EA201691216A1 - Композиции линаклотида с замедленным высвобождением - Google Patents

Композиции линаклотида с замедленным высвобождением

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Publication number
EA201691216A1
EA201691216A1 EA201691216A EA201691216A EA201691216A1 EA 201691216 A1 EA201691216 A1 EA 201691216A1 EA 201691216 A EA201691216 A EA 201691216A EA 201691216 A EA201691216 A EA 201691216A EA 201691216 A1 EA201691216 A1 EA 201691216A1
Authority
EA
Eurasian Patent Office
Prior art keywords
linaclotide
compounds
slow release
preparing
processes
Prior art date
Application number
EA201691216A
Other languages
English (en)
Inventor
Ангелика Фретцен
Марк Дж. Карри
Ахмад Хашаш
Махендра Дедия
Юнь Мо
Анил Чхеттри
Мэттью Миллер
Ритеш Сангхви
Мохаммад Мафрухул Бари
Андреас Грилл
Original Assignee
Айронвуд Фармасьютикалз, Инк.
Форест Лэборетериз Холдингз Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=52293217&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201691216(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Айронвуд Фармасьютикалз, Инк., Форест Лэборетериз Холдингз Лимитед filed Critical Айронвуд Фармасьютикалз, Инк.
Publication of EA201691216A1 publication Critical patent/EA201691216A1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
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    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
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    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
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Abstract

Настоящее изобретение относится к фармацевтическим композициям с замедленным высвобождением, содержащим линаклотид или его фармацевтически приемлемые соли, а также к различным способам и процессам получения и использования композиций.
EA201691216A 2013-12-11 2014-12-11 Композиции линаклотида с замедленным высвобождением EA201691216A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361914951P 2013-12-11 2013-12-11
US201361914952P 2013-12-11 2013-12-11
PCT/US2014/069838 WO2015089326A1 (en) 2013-12-11 2014-12-11 Delayed release compositions of linaclotide

Publications (1)

Publication Number Publication Date
EA201691216A1 true EA201691216A1 (ru) 2016-11-30

Family

ID=52293217

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201691216A EA201691216A1 (ru) 2013-12-11 2014-12-11 Композиции линаклотида с замедленным высвобождением

Country Status (28)

Country Link
US (7) US20160310560A1 (ru)
EP (2) EP3821881A1 (ru)
JP (3) JP6964380B2 (ru)
KR (3) KR102509291B1 (ru)
CN (3) CN106659687A (ru)
AU (3) AU2014362220B2 (ru)
CA (1) CA2933587C (ru)
CL (1) CL2016001424A1 (ru)
CY (1) CY1123953T1 (ru)
DK (1) DK3079669T3 (ru)
EA (1) EA201691216A1 (ru)
EC (2) ECSP16059106A (ru)
ES (1) ES2838007T3 (ru)
HR (1) HRP20201753T1 (ru)
HU (1) HUE052981T2 (ru)
IL (2) IL246155A0 (ru)
LT (1) LT3079669T (ru)
MX (2) MX2016007625A (ru)
NZ (2) NZ759512A (ru)
PE (2) PE20211976A1 (ru)
PH (1) PH12016501122A1 (ru)
PL (1) PL3079669T3 (ru)
PT (1) PT3079669T (ru)
RS (1) RS61133B1 (ru)
SG (2) SG11201604729QA (ru)
SI (1) SI3079669T1 (ru)
UA (1) UA119335C2 (ru)
WO (2) WO2015089335A1 (ru)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR101476A1 (es) 2014-08-07 2016-12-21 Acerta Pharma Bv Métodos para tratar cánceres, enfermedades inmunes y autoinmunes, y enfermedades inflamatorias en base a la tasa de ocupación de la tirosin quinasa de bruton (btk) y a la tasa de resíntesis de la tirosin quinasa de bruton (btk)
CA3018328A1 (en) 2014-10-31 2016-04-30 Purdue Pharma Methods and compositions particularly for treatment of attention deficit disorder
WO2016125064A1 (en) * 2015-02-02 2016-08-11 Aurobindo Pharma Ltd Stable compositions comprising linaclotide
WO2016197042A1 (en) * 2015-06-05 2016-12-08 Ironwood Pharmaceuticals, Inc. Modified or targeted release formulations of linaclotide
US10588864B2 (en) 2016-03-11 2020-03-17 Gateway Pharmaceuticals LLC Pharmaceutical compositions for colon-specific delivery
WO2017156214A1 (en) * 2016-03-11 2017-09-14 Gateway Pharmaceutical LLC Pharmaceutical compositions for colon-specific delivery
WO2018065826A1 (en) * 2016-10-06 2018-04-12 Sucampo Ag Multilayer beads for pharmaceutical use
CN110475564A (zh) * 2016-12-21 2019-11-19 硬木药品公司 用利那洛肽的修饰的或延迟释放制剂治疗肠易激综合征的方法
KR102227486B1 (ko) * 2017-06-30 2021-03-12 롯데정밀화학 주식회사 프로톤 펌프 저해제를 포함하는 경구용 고형제제 조성물, 이를 포함하는 경구용 고형제제 및 그 제조방법
EA202092275A1 (ru) * 2018-03-23 2021-02-09 Палатин Текнолоджиз, Инк. Составы пептидов, специфичных к рецептору меланокортина, и способы доставки в желудочно-кишечный тракт
US10722473B2 (en) 2018-11-19 2020-07-28 Purdue Pharma L.P. Methods and compositions particularly for treatment of attention deficit disorder
WO2020251923A1 (en) * 2019-06-10 2020-12-17 Ironwood Pharmaceuticals, Inc. Treatment of abdominal pain associated with diarrhea-predominant irritable bowel syndrome
KR102104507B1 (ko) * 2019-08-23 2020-04-24 브릿지바이오테라퓨틱스(주) 팔미토일-l-프롤릴-l-프롤릴-글리실-l-타이로신 나트륨을 포함하는 약제학적 제제 및 이의 제조방법
CN110935007B (zh) * 2019-12-12 2023-06-23 烟台大学 利那洛肽复方组合物、制剂及其用途和制备方法
EP4340838A1 (en) * 2021-05-19 2024-03-27 Alberto Paz Orally administered compositions for cancer treatment
WO2024076577A1 (en) * 2022-10-03 2024-04-11 Brim Biotechnology, Inc. Compositions comprising pedf-derived short peptides (pdsp) and uses thereof

