EA201792008A1 - Соединения азапиридона и способы их применения - Google Patents

Соединения азапиридона и способы их применения

Info

Publication number
EA201792008A1
EA201792008A1 EA201792008A EA201792008A EA201792008A1 EA 201792008 A1 EA201792008 A1 EA 201792008A1 EA 201792008 A EA201792008 A EA 201792008A EA 201792008 A EA201792008 A EA 201792008A EA 201792008 A1 EA201792008 A1 EA 201792008A1
Authority
EA
Eurasian Patent Office
Prior art keywords
compounds
methods
azapiridone
azapiridon
application
Prior art date
Application number
EA201792008A
Other languages
English (en)
Other versions
EA036776B1 (ru
Inventor
Роберт Тань Хендрикс
Леонид Бейгельман
Дэвид Бернард Смит
Антица Димитрова Стойчева
Original Assignee
Элиос Биофарма, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Элиос Биофарма, Инк. filed Critical Элиос Биофарма, Инк.
Publication of EA201792008A1 publication Critical patent/EA201792008A1/ru
Publication of EA036776B1 publication Critical patent/EA036776B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Emergency Medicine (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)

Abstract

В данном документе раскрыты новые соединения азапиридона, фармацевтические композиции, которые содержат одно или несколько соединений азапиридона, и способы их синтеза. Также в данном документе раскрыты способы снижения интенсивности и/или лечения заболевания и/или патологического состояния, включая инфекцию, вызванную ортомиксовирусом, соединением азапиридона. Примеры вызываемой ортомиксовирусом вирусной инфекции включают инфекцию, вызываемую вирусом гриппа.
EA201792008A 2015-03-11 2016-03-09 Соединения азапиридона и способы их применения EA036776B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562131708P 2015-03-11 2015-03-11
PCT/US2016/021598 WO2016145103A1 (en) 2015-03-11 2016-03-09 Aza-pyridone compounds and uses thereof

Publications (2)

Publication Number Publication Date
EA201792008A1 true EA201792008A1 (ru) 2018-05-31
EA036776B1 EA036776B1 (ru) 2020-12-21

Family

ID=56879649

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201792008A EA036776B1 (ru) 2015-03-11 2016-03-09 Соединения азапиридона и способы их применения

Country Status (10)

Country Link
US (1) US10208045B2 (ru)
EP (1) EP3268368A4 (ru)
CN (1) CN107531717B (ru)
AU (1) AU2016229147C1 (ru)
CA (1) CA2979216A1 (ru)
EA (1) EA036776B1 (ru)
HK (1) HK1246780A1 (ru)
MX (1) MX2017011655A (ru)
TW (1) TWI772256B (ru)
WO (1) WO2016145103A1 (ru)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2935303T3 (da) 2012-12-21 2021-05-03 Janssen Biopharma Inc 4`-fluornukleosider, 4`-fluornukleotider og analoger dertil til behandling af HCV
MX2016003199A (es) 2013-09-12 2016-06-02 Alios Biopharma Inc Compuestos de azapiridona y usos de los mismos.
WO2015038660A1 (en) 2013-09-12 2015-03-19 Alios Biopharma, Inc. Pyridazinone compounds and uses thereof
MX2017011655A (es) 2015-03-11 2018-04-30 Alios Biopharma Inc Compuestos de aza-piridona y usos de estos.
US10858366B2 (en) 2016-03-08 2020-12-08 Novartis Ag Tricyclic compounds useful to treat orthomyxovirus infections
US10183945B2 (en) 2016-03-10 2019-01-22 Alios Biopharma, Inc. Method of preparing AZA-pyridone compounds
WO2017223231A1 (en) 2016-06-21 2017-12-28 Alios Biopharma, Inc. (s)-8-(benzhydryl )-6-isopropyl-3,5-dioxo- 5, 6,7,8,-tetrahydro-3h-pyrazino-[1,2-b]pyridazin-yl-isobutyrate antiviral agent for use in treating influenza
JOP20170169A1 (ar) 2016-08-29 2019-01-30 Novartis Ag مركبات بيريدازين ثلاثية الحلقة مندمجة تفيد في علاج العدوى بفيروس أورثوميكسو
KR20230031990A (ko) 2018-02-28 2023-03-07 노파르티스 아게 인플루엔자의 치료를 위한 오르토믹소바이러스 복제의 억제제로서의 10-(디(페닐)메틸)-4-히드록시-8,9,9a,10-테트라히드로-7h-피롤로[1',2':4,5]피라지노[1,2-b]피리다진-3,5-디온 유도체 및 관련 화합물
US20220056024A1 (en) * 2018-09-10 2022-02-24 Cocrystal Pharma, Inc. Pyridopyrazine and pyridotriazine inhibitors of influenza virus replication

