EA202091262A1 - Пиперидиновые модуляторы рецепторов cxcr7 - Google Patents

Пиперидиновые модуляторы рецепторов cxcr7

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Publication number
EA202091262A1
EA202091262A1 EA202091262A EA202091262A EA202091262A1 EA 202091262 A1 EA202091262 A1 EA 202091262A1 EA 202091262 A EA202091262 A EA 202091262A EA 202091262 A EA202091262 A EA 202091262A EA 202091262 A1 EA202091262 A1 EA 202091262A1
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EA
Eurasian Patent Office
Prior art keywords
cxcr7
piperidine
receptor modulators
formula
modulators
Prior art date
Application number
EA202091262A
Other languages
English (en)
Inventor
Хамед Айссауи
Филипп Герри
Франсуа Леамбр
Жюльен Потье
Летиция Пузоль
Сильвия Рихард-Бильдштайн
Шугуан Юань
Original Assignee
Идорсия Фармасьютиклз Лтд
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Publication date
Application filed by Идорсия Фармасьютиклз Лтд filed Critical Идорсия Фармасьютиклз Лтд
Publication of EA202091262A1 publication Critical patent/EA202091262A1/ru

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
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    • A61P13/12Drugs for disorders of the urinary system of the kidneys
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
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    • A61P19/00Drugs for skeletal disorders
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
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    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
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    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
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    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07ORGANIC CHEMISTRY
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    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
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  • Veterinary Medicine (AREA)
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  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
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  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Transplantation (AREA)
  • Vascular Medicine (AREA)
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  • Hematology (AREA)
  • Obesity (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Настоящее изобретение относится к пиперидиновым производным формулы (I)где Ar, Ar, R, R, Rи Rимеют значения, указанные в описании, к их получению, к их фармацевтически приемлемым солям и к их применению в качестве фармацевтических препаратов, к фармацевтическим композициям, которые содержат одно или несколько соединений формулы (I), и в особенности к их применению в качестве модуляторов рецепторов CXCR7.
EA202091262A 2016-07-28 2017-07-27 Пиперидиновые модуляторы рецепторов cxcr7 EA202091262A1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP2016068052 2016-07-28

Publications (1)

Publication Number Publication Date
EA202091262A1 true EA202091262A1 (ru) 2020-08-13

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EA201990388A EA037507B1 (ru) 2016-07-28 2017-07-27 Пиперидиновые модуляторы рецепторов cxcr7
EA202091262A EA202091262A1 (ru) 2016-07-28 2017-07-27 Пиперидиновые модуляторы рецепторов cxcr7

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EA201990388A EA037507B1 (ru) 2016-07-28 2017-07-27 Пиперидиновые модуляторы рецепторов cxcr7

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US (2) US10752620B2 (ru)
EP (2) EP3798217B1 (ru)
JP (2) JP6655754B2 (ru)
KR (2) KR102497091B1 (ru)
CN (2) CN110563717B (ru)
AR (2) AR109180A1 (ru)
AU (2) AU2017302079B2 (ru)
BR (1) BR112019001551A2 (ru)
CA (1) CA3032017C (ru)
CL (2) CL2019000169A1 (ru)
CY (1) CY1125016T1 (ru)
DK (2) DK3490986T3 (ru)
EA (2) EA037507B1 (ru)
ES (2) ES2905755T3 (ru)
FI (1) FI3798217T3 (ru)
HR (2) HRP20230313T1 (ru)
HU (2) HUE057315T2 (ru)
IL (2) IL264424B (ru)
LT (2) LT3798217T (ru)
MA (2) MA54653B1 (ru)
MX (2) MX2019001042A (ru)
MY (1) MY198113A (ru)
NZ (1) NZ751006A (ru)
PH (1) PH12019500188A1 (ru)
PL (2) PL3798217T3 (ru)
PT (2) PT3798217T (ru)
RS (2) RS64130B1 (ru)
SG (2) SG11201900633XA (ru)
SI (2) SI3490986T1 (ru)
TW (3) TWI691497B (ru)
WO (1) WO2018019929A1 (ru)
ZA (1) ZA201901256B (ru)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2019212888B8 (en) * 2018-01-26 2024-01-04 Idorsia Pharmaceuticals Ltd Crystalline forms of the CXCR7 receptor antagonist (3s,4s)-1- cyclopropylmethyl-4-{[5-(2,4-difluoro-phenyl)-isoxazole-3-carbonyl]- amino}-piperidine-3-carboxylic acid (1-pyrimidin-2-yl-cyclopropyl)-amide
IL292529A (en) 2019-10-31 2022-06-01 Idorsia Pharmaceuticals Ltd Combination of cxcr7 antagonist with s1p1 receptor modulator
WO2023012044A1 (en) 2021-08-02 2023-02-09 Syngenta Crop Protection Ag Microbiocidal pyrazole derivatives
KR102524669B1 (ko) * 2021-10-01 2023-04-21 주식회사 넥스트젠바이오사이언스 신규한 피페리딘 유도체 및 이를 포함하는 오토탁신 저해용 약학 조성물
WO2023110871A1 (en) 2021-12-17 2023-06-22 Syngenta Crop Protection Ag Microbiocidal pyrazole derivatives
EP4238970A1 (en) 2022-03-03 2023-09-06 InterAx Biotech AG Modulators of ackr3 and uses thereof
CN115403510B (zh) * 2022-08-11 2023-04-25 南方医科大学 一种pd-l1/cxcl12双靶点抑制剂、制备方法和用途
WO2024105104A1 (en) 2022-11-16 2024-05-23 Syngenta Crop Protection Ag Microbiocidal tetrahydroisoquinoline derivatives

