CN1157614A - 取代的亚砜类化合物的合成方法 - Google Patents
取代的亚砜类化合物的合成方法 Download PDFInfo
- Publication number
- CN1157614A CN1157614A CN95194956A CN95194956A CN1157614A CN 1157614 A CN1157614 A CN 1157614A CN 95194956 A CN95194956 A CN 95194956A CN 95194956 A CN95194956 A CN 95194956A CN 1157614 A CN1157614 A CN 1157614A
- Authority
- CN
- China
- Prior art keywords
- alkyl
- alkoxyl group
- het
- hydrogen
- arbitrary
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/28—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Description
Claims (33)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9402510A SE504459C2 (sv) | 1994-07-15 | 1994-07-15 | Förfarande för framställning av substituerade sulfoxider |
SE9402510-3 | 1994-07-15 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1157614A true CN1157614A (zh) | 1997-08-20 |
CN1070489C CN1070489C (zh) | 2001-09-05 |
Family
ID=20394753
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN95194956A Expired - Lifetime CN1070489C (zh) | 1994-07-15 | 1995-07-05 | 取代的亚砜类化合物的合成方法 |
Country Status (42)
Country | Link |
---|---|
US (1) | US5948789A (zh) |
EP (1) | EP0773940B2 (zh) |
JP (1) | JP3795917B2 (zh) |
KR (1) | KR100356252B1 (zh) |
CN (1) | CN1070489C (zh) |
AR (1) | AR003443A1 (zh) |
AT (1) | ATE242233T1 (zh) |
AU (1) | AU688074B2 (zh) |
BR (1) | BR9508292A (zh) |
CA (1) | CA2193994C (zh) |
CZ (1) | CZ297987B6 (zh) |
DE (1) | DE69530987T3 (zh) |
DK (1) | DK0773940T4 (zh) |
DZ (1) | DZ1911A1 (zh) |
EE (1) | EE03354B1 (zh) |
EG (1) | EG24534A (zh) |
ES (1) | ES2199998T5 (zh) |
FI (2) | FI117830B (zh) |
HK (1) | HK1008331A1 (zh) |
HR (1) | HRP950401B1 (zh) |
HU (1) | HU226361B1 (zh) |
IL (1) | IL114477A (zh) |
IS (1) | IS1772B (zh) |
MA (1) | MA23611A1 (zh) |
MX (1) | MX9700358A (zh) |
MY (1) | MY113180A (zh) |
NO (1) | NO312101B1 (zh) |
NZ (1) | NZ289959A (zh) |
PL (1) | PL186342B1 (zh) |
PT (1) | PT773940E (zh) |
RU (1) | RU2157806C2 (zh) |
SA (1) | SA95160294B1 (zh) |
SE (1) | SE504459C2 (zh) |
SI (1) | SI0773940T2 (zh) |
SK (1) | SK284059B6 (zh) |
TN (1) | TNSN95081A1 (zh) |
TR (1) | TR199500861A2 (zh) |
TW (1) | TW372971B (zh) |
UA (1) | UA47409C2 (zh) |
WO (1) | WO1996002535A1 (zh) |
YU (1) | YU49475B (zh) |
ZA (1) | ZA955724B (zh) |
Cited By (25)
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---|---|---|---|---|
WO2009114981A1 (en) * | 2008-03-19 | 2009-09-24 | Chengdu Likai Chiral Tech Co., Ltd | Process for preparing sulfoxide compounds |
CN101098867B (zh) * | 2005-03-25 | 2010-08-11 | 丽珠医药集团股份有限公司 | 取代的亚砜类化合物和其制备方法及用途 |
CN1810803B (zh) * | 2006-02-17 | 2010-11-17 | 中国科学院上海有机化学研究所 | 高对映体选择性制备(s)-奥美拉唑的方法 |
CN101914090A (zh) * | 2010-08-13 | 2010-12-15 | 埃斯特维华义制药有限公司 | 左旋奥美拉唑的制备方法 |
CN101977909A (zh) * | 2008-03-18 | 2011-02-16 | 雷迪博士实验室有限公司 | 右兰索拉唑方法和多晶型物 |
CN101492459B (zh) * | 2008-01-25 | 2011-04-27 | 山东轩竹医药科技有限公司 | 含烷氧乙酰基二氢异噁唑并吡啶化合物 |
CN102321071A (zh) * | 2011-07-20 | 2012-01-18 | 江苏奥赛康药业股份有限公司 | 一种高纯度埃索美拉唑钠的工业化生产方法 |
