HUE054936T2 - Helyettesített indol-származékok mint a dengue-vírus replikációjának inhibitorai - Google Patents
Helyettesített indol-származékok mint a dengue-vírus replikációjának inhibitoraiInfo
- Publication number
- HUE054936T2 HUE054936T2 HUE17714750A HUE17714750A HUE054936T2 HU E054936 T2 HUE054936 T2 HU E054936T2 HU E17714750 A HUE17714750 A HU E17714750A HU E17714750 A HUE17714750 A HU E17714750A HU E054936 T2 HUE054936 T2 HU E054936T2
- Authority
- HU
- Hungary
- Prior art keywords
- viral replication
- indole derivatives
- substituted indole
- replication inhibitors
- dengue viral
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16163312 | 2016-03-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUE054936T2 true HUE054936T2 (hu) | 2021-10-28 |
Family
ID=55650292
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE17714750A HUE054936T2 (hu) | 2016-03-31 | 2017-03-31 | Helyettesített indol-származékok mint a dengue-vírus replikációjának inhibitorai |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US10646469B2 (hu) |
| EP (1) | EP3436435B1 (hu) |
| JP (1) | JP6888021B2 (hu) |
| KR (1) | KR102359743B1 (hu) |
| CN (1) | CN108884033B (hu) |
| AU (1) | AU2017242893A1 (hu) |
| BR (1) | BR112018068676A2 (hu) |
| CA (1) | CA3013405A1 (hu) |
| CL (1) | CL2018002729A1 (hu) |
| CO (1) | CO2018009559A2 (hu) |
| CR (1) | CR20180495A (hu) |
| DK (1) | DK3436435T3 (hu) |
| EA (1) | EA201892214A1 (hu) |
| EC (1) | ECSP18073245A (hu) |
| ES (1) | ES2882488T3 (hu) |
| HK (1) | HK1258142A1 (hu) |
| HR (1) | HRP20210847T1 (hu) |
| HU (1) | HUE054936T2 (hu) |
| IL (1) | IL261944A (hu) |
| LT (1) | LT3436435T (hu) |
| MX (1) | MX2018011784A (hu) |
| PH (1) | PH12018502015A1 (hu) |
| SG (1) | SG11201808138YA (hu) |
| SI (1) | SI3436435T1 (hu) |
| WO (1) | WO2017167950A1 (hu) |
| ZA (1) | ZA201806473B (hu) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201116559D0 (en) | 2011-09-26 | 2011-11-09 | Univ Leuven Kath | Novel viral replication inhibitors |
| GB201305376D0 (en) | 2013-03-25 | 2013-05-08 | Univ Leuven Kath | Novel viral replication inhibitors |
| JOP20160086B1 (ar) | 2015-05-08 | 2021-08-17 | 2 Katholieke Univ Leuven Ku Leuven Research And Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20160198B1 (ar) | 2015-09-16 | 2022-03-14 | Janssen Pharmaceuticals Inc | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JO3633B1 (ar) | 2015-09-16 | 2020-08-27 | Katholieke Univ Leuven Ku Leuven Research & Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| MA44498A (fr) * | 2016-03-31 | 2019-02-06 | Janssen Pharmaceuticals Inc | Dérivés d'indoline substituée utilisés en tant qu'inhibiteurs de la réplication du virus de la dengue |
| CR20180495A (es) | 2016-03-31 | 2018-12-06 | Univ Leuven Kath | Deribados de indol sustituidos como inhibidores de replicación viral del dengue |
| JOP20170069B1 (ar) | 2016-04-01 | 2021-08-17 | 1 Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| WO2017167952A1 (en) | 2016-04-01 | 2017-10-05 | Janssen Pharmaceuticals, Inc. | Substituted indole compound derivatives as dengue viral replication inhibitors |
