PE20030253A1 - Metodo para la preparacion de escitalopram - Google Patents

Metodo para la preparacion de escitalopram

Info

Publication number
PE20030253A1
PE20030253A1 PE2002000617A PE2002000617A PE20030253A1 PE 20030253 A1 PE20030253 A1 PE 20030253A1 PE 2002000617 A PE2002000617 A PE 2002000617A PE 2002000617 A PE2002000617 A PE 2002000617A PE 20030253 A1 PE20030253 A1 PE 20030253A1
Authority
PE
Peru
Prior art keywords
citalopram
refers
substitute
escitalopram
phenyl carbamate
Prior art date
Application number
PE2002000617A
Other languages
English (en)
Inventor
Michael Bech Sommer
Ole Nielsen
Haleh Ahmadian
Peter Broesen
James Lee
Olivier DAPREMONT
Cristina Suteu
Shankar Hariharan
Usha Nair
Sebastian P Assenza
Geoffrey Cox
Fiona Geiser
Henrik Pedersen
Hans Petersen
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27222518&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20030253(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of PE20030253A1 publication Critical patent/PE20030253A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C07C215/30—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings containing hydroxy groups and carbon atoms of six-membered aromatic rings bound to the same carbon atom of the carbon skeleton
    • C07C215/32—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings containing hydroxy groups and carbon atoms of six-membered aromatic rings bound to the same carbon atom of the carbon skeleton containing hydroxy groups and carbon atoms of two six-membered aromatic rings bound to the same carbon atom of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE REFIERE A UN PROCEDIMIENTO DE PREPARACION DE ESCITALOPRAM (ENANTIOMERO S DE CITALOPRAM (S)-1-[3-(DIMETILAMINO)-PROPIL]-1-(4-FLUOROFENIL)-1,3-DIHIDRO-5-ISOBENZOFURAN-CARBONITRILO) QUE COMPRENDE SEPARAR LOS ENANTIOMEROS DE CITALOPRAM Y COMPUESTOS INTERMEDIARIOS POR CROMATOGRAFIA LIQUIDA UTILIZANDO UNA FASE QUIRAL TAL COMO UN DERIVADO DE CARBOHIDRATO (AMILOSA, CELULOSA) CON SUSTITUYENTES FENILCARBAMATO OPCIONALMENTE SUSTITUIDOS CON METILO, EL CUAL ES ABSORBIDO SOBRE GEL DE SILICE. TAMBIEN SE REFIERE A UN METODO DE SEPARACION POR RESOLUCION OPTICA MEDIANTE CROMATOGRAFIA DE UN COMPUESTO DIMETILAMINOPROPIL BIFENIL SUSTITUIDO CON X Y Z, DONDE X ES CIANO, HALOGENO O CUALQUIER OTRO ATOMO QUE PUEDA SER CONVERTIDO EN UN GRUPO CIANO; Z ES HIDROXI O UN GRUPO SALIENTE PARA FORMAR UN COMPUESTO (S)-DIMETILAMINOPROPIL BIFENIL, SI Z ES OH SE CONVIERTE A UN GRUPO SALIENTE Y LUEGO SE PROCEDE AL CIERRE DEL ANILLO, SI X NO ES CIANO SE REALIZA LA CONVERSION SEGUIDO DEL AISLAMIENTO DE ESCITALOPRAM. TAMBIEN SE REFIERE A COMPUESTOS INTERMEDIARIOS COMO 5-BROMO-CITALOPRAM
PE2002000617A 2001-07-13 2002-07-11 Metodo para la preparacion de escitalopram PE20030253A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA200101101 2001-07-13
DKPA200101852 2001-12-11
DKPA200101851 2001-12-11

Publications (1)

Publication Number Publication Date
PE20030253A1 true PE20030253A1 (es) 2003-03-19

Family

ID=27222518

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2002000617A PE20030253A1 (es) 2001-07-13 2002-07-11 Metodo para la preparacion de escitalopram

Country Status (29)

