EA201892219A1 - Замещенные производные индолина в качестве ингибиторов репликации вирусов денге - Google Patents
Замещенные производные индолина в качестве ингибиторов репликации вирусов денгеInfo
- Publication number
- EA201892219A1 EA201892219A1 EA201892219A EA201892219A EA201892219A1 EA 201892219 A1 EA201892219 A1 EA 201892219A1 EA 201892219 A EA201892219 A EA 201892219A EA 201892219 A EA201892219 A EA 201892219A EA 201892219 A1 EA201892219 A1 EA 201892219A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- substituted
- derivatives
- indin
- inhibitors
- compounds
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Настоящее изобретение относится к замещенным производным индолина, способам предупреждения или лечения вирусных инфекций Денге посредством применения указанных соединений, а также к указанным соединениям для применения в качестве лечебного средства, более предпочтительно для применения в качестве лечебного средства для лечения или предупреждения вирусных инфекций Денге. Настоящее изобретение дополнительно относится к фармацевтическим композициям или комбинированным препаратам на основе соединений, к композициям или препаратам для применения в качестве лечебного средства, более предпочтительно для предупреждения или лечения вирусных инфекций Денге. Настоящее изобретение также относится к способам получения соединений.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP16163488 | 2016-04-01 | ||
PCT/EP2017/057661 WO2017167951A1 (en) | 2016-04-01 | 2017-03-31 | Substituted indoline derivatives as dengue viral replication inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201892219A1 true EA201892219A1 (ru) | 2019-03-29 |
EA037988B1 EA037988B1 (ru) | 2021-06-21 |
Family
ID=55650311
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201892219A EA037988B1 (ru) | 2016-04-01 | 2017-03-31 | Замещенные производные индолина в качестве ингибиторов репликации вирусов денге |
Country Status (32)
Country | Link |
---|---|
US (2) | US10689340B2 (ru) |
EP (1) | EP3436437B1 (ru) |
JP (1) | JP6970115B2 (ru) |
KR (1) | KR102359776B1 (ru) |
CN (1) | CN108884037B (ru) |
AR (1) | AR108046A1 (ru) |
AU (1) | AU2017242894B2 (ru) |
BR (1) | BR112018068640A2 (ru) |
CA (1) | CA3013406C (ru) |
CL (1) | CL2018002758A1 (ru) |
CO (1) | CO2018009563A2 (ru) |
CR (1) | CR20180493A (ru) |
DK (1) | DK3436437T3 (ru) |
EA (1) | EA037988B1 (ru) |
EC (1) | ECSP18073293A (ru) |
ES (1) | ES2884067T3 (ru) |
HR (1) | HRP20211278T1 (ru) |
HU (1) | HUE055577T2 (ru) |
IL (1) | IL261948B (ru) |
JO (1) | JOP20170069B1 (ru) |
LT (1) | LT3436437T (ru) |
MX (1) | MX2018011785A (ru) |
MY (1) | MY195194A (ru) |
PE (1) | PE20181778A1 (ru) |
PH (1) | PH12018502077A1 (ru) |
SG (1) | SG11201808409XA (ru) |
SI (1) | SI3436437T1 (ru) |
TW (1) | TWI723148B (ru) |
UA (1) | UA125296C2 (ru) |
UY (1) | UY37182A (ru) |
WO (1) | WO2017167951A1 (ru) |
ZA (1) | ZA201806482B (ru) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
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GB201116559D0 (en) | 2011-09-26 | 2011-11-09 | Univ Leuven Kath | Novel viral replication inhibitors |
GB201305376D0 (en) | 2013-03-25 | 2013-05-08 | Univ Leuven Kath | Novel viral replication inhibitors |
JOP20160086B1 (ar) | 2015-05-08 | 2021-08-17 | 2 Katholieke Univ Leuven Ku Leuven Research And Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
JOP20160198B1 (ar) | 2015-09-16 | 2022-03-14 | Janssen Pharmaceuticals Inc | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
JO3633B1 (ar) | 2015-09-16 | 2020-08-27 | Katholieke Univ Leuven Ku Leuven Research & Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
MX2018011788A (es) * | 2016-03-31 | 2019-05-20 | Janssen Pharmaceuticals Inc | Derivados de indolina sustituidos como inhibidores de la replicacion virica de dengue. |
EP3436435B1 (en) | 2016-03-31 | 2021-05-12 | Janssen Pharmaceuticals, Inc. | Substituted indole derivatives as dengue viral replication inhibitors |
JOP20170069B1 (ar) * | 2016-04-01 | 2021-08-17 | 1 Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
MA44502A (fr) | 2016-04-01 | 2019-02-06 | Janssen Pharmaceuticals Inc | Dérivés d'indole substitués utilisés en tant qu'inhibiteurs de réplication du virus de la dengue |
JOP20180026A1 (ar) | 2017-03-31 | 2019-01-30 | Univ Leuven Kath | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