| JOP20180026A1 (ar) | 2017-03-31 | 2019-01-30 | Univ Leuven Kath | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20180025B1 (ar) | 2017-03-31 | 2021-08-17 | Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| EP3630724B1 (en) | 2017-05-22 | 2021-04-28 | Janssen Pharmaceuticals, Inc. | Substituted indoline derivatives as dengue viral replication inhibitors |
| BR112019024195A2 (pt) | 2017-05-22 | 2020-06-23 | Janssen Pharmaceuticals, Inc. | Composto e composição farmacêutica de derivados de indolina substituídos como inibidores da replicação viral da dengue |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0110832D0 (en) | 2001-05-03 | 2001-06-27 | Virogen Ltd | Antiviral compounds |
| AU2002364566B2 (en) | 2001-12-12 | 2009-03-26 | Conforma Therapeutics Corporation | Assays and implements for determining and modulating HSP90 binding activity |
| GB0215293D0 (en) | 2002-07-03 | 2002-08-14 | Rega Foundation | Viral inhibitors |
| WO2006076529A1 (en) | 2005-01-14 | 2006-07-20 | Genelabs Technologies, Inc. | Indole derivatives for treating viral infections |
| US20060194835A1 (en) | 2005-02-09 | 2006-08-31 | Migenix Inc. | Compositions and methods for treating or preventing flaviviridae infections |
| CN102056483A (zh) | 2008-06-03 | 2011-05-11 | 西佳技术公司 | 用于治疗或预防登革病毒感染的小分子抑制剂 |
| US8143259B2 (en) * | 2008-08-19 | 2012-03-27 | Janssen Pharmaceutica, Nv | Cold menthol receptor antagonists |
| WO2010091413A1 (en) * | 2009-02-09 | 2010-08-12 | Enanta Pharmaceuticals, Inc. | Linked dibenzimidazole derivatives |
| GB0910003D0 (en) | 2009-06-11 | 2009-07-22 | Univ Leuven Kath | Novel compounds for the treatment of neurodegenerative diseases |
| US8993604B2 (en) | 2009-06-30 | 2015-03-31 | Siga Technologies, Inc. | Treatment and prevention of dengue virus infections |
| PE20121522A1 (es) | 2010-01-15 | 2012-11-26 | Gilead Sciences Inc | Derivados de acido 5-alquinil-3-amida-2-tiofeno-carboxilico como inhibidores del virus flaviviridae |
| GB201116559D0 (en) * | 2011-09-26 | 2011-11-09 | Univ Leuven Kath | Novel viral replication inhibitors |
| GB201305376D0 (en) | 2013-03-25 | 2013-05-08 | Univ Leuven Kath | Novel viral replication inhibitors |
| KR102290189B1 (ko) | 2013-10-23 | 2021-08-17 | 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 | 카르복스아미드 유도체 및 ｂ형 간염 치료용 의약으로서의 이의 용도 |
| LT3099687T (lt) | 2014-01-31 | 2018-09-10 | Bristol-Myers Squibb Company | Makrociklai su heterociklinėmis p2' grupėmis kaip faktoriaus xia inhibitoriai |
| TWI681951B (zh) | 2014-10-01 | 2020-01-11 | 美商健生醫藥公司 | 作為登革熱病毒複製抑制劑之單-或二-取代的吲哚衍生物 |
| NO2721243T3 (hu) | 2014-10-01 | 2018-10-20 | ||
| AU2015326920A1 (en) | 2014-10-01 | 2017-03-02 | Janssen Pharmaceuticals, Inc. | Mono- or di-substituted indoles as dengue viral replication inhibitors |
| JOP20150335B1 (ar) | 2015-01-16 | 2022-03-14 | Janssen Pharmaceuticals Inc | مشتقات اندول بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| AR103680A1 (es) | 2015-02-23 | 2017-05-24 | Lilly Co Eli | Inhibidores selectivos de bace1 |
