EA202190989A1 - Новый способ синтеза производных пиперазинил-этокси-бромфенила и их применение в получении содержащих их соединений - Google Patents

Новый способ синтеза производных пиперазинил-этокси-бромфенила и их применение в получении содержащих их соединений

Info

Publication number
EA202190989A1
EA202190989A1 EA202190989A EA202190989A EA202190989A1 EA 202190989 A1 EA202190989 A1 EA 202190989A1 EA 202190989 A EA202190989 A EA 202190989A EA 202190989 A EA202190989 A EA 202190989A EA 202190989 A1 EA202190989 A1 EA 202190989A1
Authority
EA
Eurasian Patent Office
Prior art keywords
synthesis
bromphenyl
piperazinyl
ethoxy
derivatives
Prior art date
Application number
EA202190989A
Other languages
English (en)
Inventor
Луи-Филипп Борегар
Марсьяль Бертран
Паскалль Жигер
Кристоф Ардуэн
Бруно Скьяви
Original Assignee
Ле Лаборатуар Сервье
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ле Лаборатуар Сервье filed Critical Ле Лаборатуар Сервье
Publication of EA202190989A1 publication Critical patent/EA202190989A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines

Abstract

Способ промышленного синтеза соединения формулы (I).
EA202190989A 2018-10-15 2019-10-14 Новый способ синтеза производных пиперазинил-этокси-бромфенила и их применение в получении содержащих их соединений EA202190989A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP18306354 2018-10-15
PCT/EP2019/077729 WO2020078875A1 (en) 2018-10-15 2019-10-14 New process for the synthesis of piperazinyl-ethoxy-bromophenyl derivates and their application in the production of compounds containing them

Publications (1)

Publication Number Publication Date
EA202190989A1 true EA202190989A1 (ru) 2021-07-05

Family

ID=63965576

Family Applications (1)

Application Number Title Priority Date Filing Date
EA202190989A EA202190989A1 (ru) 2018-10-15 2019-10-14 Новый способ синтеза производных пиперазинил-этокси-бромфенила и их применение в получении содержащих их соединений

Country Status (15)

Country Link
US (1) US11512062B2 (ru)
EP (1) EP3867233A1 (ru)
JP (1) JP7448532B2 (ru)
KR (1) KR20210076094A (ru)
CN (1) CN112930340A (ru)
AR (1) AR116635A1 (ru)
AU (1) AU2019362310A1 (ru)
BR (1) BR112021006467A2 (ru)
CA (1) CA3115608A1 (ru)
EA (1) EA202190989A1 (ru)
IL (1) IL282094A (ru)
MA (1) MA53897A (ru)
MX (1) MX2021004288A (ru)
TW (1) TW202033506A (ru)
WO (1) WO2020078875A1 (ru)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2022291381A1 (en) 2021-06-11 2023-11-30 Gilead Sciences, Inc. Combination mcl-1 inhibitors with anti-cancer agents
EP4351657A1 (en) 2021-06-11 2024-04-17 Gilead Sciences, Inc. Combination mcl-1 inhibitors with anti-body drug conjugates

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US4401824A (en) * 1982-03-08 1983-08-30 The Upjohn Company Benzopyran compounds, derivatives of prostaglandins
US6867203B2 (en) * 1998-12-29 2005-03-15 Abbott Laboratories Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds
GB0500029D0 (en) * 2005-01-04 2005-02-09 Univ Belfast Basic ionic liquids
US7759337B2 (en) * 2005-03-03 2010-07-20 Amgen Inc. Phthalazine compounds and methods of use
CN101304976A (zh) * 2005-10-11 2008-11-12 因特蒙公司 病毒复制抑制剂
TW201107302A (en) * 2009-06-26 2011-03-01 Glaxo Group Ltd Compounds
CN102596949B (zh) * 2009-11-11 2015-08-19 大日本住友制药株式会社 8-氮杂双环[3.2.1]辛烷-8-甲酰胺衍生物
AU2012271279B2 (en) * 2011-06-17 2016-11-03 Fluidic, Inc. Synthesis of hetero ionic compounds using dialkylcarbonate quaternization
TWI464242B (zh) * 2012-10-26 2014-12-11 Ind Tech Res Inst 負介電異方性液晶化合物、液晶顯示器、與光電裝置
KR102006994B1 (ko) * 2013-03-28 2019-08-02 주식회사 삼양사 신규 페난트렌 화합물, 이의 제조방법 및 이를 이용한 유기전자소자
WO2015024203A1 (en) * 2013-08-20 2015-02-26 Leo Pharma A/S Novel neurokinin 1 receptor antagonist compounds ii
FR3015483B1 (fr) * 2013-12-23 2016-01-01 Servier Lab Nouveaux derives de thienopyrimidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
MD20160112A2 (ru) * 2014-04-25 2017-06-30 Pfizer Inc. Гетероароматические соединения и их применение в качестве лигандов дофамина D1
EP3151833A4 (en) * 2014-06-04 2018-01-10 Thomas Helledays Stiftelse För Medicinsk Forskning Mth1 inhibitors for treatment of inflammatory and autoimmune conditions
FR3037959B1 (fr) 2015-06-23 2017-08-04 Servier Lab Nouveaux derives bicycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR3037956B1 (fr) 2015-06-23 2017-08-04 Servier Lab Nouveaux derives d'acide amine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR3037958B1 (fr) 2015-06-23 2019-01-25 Les Laboratoires Servier Nouveaux derives d'hydroxy-acide, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR3046792B1 (fr) 2016-01-19 2018-02-02 Les Laboratoires Servier Nouveaux derives d'ammonium, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US10106553B2 (en) * 2016-04-11 2018-10-23 Janssen Pharmaceutica Nv Substituted benzothiophenyl derivatives as GPR40 agonists for the treatment of type II diabetes
KR101891263B1 (ko) * 2016-07-20 2018-08-23 주식회사 엘지화학 신규한 헤테로고리 화합물 및 이를 포함하는 유기발광 소자
LT3532067T (lt) * 2016-10-28 2022-08-25 Les Laboratoires Servier Liposominė vaisto forma, skirta naudoti gydant vėžį
CN107573360B (zh) * 2017-10-27 2019-08-09 都创(上海)医药科技有限公司 一种多靶点小分子化合物s63845的制备方法

Also Published As

Publication number Publication date
EP3867233A1 (en) 2021-08-25
US11512062B2 (en) 2022-11-29
CN112930340A (zh) 2021-06-08
MX2021004288A (es) 2021-05-31
BR112021006467A2 (pt) 2021-07-13
JP2022512694A (ja) 2022-02-07
IL282094A (en) 2021-05-31
AR116635A1 (es) 2021-05-26
AU2019362310A1 (en) 2021-05-13
WO2020078875A1 (en) 2020-04-23
KR20210076094A (ko) 2021-06-23
US20210380549A1 (en) 2021-12-09
TW202033506A (zh) 2020-09-16
JP7448532B2 (ja) 2024-03-12
MA53897A (fr) 2022-01-19
CA3115608A1 (en) 2020-04-23

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