EA202091262A1 - Пиперидиновые модуляторы рецепторов cxcr7 - Google Patents

Пиперидиновые модуляторы рецепторов cxcr7

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Publication number
EA202091262A1
EA202091262A1 EA202091262A EA202091262A EA202091262A1 EA 202091262 A1 EA202091262 A1 EA 202091262A1 EA 202091262 A EA202091262 A EA 202091262A EA 202091262 A EA202091262 A EA 202091262A EA 202091262 A1 EA202091262 A1 EA 202091262A1
Authority
EA
Eurasian Patent Office
Prior art keywords
cxcr7
piperidine
receptor modulators
formula
modulators
Prior art date
Application number
EA202091262A
Other languages
English (en)
Inventor
Хамед Айссауи
Филипп Герри
Франсуа Леамбр
Жюльен Потье
Летиция Пузоль
Сильвия Рихард-Бильдштайн
Шугуан Юань
Original Assignee
Идорсия Фармасьютиклз Лтд
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Идорсия Фармасьютиклз Лтд filed Critical Идорсия Фармасьютиклз Лтд
Publication of EA202091262A1 publication Critical patent/EA202091262A1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
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    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/09—Geometrical isomers

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Transplantation (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Настоящее изобретение относится к пиперидиновым производным формулы (I)где Ar, Ar, R, R, Rи Rимеют значения, указанные в описании, к их получению, к их фармацевтически приемлемым солям и к их применению в качестве фармацевтических препаратов, к фармацевтическим композициям, которые содержат одно или несколько соединений формулы (I), и в особенности к их применению в качестве модуляторов рецепторов CXCR7.
EA202091262A 2016-07-28 2017-07-27 Пиперидиновые модуляторы рецепторов cxcr7 EA202091262A1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP2016068052 2016-07-28

Publications (1)

Publication Number Publication Date
EA202091262A1 true EA202091262A1 (ru) 2020-08-13

Family

ID=59656027

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EA201990388A EA037507B1 (ru) 2016-07-28 2017-07-27 Пиперидиновые модуляторы рецепторов cxcr7
EA202091262A EA202091262A1 (ru) 2016-07-28 2017-07-27 Пиперидиновые модуляторы рецепторов cxcr7

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US (2) US10752620B2 (ru)
EP (2) EP3798217B1 (ru)
JP (2) JP6655754B2 (ru)
KR (2) KR102497091B1 (ru)
CN (2) CN110563717B (ru)
AR (2) AR109180A1 (ru)
AU (2) AU2017302079B2 (ru)
BR (1) BR112019001551A2 (ru)
CA (1) CA3032017C (ru)
CL (2) CL2019000169A1 (ru)
CY (1) CY1125016T1 (ru)
DK (2) DK3490986T3 (ru)
EA (2) EA037507B1 (ru)
ES (2) ES2905755T3 (ru)
FI (1) FI3798217T3 (ru)
HR (2) HRP20230313T1 (ru)
HU (2) HUE057315T2 (ru)
IL (2) IL264424B (ru)
LT (2) LT3798217T (ru)
MA (2) MA54653B1 (ru)
MX (2) MX2019001042A (ru)
MY (1) MY198113A (ru)
NZ (1) NZ751006A (ru)
PH (1) PH12019500188A1 (ru)
PL (2) PL3798217T3 (ru)
PT (2) PT3798217T (ru)
RS (2) RS64130B1 (ru)
SG (2) SG11201900633XA (ru)
SI (2) SI3490986T1 (ru)
TW (3) TWI691497B (ru)
WO (1) WO2018019929A1 (ru)
ZA (1) ZA201901256B (ru)

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AU2019212888B8 (en) * 2018-01-26 2024-01-04 Idorsia Pharmaceuticals Ltd Crystalline forms of the CXCR7 receptor antagonist (3s,4s)-1- cyclopropylmethyl-4-{[5-(2,4-difluoro-phenyl)-isoxazole-3-carbonyl]- amino}-piperidine-3-carboxylic acid (1-pyrimidin-2-yl-cyclopropyl)-amide
IL292529A (en) 2019-10-31 2022-06-01 Idorsia Pharmaceuticals Ltd Combination of cxcr7 antagonist with s1p1 receptor modulator
WO2023012044A1 (en) 2021-08-02 2023-02-09 Syngenta Crop Protection Ag Microbiocidal pyrazole derivatives
KR102524669B1 (ko) * 2021-10-01 2023-04-21 주식회사 넥스트젠바이오사이언스 신규한 피페리딘 유도체 및 이를 포함하는 오토탁신 저해용 약학 조성물
WO2023110871A1 (en) 2021-12-17 2023-06-22 Syngenta Crop Protection Ag Microbiocidal pyrazole derivatives
EP4238970A1 (en) 2022-03-03 2023-09-06 InterAx Biotech AG Modulators of ackr3 and uses thereof
CN115403510B (zh) * 2022-08-11 2023-04-25 南方医科大学 一种pd-l1/cxcl12双靶点抑制剂、制备方法和用途
WO2024105104A1 (en) 2022-11-16 2024-05-23 Syngenta Crop Protection Ag Microbiocidal tetrahydroisoquinoline derivatives

