EA201892200A1 - Замещенные производные соединений индола в качестве ингибиторов репликации вирусов денге - Google Patents

Замещенные производные соединений индола в качестве ингибиторов репликации вирусов денге

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Publication number
EA201892200A1
EA201892200A1 EA201892200A EA201892200A EA201892200A1 EA 201892200 A1 EA201892200 A1 EA 201892200A1 EA 201892200 A EA201892200 A EA 201892200A EA 201892200 A EA201892200 A EA 201892200A EA 201892200 A1 EA201892200 A1 EA 201892200A1
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EA
Eurasian Patent Office
Prior art keywords
compounds
ingibitors
indol
virus replication
derivative compounds
Prior art date
Application number
EA201892200A
Other languages
English (en)
Inventor
Дороте Алис Мари-Эв Бардио
Жан-Франсуа Бонфанти
Эрвин Кусеманс
Барт Рудольф Романи Кестелейн
Арно Дидье М Маршан
Пьер Жан-Мари Бернар Рабуассон
Original Assignee
Янссен Фармасьютикалз, Инк.
Католике Университейт Левен
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Янссен Фармасьютикалз, Инк., Католике Университейт Левен filed Critical Янссен Фармасьютикалз, Инк.
Publication of EA201892200A1 publication Critical patent/EA201892200A1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

Настоящее изобретение относится к замещенным соединениям индола, к способам предупреждения или лечения вирусных инфекций денге с помощью применения указанных соединений, а также относится к указанным соединениям для применения в качестве лечебного средства, более предпочтительно для применения в качестве лечебного средства для лечения или предупреждения вирусных инфекций денге. Настоящее изобретение дополнительно относится к фармацевтическим композициям или комбинированным препаратам на основе соединений, к композициям или препаратам для применения в качестве лечебного средства, более предпочтительно для предупреждения или лечения вирусных инфекций денге. Настоящее изобретение также относится к способам получения соединений.
EA201892200A 2016-04-01 2017-03-31 Замещенные производные соединений индола в качестве ингибиторов репликации вирусов денге EA201892200A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16163482 2016-04-01
PCT/EP2017/057662 WO2017167952A1 (en) 2016-04-01 2017-03-31 Substituted indole compound derivatives as dengue viral replication inhibitors

Publications (1)

Publication Number Publication Date
EA201892200A1 true EA201892200A1 (ru) 2019-03-29

Family

ID=55650310

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201892200A EA201892200A1 (ru) 2016-04-01 2017-03-31 Замещенные производные соединений индола в качестве ингибиторов репликации вирусов денге

Country Status (20)

Country Link
US (1) US10730884B2 (ru)
EP (1) EP3436004A1 (ru)
JP (2) JP7007290B2 (ru)
KR (1) KR102359766B1 (ru)
CN (1) CN109069482B (ru)
AU (1) AU2017240076A1 (ru)
BR (1) BR112018068956A2 (ru)
CA (1) CA3013408A1 (ru)
CL (1) CL2018002784A1 (ru)
CO (1) CO2018009996A2 (ru)
CR (1) CR20180494A (ru)
EA (1) EA201892200A1 (ru)
EC (1) ECSP18073264A (ru)
IL (1) IL261947A (ru)
MA (1) MA44502A (ru)
MX (1) MX2018011786A (ru)
PH (1) PH12018502026A1 (ru)
SG (1) SG11201808237UA (ru)
SV (1) SV2018005750A (ru)
WO (1) WO2017167952A1 (ru)

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BR112018068956A2 (pt) 2019-01-22
CR20180494A (es) 2019-01-29
JP7007290B2 (ja) 2022-01-24
SV2018005750A (es) 2018-11-15
PH12018502026A1 (en) 2019-02-11
JP2022009166A (ja) 2022-01-14
AU2017240076A1 (en) 2018-08-09
CA3013408A1 (en) 2017-10-05
JP2019511502A (ja) 2019-04-25
ECSP18073264A (es) 2018-10-31
KR20180130502A (ko) 2018-12-07
IL261947A (en) 2018-10-31
KR102359766B1 (ko) 2022-02-07
CN109069482A (zh) 2018-12-21
US20190276467A1 (en) 2019-09-12
CN109069482B (zh) 2022-04-05
CO2018009996A2 (es) 2018-09-28
US10730884B2 (en) 2020-08-04
SG11201808237UA (en) 2018-10-30
MX2018011786A (es) 2019-05-20
CL2018002784A1 (es) 2018-12-14
MA44502A (fr) 2019-02-06
EP3436004A1 (en) 2019-02-06
WO2017167952A1 (en) 2017-10-05

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