CN102329302A (zh) * | 2011-10-22 | 2012-01-25 | 刘强 | 一种埃索美拉唑及其盐的制备方法 |
CN102432412A (zh) * | 2011-10-28 | 2012-05-02 | 成都欣捷高新技术开发有限公司 | 一种手性亚砜类质子泵抑制剂或其可药用盐的制备方法 |
CN102558150A (zh) * | 2010-12-31 | 2012-07-11 | 江苏正大天晴药业股份有限公司 | 取代亚砜化合物的合成方法 |
CN102633776A (zh) * | 2012-03-28 | 2012-08-15 | 中山市仁合药业有限公司 | 一种埃索美拉唑及其钠盐的制备方法 |
CN102659763A (zh) * | 2012-04-27 | 2012-09-12 | 南京优科生物医药研究有限公司 | 一种右旋兰索拉唑合成与纯化的方法 |
CN102977076A (zh) * | 2011-09-02 | 2013-03-20 | 扬子江药业集团上海海尼药业有限公司 | 一种右兰索拉唑的制备方法 |
CN103044402A (zh) * | 2012-12-31 | 2013-04-17 | 康普药业股份有限公司 | 埃索美拉唑钠合成生产方法 |
CN103113351A (zh) * | 2013-03-08 | 2013-05-22 | 苏州特瑞药业有限公司 | 一种光学纯手性亚砜类化合物的制备方法 |
CN104610226A (zh) * | 2014-12-31 | 2015-05-13 | 广东东阳光药业有限公司 | 一种右兰索拉唑的不对称氧化方法 |
CN106083818A (zh) * | 2016-06-08 | 2016-11-09 | 扬子江药业集团有限公司 | 一种高纯度埃索美拉唑钠的制备方法 |
CN106366070A (zh) * | 2016-08-10 | 2017-02-01 | 上海万代制药有限公司 | 一种高纯度埃索美拉唑钠的制备方法 |
CN106632249A (zh) * | 2016-09-30 | 2017-05-10 | 青岛云天生物技术有限公司 | 一种制备(s)‑泮托拉唑钠的方法 |
CN106632248A (zh) * | 2016-09-30 | 2017-05-10 | 青岛云天生物技术有限公司 | 一种左旋泮托拉唑钠的制备工艺 |
CN106866630A (zh) * | 2017-04-01 | 2017-06-20 | 上海华源医药科技发展有限公司 | 一种右兰索拉唑的制备方法 |
CN107428726A (zh) * | 2014-12-26 | 2017-12-01 | 国立大学法人东京大学 | 光学活性的质子泵抑制剂化合物的制备方法 |
CN110698482A (zh) * | 2019-10-29 | 2020-01-17 | 株洲千金药业股份有限公司 | 一种s型手性亚砜类化合物的制备方法 |
CN110746428A (zh) * | 2019-10-29 | 2020-02-04 | 株洲千金药业股份有限公司 | 一种r型手性亚砜类化合物的制备方法 |
CN113845510A (zh) * | 2020-06-27 | 2021-12-28 | 鲁南制药集团股份有限公司 | 一种埃索美拉唑的制备方法 |
Families Citing this family (128)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE9301830D0 (sv) * | 1993-05-28 | 1993-05-28 | Ab Astra | New compounds |
US6875872B1 (en) | 1993-05-28 | 2005-04-05 | Astrazeneca | Compounds |
SE504459C2 (sv) * | 1994-07-15 | 1997-02-17 | Astra Ab | Förfarande för framställning av substituerade sulfoxider |
US6489346B1 (en) * | 1996-01-04 | 2002-12-03 | The Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and method of using same |
US5840737A (en) | 1996-01-04 | 1998-11-24 | The Curators Of The University Of Missouri | Omeprazole solution and method for using same |
US6645988B2 (en) | 1996-01-04 | 2003-11-11 | Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and method of using same |
US6699885B2 (en) * | 1996-01-04 | 2004-03-02 | The Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and methods of using same |
SE510650C2 (sv) * | 1997-05-30 | 1999-06-14 | Astra Ab | Ny förening |
US6747155B2 (en) | 1997-05-30 | 2004-06-08 | Astrazeneca Ab | Process |
SE510643C2 (sv) * | 1997-06-27 | 1999-06-14 | Astra Ab | Termodynamiskt stabil omeprazol natrium form B |
WO1999001454A1 (en) | 1997-07-03 | 1999-01-14 | Du Pont Pharmaceuticals Company | Imidazopyrimidines and imidazopyridines for the treatment of neurological disorders |
US6174548B1 (en) | 1998-08-28 | 2001-01-16 | Andrx Pharmaceuticals, Inc. | Omeprazole formulation |
SE9704183D0 (sv) | 1997-11-14 | 1997-11-14 | Astra Ab | New process |
