EA201491584A1 - Способы лечения немелкоклеточного рака легких c применением комбинированного лечения с ингибитором киназы tor - Google Patents
Способы лечения немелкоклеточного рака легких c применением комбинированного лечения с ингибитором киназы torInfo
- Publication number
- EA201491584A1 EA201491584A1 EA201491584A EA201491584A EA201491584A1 EA 201491584 A1 EA201491584 A1 EA 201491584A1 EA 201491584 A EA201491584 A EA 201491584A EA 201491584 A EA201491584 A EA 201491584A EA 201491584 A1 EA201491584 A1 EA 201491584A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- lung cancer
- cell lung
- small
- methods
- combined treatment
- Prior art date
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Abstract
В настоящем документе представлены способы лечения или профилактики немелкоклеточного рака легких на поздних стадиях, включающие введение пациенту с немелкоклеточным раком легких на поздних стадиях эффективного количества ингибитора киназы TOR и эффективного количества эрлотиниба или аналога цитидина.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261603012P | 2012-02-24 | 2012-02-24 | |
US201261716424P | 2012-10-19 | 2012-10-19 | |
US201261725805P | 2012-11-13 | 2012-11-13 | |
PCT/US2013/027235 WO2013126636A1 (en) | 2012-02-24 | 2013-02-22 | Methods for treating non- small cell lung cancer using tor kinase inhibitor combination therapy |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201491584A1 true EA201491584A1 (ru) | 2014-12-30 |
EA028462B1 EA028462B1 (ru) | 2017-11-30 |
Family
ID=47790539
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201491584A EA028462B1 (ru) | 2012-02-24 | 2013-02-22 | Способы лечения немелкоклеточного рака легких на поздних стадиях c применением комбинированного лечения с ингибитором киназы tor |
Country Status (21)
Country | Link |
---|---|
US (1) | US9375443B2 (ru) |
EP (1) | EP2817029B1 (ru) |
JP (1) | JP6114317B2 (ru) |
KR (1) | KR102064626B1 (ru) |
CN (1) | CN104271159B (ru) |
AU (1) | AU2013202305B2 (ru) |
BR (1) | BR112014020786A2 (ru) |
CA (1) | CA2864905A1 (ru) |
EA (1) | EA028462B1 (ru) |
ES (1) | ES2742398T3 (ru) |
HK (1) | HK1199825A1 (ru) |
IL (2) | IL234169B (ru) |
MX (1) | MX358303B (ru) |
MY (1) | MY174308A (ru) |
NI (1) | NI201400095A (ru) |
NZ (1) | NZ628410A (ru) |
PH (2) | PH12014501880A1 (ru) |
SG (1) | SG11201405064RA (ru) |
TW (1) | TWI615143B (ru) |
WO (1) | WO2013126636A1 (ru) |
ZA (1) | ZA201406052B (ru) |
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PH12014501880B1 (en) | 2014-11-24 |
TW201338778A (zh) | 2013-10-01 |
EP2817029B1 (en) | 2019-07-10 |
WO2013126636A1 (en) | 2013-08-29 |
CN104271159B (zh) | 2017-11-28 |
JP2015508103A (ja) | 2015-03-16 |
PH12017501500A1 (en) | 2018-12-17 |
AU2013202305A1 (en) | 2013-09-12 |
CN104271159A (zh) | 2015-01-07 |
HK1199825A1 (en) | 2015-07-24 |
CA2864905A1 (en) | 2013-08-29 |
MY174308A (en) | 2020-04-06 |
ES2742398T3 (es) | 2020-02-14 |
SG11201405064RA (en) | 2014-09-26 |
BR112014020786A2 (pt) | 2020-10-27 |
EP2817029A1 (en) | 2014-12-31 |
PH12014501880A1 (en) | 2014-11-24 |
MX358303B (es) | 2018-08-14 |
IL234169B (en) | 2020-06-30 |
IL274647A (en) | 2020-06-30 |
NZ628410A (en) | 2016-03-31 |
JP6114317B2 (ja) | 2017-04-12 |
ZA201406052B (en) | 2015-11-25 |
AU2013202305B2 (en) | 2015-03-12 |
US9375443B2 (en) | 2016-06-28 |
KR20140123112A (ko) | 2014-10-21 |
US20130225518A1 (en) | 2013-08-29 |
KR102064626B1 (ko) | 2020-01-09 |
EA028462B1 (ru) | 2017-11-30 |
TWI615143B (zh) | 2018-02-21 |
MX2014010198A (es) | 2014-11-21 |
NI201400095A (es) | 2016-12-02 |
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