EA201992147A1 - Ингибиторы тирозинкиназы брутона - Google Patents

Ингибиторы тирозинкиназы брутона

Info

Publication number
EA201992147A1
EA201992147A1 EA201992147A EA201992147A EA201992147A1 EA 201992147 A1 EA201992147 A1 EA 201992147A1 EA 201992147 A EA201992147 A EA 201992147A EA 201992147 A EA201992147 A EA 201992147A EA 201992147 A1 EA201992147 A1 EA 201992147A1
Authority
EA
Eurasian Patent Office
Prior art keywords
bruton
inhibitors
tyrosinkinase
tyrosinkinase inhibitors
btk
Prior art date
Application number
EA201992147A
Other languages
English (en)
Inventor
Ксибин Лиао
Джиа Ли
Джижиан Лю
Юубо Жоу
Анхуи Гао
Original Assignee
Сужоу Байджибугонг Фрамасьютикал Текнолоджи Ко.Лтд
Ксибин Лиао
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Сужоу Байджибугонг Фрамасьютикал Текнолоджи Ко.Лтд, Ксибин Лиао filed Critical Сужоу Байджибугонг Фрамасьютикал Текнолоджи Ко.Лтд
Publication of EA201992147A1 publication Critical patent/EA201992147A1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Abstract

Ингибиторы тирозинкиназы Брутона (Btk) имеют следующую формулу (I):
EA201992147A 2017-03-22 2018-03-21 Ингибиторы тирозинкиназы брутона EA201992147A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762474686P 2017-03-22 2017-03-22
PCT/US2018/023455 WO2018175512A1 (en) 2017-03-22 2018-03-21 Bruton's tyrosine kinase inhibitors

Publications (1)

Publication Number Publication Date
EA201992147A1 true EA201992147A1 (ru) 2020-02-20

Family

ID=63585694

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201992147A EA201992147A1 (ru) 2017-03-22 2018-03-21 Ингибиторы тирозинкиназы брутона

Country Status (13)

Country Link
US (3) US11554118B2 (ru)
EP (1) EP3601264A4 (ru)
JP (1) JP7219902B2 (ru)
KR (1) KR102627756B1 (ru)
CN (1) CN110494433B (ru)
AU (1) AU2018237123B2 (ru)
BR (1) BR112019019588A2 (ru)
CA (1) CA3055602A1 (ru)
EA (1) EA201992147A1 (ru)
IL (1) IL269152B2 (ru)
MX (1) MX2019011116A (ru)
WO (1) WO2018175512A1 (ru)
ZA (1) ZA201906887B (ru)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2018237123B2 (en) * 2017-03-22 2022-08-04 Xibin Liao Bruton's tyrosine kinase inhibitors
CN113365631A (zh) * 2019-01-18 2021-09-07 杭州邦顺制药有限公司 布鲁顿酪氨酸激酶抑制剂
AU2020242287A1 (en) 2019-03-21 2021-09-02 INSERM (Institut National de la Santé et de la Recherche Médicale) A Dbait molecule in combination with kinase inhibitor for the treatment of cancer
US20220259181A1 (en) 2019-05-10 2022-08-18 Henan Zhiwei Biomedicine Co., Ltd. Substituted 1-amino-1h-imidazole-5-carboxamide as bruton's tyrosine kinase inhibitors
WO2021089791A1 (en) 2019-11-08 2021-05-14 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the treatment of cancers that have acquired resistance to kinase inhibitors
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
CN111471048B (zh) * 2020-04-30 2021-06-15 成都海博为药业有限公司 一种具有含氮桥环、螺环或并环结构的化合物及其用途
CN115073468B (zh) * 2021-03-15 2023-12-22 药雅科技(上海)有限公司 咪唑并吡嗪类btk抑制剂的制备及用途
WO2022228302A1 (en) * 2021-04-25 2022-11-03 Bionova Pharmaceuticals (Shanghai) Limited Heteroaromatic carboxamide compounds and its use