Family Cites Families (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPM354694A0 (en) 1994-01-27 1994-02-17 Biota Scientific Management Pty Ltd Chemical compounds
TW200510425A (en) 2003-08-13 2005-03-16 Japan Tobacco Inc Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor
CN100357284C (zh) 2003-09-11 2007-12-26 浙江海正药业股份有限公司 抗流感病毒化合物及其制备方法和用途
EP1732541A4 (en) 2004-04-07 2008-03-05 Takeda Pharmaceutical CYCLIC COMPOUNDS
ZA200702380B (en) 2004-09-03 2008-09-25 Celgene Corp Substituted heterocyclic compounds and uses thereof
CN101340902B (zh) 2005-11-28 2011-01-26 奥加生物药业（香港）有限公司 用半胱胺化合物处理病毒感染的材料和方法
AR057623A1 (es) 2005-11-28 2007-12-05 Omega Bio Pharma H K Ltd Materiales y metodos para el tratamiento de las infecciones virales
FR2909090B1 (fr) 2006-11-23 2009-01-09 Sanofi Aventis Sa Derives de 2,5-dihydro-3h-pyrazolo[4,3-c]pyridazin-3-one substitues,leur preparation et leur application en therapeutique.
WO2008077188A1 (en) 2006-12-22 2008-07-03 Avexa Limited Bicyclic pyrimidinones and uses thereof
WO2009053799A1 (en) 2007-10-24 2009-04-30 Glenmark Pharmaceuticals, S.A. Novel cannabinoid receptor ligands, pharmaceutical compositions containing them, and process for their preparation
ES2467108T3 (es) 2008-12-09 2014-06-11 Gilead Sciences, Inc. Moduladores de receptores tipo toll
US8809538B2 (en) 2009-01-12 2014-08-19 Array Biopharma Inc. Piperidine-containing compounds and use thereof
MY170610A (en) 2009-02-05 2019-08-20 Takeda Pharmaceuticals Co Pyridazinone compounds
US8486946B2 (en) 2009-02-23 2013-07-16 Merck Sharp & Dohme Corp. Pyrazolo [4,3-c] cinnolin-3-one M1 receptor positive allosteric modulators
AU2010226466A1 (en) 2009-03-20 2011-10-20 Alios Biopharma, Inc. Substituted nucleoside and nucleotide analogs
TW201038572A (en) 2009-03-25 2010-11-01 Gruenenthal Gmbh Substituted spiro-amide compounds
TWI518084B (zh) 2009-03-26 2016-01-21 鹽野義製藥股份有限公司 哌喃酮與吡啶酮衍生物之製造方法
EP2412708A4 (en) 2009-03-26 2014-07-23 Shionogi & Co SUBSTITUTED 3-HYDROXY-4-PYRIDONE DERIVATIVE
WO2010138419A2 (en) 2009-05-23 2010-12-02 Obio Pharmaceutical (H.K.) Ltd. Materials and methods for treating viral infections
CN102803260B (zh) 2009-06-15 2016-02-10 盐野义制药株式会社 被取代的多环性氨基甲酰基吡啶酮衍生物
WO2011084371A1 (en) 2009-12-21 2011-07-14 Merck Sharp & Dohme Corp. Aminobenzoquinazolinone m1 receptor positive allosteric modulators
WO2011120153A1 (en) 2010-04-01 2011-10-06 Critical Outcome Technologies Inc. Compounds and method for treatment of hiv
US20130116231A1 (en) 2010-07-12 2013-05-09 Merck Sharp & Dohme Corp. Tyrosine kinase inhibitors
US20120070411A1 (en) 2010-09-22 2012-03-22 Alios Biopharma, Inc. Substituted nucleotide analogs
AP3584A (en) 2010-09-22 2016-02-09 Alios Biopharma Inc Substituted nucleotide analogs
CA2812962C (en) 2010-09-22 2020-03-31 Alios Biopharma, Inc. Azido nucleosides and nucleotide analogs
CN103228653B (zh) * 2010-09-24 2016-03-16 盐野义制药株式会社 被取代的多环性氨基甲酰基吡啶酮衍生物的前药
CA2819041A1 (en) 2010-12-22 2012-06-28 Alios Biopharma, Inc. Cyclic nucleotide analogs
JP2014528410A (ja) 2011-09-30 2014-10-27 キネタ・インコーポレイテツド 抗ウイルス化合物
DK2794627T3 (en) 2011-12-22 2019-01-14 Alios Biopharma Inc SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGUES THEREOF