| JOP20160086B1 (ar) | 2015-05-08 | 2021-08-17 | 2 Katholieke Univ Leuven Ku Leuven Research And Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JO3633B1 (ar) | 2015-09-16 | 2020-08-27 | Katholieke Univ Leuven Ku Leuven Research & Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20160198B1 (ar) | 2015-09-16 | 2022-03-14 | Janssen Pharmaceuticals Inc | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| AU2016350868B2 (en) | 2015-11-03 | 2022-03-31 | Zoetis Services Llc | Sol-gel polymer composites and uses thereof |
| MA44498A (fr) | 2016-03-31 | 2019-02-06 | Janssen Pharmaceuticals Inc | Dérivés d'indoline substituée utilisés en tant qu'inhibiteurs de la réplication du virus de la dengue |
| JP6788683B2 (ja) | 2016-03-31 | 2020-11-25 | 武田薬品工業株式会社 | 複素環化合物 |
| CR20180495A (es) | 2016-03-31 | 2018-12-06 | Univ Leuven Kath | Deribados de indol sustituidos como inhibidores de replicación viral del dengue |
| JP2019513370A (ja) | 2016-04-01 | 2019-05-30 | カイト ファーマ インコーポレイテッドＫｉｔｅ Ｐｈａ | キメラ受容体及びその使用方法 |
| BR112018068851B1 (pt) | 2016-04-01 | 2022-11-22 | Basf Se | Composto de fórmula i, composição, métodos de combate ou controle de pragas invertebradas e de proteção de plantas, semente revestida e uso de pelo menos um composto |
| SG10201911963VA (en) | 2016-04-01 | 2020-02-27 | Amgen Inc | Chimeric receptors to flt3 and methods of use thereof |
| WO2017167952A1 (en) | 2016-04-01 | 2017-10-05 | Janssen Pharmaceuticals, Inc. | Substituted indole compound derivatives as dengue viral replication inhibitors |
| MX2018011992A (es) | 2016-04-01 | 2019-01-24 | Signal Pharm Llc | Compuestos de aminopurina sustituida, composiciones de estos y metodos de tratamiento con estos. |
| IL303785A (en) | 2016-04-01 | 2023-08-01 | Kite Pharma Inc | Chimeric antigen and T cell receptors and methods of use |
| JOP20170069B1 (ar) | 2016-04-01 | 2021-08-17 | 1 Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20180026A1 (ar) | 2017-03-31 | 2019-01-30 | Univ Leuven Kath | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20180025B1 (ar) | 2017-03-31 | 2021-08-17 | Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| BR112019024195A2 (pt) | 2017-05-22 | 2020-06-23 | Janssen Pharmaceuticals, Inc. | Composto e composição farmacêutica de derivados de indolina substituídos como inibidores da replicação viral da dengue |
| EP3630724B1 (en) | 2017-05-22 | 2021-04-28 | Janssen Pharmaceuticals, Inc. | Substituted indoline derivatives as dengue viral replication inhibitors |
-
2017
- 2017-03-31 CR CR20180495A patent/CR20180495A/es unknown
- 2017-03-31 JP JP2018549441A patent/JP6888021B2/ja active Active
- 2017-03-31 CN CN201780021395.5A patent/CN108884033B/zh active Active
- 2017-03-31 US US16/087,800 patent/US10646469B2/en active Active
- 2017-03-31 MX MX2018011784A patent/MX2018011784A/es unknown
- 2017-03-31 AU AU2017242893A patent/AU2017242893A1/en not_active Abandoned
- 2017-03-31 SG SG11201808138YA patent/SG11201808138YA/en unknown
- 2017-03-31 DK DK17714750.1T patent/DK3436435T3/da active
- 2017-03-31 ES ES17714750T patent/ES2882488T3/es active Active
- 2017-03-31 BR BR112018068676A patent/BR112018068676A2/pt not_active Application Discontinuation
- 2017-03-31 CO CONC2018/0009559A patent/CO2018009559A2/es unknown
- 2017-03-31 HU HUE17714750A patent/HUE054936T2/hu unknown