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003290333A1 (en) * 2002-12-24 2004-07-22 Biofocus Plc Compound libraries of imidazo(1,5-a)pyridin-3-yl derivatives and related heterobicycles for targetting compounds capable of binding to g-protein coupled receptors
JP2007504220A (ja) * 2003-09-03 2007-03-01 ガラパゴス・エヌブイ イミダゾ［１，５−ａ］ピリジン又はイミダゾ［１，５−ａ］ピペリジン誘導体および５ＨＴ２Ａ受容体関連障害に対する薬剤の製造のためのその使用
WO2008022060A2 (en) * 2006-08-14 2008-02-21 Novartis Ag Imidazo-pyridine derivatives for modulating protein kinase activity
KR101315610B1 (ko) 2006-09-22 2013-10-10 파마시클릭스, 인코포레이티드 브루톤 티로신 키나제 억제제
CA2874756C (en) 2007-03-28 2018-05-29 Pharmacyclics, Inc. Inhibitors of bruton's tyrosine kinase
ES2396613T3 (es) 2008-05-19 2013-02-22 OSI Pharmaceuticals, LLC Imidazopirazinas e imidazotriazinas sustituidas
MX2012009208A (es) * 2010-02-08 2012-09-07 Msd Oss Bv Compuestos de 8-metil-1-fenil-imidazol[1, 5-a]pirazina.
EP2691392A1 (en) * 2011-03-31 2014-02-05 EMBLEM Technology Transfer GmbH Imidazo [1,2-a]pyridine compounds for use in therapy
GB2486038B (en) * 2011-06-28 2013-09-25 Andrew Levine Speech-to-text conversion
JP2014522860A (ja) 2011-07-19 2014-09-08 メルク・シャープ・アンド・ドーム・ベー・フェー Ｂｔｋ阻害剤としての４−イミダゾピリダジン−１−イル−ベンズアミドおよび４−イミダゾトリアジン−１−イル−ベンズアミド
ES2950569T3 (es) * 2011-07-19 2023-10-11 Merck Sharp & Dohme (S)-4-(8-amino-3-(1-(but-2-inoil)pirrolidin-2-il)imidazo[1,5-a]pirazin-1-il)-2-metoxi-n-(piridin-2-il)benzamida como inhibidor de la Btk
EP2548877A1 (en) * 2011-07-19 2013-01-23 MSD Oss B.V. 4-(5-Membered fused pyridinyl)benzamides as BTK-inhibitors
FR2985185B1 (fr) * 2012-01-04 2013-12-27 Sanofi Sa Utilisation en therapeutique de derives d'imidazopyridine
EP2809673B1 (en) * 2012-01-31 2016-11-02 Nanjing Allgen Pharma Co. Ltd. Spirocyclic molecules as bruton's tyrosine kinase inhibitors
WO2014113942A1 (en) * 2013-01-23 2014-07-31 Merck Sharp & Dohme Corp. Btk inhibitors
US20140206681A1 (en) * 2013-01-23 2014-07-24 Ronald M. Kim Btk inhibitors
TW201512173A (zh) * 2013-08-22 2015-04-01 Hoffmann La Roche 炔基醇及其使用方法
WO2015057992A1 (en) * 2013-10-16 2015-04-23 Izumi Raquel Btk inhibitors for hematopoietic mobilization
WO2015157955A1 (en) * 2014-04-17 2015-10-22 Abbvie Inc. Heterocyclic btk inhibit ors
CN105017256A (zh) 2014-04-29 2015-11-04 浙江导明医药科技有限公司 多氟化合物作为布鲁顿酪氨酸激酶抑制剂
WO2016106623A1 (en) * 2014-12-31 2016-07-07 Merck Sharp & Dohme Corp. Benzamide imidazopyrazine btk inhibitors
WO2016106626A1 (en) 2014-12-31 2016-07-07 Merck Sharp & Dohme Corp. Imidazopyrazine analogs with 3-tertiary carbon substitutions as btk inhibitors
WO2016106652A1 (en) * 2014-12-31 2016-07-07 Merck Sharp & Dohme Corp. Biarylether imidazopyrazine btk inhibitors
MA41614A (fr) * 2015-02-25 2018-01-02 Alios Biopharma Inc Composés antiviraux
EP3313839A1 (en) * 2015-06-24 2018-05-02 Principia Biopharma Inc. Tyrosine kinase inhibitors
US20190008859A1 (en) * 2015-08-21 2019-01-10 Acerta Pharma B.V. Therapeutic Combinations of a MEK Inhibitor and a BTK Inhibitor
CN106478633A (zh) * 2015-08-27 2017-03-08 正大天晴药业集团股份有限公司 一类布鲁顿酪氨酸激酶抑制剂
US20170071962A1 (en) 2015-09-11 2017-03-16 Acerta Pharma B.V. Therapeutic Combinations of a Proteasome Inhibitor and a BTK Inhibitor
US20170035881A1 (en) * 2015-10-19 2017-02-09 Acerta Pharma B.V. Therapeutic Combinations of an IRAK4 Inhibitor and a BTK Inhibitor
EP3371189A1 (en) * 2015-11-06 2018-09-12 Acerta Pharma B.V. Imidazopyrazine inhibitors of bruton's tyrosine kinase
JP6972002B2 (ja) 2016-03-11 2021-11-24 エンジェル・ファーマシューティカル・カンパニー・リミテッド ブルトン型チロシンキナーゼを調節する化合物及び方法
JP6715357B2 (ja) * 2016-06-30 2020-07-01 杭州三因泰医薬科技有限公司Ｈａｎｇｚｈｏｕ Ｓａｎｙｉｎｔａｉ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏ．， Ｌｔｄ． イミダゾピリジンアミンフェニル誘導体およびその使用
JP6737952B2 (ja) * 2016-08-17 2020-08-12 深▲セン▼市塔吉瑞生物医▲薬▼有限公司Ｓｈｅｎｚｈｅｎ ＴａｒｇｅｔＲｘ，Ｉｎｃ． チロシンキナーゼ活性を阻害するための縮合二環式化合物
AU2018237123B2 (en) * 2017-03-22 2022-08-04 Xibin Liao Bruton's tyrosine kinase inhibitors

