EA201890726A1 - Кристаллические формы - Google Patents
Кристаллические формыInfo
- Publication number
- EA201890726A1 EA201890726A1 EA201890726A EA201890726A EA201890726A1 EA 201890726 A1 EA201890726 A1 EA 201890726A1 EA 201890726 A EA201890726 A EA 201890726A EA 201890726 A EA201890726 A EA 201890726A EA 201890726 A1 EA201890726 A1 EA 201890726A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- crystal forms
- crystalline forms
- crystalline
- crth
- chloropyrimidin
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Изобретение относится к кристаллической форме (S)-2-(8-((5-хлорпиримидин-2-ил)(метил)амино)-2-фтор-6,7,8,9-тетрагидро-5H-пиридо[3,2-b]индол-5-ил)уксусной кислоты, способам получения ее фармацевтической композиции, включающим в себя указанные кристаллические формы, фармацевтические композиции, полученные из таких кристаллических форм, и их применение в качестве лекарств, особенно в качестве модуляторов рецептора CRTH.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP2015071060 | 2015-09-15 | ||
PCT/EP2016/071637 WO2017046125A1 (en) | 2015-09-15 | 2016-09-14 | Crystalline forms |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201890726A1 true EA201890726A1 (ru) | 2018-10-31 |
EA035752B1 EA035752B1 (ru) | 2020-08-05 |
Family
ID=56979537
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201890726A EA035752B1 (ru) | 2015-09-15 | 2016-09-14 | КРИСТАЛЛИЧЕСКАЯ ФОРМА (S)-2-(8-((5-ХЛОРПИРИМИДИН-2-ИЛ)(МЕТИЛ)-АМИНО)-2-ФТОР-6,7,8,9-ТЕТРАГИДРО-5Н-ПИРИДО[3,2-b]ИНДОЛ-5-ИЛ)УКСУСНОЙ КИСЛОТЫ И СОДЕРЖАЩИЕ ЕЁ ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ |
Country Status (18)
Country | Link |
---|---|
US (1) | US10351560B2 (ru) |
EP (1) | EP3350179B1 (ru) |
JP (1) | JP6833852B2 (ru) |
KR (1) | KR20180053345A (ru) |
CN (1) | CN108026093B (ru) |
AU (1) | AU2016323262B2 (ru) |
CA (1) | CA2993893A1 (ru) |
CL (1) | CL2018000665A1 (ru) |
EA (1) | EA035752B1 (ru) |
ES (1) | ES2867757T3 (ru) |
HK (1) | HK1255148A1 (ru) |
IL (1) | IL258039A (ru) |
MX (1) | MX2018003202A (ru) |
PH (1) | PH12018500505A1 (ru) |
PL (1) | PL3350179T3 (ru) |
TW (1) | TWI711616B (ru) |
UA (1) | UA123156C2 (ru) |
WO (1) | WO2017046125A1 (ru) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HUE039614T2 (hu) | 2014-03-17 | 2019-01-28 | Idorsia Pharmaceuticals Ltd | Azaindol-ecetsav-származékok és prosztaglandin D2 receptor modulátorokként történõ alkalmazásuk |
US20230159913A1 (en) | 2020-04-28 | 2023-05-25 | The Broad Institute, Inc. | Targeted base editing of the ush2a gene |
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2016
- 2016-09-14 UA UAA201803820A patent/UA123156C2/uk unknown
- 2016-09-14 EP EP16769914.9A patent/EP3350179B1/en active Active
- 2016-09-14 EA EA201890726A patent/EA035752B1/ru not_active IP Right Cessation
- 2016-09-14 CA CA2993893A patent/CA2993893A1/en active Pending
- 2016-09-14 KR KR1020187010162A patent/KR20180053345A/ko unknown
- 2016-09-14 US US15/759,710 patent/US10351560B2/en active Active
- 2016-09-14 TW TW105129954A patent/TWI711616B/zh active
- 2016-09-14 CN CN201680051683.0A patent/CN108026093B/zh active Active
- 2016-09-14 PL PL16769914T patent/PL3350179T3/pl unknown
- 2016-09-14 ES ES16769914T patent/ES2867757T3/es active Active
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2018
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US20190047996A1 (en) | 2019-02-14 |
TWI711616B (zh) | 2020-12-01 |
AU2016323262B2 (en) | 2020-11-19 |
TW201718578A (zh) | 2017-06-01 |
ES2867757T3 (es) | 2021-10-20 |
HK1255148A1 (zh) | 2019-08-09 |
UA123156C2 (uk) | 2021-02-24 |
CN108026093B (zh) | 2021-11-16 |
JP2018527411A (ja) | 2018-09-20 |
EP3350179B1 (en) | 2021-01-13 |
CA2993893A1 (en) | 2017-03-23 |
MX2018003202A (es) | 2018-06-08 |
EP3350179A1 (en) | 2018-07-25 |
IL258039A (en) | 2018-05-31 |
AU2016323262A1 (en) | 2018-05-10 |
US10351560B2 (en) | 2019-07-16 |
EA035752B1 (ru) | 2020-08-05 |
WO2017046125A1 (en) | 2017-03-23 |
JP6833852B2 (ja) | 2021-02-24 |
KR20180053345A (ko) | 2018-05-21 |
PH12018500505A1 (en) | 2018-09-24 |
CN108026093A (zh) | 2018-05-11 |
PL3350179T3 (pl) | 2021-08-02 |
CL2018000665A1 (es) | 2018-07-13 |
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