MX2016015862A - Compuestos inhibidores de la cinasa de union a tank. - Google Patents
Compuestos inhibidores de la cinasa de union a tank.Info
- Publication number
- MX2016015862A MX2016015862A MX2016015862A MX2016015862A MX2016015862A MX 2016015862 A MX2016015862 A MX 2016015862A MX 2016015862 A MX2016015862 A MX 2016015862A MX 2016015862 A MX2016015862 A MX 2016015862A MX 2016015862 A MX2016015862 A MX 2016015862A
- Authority
- MX
- Mexico
- Prior art keywords
- tank
- kinase inhibitor
- inhibitor compounds
- binding kinase
- binding
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Abstract
Se divulgan compuestos que tienen la siguiente fórmula (I) y métodos de su uso y preparación: (ver Fórmula).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462007322P | 2014-06-03 | 2014-06-03 | |
PCT/US2015/033769 WO2015187684A1 (en) | 2014-06-03 | 2015-06-02 | Tank-binding kinase inhibitor compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2016015862A true MX2016015862A (es) | 2017-03-27 |
Family
ID=53546688
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2016015862A MX2016015862A (es) | 2014-06-03 | 2015-06-02 | Compuestos inhibidores de la cinasa de union a tank. |
Country Status (19)
Country | Link |
---|---|
US (2) | US10072001B2 (es) |
EP (1) | EP3152210B1 (es) |
JP (2) | JP6378785B2 (es) |
KR (2) | KR20180131640A (es) |
CN (1) | CN106459044A (es) |
AR (1) | AR100702A1 (es) |
AU (2) | AU2015271837B2 (es) |
BR (1) | BR112016028288A2 (es) |
CA (1) | CA2951126A1 (es) |
EA (1) | EA031757B1 (es) |
ES (1) | ES2961577T3 (es) |
HK (1) | HK1231475A1 (es) |
IL (1) | IL248888A0 (es) |
MA (1) | MA40058A (es) |
MX (1) | MX2016015862A (es) |
NZ (1) | NZ726317A (es) |
SG (1) | SG11201609570SA (es) |
TW (1) | TW201613916A (es) |
WO (1) | WO2015187684A1 (es) |
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GB201311888D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
GB201311891D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compound |
TW201613916A (en) | 2014-06-03 | 2016-04-16 | Gilead Sciences Inc | TANK-binding kinase inhibitor compounds |
US10071164B2 (en) | 2014-08-11 | 2018-09-11 | Yale University | Estrogen-related receptor alpha based protac compounds and associated methods of use |
SG11201701724VA (en) | 2014-09-26 | 2017-04-27 | Gilead Sciences Inc | Aminotriazine derivatives useful as tank-binding kinase inhibitor compounds |
WO2016077595A1 (en) | 2014-11-12 | 2016-05-19 | The General Hospital Corporation | Methods for treating neurodegenerative diseases |
KR20230119040A (ko) | 2015-01-20 | 2023-08-14 | 아비나스 오퍼레이션스, 인코포레이티드 | 안드로겐 수용체의 표적화된 분해를 위한 화합물 및방법 |
US20170327469A1 (en) | 2015-01-20 | 2017-11-16 | Arvinas, Inc. | Compounds and methods for the targeted degradation of androgen receptor |
BR112017019751A2 (pt) | 2015-03-18 | 2018-05-29 | Arvinas Inc | composto bifuncional, composição farmacêutica, e, métodos para tratar ou prevenir uma doença ou um distúrbio, e para degradar uma proteína alvo em uma célula |
EP3302482A4 (en) | 2015-06-05 | 2018-12-19 | Arvinas, Inc. | Tank-binding kinase-1 protacs and associated methods of use |
WO2017030814A1 (en) | 2015-08-19 | 2017-02-23 | Arvinas, Inc. | Compounds and methods for the targeted degradation of bromodomain-containing proteins |
WO2017064217A1 (en) * | 2015-10-13 | 2017-04-20 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Sibiriline derivatives for use for preventing and/or treating disorders associated with cellular necroptosis |
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JP2019500368A (ja) | 2015-12-17 | 2019-01-10 | ギリアード サイエンシーズ, インコーポレイテッド | Tank結合キナーゼ阻害剤化合物 |
US10894784B2 (en) | 2015-12-18 | 2021-01-19 | Bayer Pharma Aktiengesellschaft | Heteroarylbenzimidazole compounds |
WO2017173451A1 (en) * | 2016-04-01 | 2017-10-05 | The General Hospital Corporation | Targeting innate immune signaling in neuroinflammation and neurodegeneration |
HUE063042T2 (hu) | 2016-04-15 | 2023-12-28 | Blueprint Medicines Corp | Az aktivin receptorszerû kináz inhibitorai |