Country Link
US (2) US20050065207A1 (es)
EP (1) EP1409472A1 (es)
JP (1) JP2004538276A (es)
KR (4) KR20080108629A (es)
CN (2) CN100457746C (es)
AR (1) AR034759A1 (es)
AU (1) AU2009200448A1 (es)
BG (1) BG108572A (es)
BR (1) BR0210817A (es)
CA (1) CA2451124C (es)
CO (1) CO5550496A2 (es)
EA (1) EA014823B1 (es)
HK (1) HK1069386A1 (es)
HR (1) HRPK20031074B3 (es)
HU (1) HUP0401451A3 (es)
IL (1) IL159183A0 (es)
IS (1) IS7064A (es)
ME (1) MEP2008A (es)
MX (1) MXPA04000205A (es)
MY (1) MY144333A (es)
NO (1) NO328561B1 (es)
PE (1) PE20030253A1 (es)
PL (1) PL366383A1 (es)
RS (1) RS1804A (es)
TW (1) TWI268926B (es)
UA (1) UA84258C2 (es)
UY (1) UY27379A1 (es)
WO (1) WO2003006449A1 (es)
ZA (1) ZA200309471B (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20040991A1 (es) 2002-08-12 2004-12-27 Lundbeck & Co As H Separacion de intermediarios para la preparacion de escitalopram
JP4505335B2 (ja) 2002-12-23 2010-07-21 ハー・ルンドベック・アクチエゼルスカベット ラセミ体シタロプラムジオール（ｒａｃｅｍｉｃｃｉｔａｌｏｐｒａｍｄｉｏｌ）および／またはＳ−もしくはＲ−シタロプラムジオールの製造方法、およびラセミ体シタロプラム、Ｒ−シタロプラムおよび／またはＳ−シタロプラムを製造するために、上記ジオールを使用する方法。
FR2853650B1 (fr) * 2003-04-10 2006-07-07 Merck Sante Sas Procede de dedoublement d'amines utiles pour le traitement de desordres associes au syndrome d'insulino-resistance
ES2228274B1 (es) * 2003-09-24 2006-06-01 Astur Pharma, S.A. Sintesis quimioenzimatica de (+)-citalopram y (-)-citalopram.
TWI339651B (en) * 2004-02-12 2011-04-01 Lundbeck & Co As H Method for the separation of intermediates which may be used for the preparation of escitalopram
US20050196453A1 (en) 2004-03-05 2005-09-08 H. Lundbeck A/S Crystalline composition containing escitalopram
ITMI20040717A1 (it) 2004-04-09 2004-07-09 Adorkem Technology Spa Procedimento chemo-enzimatico per la preparazione dell'escitalopram
JP2006008603A (ja) * 2004-06-25 2006-01-12 Sumitomo Chemical Co Ltd 光学活性シタロプラムの製造方法、その中間体およびその製造方法
US7989645B2 (en) * 2004-08-23 2011-08-02 Sun Pharma Global Fze Process for preparation of citalopram and enantiomers
WO2006021971A2 (en) 2004-08-23 2006-03-02 Sun Pharmaceutical Industries Limited 'process for preparation of citalopram and enantiomers'
ITMI20041872A1 (it) * 2004-10-01 2005-01-01 Adorkem Technology Spa Processo per la preparazione di citalopram e di scitalopram
WO2006106531A1 (en) * 2005-04-04 2006-10-12 Jubilant Organosys Ltd Process for the preparation of escitalopram or its acid addition salts
US7834201B2 (en) 2005-06-22 2010-11-16 H. Lundbeck A/S Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base
TWI358407B (en) 2005-06-22 2012-02-21 Lundbeck & Co As H Crystalline base of escitalopram and orodispersibl
WO2007053796A2 (en) 2005-10-14 2007-05-10 Forest Laboratories, Inc. Methods of treating central nervous system disorders with a low dose combination of escitalopram and bupropion
CN101309924A (zh) * 2005-11-14 2008-11-19 H.隆德贝克有限公司 依地普仑的制备方法
GB0601286D0 (en) 2006-01-23 2006-03-01 Sandoz Ag Asymmetric synthesis
US7566793B2 (en) 2007-04-23 2009-07-28 Synthon Bv Process for resolving citalopram
EP2017271A1 (en) 2007-07-06 2009-01-21 Aurobindo Pharma Limited Process for the preparation of escitalopram
FI121570B (fi) * 2007-09-11 2011-01-14 Lundbeck & Co As H Menetelmä essitalopraamin valmistamiseksi
US8022232B2 (en) * 2007-09-11 2011-09-20 H. Lundbeck A/S Method for manufacture of escitalopram
CN106568863A (zh) * 2016-11-04 2017-04-19 北京万全德众医药生物技术有限公司 一种用高效液相色谱法分离测定草酸艾司西肽普兰中间体光学异构体的方法
CN107941962A (zh) * 2017-12-28 2018-04-20 北京和合医学诊断技术股份有限公司 检测血液中艾司西酞普兰药物含量的液相色谱分析方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1526331A (en) * 1976-01-14 1978-09-27 Kefalas As Phthalanes
GB8419963D0 (en) * 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
GB8814057D0 (en) * 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
JP3010816B2 (ja) * 1991-08-22 2000-02-21 ダイセル化学工業株式会社 光学分割における光学異性体と溶媒との回収方法、溶媒の循環使用方法、および光学異性体の再利用方法
US5514818A (en) * 1993-09-17 1996-05-07 Daicel Chemical Industries, Ltd. Resolution of stereoisomers of aliphatic epoxides
US5889180A (en) * 1997-11-10 1999-03-30 Uop Llc Use of small pore silicas as a support for a chiral stationary phase
FR2805812A1 (fr) * 2000-02-24 2001-09-07 Lundbeck & Co As H Procede de preparation du citalopram
US6967259B2 (en) * 2001-09-24 2005-11-22 Pharmachem Technologies Limited Process for the preparation of Citalopram intermediate
US6764200B1 (en) * 2003-01-15 2004-07-20 Hsiang Lan Wu Liu Decorative lantern