WO2013096680A1 (en) 2011-12-22 2013-06-27 Alios Biopharma, Inc. Substituted phosphorothioate nucleotide analogs
CN104321333A (zh) 2012-03-21 2015-01-28 沃泰克斯药物股份有限公司 硫代氨基磷酸酯核苷酸前药的固体形式
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
PL2827875T3 (pl) 2012-03-21 2019-07-31 Janssen Biopharma, Inc. Podstawione nukleozydy, nukleotydy i ich analogi
NZ630800A (en) 2012-03-21 2016-06-24 Alios Biopharma Inc Methods of preparing substituted nucleotide analogs
WO2013142159A1 (en) 2012-03-21 2013-09-26 Alios Biopharma, Inc. Pharmaceutical combinations comprising a thionucleotide analog
NZ630805A (en) 2012-03-22 2016-01-29 Alios Biopharma Inc Pharmaceutical combinations comprising a thionucleotide analog
DK2935303T3 (da) 2012-12-21 2021-05-03 Janssen Biopharma Inc 4`-fluornukleosider, 4`-fluornukleotider og analoger dertil til behandling af HCV
CA2894541A1 (en) 2012-12-21 2014-06-26 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
AR094378A1 (es) 2013-01-08 2015-07-29 Savira Pharmaceuticals Gmbh Derivados de pirimidona y su uso en el tratamiento, mejora o prevención de una enfermedad viral
WO2014134251A1 (en) 2013-02-28 2014-09-04 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions
US20140309413A1 (en) 2013-03-11 2014-10-16 Vertex Pharmaceuticals Incorporated Methods of stereoselective synthesis of substituted nucleoside analogs
US9504705B2 (en) 2013-04-05 2016-11-29 Alios Biopharma, Inc. Hepatitis C viral infection treatment using a combination of compounds
TW201542578A (zh) 2013-06-26 2015-11-16 Alios Biopharma Inc 經取代之核苷、核苷酸及其類似物
TWI655199B (zh) 2013-06-26 2019-04-01 美商艾洛斯生物製藥公司 經取代之核苷、核苷酸及其類似物
MX2016003199A (es) * 2013-09-12 2016-06-02 Alios Biopharma Inc Compuestos de azapiridona y usos de los mismos.
WO2015038660A1 (en) 2013-09-12 2015-03-19 Alios Biopharma, Inc. Pyridazinone compounds and uses thereof
AU2014331863C1 (en) 2013-10-11 2019-05-16 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
WO2015200205A1 (en) 2014-06-24 2015-12-30 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
US9603864B2 (en) 2014-06-24 2017-03-28 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
EP3160979A4 (en) 2014-06-24 2018-01-03 Alios Biopharma, Inc. Methods of preparing substituted nucleotide analogs
RU2017105470A (ru) 2014-07-22 2018-08-22 Элиос Биофарма, Инк. Способы лечения парамиксовирусов
EP3177299A4 (en) 2014-08-05 2018-04-04 Alios Biopharma, Inc. Combination therapy for treating a paramyxovirus
EP3212657A4 (en) 2014-10-28 2018-04-11 Alios Biopharma, Inc. Methods of preparing substituted nucleoside analogs
MA41441A (fr) 2014-12-19 2017-12-12 Alios Biopharma Inc Nucléosides substitués, nucléotides et analogues de ceux-ci
MA41213A (fr) 2014-12-19 2017-10-24 Alios Biopharma Inc Nucléosides substitués, nucléotides et analogues de ceux-ci
MX2017011655A (es) 2015-03-11 2018-04-30 Alios Biopharma Inc Compuestos de aza-piridona y usos de estos.
US10183945B2 (en) 2016-03-10 2019-01-22 Alios Biopharma, Inc. Method of preparing AZA-pyridone compounds
WO2017223231A1 (en) 2016-06-21 2017-12-28 Alios Biopharma, Inc. (s)-8-(benzhydryl )-6-isopropyl-3,5-dioxo- 5, 6,7,8,-tetrahydro-3h-pyrazino-[1,2-b]pyridazin-yl-isobutyrate antiviral agent for use in treating influenza

