EA201892214A1 - Замещенные производные индола в качестве ингибиторов репликации вирусов денге - Google Patents
Замещенные производные индола в качестве ингибиторов репликации вирусов денгеInfo
- Publication number
- EA201892214A1 EA201892214A1 EA201892214A EA201892214A EA201892214A1 EA 201892214 A1 EA201892214 A1 EA 201892214A1 EA 201892214 A EA201892214 A EA 201892214A EA 201892214 A EA201892214 A EA 201892214A EA 201892214 A1 EA201892214 A1 EA 201892214A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- indol
- inhibitors
- compounds
- substituted derivatives
- virus replication
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Настоящее изобретение относится к замещенным производным индола, способам предупреждения или лечения вирусных инфекций Денге посредством применения указанных соединений, а также к указанным соединениям для применения в качестве медикамента, более предпочтительно для применения в качестве медикамента для лечения или предупреждения вирусных инфекций Денге. Настоящее изобретение дополнительно относится к фармацевтическим композициям или комбинированным препаратам на основе соединений, к композициям или препаратам для применения в качестве медикамента, более предпочтительно для предупреждения или лечения вирусных инфекций Денге. Настоящее изобретение также относится к способам получения таких соединений.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16163312 | 2016-03-31 | ||
| PCT/EP2017/057660 WO2017167950A1 (en) | 2016-03-31 | 2017-03-31 | Substituted indole derivatives as dengue viral replication inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA201892214A1 true EA201892214A1 (ru) | 2019-03-29 |
Family
ID=55650292
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201892214A EA201892214A1 (ru) | 2016-03-31 | 2017-03-31 | Замещенные производные индола в качестве ингибиторов репликации вирусов денге |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US10646469B2 (ru) |
| EP (1) | EP3436435B1 (ru) |
| JP (1) | JP6888021B2 (ru) |
| KR (1) | KR102359743B1 (ru) |
| CN (1) | CN108884033B (ru) |
| AU (1) | AU2017242893A1 (ru) |
| BR (1) | BR112018068676A2 (ru) |
| CA (1) | CA3013405A1 (ru) |
| CL (1) | CL2018002729A1 (ru) |
| CO (1) | CO2018009559A2 (ru) |
| CR (1) | CR20180495A (ru) |
| DK (1) | DK3436435T3 (ru) |
| EA (1) | EA201892214A1 (ru) |
| EC (1) | ECSP18073245A (ru) |
| ES (1) | ES2882488T3 (ru) |
| HK (1) | HK1258142A1 (ru) |
| HR (1) | HRP20210847T1 (ru) |
| HU (1) | HUE054936T2 (ru) |
| IL (1) | IL261944A (ru) |
| LT (1) | LT3436435T (ru) |
| MX (1) | MX2018011784A (ru) |
| PH (1) | PH12018502015A1 (ru) |
| SG (1) | SG11201808138YA (ru) |
| SI (1) | SI3436435T1 (ru) |
| WO (1) | WO2017167950A1 (ru) |
| ZA (1) | ZA201806473B (ru) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201116559D0 (en) | 2011-09-26 | 2011-11-09 | Univ Leuven Kath | Novel viral replication inhibitors |
| GB201305376D0 (en) | 2013-03-25 | 2013-05-08 | Univ Leuven Kath | Novel viral replication inhibitors |
