EE03354B1 - Asendatud sulfoksiidide sünteesi protsess - Google Patents
Asendatud sulfoksiidide sünteesi protsessInfo
- Publication number
- EE03354B1 EE03354B1 EE9700006A EE9700006A EE03354B1 EE 03354 B1 EE03354 B1 EE 03354B1 EE 9700006 A EE9700006 A EE 9700006A EE 9700006 A EE9700006 A EE 9700006A EE 03354 B1 EE03354 B1 EE 03354B1
- Authority
- EE
- Estonia
- Prior art keywords
- synthesis
- substituted sulfoxides
- sulfoxides
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/28—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9402510A SE504459C2 (sv) | 1994-07-15 | 1994-07-15 | Förfarande för framställning av substituerade sulfoxider |
PCT/SE1995/000818 WO1996002535A1 (en) | 1994-07-15 | 1995-07-03 | Process for synthesis of substituted sulphoxides |
Publications (1)
Publication Number | Publication Date |
---|---|
EE03354B1 true EE03354B1 (et) | 2001-02-15 |
Family
ID=20394753
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EE9700006A EE03354B1 (et) | 1994-07-15 | 1995-07-03 | Asendatud sulfoksiidide sünteesi protsess |
Country Status (42)
Country | Link |
---|---|
US (1) | US5948789A (sv) |
EP (1) | EP0773940B2 (sv) |
JP (1) | JP3795917B2 (sv) |
KR (1) | KR100356252B1 (sv) |
CN (1) | CN1070489C (sv) |
AR (1) | AR003443A1 (sv) |
AT (1) | ATE242233T1 (sv) |
AU (1) | AU688074B2 (sv) |
BR (1) | BR9508292A (sv) |
CA (1) | CA2193994C (sv) |
CZ (1) | CZ297987B6 (sv) |
DE (1) | DE69530987T3 (sv) |
DK (1) | DK0773940T4 (sv) |
DZ (1) | DZ1911A1 (sv) |
EE (1) | EE03354B1 (sv) |
EG (1) | EG24534A (sv) |
ES (1) | ES2199998T5 (sv) |
FI (2) | FI117672B (sv) |
HK (1) | HK1008331A1 (sv) |
HR (1) | HRP950401B1 (sv) |
HU (1) | HU226361B1 (sv) |
IL (1) | IL114477A (sv) |
IS (1) | IS1772B (sv) |
MA (1) | MA23611A1 (sv) |
MX (1) | MX9700358A (sv) |
MY (1) | MY113180A (sv) |
NO (1) | NO312101B1 (sv) |
NZ (1) | NZ289959A (sv) |
PL (1) | PL186342B1 (sv) |
PT (1) | PT773940E (sv) |
RU (1) | RU2157806C2 (sv) |
SA (1) | SA95160294B1 (sv) |
SE (1) | SE504459C2 (sv) |
SI (1) | SI0773940T2 (sv) |
SK (1) | SK284059B6 (sv) |
TN (1) | TNSN95081A1 (sv) |
TR (1) | TR199500861A2 (sv) |
TW (1) | TW372971B (sv) |
UA (1) | UA47409C2 (sv) |
WO (1) | WO1996002535A1 (sv) |
YU (1) | YU49475B (sv) |
ZA (1) | ZA955724B (sv) |
Families Citing this family (153)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6875872B1 (en) | 1993-05-28 | 2005-04-05 | Astrazeneca | Compounds |
SE9301830D0 (sv) * | 1993-05-28 | 1993-05-28 | Ab Astra | New compounds |
SE504459C2 (sv) * | 1994-07-15 | 1997-02-17 | Astra Ab | Förfarande för framställning av substituerade sulfoxider |
US6699885B2 (en) * | 1996-01-04 | 2004-03-02 | The Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and methods of using same |
US6489346B1 (en) | 1996-01-04 | 2002-12-03 | The Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and method of using same |
US6645988B2 (en) * | 1996-01-04 | 2003-11-11 | Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and method of using same |
US5840737A (en) | 1996-01-04 | 1998-11-24 | The Curators Of The University Of Missouri | Omeprazole solution and method for using same |
