EA202091979A1 - Кристаллические формы и способы получения кристаллических форм соединения - Google Patents

Кристаллические формы и способы получения кристаллических форм соединения

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Publication number
EA202091979A1
EA202091979A1 EA202091979A EA202091979A EA202091979A1 EA 202091979 A1 EA202091979 A1 EA 202091979A1 EA 202091979 A EA202091979 A EA 202091979A EA 202091979 A EA202091979 A EA 202091979A EA 202091979 A1 EA202091979 A1 EA 202091979A1
Authority
EA
Eurasian Patent Office
Prior art keywords
crystalline forms
crystalline form
solvate
methods
compounds
Prior art date
Application number
EA202091979A
Other languages
English (en)
Inventor
Брайан Лиан
Хироко Масамунэ
Джеффри Баркер
Original Assignee
Вайкинг Терапьютикс, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Вайкинг Терапьютикс, Инк. filed Critical Вайкинг Терапьютикс, Инк.
Publication of EA202091979A1 publication Critical patent/EA202091979A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/6574—Esters of oxyacids of phosphorus
    • C07F9/65742—Esters of oxyacids of phosphorus non-condensed with carbocyclic rings or heterocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/657163—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom
    • C07F9/657181—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom the ring phosphorus atom and, at least, one ring oxygen atom being part of a (thio)phosphonic acid derivative
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Abstract

В настоящей заявке раскрыты способы кристаллизации соединения формулы (I), a также его кристаллические формы. Раскрытые кристаллические формы соединения формулы (I) включают кристаллическую форму сольвата МТБЭ, кристаллическую форму сольвата толуола, кристаллическую форму сольвата этанола, кристаллическую форму сольвата ТГФ, кристаллическую форму сольвата этилацетата, кристаллическую форму сольвата ацетона и кристаллическую форму С.
EA202091979A 2018-03-22 2019-03-18 Кристаллические формы и способы получения кристаллических форм соединения EA202091979A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862646540P 2018-03-22 2018-03-22
PCT/US2019/022824 WO2019183004A1 (en) 2018-03-22 2019-03-18 Crystalline forms and methods of producing crystalline forms of a compound

Publications (1)

Publication Number Publication Date
EA202091979A1 true EA202091979A1 (ru) 2021-06-22

Family

ID=67987510

Family Applications (1)

Application Number Title Priority Date Filing Date
EA202091979A EA202091979A1 (ru) 2018-03-22 2019-03-18 Кристаллические формы и способы получения кристаллических форм соединения

Country Status (10)

Country Link
US (1) US11787828B2 (ru)
EP (1) EP3768690A4 (ru)
JP (2) JP2021518403A (ru)
KR (1) KR20200138283A (ru)
CN (1) CN112135832A (ru)
AU (1) AU2019238090A1 (ru)
CA (1) CA3094167A1 (ru)
EA (1) EA202091979A1 (ru)
MX (1) MX2020009843A (ru)
WO (1) WO2019183004A1 (ru)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11752161B2 (en) 2020-03-27 2023-09-12 Gannex Pharma Co., Ltd. Pharmaceutical compositions, method of making and method of using thereof
AU2021244791B2 (en) 2020-03-27 2024-02-15 Gannex Pharma Co., Ltd. Pharmaceutical compositions, method of making and method of using thereof
CN114315902A (zh) * 2020-09-30 2022-04-12 甘莱制药有限公司 一种甲状腺激素β受体激动剂的晶体及其制备方法和用途
JP2023543612A (ja) * 2020-09-30 2023-10-17 ガンネックス ファーマ カンパニー リミテッド 甲状腺ホルモンβ受容体作動薬の結晶、その調製方法、およびその使用

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AU2019238090A1 (en) 2020-10-08
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