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US11173211B2 (en) | 2016-12-23 | 2021-11-16 | Arvinas Operations, Inc. | Compounds and methods for the targeted degradation of rapidly accelerated Fibrosarcoma polypeptides |
US10994015B2 (en) | 2016-12-23 | 2021-05-04 | Arvinas Operations, Inc. | EGFR proteolysis targeting chimeric molecules and associated methods of use |
BR112019012878A2 (pt) | 2016-12-23 | 2019-11-26 | Arvinas Operations Inc | compostos e métodos para a degradação alvo de polipeptídos de fibrossarcoma rapidamente acelerados |
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KR20190043437A (ko) | 2017-10-18 | 2019-04-26 | 씨제이헬스케어 주식회사 | 단백질 키나제 억제제로서의 헤테로고리 화합물 |
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EP3841100A1 (en) | 2018-08-20 | 2021-06-30 | Arvinas Operations, Inc. | Proteolysis targeting chimeric (protac) compound with e3 ubiquitin ligase binding activity and targeting alpha-synuclein protein for treating neurodegenerative diseases |
CN114867727A (zh) | 2019-07-17 | 2022-08-05 | 阿尔维纳斯运营股份有限公司 | Tau蛋白靶向化合物及相关使用方法 |
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-
2015
- 2015-05-28 TW TW104117267A patent/TW201613916A/zh unknown
- 2015-06-01 AR ARP150101733A patent/AR100702A1/es unknown
- 2015-06-02 EP EP15738156.7A patent/EP3152210B1/en active Active
- 2015-06-02 NZ NZ726317A patent/NZ726317A/en not_active IP Right Cessation
- 2015-06-02 EA EA201692203A patent/EA031757B1/ru not_active IP Right Cessation
- 2015-06-02 MA MA040058A patent/MA40058A/fr unknown
- 2015-06-02 BR BR112016028288A patent/BR112016028288A2/pt not_active IP Right Cessation
- 2015-06-02 SG SG11201609570SA patent/SG11201609570SA/en unknown
- 2015-06-02 MX MX2016015862A patent/MX2016015862A/es unknown
- 2015-06-02 AU AU2015271837A patent/AU2015271837B2/en not_active Ceased
- 2015-06-02 KR KR1020187034637A patent/KR20180131640A/ko not_active Application Discontinuation
- 2015-06-02 JP JP2016570275A patent/JP6378785B2/ja not_active Expired - Fee Related
- 2015-06-02 WO PCT/US2015/033769 patent/WO2015187684A1/en active Application Filing
- 2015-06-02 CA CA2951126A patent/CA2951126A1/en not_active Abandoned
- 2015-06-02 US US14/728,562 patent/US10072001B2/en active Active
- 2015-06-02 KR KR1020167036819A patent/KR101926245B1/ko active IP Right Grant
- 2015-06-02 ES ES15738156T patent/ES2961577T3/es active Active
- 2015-06-02 CN CN201580030007.0A patent/CN106459044A/zh active Pending
-
2016
- 2016-11-10 IL IL248888A patent/IL248888A0/en unknown
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2017
- 2017-05-22 HK HK17105166.8A patent/HK1231475A1/zh unknown
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2018
- 2018-05-31 JP JP2018104601A patent/JP2018150358A/ja active Pending
- 2018-07-24 US US16/044,054 patent/US10259811B2/en active Active
- 2018-07-30 AU AU2018208766A patent/AU2018208766A1/en not_active Abandoned
Also Published As
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BR112016028288A2 (pt) | 2017-08-22 |
JP6378785B2 (ja) | 2018-08-22 |
CN106459044A (zh) | 2017-02-22 |
EP3152210A1 (en) | 2017-04-12 |
SG11201609570SA (en) | 2016-12-29 |
AR100702A1 (es) | 2016-10-26 |
JP2018150358A (ja) | 2018-09-27 |
AU2015271837B2 (en) | 2018-06-14 |
EP3152210C0 (en) | 2023-07-05 |
AU2018208766A1 (en) | 2018-08-16 |
KR101926245B1 (ko) | 2018-12-06 |
IL248888A0 (en) | 2017-01-31 |
US20190016717A1 (en) | 2019-01-17 |
AU2015271837A1 (en) | 2016-12-01 |
TW201613916A (en) | 2016-04-16 |
EA031757B1 (ru) | 2019-02-28 |
US10072001B2 (en) | 2018-09-11 |
EA201692203A1 (ru) | 2017-06-30 |
WO2015187684A1 (en) | 2015-12-10 |
CA2951126A1 (en) | 2015-12-10 |
ES2961577T3 (es) | 2024-03-12 |
KR20180131640A (ko) | 2018-12-10 |
MA40058A (fr) | 2015-12-10 |
NZ726317A (en) | 2018-05-25 |
HK1231475A1 (zh) | 2017-12-22 |
JP2017516814A (ja) | 2017-06-22 |
US20150344473A1 (en) | 2015-12-03 |
US10259811B2 (en) | 2019-04-16 |
EP3152210B1 (en) | 2023-07-05 |
KR20170005876A (ko) | 2017-01-16 |
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