SE510650C2 (sv) | 1997-05-30 | 1999-06-14 | Astra Ab | Ny förening |
US6747155B2 (en) | 1997-05-30 | 2004-06-08 | Astrazeneca Ab | Process |
SE510643C2 (sv) * | 1997-06-27 | 1999-06-14 | Astra Ab | Termodynamiskt stabil omeprazol natrium form B |
HUP0100179A3 (en) | 1997-07-03 | 2002-12-28 | Bristol Myers Squibb Pharma Co | Imidazopyrimidine and imidazopyridine derivatives and pharmaceutical compositions thereof |
US6174548B1 (en) | 1998-08-28 | 2001-01-16 | Andrx Pharmaceuticals, Inc. | Omeprazole formulation |
US6096340A (en) | 1997-11-14 | 2000-08-01 | Andrx Pharmaceuticals, Inc. | Omeprazole formulation |
SE9704183D0 (sv) * | 1997-11-14 | 1997-11-14 | Astra Ab | New process |
EP1056456A4 (en) * | 1998-01-30 | 2006-10-25 | Sepracor Inc | R-LANSOPRAZOL COMPOSITIONS AND TREATMENTS THEREFOR |
EP1073333A4 (en) * | 1998-04-30 | 2005-06-15 | Sepracor Inc | S-RABEPRAZOL COMPOSITIONS AND METHODS |
JP2002512262A (ja) * | 1998-04-30 | 2002-04-23 | セプラコール, インク. | R−レイブプラゾール組成物及び方法 |
US6365589B1 (en) | 1998-07-02 | 2002-04-02 | Bristol-Myers Squibb Pharma Company | Imidazo-pyridines, -pyridazines, and -triazines as corticotropin releasing factor antagonists |
US6733778B1 (en) | 1999-08-27 | 2004-05-11 | Andrx Pharmaceuticals, Inc. | Omeprazole formulation |
CN1087739C (zh) * | 1998-12-28 | 2002-07-17 | 中国科学院成都有机化学研究所 | 光学纯的苯并咪唑类抗消化性溃疡药物的包结拆分制备法 |
SE9900274D0 (sv) | 1999-01-28 | 1999-01-28 | Astra Ab | New compound |
TWI289557B (en) | 1999-06-17 | 2007-11-11 | Takeda Chemical Industries Ltd | A crystal of a hydrate of (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]-1H-benzimidazole |
ES2240113T3 (es) * | 1999-06-30 | 2005-10-16 | Takeda Pharmaceutical Company Limited | Cristales de lansoprazol. |
WO2001014366A1 (fr) * | 1999-08-25 | 2001-03-01 | Takeda Chemical Industries, Ltd. | Procede de preparation de derives optiquement actifs de sulfoxyde |
US6312723B1 (en) | 1999-08-26 | 2001-11-06 | Robert R. Whittle | Pharmaceutical unit dosage form |
US6268385B1 (en) | 1999-08-26 | 2001-07-31 | Robert R. Whittle | Dry blend pharmaceutical formulations |
US6369087B1 (en) | 1999-08-26 | 2002-04-09 | Robert R. Whittle | Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same |
US6262085B1 (en) | 1999-08-26 | 2001-07-17 | Robert R. Whittle | Alkoxy substituted Benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same |
US6262086B1 (en) | 1999-08-26 | 2001-07-17 | Robert R. Whittle | Pharmaceutical unit dosage form |
US6780880B1 (en) | 1999-08-26 | 2004-08-24 | Robert R. Whittle | FT-Raman spectroscopic measurement |
US6326384B1 (en) | 1999-08-26 | 2001-12-04 | Robert R. Whittle | Dry blend pharmaceutical unit dosage form |
US6312712B1 (en) | 1999-08-26 | 2001-11-06 | Robert R. Whittle | Method of improving bioavailability |
US6316020B1 (en) * | 1999-08-26 | 2001-11-13 | Robert R. Whittle | Pharmaceutical formulations |
WO2001083473A1 (fr) * | 2000-04-28 | 2001-11-08 | Takeda Chemical Industries, Ltd. | Procede de production d'un derive de sulfoxide optiquement actif |