US6096340A (en) * | 1997-11-14 | 2000-08-01 | Andrx Pharmaceuticals, Inc. | Omeprazole formulation |
WO1999038513A1 (en) * | 1998-01-30 | 1999-08-05 | Sepracor Inc. | R-lansoprazole compositions and methods |
AU3967399A (en) * | 1998-04-30 | 1999-11-16 | Sepracor, Inc. | S-rabeprazole compositions and methods |
EP1073332A4 (en) * | 1998-04-30 | 2005-06-15 | Sepracor Inc | R-RABEPRAZOL COMPOSITIONS AND METHODS |
US6365589B1 (en) | 1998-07-02 | 2002-04-02 | Bristol-Myers Squibb Pharma Company | Imidazo-pyridines, -pyridazines, and -triazines as corticotropin releasing factor antagonists |
US6733778B1 (en) | 1999-08-27 | 2004-05-11 | Andrx Pharmaceuticals, Inc. | Omeprazole formulation |
CN1087739C (zh) * | 1998-12-28 | 2002-07-17 | 中国科学院成都有机化学研究所 | 光学纯的苯并咪唑类抗消化性溃疡药物的包结拆分制备法 |
SE9900274D0 (sv) * | 1999-01-28 | 1999-01-28 | Astra Ab | New compound |
TWI275587B (en) | 1999-06-17 | 2007-03-11 | Takeda Chemical Industries Ltd | A crystal of (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]-1H-benzimidazole |
PT1191025E (pt) | 1999-06-30 | 2005-09-30 | Takeda Pharmaceutical | Cristais de lansoprazol |
WO2001014366A1 (fr) * | 1999-08-25 | 2001-03-01 | Takeda Chemical Industries, Ltd. | Procede de preparation de derives optiquement actifs de sulfoxyde |
US6268385B1 (en) | 1999-08-26 | 2001-07-31 | Robert R. Whittle | Dry blend pharmaceutical formulations |
US6312712B1 (en) | 1999-08-26 | 2001-11-06 | Robert R. Whittle | Method of improving bioavailability |
US6326384B1 (en) | 1999-08-26 | 2001-12-04 | Robert R. Whittle | Dry blend pharmaceutical unit dosage form |
US6369087B1 (en) | 1999-08-26 | 2002-04-09 | Robert R. Whittle | Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same |
US6780880B1 (en) | 1999-08-26 | 2004-08-24 | Robert R. Whittle | FT-Raman spectroscopic measurement |
US6262086B1 (en) | 1999-08-26 | 2001-07-17 | Robert R. Whittle | Pharmaceutical unit dosage form |
US6262085B1 (en) | 1999-08-26 | 2001-07-17 | Robert R. Whittle | Alkoxy substituted Benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same |
US6316020B1 (en) * | 1999-08-26 | 2001-11-13 | Robert R. Whittle | Pharmaceutical formulations |
US6312723B1 (en) | 1999-08-26 | 2001-11-06 | Robert R. Whittle | Pharmaceutical unit dosage form |
AU2001252595A1 (en) * | 2000-04-28 | 2001-11-12 | Takeda Chemical Industries Ltd. | Process for producing optically active sulfoxide derivative |
ES2511774T3 (es) | 2000-05-15 | 2014-10-23 | Takeda Pharmaceutical Company Limited | Formas cristalinas de (R)-lansoprazol |
KR100869677B1 (ko) | 2000-05-15 | 2008-11-21 | 다케다 야쿠힌 고교 가부시키가이샤 | 결정의 제조방법 |
WO2002012225A1 (fr) * | 2000-08-04 | 2002-02-14 | Takeda Chemical Industries, Ltd. | Sels de composé à base de benzimidazole et leurs applications |
DK1337525T3 (da) | 2000-12-01 | 2011-09-19 | Takeda Pharmaceutical | Fremgangsmåde til krystallisering af (R)- eller (S)-lansoprazol |