| JOP20160086B1 (ar) | 2015-05-08 | 2021-08-17 | 2 Katholieke Univ Leuven Ku Leuven Research And Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20160198B1 (ar) | 2015-09-16 | 2022-03-14 | Janssen Pharmaceuticals Inc | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JO3633B1 (ar) | 2015-09-16 | 2020-08-27 | Katholieke Univ Leuven Ku Leuven Research & Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| MX2018011788A (es) * | 2016-03-31 | 2019-05-20 | Janssen Pharmaceuticals Inc | Derivados de indolina sustituidos como inhibidores de la replicacion virica de dengue. |
| EP3436435B1 (en) | 2016-03-31 | 2021-05-12 | Janssen Pharmaceuticals, Inc. | Substituted indole derivatives as dengue viral replication inhibitors |
| JOP20170069B1 (ar) | 2016-04-01 | 2021-08-17 | 1 Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| MA44502A (fr) * | 2016-04-01 | 2019-02-06 | Janssen Pharmaceuticals Inc | Dérivés d'indole substitués utilisés en tant qu'inhibiteurs de réplication du virus de la dengue |
| JOP20180026A1 (ar) | 2017-03-31 | 2019-01-30 | Univ Leuven Kath | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20180025B1 (ar) | 2017-03-31 | 2021-08-17 | Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JP7179773B2 (ja) | 2017-05-22 | 2022-11-29 | ヤンセン ファーマシューティカルズ，インコーポレーテッド | デングウイルス複製阻害剤としての置換インドリン誘導体 |
| KR102625988B1 (ko) | 2017-05-22 | 2024-01-16 | 얀센 파마슈티칼즈, 인코포레이티드 | 뎅기 바이러스 복제 억제제로서의 치환 인돌린 유도체 |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0110832D0 (en) | 2001-05-03 | 2001-06-27 | Virogen Ltd | Antiviral compounds |
| JP2005520795A (ja) | 2001-12-12 | 2005-07-14 | コンフォーマ・セラピューティクス・コーポレイション | Ｈｓｐ９０阻害活性を有するプリン類似体 |
| GB0215293D0 (en) | 2002-07-03 | 2002-08-14 | Rega Foundation | Viral inhibitors |
| US20060211698A1 (en) | 2005-01-14 | 2006-09-21 | Genelabs, Inc. | Bicyclic heteroaryl derivatives for treating viruses |
| AU2006221080A1 (en) | 2005-02-09 | 2006-09-14 | Migenix Inc. | Compositions and methods for treating or preventing flaviviridae infections |
| US9029376B2 (en) | 2008-06-03 | 2015-05-12 | Siga Technologies, Inc. | Small molecule inhibitors for the treatment or prevention of dengue virus infection |
| JP5559174B2 (ja) | 2008-08-19 | 2014-07-23 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 冷感−メントール受容体拮抗剤 |
| EP2393359A4 (en) * | 2009-02-09 | 2012-10-03 | Enanta Pharm Inc | COMPOUND DIBENZIMIDAZOLE DERIVATIVES |
| GB0910003D0 (en) | 2009-06-11 | 2009-07-22 | Univ Leuven Kath | Novel compounds for the treatment of neurodegenerative diseases |
| US8993604B2 (en) | 2009-06-30 | 2015-03-31 | Siga Technologies, Inc. | Treatment and prevention of dengue virus infections |
| CA2785563C (en) | 2010-01-15 | 2019-05-14 | Gilead Sciences, Inc. | Inhibitors of flaviviridae viruses |
| GB201116559D0 (en) * | 2011-09-26 | 2011-11-09 | Univ Leuven Kath | Novel viral replication inhibitors |
| GB201305376D0 (en) | 2013-03-25 | 2013-05-08 | Univ Leuven Kath | Novel viral replication inhibitors |
| WO2015059212A1 (en) | 2013-10-23 | 2015-04-30 | Janssen R&D Ireland | Carboxamide derivatives and the use thereof as medicaments for the treatment of hepatitis b |