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AU2019212888B8 (en) 2018-01-26 2024-01-04 Idorsia Pharmaceuticals Ltd Crystalline forms of the CXCR7 receptor antagonist (3s,4s)-1- cyclopropylmethyl-4-{[5-(2,4-difluoro-phenyl)-isoxazole-3-carbonyl]- amino}-piperidine-3-carboxylic acid (1-pyrimidin-2-yl-cyclopropyl)-amide

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IL282942B (en) 2022-01-01
MX2019001042A (es) 2019-06-10
US10752620B2 (en) 2020-08-25
LT3798217T (lt) 2023-05-25
MX2021004000A (es) 2021-06-23
JP6655754B2 (ja) 2020-02-26
TW201922738A (zh) 2019-06-16
ES2954152T3 (es) 2023-11-20
CL2019000169A1 (es) 2019-06-21
CN110563717B (zh) 2022-08-09
KR102497095B1 (ko) 2023-02-06
RS62855B1 (sr) 2022-02-28
AU2017302079B2 (en) 2021-07-22
EP3798217B1 (en) 2023-02-22
MA54653A (fr) 2021-12-29
EA037507B1 (ru) 2021-04-06
HRP20211988T1 (hr) 2022-03-18
CA3032017C (en) 2023-04-18
MA45782A (fr) 2019-06-05
DK3798217T3 (da) 2023-05-22
IL264424B (en) 2021-08-31
EP3798217A1 (en) 2021-03-31
PL3490986T3 (pl) 2022-04-04
JP2019142874A (ja) 2019-08-29
PH12019500188A1 (en) 2019-10-21
CN110563717A (zh) 2019-12-13
EP3490986A1 (en) 2019-06-05
US20190169180A1 (en) 2019-06-06
MA54653B1 (fr) 2023-04-28
PT3490986T (pt) 2022-02-01
JP6655742B2 (ja) 2020-02-26
TWI683812B (zh) 2020-02-01
AR115662A2 (es) 2021-02-10
CN109563085A (zh) 2019-04-02
TW201932454A (zh) 2019-08-16
TWI691497B (zh) 2020-04-21
AR109180A1 (es) 2018-11-07
MA45782B1 (fr) 2021-12-31
IL264424A (en) 2019-02-28
AU2020204578A1 (en) 2020-07-30
TWI691494B (zh) 2020-04-21
JP2019525927A (ja) 2019-09-12
BR112019001551A2 (pt) 2019-05-14
LT3490986T (lt) 2022-02-10
TW201806940A (zh) 2018-03-01
HUE057315T2 (hu) 2022-04-28
WO2018019929A1 (en) 2018-02-01
US11306078B2 (en) 2022-04-19
US20200385373A1 (en) 2020-12-10
NZ751006A (en) 2021-07-30
CA3032017A1 (en) 2018-02-01
ES2905755T3 (es) 2022-04-12
DK3490986T3 (da) 2022-03-07
ZA201901256B (en) 2021-08-25
EP3490986B1 (en) 2021-11-24
SI3798217T1 (sl) 2023-05-31
HRP20230313T1 (hr) 2023-05-12
EA201990388A1 (ru) 2019-08-30
FI3798217T3 (fi) 2023-05-03
SI3490986T1 (sl) 2022-02-28
KR20200092420A (ko) 2020-08-03
KR102497091B1 (ko) 2023-02-06
AU2020204578B2 (en) 2022-03-10
KR20190034620A (ko) 2019-04-02
PT3798217T (pt) 2023-05-23
MY198113A (en) 2023-08-03
HUE062019T2 (hu) 2023-09-28
SG10201906942PA (en) 2019-09-27
AU2017302079A1 (en) 2019-03-21
SG11201900633XA (en) 2019-02-27
CN109563085B (zh) 2022-08-09
RS64130B1 (sr) 2023-05-31
IL282942A (en) 2021-06-30
CL2019003281A1 (es) 2020-05-04
CY1125016T1 (el) 2023-03-24
PL3798217T3 (pl) 2023-06-12

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