ES2521690T3 (es) | 2000-05-15 | 2014-11-13 | Takeda Pharmaceutical Company Limited | Procedimiento para producir un cristal de (R)-2-[[[3-metil-4-(2,2,2-trifluoroetoxi)-2-piridil]metil]sulfinil]-bencimidazol |
KR100869677B1 (ko) | 2000-05-15 | 2008-11-21 | 다케다 야쿠힌 고교 가부시키가이샤 | 결정의 제조방법 |
DE60123800T2 (de) | 2000-08-04 | 2007-10-11 | Takeda Pharmaceutical Co. Ltd. | Salze von benzimidazol-derivaten und deren verwendung |
AU2002218506A1 (en) * | 2000-12-01 | 2002-06-11 | Takeda Chemical Industries Ltd. | Process for the crystallization of (r)- or (s)-lansoprazole |
WO2002083608A2 (en) * | 2001-04-13 | 2002-10-24 | Apsinterm Llc | Methods of preparing sulfinamide and sulfoxides |
GB2376231A (en) * | 2001-06-06 | 2002-12-11 | Cipla Ltd | Benzimidazole-cyclodextrin inclusion complex |
MXPA04007169A (es) * | 2002-01-25 | 2004-10-29 | Santarus Inc | Suministro transmucosal de inhibidores de bomba de protones. |
PT1487818E (pt) | 2002-03-05 | 2007-07-18 | Astrazeneca Ab | Sais de alquilamónio de omeprazole e esomeprazole |
WO2003089408A2 (en) * | 2002-04-22 | 2003-10-30 | Sun Pharmaceutical Industries Limited | Optically active substituted pyridinylmethyl-sulphinyl-benzimidazole and salts |
EP1515963B1 (en) * | 2002-06-27 | 2007-02-14 | Dr. Reddy's Laboratories Ltd. | A process for preparation of optically pure or optically enriched sulfoxide compounds, including amorphous esomeprazole and salts thereof |
WO2004035052A1 (ja) | 2002-10-16 | 2004-04-29 | Takeda Pharmaceutical Company Limited | 安定な固形製剤 |
MY148805A (en) | 2002-10-16 | 2013-05-31 | Takeda Pharmaceutical | Controlled release preparation |
WO2004037253A1 (en) | 2002-10-22 | 2004-05-06 | Ranbaxy Laboratories Limited | Amorphous form of esomeprazole salts |
DE10254167A1 (de) | 2002-11-20 | 2004-06-09 | Icon Genetics Ag | Verfahren zur Kontrolle von zellulären Prozessen in Pflanzen |
JP4612542B2 (ja) | 2002-12-06 | 2011-01-12 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | 光学的に純粋な有効化合物の製造方法 |
AU2003293749B2 (en) * | 2002-12-06 | 2009-12-24 | Takeda Gmbh | Process for preparing (S)-pantoprazole |
FR2848555B1 (fr) | 2002-12-16 | 2006-07-28 | Negma Gild | Enantiomere(-)du tenatoprazole et son application en therapeutique |
AR046245A1 (es) * | 2002-12-16 | 2005-11-30 | Ranbaxy Lab Ltd | Sales de calcio de rabeprazol |
EP1572680A2 (en) | 2002-12-19 | 2005-09-14 | Eva Pharmaceutical Industries Ltd. | Solid states of pantoprazole sodium, known pantoprazole sodium hydrates, processes for their preparation. |
CN1723208A (zh) * | 2003-01-07 | 2006-01-18 | 兰贝克赛实验室有限公司 | 咪唑衍生物的镁盐 |
JP2006518751A (ja) * | 2003-02-20 | 2006-08-17 | サンタラス インコーポレイティッド | 胃酸の急速かつ持続的な抑制のための新規製剤、オメプラゾール制酸剤複合体−即時放出物 |
US20060247277A1 (en) * | 2003-02-28 | 2006-11-02 | Yatendra Kumar | Polymorphs of s-omeprazole |
EP1601667A2 (en) * | 2003-03-12 | 2005-12-07 | Teva Pharmaceutical Industries Limited | Crystalline and amorphous solids of pantoprazole and processes for their preparation |
