07-06 Method for the preparation of citalopram

Publications (2)

Publication Number Publication Date
NO20021118D0 NO20021118D0 (no) 2002-03-06
NO20021118L true NO20021118L (no) 2002-04-24

Family

ID=8164018

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20021118A NO20021118L (no) 2000-07-06 2002-03-06 Fremgangsmåte for fremstilling av citalopram

Country Status (11)

Country Link
US (1) US20020128497A1 (no)
AU (1) AU2001272368A1 (no)
BR (1) BR0106976A (no)
CA (1) CA2383963A1 (no)
CZ (1) CZ2002832A3 (no)
EA (1) EA200200332A1 (no)
IL (1) IL148525A0 (no)
IS (1) IS6293A (no)
NO (1) NO20021118L (no)
SK (1) SK3362002A3 (no)
WO (1) WO2002004435A1 (no)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1173431B2 (en) 1999-04-14 2009-08-26 H. Lundbeck A/S Method for the preparation of citalopram
IES20010157A2 (en) 2000-03-03 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
IES20010206A2 (en) 2000-03-13 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
TR200202195T2 (tr) * 2000-03-13 2002-12-23 H. Lundbeck A/S 5-Yer değiştirmiş 1-(4-florofenil)-1,3- dihidroizobenzofuran'ın adım adım alkillenmesi
CZ20023384A3 (cs) 2000-03-13 2003-01-15 H. Lundbeck A/S Způsob výroby citalopramu a meziprodukt
CA2402557A1 (en) 2000-03-14 2001-09-20 Hans Petersen Method for the preparation of citalopram
MXPA02008652A (es) * 2000-03-16 2003-02-24 Lundbeck & Co As H Metodo para la preparacion de 5-ciano-1-(4-fluorofenil)-1,3-dihidroisobenzofuranos.
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
AU2003223105A1 (en) * 2003-03-24 2004-10-18 Hetero Drugs Limited Novel crystalline forms of (s)-citalopram oxalate

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1526331A (en) * 1976-01-14 1978-09-27 Kefalas As Phthalanes
ITMI991579A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991486A1 (it) * 1999-07-06 2001-01-06 Vis Farmaceutici S P A Processo per la sintesi di citalopram

Also Published As

Publication number Publication date
SK3362002A3 (en) 2002-08-06
EA200200332A1 (ru) 2002-06-27
BR0106976A (pt) 2002-07-23
IS6293A (is) 2002-03-05
IL148525A0 (en) 2002-09-12
CA2383963A1 (en) 2002-01-17
WO2002004435A1 (en) 2002-01-17
CZ2002832A3 (cs) 2002-05-15
AU2001272368A1 (en) 2002-01-21
NO20021118D0 (no) 2002-03-06
US20020128497A1 (en) 2002-09-12

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