EA201790649A1 - Бензилзамещенные индазолы в качестве ингибиторов bub 1 - Google Patents

Бензилзамещенные индазолы в качестве ингибиторов bub 1

Info

Publication number
EA201790649A1
EA201790649A1 EA201790649A EA201790649A EA201790649A1 EA 201790649 A1 EA201790649 A1 EA 201790649A1 EA 201790649 A EA201790649 A EA 201790649A EA 201790649 A EA201790649 A EA 201790649A EA 201790649 A1 EA201790649 A1 EA 201790649A1
Authority
EA
Eurasian Patent Office
Prior art keywords
benze
bub
inhibitors
substituted indazoles
indazoles
Prior art date
Application number
EA201790649A
Other languages
English (en)
Other versions
EA032401B1 (ru
Inventor
Анне Менгель
Ханс-Георг Лерхен
Манфред Мёвес
Томас Мюллер
Ларс Берфаккер
Марион Хитчкок
Арвед Клеве
Йоахим Кунке
Ханс Брим
Герхард Зимайстер
Вильхельм Боне
Амаури-Эрнесто Фернандес-Монтальван
Йенс Шрёдер
Урсула Мённинг
Зимон Хольтон
Original Assignee
Байер Фарма Акциенгезельшафт
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Байер Фарма Акциенгезельшафт filed Critical Байер Фарма Акциенгезельшафт
Publication of EA201790649A1 publication Critical patent/EA201790649A1/ru
Publication of EA032401B1 publication Critical patent/EA032401B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Abstract

Соединения формулы (I)в соответствии с определением в настоящей заявке и их применение в качестве лекарственных препаратов.
EA201790649A 2014-09-19 2015-09-17 Бензилзамещенные индазолы в качестве ингибиторов bub1 EA032401B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14185604 2014-09-19
EP15176903 2015-07-15
PCT/EP2015/071340 WO2016042084A1 (en) 2014-09-19 2015-09-17 Benzyl substituted indazoles as bub1 inhibitors

Publications (2)

Publication Number Publication Date
EA201790649A1 true EA201790649A1 (ru) 2017-09-29
EA032401B1 EA032401B1 (ru) 2019-05-31

Family

ID=54140475

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201790649A EA032401B1 (ru) 2014-09-19 2015-09-17 Бензилзамещенные индазолы в качестве ингибиторов bub1

Country Status (27)

Country Link
US (1) US10350206B2 (ru)
EP (1) EP3194379A1 (ru)
JP (1) JP6664385B2 (ru)
KR (1) KR20170049604A (ru)
CN (1) CN107001331A (ru)
AP (1) AP2017009803A0 (ru)
AU (1) AU2015316796A1 (ru)
BR (1) BR112017005444A2 (ru)
CA (1) CA2961589A1 (ru)
CL (1) CL2017000654A1 (ru)
CO (1) CO2017002532A2 (ru)
CR (1) CR20170100A (ru)
CU (1) CU20170029A7 (ru)
DO (1) DOP2017000078A (ru)
EA (1) EA032401B1 (ru)
EC (1) ECSP17016797A (ru)
IL (1) IL251071A0 (ru)
MA (1) MA39484A (ru)
MX (1) MX2017003664A (ru)
NI (1) NI201700034A (ru)
PE (1) PE20170697A1 (ru)
PH (1) PH12017500509A1 (ru)
SG (1) SG11201702082VA (ru)
TN (1) TN2017000092A1 (ru)
TW (1) TW201615636A (ru)
UY (1) UY36311A (ru)
WO (1) WO2016042084A1 (ru)

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EA202092649A1 (ru) 2018-05-04 2021-06-21 Инсайт Корпорейшн Соли ингибитора fgfr
US11466004B2 (en) 2018-05-04 2022-10-11 Incyte Corporation Solid forms of an FGFR inhibitor and processes for preparing the same
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Also Published As

Publication number Publication date
ECSP17016797A (es) 2017-05-31
NI201700034A (es) 2017-06-16
PH12017500509A1 (en) 2017-08-30
CN107001331A (zh) 2017-08-01
JP6664385B2 (ja) 2020-03-13
PE20170697A1 (es) 2017-06-24
WO2016042084A1 (en) 2016-03-24
BR112017005444A2 (pt) 2018-04-24
CA2961589A1 (en) 2016-03-24
US10350206B2 (en) 2019-07-16
JP2017530962A (ja) 2017-10-19
KR20170049604A (ko) 2017-05-10
CO2017002532A2 (es) 2017-07-11
EP3194379A1 (en) 2017-07-26
CR20170100A (es) 2017-04-24
SG11201702082VA (en) 2017-04-27
AP2017009803A0 (en) 2017-03-31
EA032401B1 (ru) 2019-05-31
MX2017003664A (es) 2017-07-13
CL2017000654A1 (es) 2017-12-11
CU20170029A7 (es) 2017-08-08
IL251071A0 (en) 2017-04-30
TW201615636A (zh) 2016-05-01
TN2017000092A1 (en) 2018-07-04
DOP2017000078A (es) 2017-06-30
UY36311A (es) 2016-04-29
US20170273980A1 (en) 2017-09-28
MA39484A (fr) 2016-03-24
AU2015316796A1 (en) 2017-03-30

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