Also Published As

Publication number Publication date
HK1246780A1 (zh) 2018-09-14
AU2016229147A1 (en) 2017-09-28
WO2016145103A1 (en) 2016-09-15
TW201639850A (zh) 2016-11-16
AU2016229147C1 (en) 2021-03-25
AU2016229147B2 (en) 2020-10-22
EP3268368A4 (en) 2018-11-14
EA036776B1 (ru) 2020-12-21
MX2017011655A (es) 2018-04-30
CA2979216A1 (en) 2016-09-15
CN107531717B (zh) 2021-07-27
CN107531717A (zh) 2018-01-02
EP3268368A1 (en) 2018-01-17
US20160264581A1 (en) 2016-09-15
US10208045B2 (en) 2019-02-19
TWI772256B (zh) 2022-08-01

Similar Documents

Publication Publication Date Title
EA201792008A1 (ru) Соединения азапиридона и способы их применения
EA201690372A1 (ru) Азапиридоновые соединения и их применение
EA201791886A1 (ru) Антивирусные соединения
EA201790630A1 (ru) Способы получения рибозидов
MX2019002356A (es) Compuestos de biarilo utiles como inmunomoduladores.
EA201791420A1 (ru) Соединения триазолопиримидина и их применения
EA201890857A1 (ru) Соединения, применимые в качестве иммуномодуляторов
EA201691726A1 (ru) Новые 6-конденсированные гетероарилдигидропиримидины для лечения и профилактики заражения вирусом гепатита b
EA201691261A1 (ru) Новые дигидрохинолизиноны для лечения и профилактики инфекции, вызванной вирусом гепатита b
EA201592126A1 (ru) 6-мостиковые гетероарилдигидропиримидины для лечения и профилактики заражения вирусом гепатита b
EA201691857A1 (ru) Соединения, применимые в качестве иммуномодуляторов
EA201590384A1 (ru) 6-аминокислота-гетероарилдигидропиримидины для лечения и профилактики инфекции вируса гепатита в
EA201690224A1 (ru) Противовирусные соединения
EA201690371A1 (ru) Пиридазиноновые соединения и их применение
EA201790700A1 (ru) Моно- или дизамещенные индолы в качестве ингибиторов репликации вирусов денге
EA201790758A1 (ru) Производные моно- или дизамещенных индолов в качестве ингибиторов репликации вирусов денге
EA201591457A1 (ru) Терапевтические соединения
EA201892216A1 (ru) Замещенные производные индолина в качестве ингибиторов репликации вирусов денге
EA201892219A1 (ru) Замещенные производные индолина в качестве ингибиторов репликации вирусов денге
EA201792021A1 (ru) Ингибитор jak
EA201790571A1 (ru) Пирролопиримидины для применения при инфекции, вызванной вирусом гриппа
GEP20237457B (en) Nucleotide hemi-sulfate salt for treatment of hepatitis c virus
EA201691141A1 (ru) Соединения против ccr6
EA202090720A1 (ru) ПРОИЗВОДНЫЕ GalNAc
EA201791896A1 (ru) Дезацетокситубулизин н и его аналоги

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG TJ TM