JOP20180025B1 (ar) | 2017-03-31 | 2021-08-17 | Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
JP7179773B2 (ja) * | 2017-05-22 | 2022-11-29 | ヤンセン ファーマシューティカルズ,インコーポレーテッド | デングウイルス複製阻害剤としての置換インドリン誘導体 |
KR102625988B1 (ko) | 2017-05-22 | 2024-01-16 | 얀센 파마슈티칼즈, 인코포레이티드 | 뎅기 바이러스 복제 억제제로서의 치환 인돌린 유도체 |
EP4058019A1 (en) | 2019-11-15 | 2022-09-21 | Janssen Pharmaceuticals, Inc. | Treatment and prevention of dengue disease |
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JP2005520795A (ja) | 2001-12-12 | 2005-07-14 | コンフォーマ・セラピューティクス・コーポレイション | Hsp90阻害活性を有するプリン類似体 |
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JOP20160198B1 (ar) | 2015-09-16 | 2022-03-14 | Janssen Pharmaceuticals Inc | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
JO3633B1 (ar) | 2015-09-16 | 2020-08-27 | Katholieke Univ Leuven Ku Leuven Research & Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
BR112018009010B1 (pt) | 2015-11-03 | 2023-09-26 | Zoetis Services Llc | Uso de um compósito polimérico de sol-gel para prevenir ou tratar mastite em um mamífero não humano fêmea que tem um período de lactação e sistema para formar uma barreira física no canal ou cisterna da teta do dito mamífero |
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JP2019516352A (ja) | 2016-04-01 | 2019-06-20 | アムジエン・インコーポレーテツド | Flt3に対するキメラ受容体及びその使用方法 |
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MA44502A (fr) | 2016-04-01 | 2019-02-06 | Janssen Pharmaceuticals Inc | Dérivés d'indole substitués utilisés en tant qu'inhibiteurs de réplication du virus de la dengue |
JOP20180026A1 (ar) | 2017-03-31 | 2019-01-30 | Univ Leuven Kath | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
JOP20180025B1 (ar) | 2017-03-31 | 2021-08-17 | Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
JP7179773B2 (ja) | 2017-05-22 | 2022-11-29 | ヤンセン ファーマシューティカルズ,インコーポレーテッド | デングウイルス複製阻害剤としての置換インドリン誘導体 |
KR102625988B1 (ko) | 2017-05-22 | 2024-01-16 | 얀센 파마슈티칼즈, 인코포레이티드 | 뎅기 바이러스 복제 억제제로서의 치환 인돌린 유도체 |
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2017
- 2017-03-22 JO JOP/2017/0069A patent/JOP20170069B1/ar active
- 2017-03-30 TW TW106110686A patent/TWI723148B/zh active
- 2017-03-30 AR ARP170100795A patent/AR108046A1/es unknown
- 2017-03-31 US US16/088,090 patent/US10689340B2/en active Active
- 2017-03-31 EA EA201892219A patent/EA037988B1/ru unknown
- 2017-03-31 LT LTEP17714751.9T patent/LT3436437T/lt unknown
- 2017-03-31 UY UY0001037182A patent/UY37182A/es unknown
- 2017-03-31 MX MX2018011785A patent/MX2018011785A/es unknown
- 2017-03-31 SI SI201730871T patent/SI3436437T1/sl unknown
- 2017-03-31 CO CONC2018/0009563A patent/CO2018009563A2/es unknown
- 2017-03-31 CR CR20180493A patent/CR20180493A/es unknown
- 2017-03-31 CN CN201780021323.0A patent/CN108884037B/zh active Active
- 2017-03-31 WO PCT/EP2017/057661 patent/WO2017167951A1/en active Application Filing
- 2017-03-31 BR BR112018068640A patent/BR112018068640A2/pt active Search and Examination
- 2017-03-31 JP JP2018550545A patent/JP6970115B2/ja active Active
- 2017-03-31 KR KR1020187028180A patent/KR102359776B1/ko active IP Right Grant
- 2017-03-31 PE PE2018001870A patent/PE20181778A1/es unknown
- 2017-03-31 UA UAA201810728A patent/UA125296C2/uk unknown
- 2017-03-31 ES ES17714751T patent/ES2884067T3/es active Active
- 2017-03-31 HR HRP20211278TT patent/HRP20211278T1/hr unknown
- 2017-03-31 CA CA3013406A patent/CA3013406C/en active Active
- 2017-03-31 HU HUE17714751A patent/HUE055577T2/hu unknown
- 2017-03-31 AU AU2017242894A patent/AU2017242894B2/en active Active
- 2017-03-31 SG SG11201808409XA patent/SG11201808409XA/en unknown
- 2017-03-31 DK DK17714751.9T patent/DK3436437T3/da active
- 2017-03-31 MY MYPI2018001596A patent/MY195194A/en unknown
- 2017-03-31 EP EP17714751.9A patent/EP3436437B1/en active Active
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2018
- 2018-09-26 IL IL261948A patent/IL261948B/en unknown
- 2018-09-27 PH PH12018502077A patent/PH12018502077A1/en unknown
- 2018-09-27 CL CL2018002758A patent/CL2018002758A1/es unknown
- 2018-09-28 EC ECSENADI201873293A patent/ECSP18073293A/es unknown
- 2018-09-28 ZA ZA2018/06482A patent/ZA201806482B/en unknown
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2020
- 2020-06-05 US US16/893,685 patent/US11180450B2/en active Active
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