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7304036B2 (en) 2003-01-28 2007-12-04 Microbia, Inc. Methods and compositions for the treatment of gastrointestinal disorders
US7371727B2 (en) 2003-01-28 2008-05-13 Microbia, Inc. Methods and compositions for the treatment of gastrointestinal disorders
CN201252259Y (zh) * 2008-07-24 2009-06-03 富士康(昆山)电脑接插件有限公司 电连接器
MX2020005326A (es) * 2008-08-15 2022-03-03 Ironwood Pharmaceuticals Inc Formulaciones que contienen linaclotida para administracion oral.
CA2745694C (en) * 2008-12-03 2018-03-27 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase c agonists and methods of use
US20130012454A1 (en) * 2009-07-06 2013-01-10 Ironwood Pharmaceuticals, Inc. Orally Disintegrating Compositions of Linaclotide
MX2012001660A (es) * 2009-08-06 2012-03-26 Ironwood Pharmaceuticals Inc Formulaciones que contienen linaclotida para adminstracion oral.
EP2464373A1 (en) * 2009-08-13 2012-06-20 Ironwood Pharmaceuticals, Inc. Method for modulating the pharmacodynamic effect of orally administered guanylate cyclase receptor agonists
WO2011103311A2 (en) * 2010-02-17 2011-08-25 Ironwood Pharmaceuticals, Inc Treatments for gastrointestinal disorders
US20140005128A1 (en) * 2010-08-11 2014-01-02 Forest Laboratories Holdings Limited Treatments of gastrointestinal disorders
US20140162963A1 (en) * 2010-09-11 2014-06-12 Forest Laboratories Holdings Limited Treatment of Constipation-Predominant Irritable Bowel Syndrome
JP2012155108A (ja) * 2011-01-26 2012-08-16 Kyocera Document Solutions Inc 現像ローラ、現像装置および画像形成装置
EP2776055B1 (en) * 2011-08-17 2016-12-14 Ironwood Pharmaceuticals, Inc. Treatments for gastrointestinal disorders
JP5553132B2 (ja) * 2011-09-30 2014-07-16 アステラス製薬株式会社 粒子状医薬組成物
JP2016521249A (ja) * 2012-07-12 2016-07-21 フォレスト ラボラトリーズ ホールディングス リミテッド リナクロチド組成物
US9545446B2 (en) * 2013-02-25 2017-01-17 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses

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WO2015089335A1 (en) 2015-06-18
EP3079669B1 (en) 2020-09-30
MX2016007625A (es) 2016-12-09
ECSP16059106A (es) 2017-02-24
CL2016001424A1 (es) 2017-09-08
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