EA201491013A1 - Пиразиновые ингибиторы киназы - Google Patents

Пиразиновые ингибиторы киназы

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Publication number
EA201491013A1
EA201491013A1 EA201491013A EA201491013A EA201491013A1 EA 201491013 A1 EA201491013 A1 EA 201491013A1 EA 201491013 A EA201491013 A EA 201491013A EA 201491013 A EA201491013 A EA 201491013A EA 201491013 A1 EA201491013 A1 EA 201491013A1
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EA
Eurasian Patent Office
Prior art keywords
kinase inhibitors
methods
pyrazine
syk kinase
kinase activity
Prior art date
Application number
EA201491013A
Other languages
English (en)
Other versions
EA026939B1 (ru
Inventor
Юнхун Сун
Цин Сюй
Чжаохун Цз. Цзя
Брайан Кейн
Шон М. Бауэр
Анджали Пандей
Original Assignee
Портола Фармасьютикалз, Инк.
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Publication date
Application filed by Портола Фармасьютикалз, Инк. filed Critical Портола Фармасьютикалз, Инк.
Publication of EA201491013A1 publication Critical patent/EA201491013A1/ru
Publication of EA026939B1 publication Critical patent/EA026939B1/ru

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    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D513/04—Ortho-condensed systems

Abstract

Обеспечиваются пиразиновые соединения для ингибирования Syk киназы, промежуточные соединения, используемые для получения таких соединений, способы их получения, включающие их фармацевтический композиции, способы ингибирования Syk киназной активности и способы лечения состояний, опосредованных, по меньшей мере частично, киназной активностью Syk.
EA201491013A 2011-11-23 2012-11-23 Пиразиновые ингибиторы киназы EA026939B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161563466P 2011-11-23 2011-11-23
PCT/US2012/066468 WO2013078466A1 (en) 2011-11-23 2012-11-23 Pyrazine kinase inhibitors

Publications (2)

Publication Number Publication Date
EA201491013A1 true EA201491013A1 (ru) 2014-10-30
EA026939B1 EA026939B1 (ru) 2017-06-30

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EA201491013A EA026939B1 (ru) 2011-11-23 2012-11-23 Пиразиновые ингибиторы киназы

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US (2) US9359308B2 (ru)
EP (1) EP2782579B1 (ru)
JP (1) JP6039683B2 (ru)
KR (1) KR102019530B1 (ru)
CN (1) CN104066431B (ru)
AU (1) AU2012340555B2 (ru)
BR (1) BR112014012396B1 (ru)
CA (2) CA2856301C (ru)
CL (1) CL2014001346A1 (ru)
CO (1) CO6990735A2 (ru)
EA (1) EA026939B1 (ru)
HK (1) HK1201460A1 (ru)
IL (1) IL232701A (ru)
IN (1) IN2014CN04065A (ru)
MX (1) MX363551B (ru)
SG (2) SG11201402570QA (ru)
WO (1) WO2013078466A1 (ru)
ZA (1) ZA201403651B (ru)

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