Also Published As

Publication number Publication date
CN110494433B (zh) 2023-03-17
US20210107903A1 (en) 2021-04-15
AU2018237123B2 (en) 2022-08-04
EP3601264A4 (en) 2021-03-24
IL269152A (en) 2019-11-28
CN110494433A (zh) 2019-11-22
JP7219902B2 (ja) 2023-02-09
US11554118B2 (en) 2023-01-17
IL269152B2 (en) 2023-11-01
KR102627756B1 (ko) 2024-01-23
EP3601264A1 (en) 2020-02-05
US20210121458A1 (en) 2021-04-29
MX2019011116A (es) 2020-02-05
KR20190133199A (ko) 2019-12-02
US20190275037A1 (en) 2019-09-12
BR112019019588A2 (pt) 2020-04-22
US11974999B2 (en) 2024-05-07
WO2018175512A1 (en) 2018-09-27
US10933063B2 (en) 2021-03-02
AU2018237123A1 (en) 2019-10-10
ZA201906887B (en) 2022-03-30
CA3055602A1 (en) 2018-09-27
IL269152B1 (en) 2023-07-01
JP2020511547A (ja) 2020-04-16

Similar Documents

Publication Publication Date Title
EA201992147A1 (ru) Ингибиторы тирозинкиназы брутона
MX2018008815A (es) Inhibidores de tirosina quinasa de bruton.
EA201891024A1 (ru) Соединения-ингибиторы tank-связывающей киназы
CL2022000448A1 (es) Autoinyector (divisional solicitud no. 201903061)
EA201991697A1 (ru) Сульфоксиминовые ингибиторы гликозидазы
CO2019003709A2 (es) Conjugados de pirrolobenzodiazepina
CY1120517T1 (el) Διαρυλικες ενωσεις χρησιμες για την αγωγη ανθρωπινων νοσων στην ογκολογια, νευρολογια και ανοσολογια
EA201790271A1 (ru) Ингибиторы гликозидазы
MX2016015862A (es) Compuestos inhibidores de la cinasa de union a tank.
TN2017000544A1 (en) 1,1,1-trifluoro-3-hydroxypropan-2-yl carbamate derivatives and 1,1,1-trifluoro-4-hydroxybutan-2-yl carbamate derivatives as magl inhibitors
EA201790649A1 (ru) Бензилзамещенные индазолы в качестве ингибиторов bub 1
PH12020500655A1 (en) Compounds
EA201790395A1 (ru) Производные аминотриазина, подходящие для применения в качестве соединений-ингибиторов tank-связывающей киназы
CY1123263T1 (el) Πολυκυκλικες ενωσεις ως αναστολεις κινασης τυροσινης bruton
MX2016015565A (es) Ciertos inhibidores de la proteina quinasa.
CL2017002856A1 (es) Compuestos de tioéter como inhibidores de la nitrificación
BR112018012177A2 (pt) ?moduladores de hidantação de canais kv 3?
EA201990400A1 (ru) Соединения и композиции и их применение
MX2018007084A (es) Inhibidores de la tirosina quinasa de bruton y metodos de su uso.
EA201690523A1 (ru) Триазолопиридины, композиции и способы их применения
EA201992259A1 (ru) Замещенные n-(1,3,4-оксадиазол-2-ил)арилкарбоксамиды и их применение в качестве гербицидов
MA52629A (fr) Agents inhibiteurs de la tyrosine kinase de bruton
CR20150417A (es) Compuestos de azetidiniloxifenilpirrolidina
EA202191051A1 (ru) Ингибитор аврора-киназы a для применения для лечения нейробластомы
EA201790687A1 (ru) Хинолинкарбоксамиды для применения в лечении множественной миеломы