| TWI688564B (zh) | 2014-01-31 | 2020-03-21 | 美商必治妥美雅史谷比公司 | 作為凝血因子ｘｉａ抑制劑之具有雜環p2'基團之巨環化合物 |
| WO2016050841A1 (en) | 2014-10-01 | 2016-04-07 | Janssen Pharmaceuticals, Inc. | Mono- or di-substituted indole derivatives as dengue viral replication inhibitors |
| PL3201177T3 (pl) | 2014-10-01 | 2019-05-31 | Janssen Pharmaceuticals Inc | Mono- lub di-podstawione indole jako inhibitory replikacji wirusa dengi |
| NO2721243T3 (ru) | 2014-10-01 | 2018-10-20 | ||
| JOP20150335B1 (ar) | 2015-01-16 | 2022-03-14 | Janssen Pharmaceuticals Inc | مشتقات اندول بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| AR103680A1 (es) | 2015-02-23 | 2017-05-24 | Lilly Co Eli | Inhibidores selectivos de bace1 |
| JOP20160086B1 (ar) | 2015-05-08 | 2021-08-17 | 2 Katholieke Univ Leuven Ku Leuven Research And Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JO3633B1 (ar) | 2015-09-16 | 2020-08-27 | Katholieke Univ Leuven Ku Leuven Research & Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20160198B1 (ar) | 2015-09-16 | 2022-03-14 | Janssen Pharmaceuticals Inc | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| BR112018009010B1 (pt) | 2015-11-03 | 2023-09-26 | Zoetis Services Llc | Uso de um compósito polimérico de sol-gel para prevenir ou tratar mastite em um mamífero não humano fêmea que tem um período de lactação e sistema para formar uma barreira física no canal ou cisterna da teta do dito mamífero |
| MX2018011788A (es) | 2016-03-31 | 2019-05-20 | Janssen Pharmaceuticals Inc | Derivados de indolina sustituidos como inhibidores de la replicacion virica de dengue. |
| TWI738753B (zh) | 2016-03-31 | 2021-09-11 | 日商武田藥品工業股份有限公司 | 雜環化合物 |
| EP3436435B1 (en) | 2016-03-31 | 2021-05-12 | Janssen Pharmaceuticals, Inc. | Substituted indole derivatives as dengue viral replication inhibitors |
| ES2930058T3 (es) | 2016-04-01 | 2022-12-05 | Kite Pharma Inc | Receptores quiméricos y métodos de uso de los mismos |
| US10576085B2 (en) | 2016-04-01 | 2020-03-03 | Signal Pharmaceuticals, Llc | Substituted aminopurine compounds, compositions thereof, and methods of treatment therewith |
| JOP20170069B1 (ar) | 2016-04-01 | 2021-08-17 | 1 Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| MA44502A (fr) | 2016-04-01 | 2019-02-06 | Janssen Pharmaceuticals Inc | Dérivés d'indole substitués utilisés en tant qu'inhibiteurs de réplication du virus de la dengue |
| CN108779121A (zh) | 2016-04-01 | 2018-11-09 | 巴斯夫欧洲公司 | 双环化合物 |
| BR112018070073A2 (pt) | 2016-04-01 | 2019-02-12 | Kite Pharma, Inc. | receptores de antígeno quimérico e célula t e métodos de uso |
| JP2019516352A (ja) | 2016-04-01 | 2019-06-20 | アムジエン・インコーポレーテツド | Ｆｌｔ３に対するキメラ受容体及びその使用方法 |
| JOP20180025B1 (ar) | 2017-03-31 | 2021-08-17 | Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20180026A1 (ar) | 2017-03-31 | 2019-01-30 | Univ Leuven Kath | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| KR102625988B1 (ko) | 2017-05-22 | 2024-01-16 | 얀센 파마슈티칼즈, 인코포레이티드 | 뎅기 바이러스 복제 억제제로서의 치환 인돌린 유도체 |