US7608625B2 (en) * | 2003-03-13 | 2009-10-27 | Eisai R & D Management Co., Ltd. | Method for treating bruxism and bruxism-related diseases |
EP1608649A2 (fr) * | 2003-03-28 | 2005-12-28 | Sidem Pharma SA | Procede de preparation enantioselective de derives de sulfoxydes. |
FR2852956B1 (fr) * | 2003-03-28 | 2006-08-04 | Negma Gild | Procede de preparation enantioselective de derives de sulfoxydes |
EP1633736A1 (en) * | 2003-05-05 | 2006-03-15 | Ranbaxy Laboratories Limited | Barium salt of benzimidazole derivative |
EP1615913A2 (en) | 2003-06-10 | 2006-01-18 | Teva Pharmaceutical Industries Limited | Process for preparing 2-(pyridinyl)methyl sulfinyl-substituted benzimidazoles and novel chlorinated derivatives of pantoprazole |
US8993599B2 (en) | 2003-07-18 | 2015-03-31 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
SE0302382D0 (sv) | 2003-09-04 | 2003-09-04 | Astrazeneca Ab | New salts II |
SE0302381D0 (sv) | 2003-09-04 | 2003-09-04 | Astrazeneca Ab | New salts I |
AU2003288703A1 (en) * | 2003-12-05 | 2005-06-24 | Hetero Drugs Limited | A process for the preparation of substitited pyridinylmethylsulfinyl- benzimidazole enantiomers |
SE0400410D0 (sv) * | 2004-02-20 | 2004-02-20 | Astrazeneca Ab | New compounds |
EP1740571B1 (en) | 2004-04-28 | 2009-07-29 | Hetero Drugs Limited | A process for preparing pyridinylmethyl-1h- benzimidazole compounds in enantiomerically enriched form or as single enantiomers |
US8906940B2 (en) | 2004-05-25 | 2014-12-09 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
US8815916B2 (en) | 2004-05-25 | 2014-08-26 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
DK1748998T3 (da) * | 2004-05-28 | 2010-05-10 | Hetero Drugs Ltd | Ny stereoselektiv syntese af benzimidazolsulfoxider |
US20070225500A1 (en) * | 2004-06-02 | 2007-09-27 | Altana Pharma Ag | Process for the Preparation of Pyridin-2-Ylmethylsulphinyl-1H-Benzimidazol Compounds |
JP5563735B2 (ja) | 2004-06-16 | 2014-07-30 | タケダ ファーマシューティカルズ ユー.エス.エー. インコーポレイティド | Ppi多回剤形 |
US20080249134A1 (en) * | 2004-06-24 | 2008-10-09 | Ursula Hohlneicher | New Esomeprazole Sodium Salt Crystal Modification |
KR20130038949A (ko) * | 2004-06-24 | 2013-04-18 | 아스트라제네카 아베 | 에소메프라졸 나트륨염의 제조에서 사용하기 위한 결정 변형의 제조를 위한 신규한 방법 |
FR2876101B1 (fr) * | 2004-10-05 | 2007-03-02 | Sidem Pharma Sa Sa | Procede de preparation enantioselective de derives de sulfoxydes |
SI1802584T1 (sl) * | 2004-10-11 | 2010-01-29 | Ranbaxy Lab Ltd | Postopki za pripravo substituiranih sulfoksidov |
US7592111B2 (en) * | 2004-11-05 | 2009-09-22 | Xerox Corporation | Imaging member |
CN101098867B (zh) * | 2005-03-25 | 2010-08-11 | 丽珠医药集团股份有限公司 | 取代的亚砜类化合物和其制备方法及用途 |
ES2375298T3 (es) | 2005-03-25 | 2012-02-28 | Livzon Pharmaceutical Group Inc. | Procedimiento para preparar derivados de sulfóxido sustituidos. |
WO2006120520A1 (en) * | 2005-05-06 | 2006-11-16 | Glenmark Pharmaceuticals Limited | Esomeprazole strontium salt, process for its preparation and pharmaceutical compositions containing same |
EP1907375B1 (en) * | 2005-06-08 | 2013-07-24 | LEK Pharmaceuticals d.d. | Crystalline solvate of omeprazole sodium |
