ECSP077212A - Derivativas de pirimidina fusionado y compuestos del mismo como moduladores de receptores cxcr3, útil en prevención y tratamiento de trastornos y enfermedades inmuno-reguladores y inflamatorios - Google Patents

Derivativas de pirimidina fusionado y compuestos del mismo como moduladores de receptores cxcr3, útil en prevención y tratamiento de trastornos y enfermedades inmuno-reguladores y inflamatorios

Info

Publication number
ECSP077212A
ECSP077212A EC2007007212A ECSP077212A ECSP077212A EC SP077212 A ECSP077212 A EC SP077212A EC 2007007212 A EC2007007212 A EC 2007007212A EC SP077212 A ECSP077212 A EC SP077212A EC SP077212 A ECSP077212 A EC SP077212A
Authority
EC
Ecuador
Prior art keywords
treatment
useful
immune
fusionated
regulatory
Prior art date
Application number
EC2007007212A
Other languages
English (en)
Inventor
Zice Fu
Michael G Johnson
An-Ron Li
Andrew P Marcus
Philippe Bergeron
Xiao Chen
Jeffrey Deignan
Xiaohui Du
Jason A Duquette
Darin Gustin
Julio C Medina
Jeffrey Mihalic
Jiwen Liu
Original Assignee
Amgen Sf Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35197976&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP077212(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Amgen Sf Llc filed Critical Amgen Sf Llc
Publication of ECSP077212A publication Critical patent/ECSP077212A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P11/02—Nasal agents, e.g. decongestants
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
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    • A61P17/00—Drugs for dermatological disorders
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    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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    • A61P19/00—Drugs for skeletal disorders
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    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
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    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • A61P37/08—Antiallergic agents
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/91—Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Un compuesto que es proporcionado teniendo la fórmula donde las variables Ra R1R2 R3 R4 A1 A4, y subíndice n como descritos aquí. El compuesto será útil en el tratamiento de condiciones y enfermedades inflamatorias e inmunes. La composición y métodos de tratamiento usando el compuesto son también proporcionados. Por ejemplo los métodos son útiles para el tratamiento de desordenes y enfermedades inflamatorias inmunes tales como esclerosis múltiples, artritis reumatoide, soriasis y enfermedad inflamatoria del intestino.
EC2007007212A 2004-06-28 2007-01-29 Derivativas de pirimidina fusionado y compuestos del mismo como moduladores de receptores cxcr3, útil en prevención y tratamiento de trastornos y enfermedades inmuno-reguladores y inflamatorios ECSP077212A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US58390104P 2004-06-28 2004-06-28

Publications (1)

Publication Number Publication Date
ECSP077212A true ECSP077212A (es) 2007-03-29

Family

ID=35197976

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2007007212A ECSP077212A (es) 2004-06-28 2007-01-29 Derivativas de pirimidina fusionado y compuestos del mismo como moduladores de receptores cxcr3, útil en prevención y tratamiento de trastornos y enfermedades inmuno-reguladores y inflamatorios

Country Status (19)

Country Link
US (1) US7939538B2 (es)
EP (1) EP1771447A1 (es)
JP (1) JP2008504301A (es)
KR (1) KR20070045203A (es)
CN (1) CN101006088A (es)
AR (1) AR049558A1 (es)
AU (1) AU2005260620A1 (es)
BR (1) BRPI0512703A (es)
CA (1) CA2572083A1 (es)
EA (1) EA011439B1 (es)
EC (1) ECSP077212A (es)
IL (1) IL180327A0 (es)
MA (1) MA28755B1 (es)
MX (1) MX2007000051A (es)
NO (1) NO20070484L (es)
TN (1) TNSN06430A1 (es)
TW (1) TW200611699A (es)
WO (1) WO2006004915A1 (es)
ZA (1) ZA200700752B (es)

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WO2006004915A1 (en) 2006-01-12
AU2005260620A1 (en) 2006-01-12
NO20070484L (no) 2007-03-26
US20060069099A1 (en) 2006-03-30
KR20070045203A (ko) 2007-05-02
CN101006088A (zh) 2007-07-25
JP2008504301A (ja) 2008-02-14
AR049558A1 (es) 2006-08-16
MX2007000051A (es) 2007-05-11
MA28755B1 (fr) 2007-07-02
EP1771447A1 (en) 2007-04-11
BRPI0512703A (pt) 2008-04-01
EA011439B1 (ru) 2009-02-27
TNSN06430A1 (en) 2008-02-22
CA2572083A1 (en) 2006-01-12
US7939538B2 (en) 2011-05-10
IL180327A0 (en) 2007-07-04
TW200611699A (en) 2006-04-16
EA200700169A1 (ru) 2007-08-31
ZA200700752B (en) 2008-09-25

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