- 2017-03-31 EP EP17714750.1A patent/EP3436435B1/en active Active
- 2017-03-31 WO PCT/EP2017/057660 patent/WO2017167950A1/en active Application Filing
- 2017-03-31 CA CA3013405A patent/CA3013405A1/en not_active Abandoned
- 2017-03-31 EA EA201892214A patent/EA201892214A1/ru unknown
- 2017-03-31 LT LTEP17714750.1T patent/LT3436435T/lt unknown
- 2017-03-31 KR KR1020187027072A patent/KR102359743B1/ko active IP Right Grant
- 2017-03-31 SI SI201730800T patent/SI3436435T1/sl unknown
-
2018
- 2018-09-20 PH PH12018502015A patent/PH12018502015A1/en unknown
- 2018-09-26 CL CL2018002729A patent/CL2018002729A1/es unknown
- 2018-09-26 IL IL261944A patent/IL261944A/en unknown
- 2018-09-28 EC ECSENADI201873245A patent/ECSP18073245A/es unknown
- 2018-09-28 ZA ZA2018/06473A patent/ZA201806473B/en unknown
-
2019
- 2019-01-14 HK HK19100496.8A patent/HK1258142A1/zh unknown
-
2021
- 2021-05-27 HR HRP20210847TT patent/HRP20210847T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BR112018068676A2 (pt) | 2019-01-15 |
| LT3436435T (lt) | 2021-08-25 |
| US10646469B2 (en) | 2020-05-12 |
| ZA201806473B (en) | 2020-05-27 |
| HK1258142A1 (zh) | 2019-11-08 |
| JP6888021B2 (ja) | 2021-06-16 |
| KR20180130498A (ko) | 2018-12-07 |
| DK3436435T3 (da) | 2021-08-09 |
| JP2019510024A (ja) | 2019-04-11 |
| US20190274999A1 (en) | 2019-09-12 |
| EP3436435A1 (en) | 2019-02-06 |
| CR20180495A (es) | 2018-12-06 |
| MX2018011784A (es) | 2019-02-13 |
| CA3013405A1 (en) | 2017-10-05 |
| ES2882488T3 (es) | 2021-12-02 |
| AU2017242893A1 (en) | 2018-08-09 |
| IL261944A (en) | 2018-10-31 |
| SI3436435T1 (sl) | 2021-08-31 |
| KR102359743B1 (ko) | 2022-02-07 |
| CN108884033A (zh) | 2018-11-23 |
| ECSP18073245A (es) | 2018-10-31 |
| EP3436435B1 (en) | 2021-05-12 |
| HRP20210847T1 (hr) | 2021-07-23 |
| CN108884033B (zh) | 2021-03-09 |
| EA201892214A1 (ru) | 2019-03-29 |
| CL2018002729A1 (es) | 2018-11-23 |
| SG11201808138YA (en) | 2018-10-30 |
| PH12018502015A1 (en) | 2019-07-15 |
| WO2017167950A1 (en) | 2017-10-05 |
| CO2018009559A2 (es) | 2018-09-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HK1258142A1 (zh) | 作為登革病毒複製抑制劑的經取代的吲哚衍生物 | |
| IL261947A (en) | History of converted indole compounds as inhibitors of dengue virus replication | |
| ZA201806482B (en) | Substituted indoline derivatives as dengue viral replication inhibitors | |
| IL261943A (en) | Transformed indulin derivatives as inhibitors of dengue virus replication | |
| ZA201907713B (en) | Substituted indoline derivatives as dengue viral replication inhibitors | |
| ZA201906395B (en) | Substituted indoline derivatives as dengue viral replication inhibitors | |
| HK1252496A1 (zh) | 作為登革熱病毒複製抑制劑的單取代的或二取代的吲哚衍生物 | |
| HK1247611A1 (zh) | 作為登革熱病毒複製抑制劑的吲哚衍生物 | |
| IL269657A (en) | Transduced indulin derivatives as inhibitors of dengue virus replication | |
| IL270726A (en) | Transduced indulin derivatives as inhibitors of dengue virus replication | |
| HK1258320A1 (zh) | 作為登革熱病毒複製抑制劑的單取代或二取代吲哚衍生物 | |
| HK1257842A1 (zh) | 作為登革熱病毒複製抑制劑的單取代的或二取代的吲哚衍生物 | |
| PT3294738T (pt) | Derivados mono ou di-substituídos de indol como inibidores da replicação viral da dengue |