US20070043085A1 (en) * | 2005-08-19 | 2007-02-22 | Glenmark Pharmaceuticals Limited | Process for the preparation of amorphous form of neutral esomeprazole |
CA2631919A1 (en) * | 2005-12-05 | 2007-06-14 | Astrazeneca Ab | New process for the preparation of esomeprazole non-salt form |
DE102005061720B3 (de) * | 2005-12-22 | 2006-10-19 | Ratiopharm Gmbh | Enantioselektive Herstellung von Benzimidazolderivaten und ihren Salzen |
EP1801110A1 (en) | 2005-12-22 | 2007-06-27 | KRKA, tovarna zdravil, d.d., Novo mesto | Esomeprazole arginine salt |
US7553857B2 (en) | 2005-12-23 | 2009-06-30 | Lek Pharmaceuticals D.D. | S-omeprazole magnesium |
ES2325336T3 (es) | 2005-12-28 | 2009-09-01 | Union Quimico-Farmaceutica, S.A. | Procedimiento para la preparacion del enantiomero (s) de omeprazol. |
CN1810803B (zh) * | 2006-02-17 | 2010-11-17 | 中国科学院上海有机化学研究所 | 高对映体选择性制备(s)-奥美拉唑的方法 |
US7579476B2 (en) * | 2006-02-24 | 2009-08-25 | Praktikatalyst Pharma, Llc | Transition metal mediated oxidation of hetero atoms in organic molecules coordinated to transition metals |
US8063074B2 (en) * | 2006-05-04 | 2011-11-22 | Dr. Reddy's Laboratories Limited | Polymorphic forms of esomeprazole sodium |
US7786309B2 (en) * | 2006-06-09 | 2010-08-31 | Apotex Pharmachem Inc. | Process for the preparation of esomeprazole and salts thereof |
JP2009542624A (ja) | 2006-07-05 | 2009-12-03 | ルピン・リミテッド | スルホキシド化合物の光学的に純粋な又は光学的に富化されたエナンチオマーの調製方法 |
EP2054403A1 (en) * | 2006-08-08 | 2009-05-06 | Jubilant Organosys Limited | Process for producing sulphoxide compounds |
JP5492417B2 (ja) | 2006-10-13 | 2014-05-14 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 胃酸分泌抑制作用を有するベンズイミダゾール化合物 |
JP2009196894A (ja) * | 2006-10-13 | 2009-09-03 | Eisai R & D Management Co Ltd | スルフィニルベンズイミダゾール化合物またはその塩の製造方法 |
EP1947099A1 (en) | 2007-01-18 | 2008-07-23 | LEK Pharmaceuticals D.D. | Process for solvent removal from omeprazole salts |
ES2532854T3 (es) | 2007-02-21 | 2015-04-01 | Cipla Limited | Proceso para la preparación de esomeprazol magnésico dihidrato |
WO2008149204A1 (en) * | 2007-06-07 | 2008-12-11 | Aurobindo Pharma Limited | An improved process for preparing an optically active proton pump inhibitor |
CN101323609B (zh) * | 2007-06-15 | 2013-05-01 | 成都福瑞生物工程有限公司 | 不对称氧化硫醚成亚砜合成对映体含量高的苯并咪唑衍生物的方法 |
US20100210848A1 (en) * | 2007-10-03 | 2010-08-19 | Ipca Laboratories Ltd. | Process for optically active sulfoxide compounds |
US8106210B2 (en) | 2007-10-08 | 2012-01-31 | Hetero Drugs Limited | Polymorphs of esomeprazole salts |
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FR2925899B1 (fr) * | 2007-12-27 | 2012-12-21 | Sidem Pharma Sa | Procede de preparation enantioselective de sulfoxydes. |
CN101492459B (zh) * | 2008-01-25 | 2011-04-27 | 山东轩竹医药科技有限公司 | 含烷氧乙酰基二氢异噁唑并吡啶化合物 |
CN101497603B (zh) * | 2008-01-30 | 2012-11-07 | 山东轩竹医药科技有限公司 | 含有被烷氧烷胺氧基取代的吡啶的苯并咪唑衍生物 |
GEP20125649B (en) | 2008-03-10 | 2012-09-25 | Takeda Pharmaceutical | Benzimidazole compound crystal |
US20110028518A1 (en) * | 2008-03-18 | 2011-02-03 | Dr. Reddy's Laboratories Ltd. | Dexlansoprazole process and polymorphs |