| JP7179773B2 (ja) | 2017-05-22 | 2022-11-29 | ヤンセン ファーマシューティカルズ，インコーポレーテッド | デングウイルス複製阻害剤としての置換インドリン誘導体 |
-
2017
- 2017-03-31 EP EP17714750.1A patent/EP3436435B1/en active Active
- 2017-03-31 EA EA201892214A patent/EA201892214A1/ru unknown
- 2017-03-31 WO PCT/EP2017/057660 patent/WO2017167950A1/en active Application Filing
- 2017-03-31 DK DK17714750.1T patent/DK3436435T3/da active
- 2017-03-31 LT LTEP17714750.1T patent/LT3436435T/lt unknown
- 2017-03-31 JP JP2018549441A patent/JP6888021B2/ja active Active
- 2017-03-31 SG SG11201808138YA patent/SG11201808138YA/en unknown
- 2017-03-31 ES ES17714750T patent/ES2882488T3/es active Active
- 2017-03-31 CR CR20180495A patent/CR20180495A/es unknown
- 2017-03-31 BR BR112018068676A patent/BR112018068676A2/pt not_active Application Discontinuation
- 2017-03-31 CO CONC2018/0009559A patent/CO2018009559A2/es unknown
- 2017-03-31 SI SI201730800T patent/SI3436435T1/sl unknown
- 2017-03-31 CN CN201780021395.5A patent/CN108884033B/zh active Active
- 2017-03-31 KR KR1020187027072A patent/KR102359743B1/ko active IP Right Grant
- 2017-03-31 MX MX2018011784A patent/MX2018011784A/es unknown
- 2017-03-31 CA CA3013405A patent/CA3013405A1/en not_active Abandoned
- 2017-03-31 US US16/087,800 patent/US10646469B2/en active Active
- 2017-03-31 AU AU2017242893A patent/AU2017242893A1/en not_active Abandoned
- 2017-03-31 HU HUE17714750A patent/HUE054936T2/hu unknown
-
2018
- 2018-09-20 PH PH12018502015A patent/PH12018502015A1/en unknown
- 2018-09-26 IL IL261944A patent/IL261944A/en unknown
- 2018-09-26 CL CL2018002729A patent/CL2018002729A1/es unknown
- 2018-09-28 EC ECSENADI201873245A patent/ECSP18073245A/es unknown
- 2018-09-28 ZA ZA2018/06473A patent/ZA201806473B/en unknown
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2019
- 2019-01-14 HK HK19100496.8A patent/HK1258142A1/zh unknown
-
2021
- 2021-05-27 HR HRP20210847TT patent/HRP20210847T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA3013405A1 (en) | 2017-10-05 |
| MX2018011784A (es) | 2019-02-13 |
| PH12018502015A1 (en) | 2019-07-15 |
| ECSP18073245A (es) | 2018-10-31 |
| US20190274999A1 (en) | 2019-09-12 |
| ES2882488T3 (es) | 2021-12-02 |
| SI3436435T1 (sl) | 2021-08-31 |
| AU2017242893A1 (en) | 2018-08-09 |
| LT3436435T (lt) | 2021-08-25 |
| CN108884033B (zh) | 2021-03-09 |
| WO2017167950A1 (en) | 2017-10-05 |
| KR20180130498A (ko) | 2018-12-07 |
| HUE054936T2 (hu) | 2021-10-28 |
| ZA201806473B (en) | 2020-05-27 |
| CN108884033A (zh) | 2018-11-23 |
| IL261944A (en) | 2018-10-31 |
| JP6888021B2 (ja) | 2021-06-16 |
| SG11201808138YA (en) | 2018-10-30 |
| DK3436435T3 (da) | 2021-08-09 |
| KR102359743B1 (ko) | 2022-02-07 |
| EP3436435A1 (en) | 2019-02-06 |
| CO2018009559A2 (es) | 2018-09-20 |
| JP2019510024A (ja) | 2019-04-11 |
| HK1258142A1 (zh) | 2019-11-08 |
| BR112018068676A2 (pt) | 2019-01-15 |
| CR20180495A (es) | 2018-12-06 |
| US10646469B2 (en) | 2020-05-12 |
| CL2018002729A1 (es) | 2018-11-23 |
| EP3436435B1 (en) | 2021-05-12 |
| HRP20210847T1 (hr) | 2021-07-23 |
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