US7064214B2 (en) * | 2001-04-13 | 2006-06-20 | Apsinterm Llc | Methods of preparing sulfinamides and sulfoxides |
GB2376231A (en) * | 2001-06-06 | 2002-12-11 | Cipla Ltd | Benzimidazole-cyclodextrin inclusion complex |
MXPA04007169A (es) * | 2002-01-25 | 2004-10-29 | Santarus Inc | Suministro transmucosal de inhibidores de bomba de protones. |
ES2286408T3 (es) * | 2002-03-05 | 2007-12-01 | Astrazeneca Ab | Sales de alquilamonio de omeprazol e esomeprazol. |
AU2003262375A1 (en) * | 2002-04-22 | 2003-11-03 | Sun Pharmaceutical Industries Limited | Optically active substituted pyridinylmethyl-sulphinyl-benzimidazole and salts |
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EP1556043A1 (en) | 2002-10-22 | 2005-07-27 | Ranbaxy Laboratories, Ltd. | Amorphous form of esomeprazole salts |
DE10254167A1 (de) | 2002-11-20 | 2004-06-09 | Icon Genetics Ag | Verfahren zur Kontrolle von zellulären Prozessen in Pflanzen |
BR0316702A (pt) * | 2002-12-06 | 2005-10-18 | Altana Pharma Ag | xprocesso para preparação de (s)-pantoprazol |
PT1578742E (pt) * | 2002-12-06 | 2013-01-24 | Nycomed Gmbh | Processo para preparar compostos activos opticamente puros |
FR2848555B1 (fr) | 2002-12-16 | 2006-07-28 | Negma Gild | Enantiomere(-)du tenatoprazole et son application en therapeutique |
AR046245A1 (es) * | 2002-12-16 | 2005-11-30 | Ranbaxy Lab Ltd | Sales de calcio de rabeprazol |
WO2004056804A2 (en) | 2002-12-19 | 2004-07-08 | Teva Pharmaceutical Industries Ltd. | Solid states of pantoprazole sodium, processes for preparing them and processes for preparing known pantoprazole sodium hydrates |
WO2004060263A2 (en) * | 2003-01-07 | 2004-07-22 | Ranbaxy Laboratories Limited | Magnesium salt of imidazole derivative |
TWI367759B (en) * | 2003-02-20 | 2012-07-11 | Santarus Inc | A novel formulation, omeprazole antacid complex-immediate release, for rapid and sustained suppression of gastric acid |
BRPI0407906A (pt) * | 2003-02-28 | 2006-02-14 | Ranbaxy Lab Ltd | polimorfos de s-omeprazol |
WO2004080961A2 (en) * | 2003-03-12 | 2004-09-23 | Teva Pharmaceutical Industries Ltd. | Crystalline and amorphous solids of pantoprazole and processes for their preparation |
EP1611901B1 (en) * | 2003-03-13 | 2013-07-10 | Eisai R&D Management Co., Ltd. | Preventive or remedy for teeth grinding |
FR2852956B1 (fr) * | 2003-03-28 | 2006-08-04 | Negma Gild | Procede de preparation enantioselective de derives de sulfoxydes |
KR20060002878A (ko) * | 2003-03-28 | 2006-01-09 | 지뎀 파마 | 술폭시화물 유도체의 광학 선택적 제조 방법 |
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WO2006120520A1 (en) * | 2005-05-06 | 2006-11-16 | Glenmark Pharmaceuticals Limited | Esomeprazole strontium salt, process for its preparation and pharmaceutical compositions containing same |
ES2432563T3 (es) * | 2005-06-08 | 2013-12-04 | Lek Pharmaceuticals D.D. | Solvato cristalino de omeprazol sódico |
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