CN101538264A (zh) * | 2008-03-19 | 2009-09-23 | 中国科学院成都有机化学有限公司 | 手性亚砜类化合物的制备新方法 |
WO2009145368A1 (en) * | 2008-05-27 | 2009-12-03 | Sk Chemicals Co., Ltd. | Improved preparing method of (s)-omeprazole from omeprazole racemate using optical resolution agent |
EP2143722A1 (en) | 2008-07-09 | 2010-01-13 | Lek Pharmaceuticals D.D. | Process for preparation of esomeprazole sodium of high chemical purity and new forms of esomeprazole sodium |
US20100113527A1 (en) * | 2008-09-30 | 2010-05-06 | Teva Pharmaceutical Industries Ltd. | Crystalline forms of dexlansoprazole |
EP2264024A1 (en) | 2008-10-14 | 2010-12-22 | LEK Pharmaceuticals d.d. | Process for the preparation of enantiomerically enriched proton pump inhibitors |
IT1391776B1 (it) | 2008-11-18 | 2012-01-27 | Dipharma Francis Srl | Procedimento per la preparazione di dexlansoprazolo |
CZ200990A3 (cs) * | 2009-02-16 | 2010-08-25 | Zentiva, K.S. | Zpusob výroby (S)-5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazolu |
WO2010097583A1 (en) | 2009-02-24 | 2010-09-02 | Cipla Limited | Esomeprazole potassium polymorph and its preparation |
CZ2009172A3 (cs) * | 2009-03-17 | 2010-09-29 | Zentiva, K.S. | Zpusob výroby (S)-5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazolu |
WO2010150276A2 (en) * | 2009-06-02 | 2010-12-29 | Sun Pharmaceutical Industries Limited | Process for preparing sulphoxide compounds |
IT1395118B1 (it) | 2009-07-29 | 2012-09-05 | Dipharma Francis Srl | Procedimento per la preparazione di dexlansoprazolo cristallino |
US8748619B2 (en) | 2009-11-12 | 2014-06-10 | Hetero Research Foundation | Process for the resolution of omeprazole |
AU2011210328A1 (en) | 2010-01-29 | 2012-08-16 | Ranbaxy Laboratories Limited | Process for the preparation of crystalline forms of dexlansoprazole |
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WO2015155281A1 (en) | 2014-04-11 | 2015-10-15 | Sanovel Ilac Sanayi Ve Ticaret A.S. | Pharmaceutical combinations of dabigatran and proton pump inhibitors |
EP2980086B1 (en) | 2014-07-29 | 2016-06-15 | F.I.S.- Fabbrica Italiana Sintetici S.p.A. | Efficient process for the preparation of esomeprazole (S)-binol complex |
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CN110746428A (zh) * | 2019-10-29 | 2020-02-04 | 株洲千金药业股份有限公司 | 一种r型手性亚砜类化合物的制备方法 |
CN113845510A (zh) * | 2020-06-27 | 2021-12-28 | 鲁南制药集团股份有限公司 | 一种埃索美拉唑的制备方法 |
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SE7804231L (sv) * | 1978-04-14 | 1979-10-15 | Haessle Ab | Magsyrasekretionsmedel |
GB2189698A (en) * | 1986-04-30 | 1987-11-04 | Haessle Ab | Coated omeprazole tablets |
DE4035455A1 (de) * | 1990-11-08 | 1992-05-14 | Byk Gulden Lomberg Chem Fab | Enantiomerentrennung |
SE9301830D0 (sv) * | 1993-05-28 | 1993-05-28 | Ab Astra | New compounds |
SE504459C2 (sv) * | 1994-07-15 | 1997-02-17 | Astra Ab | Förfarande för framställning av substituerade sulfoxider |
GB9423970D0 (en) * | 1994-11-28 | 1995-01-11 | Astra Ab | Oxidation |
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