Also Published As

Publication number Publication date
AR034759A1 (es) 2004-03-17
KR100956260B1 (ko) 2010-05-07
MEP2008A (xx) 2010-02-10
NO20040027L (no) 2004-01-05
UY27379A1 (es) 2003-02-28
BR0210817A (pt) 2004-06-22
US20110065938A1 (en) 2011-03-17
CA2451124A1 (en) 2003-01-23
MY144333A (en) 2011-08-29
KR20080108629A (ko) 2008-12-15
EA200400177A1 (ru) 2004-06-24
CO5550496A2 (es) 2005-08-31
JP2004538276A (ja) 2004-12-24
KR20040030046A (ko) 2004-04-08
CN1527825A (zh) 2004-09-08
HRPK20031074B3 (en) 2009-10-31
CN100457746C (zh) 2009-02-04
PL366383A1 (en) 2005-01-24
RS1804A (en) 2006-12-15
MXPA04000205A (es) 2004-03-18
HUP0401451A2 (hu) 2004-11-29
HRP20031074A2 (en) 2004-04-30
UA84258C2 (en) 2008-10-10
BG108572A (bg) 2005-03-31
US20050065207A1 (en) 2005-03-24
EA014823B1 (ru) 2011-02-28
CA2451124C (en) 2009-11-24
CN101265199A (zh) 2008-09-17
KR20080108628A (ko) 2008-12-15
IS7064A (is) 2003-12-04
NO328561B1 (no) 2010-03-22
TWI268926B (en) 2006-12-21
AU2009200448A1 (en) 2009-03-05
HUP0401451A3 (en) 2007-05-29
KR20100036387A (ko) 2010-04-07
ZA200309471B (en) 2004-12-06
EP1409472A1 (en) 2004-04-21
WO2003006449A1 (en) 2003-01-23
IL159183A0 (en) 2004-06-01
HK1069386A1 (en) 2005-05-20

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