EA200700169A1 - Конденсированные производные пиримидина и их композиции, применимые в качестве модуляторов cxcr3 рецепторов для профилактики и лечения воспалительных и иммунорегуляторных расстройств и заболеваний - Google Patents

Конденсированные производные пиримидина и их композиции, применимые в качестве модуляторов cxcr3 рецепторов для профилактики и лечения воспалительных и иммунорегуляторных расстройств и заболеваний

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Publication number
EA200700169A1
EA200700169A1 EA200700169A EA200700169A EA200700169A1 EA 200700169 A1 EA200700169 A1 EA 200700169A1 EA 200700169 A EA200700169 A EA 200700169A EA 200700169 A EA200700169 A EA 200700169A EA 200700169 A1 EA200700169 A1 EA 200700169A1
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EA
Eurasian Patent Office
Prior art keywords
treatment
inflammatory
diseases
disorders
immunodulatory
Prior art date
Application number
EA200700169A
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English (en)
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EA011439B1 (ru
Inventor
Цзыцэ Фу
Майкл Дж. Джонсон
Ань-Жун Ли
Эндрю П. Маркус
Хулио К. Медина
Филипп Бергерон
Сяоци Чэнь
Джеффри Дейгнан
Сяохой Ду
Джейсон А. Дукветт
Дарин Гастин
Джеффри Т. Михалик
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ЭМДЖЕН ЭсЭф ЭлЭлСи
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Application filed by ЭМДЖЕН ЭсЭф ЭлЭлСи filed Critical ЭМДЖЕН ЭсЭф ЭлЭлСи
Publication of EA200700169A1 publication Critical patent/EA200700169A1/ru
Publication of EA011439B1 publication Critical patent/EA011439B1/ru

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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Заявляются соединения представленной формулы, где переменные R, R, R, R, R, A, A, L, Q, Х и подстрочный индекс n принимают значения, определенные в описании. Представленные соединения применимы для лечения воспалительных и иммунных расстройств и заболеваний. Патентуются также композиции и способы лечения с использованием упомянутых соединений. Например, указанные способы применимы для лечения воспалительных и иммунных расстройств и заболеваний, таких как рассеянный склероз, ревматоидный артрит, псориаз и воспалительное заболевание кишечника.
EA200700169A 2004-06-28 2005-06-28 Конденсированные производные пиримидина и их композиции, применимые в качестве модуляторов cxcr3 рецепторов для профилактики и лечения воспалительных и иммунорегуляторных расстройств и заболеваний EA011439B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58390104P 2004-06-28 2004-06-28
PCT/US2005/023251 WO2006004915A1 (en) 2004-06-28 2005-06-28 Fused pyrimidine derivatives and compositions thereof as cxcr3 receptor modulators, useful in prevention and treatment of inflammatory and immunoregulatory disorders and diseases

Publications (2)

Publication Number Publication Date
EA200700169A1 true EA200700169A1 (ru) 2007-08-31
EA011439B1 EA011439B1 (ru) 2009-02-27

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EA200700169A EA011439B1 (ru) 2004-06-28 2005-06-28 Конденсированные производные пиримидина и их композиции, применимые в качестве модуляторов cxcr3 рецепторов для профилактики и лечения воспалительных и иммунорегуляторных расстройств и заболеваний

Country Status (19)

Country Link
US (1) US7939538B2 (ru)
EP (1) EP1771447A1 (ru)
JP (1) JP2008504301A (ru)
KR (1) KR20070045203A (ru)
CN (1) CN101006088A (ru)
AR (1) AR049558A1 (ru)
AU (1) AU2005260620A1 (ru)
BR (1) BRPI0512703A (ru)
CA (1) CA2572083A1 (ru)
EA (1) EA011439B1 (ru)
EC (1) ECSP077212A (ru)
IL (1) IL180327A0 (ru)
MA (1) MA28755B1 (ru)
MX (1) MX2007000051A (ru)
NO (1) NO20070484L (ru)
TN (1) TNSN06430A1 (ru)
TW (1) TW200611699A (ru)
WO (1) WO2006004915A1 (ru)
ZA (1) ZA200700752B (ru)

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BRPI0512703A (pt) 2008-04-01
ECSP077212A (es) 2007-03-29
NO20070484L (no) 2007-03-26
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CN101006088A (zh) 2007-07-25
AU2005260620A1 (en) 2006-01-12
AR049558A1 (es) 2006-08-16
US20060069099A1 (en) 2006-03-30
MX2007000051A (es) 2007-05-11
EA011439B1 (ru) 2009-02-27
EP1771447A1 (en) 2007-04-11
WO2006004915A1 (en) 2006-01-12
MA28755B1 (fr) 2007-07-02
CA2572083A1 (en) 2006-01-12
US7939538B2 (en) 2011-05-10
TW200611699A (en) 2006-04-16
TNSN06430A1 (en) 2008-02-22
ZA200700752B (en) 2008-09-25
IL180327A0 (en) 2007-07-04

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