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AU2019212888B8 (en) 2018-01-26 2024-01-04 Idorsia Pharmaceuticals Ltd Crystalline forms of the CXCR7 receptor antagonist (3s,4s)-1- cyclopropylmethyl-4-{[5-(2,4-difluoro-phenyl)-isoxazole-3-carbonyl]- amino}-piperidine-3-carboxylic acid (1-pyrimidin-2-yl-cyclopropyl)-amide

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IL282942B (en) 2022-01-01
MX2019001042A (es) 2019-06-10
US10752620B2 (en) 2020-08-25
LT3798217T (lt) 2023-05-25
MX2021004000A (es) 2021-06-23
JP6655754B2 (ja) 2020-02-26
TW201922738A (zh) 2019-06-16
ES2954152T3 (es) 2023-11-20
CL2019000169A1 (es) 2019-06-21
CN110563717B (zh) 2022-08-09
KR102497095B1 (ko) 2023-02-06
RS62855B1 (sr) 2022-02-28
AU2017302079B2 (en) 2021-07-22
EP3798217B1 (en) 2023-02-22
MA54653A (fr) 2021-12-29
EA037507B1 (ru) 2021-04-06
HRP20211988T1 (hr) 2022-03-18
CA3032017C (en) 2023-04-18
MA45782A (fr) 2019-06-05
DK3798217T3 (da) 2023-05-22
IL264424B (en) 2021-08-31
EP3798217A1 (en) 2021-03-31
PL3490986T3 (pl) 2022-04-04
JP2019142874A (ja) 2019-08-29
PH12019500188A1 (en) 2019-10-21
CN110563717A (zh) 2019-12-13
EP3490986A1 (en) 2019-06-05
US20190169180A1 (en) 2019-06-06
MA54653B1 (fr) 2023-04-28
PT3490986T (pt) 2022-02-01
JP6655742B2 (ja) 2020-02-26
TWI683812B (zh) 2020-02-01
AR115662A2 (es) 2021-02-10
CN109563085A (zh) 2019-04-02
TW201932454A (zh) 2019-08-16
TWI691497B (zh) 2020-04-21
AR109180A1 (es) 2018-11-07
MA45782B1 (fr) 2021-12-31
IL264424A (en) 2019-02-28
AU2020204578A1 (en) 2020-07-30
TWI691494B (zh) 2020-04-21
JP2019525927A (ja) 2019-09-12
BR112019001551A2 (pt) 2019-05-14
LT3490986T (lt) 2022-02-10
TW201806940A (zh) 2018-03-01
HUE057315T2 (hu) 2022-04-28
WO2018019929A1 (en) 2018-02-01
US11306078B2 (en) 2022-04-19
US20200385373A1 (en) 2020-12-10
NZ751006A (en) 2021-07-30
CA3032017A1 (en) 2018-02-01
ES2905755T3 (es) 2022-04-12
DK3490986T3 (da) 2022-03-07
ZA201901256B (en) 2021-08-25
EP3490986B1 (en) 2021-11-24
SI3798217T1 (sl) 2023-05-31
HRP20230313T1 (hr) 2023-05-12
EA201990388A1 (ru) 2019-08-30
FI3798217T3 (fi) 2023-05-03
SI3490986T1 (sl) 2022-02-28
KR20200092420A (ko) 2020-08-03
KR102497091B1 (ko) 2023-02-06
AU2020204578B2 (en) 2022-03-10
KR20190034620A (ko) 2019-04-02
PT3798217T (pt) 2023-05-23
MY198113A (en) 2023-08-03
HUE062019T2 (hu) 2023-09-28
SG10201906942PA (en) 2019-09-27
AU2017302079A1 (en) 2019-03-21
SG11201900633XA (en) 2019-02-27
CN109563085B (zh) 2022-08-09
RS64130B1 (sr) 2023-05-31
IL282942A (en) 2021-06-30
CL2019003281A1 (es) 2020-05-04
CY1125016T1 (el) 2023-03-24
PL3798217T3 (pl) 2023-06-12

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