DK2004632T3 - Hiv-inhiberende 5-amidosubstituerede pyrimidiner - Google Patents
Hiv-inhiberende 5-amidosubstituerede pyrimidinerInfo
- Publication number
- DK2004632T3 DK2004632T3 DK07727583T DK07727583T DK2004632T3 DK 2004632 T3 DK2004632 T3 DK 2004632T3 DK 07727583 T DK07727583 T DK 07727583T DK 07727583 T DK07727583 T DK 07727583T DK 2004632 T3 DK2004632 T3 DK 2004632T3
- Authority
- DK
- Denmark
- Prior art keywords
- amidosubstituted
- inhibitive
- pyrimidines
- hiv
- hiv inhibitive
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06112044 | 2006-03-30 | ||
| PCT/EP2007/053111 WO2007113254A1 (en) | 2006-03-30 | 2007-03-30 | Hiv inhibiting 5-amido substituted pyrimidines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2004632T3 true DK2004632T3 (da) | 2014-06-16 |
Family
ID=36791649
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK07727583T DK2004632T3 (da) | 2006-03-30 | 2007-03-30 | Hiv-inhiberende 5-amidosubstituerede pyrimidiner |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US8933089B2 (da) |
| EP (1) | EP2004632B1 (da) |
| JP (1) | JP5078986B2 (da) |
| KR (1) | KR20080114741A (da) |
| CN (1) | CN101405283B (da) |
| AU (1) | AU2007233737B2 (da) |
| BR (1) | BRPI0709690B8 (da) |
| CA (1) | CA2645958C (da) |
| DK (1) | DK2004632T3 (da) |
| ES (1) | ES2465666T3 (da) |
| IL (1) | IL193610A (da) |
| MX (1) | MX2008012576A (da) |
| RU (1) | RU2480464C2 (da) |
| WO (1) | WO2007113254A1 (da) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101031558B (zh) | 2004-09-30 | 2011-10-05 | 泰博特克药品有限公司 | 抑制人类免疫缺陷病毒的5-杂环基嘧啶 |
| AU2005288866B2 (en) | 2004-09-30 | 2012-07-26 | Janssen Sciences Ireland Uc | HIV inhibiting 5-substituted pyrimidines |
| MX2007010051A (es) * | 2005-02-18 | 2007-09-21 | Tibotec Pharm Ltd | Derivados de oxido de 2-(4-cianofenilamino)pirimidina que inhiben el virus de inmunodeficiencia humana. |
| MX2008012576A (es) | 2006-03-30 | 2008-10-10 | Tibotec Pharm Ltd | Pirimidinas 5-amido sustituidas inhibidoras del virus de inmunodeficiencia humana. |
| JP5283633B2 (ja) | 2006-12-29 | 2013-09-04 | テイボテク・フアーマシユーチカルズ | Ｈｉｖ阻害性５，６−置換ピリミジン |
| DK2114901T3 (da) | 2006-12-29 | 2014-06-30 | Janssen R & D Ireland | Hiv-inhiberende 6-substituerede pyrimidiner |
| US8138339B2 (en) | 2008-04-16 | 2012-03-20 | Portola Pharmaceuticals, Inc. | Inhibitors of protein kinases |
| US8063058B2 (en) | 2008-04-16 | 2011-11-22 | Portola Pharmaceuticals, Inc. | Inhibitors of syk and JAK protein kinases |
| EP3210609A1 (en) | 2008-05-21 | 2017-08-30 | Ariad Pharmaceuticals, Inc. | Phosphorous derivatives as kinase inhibitors |
| US9273077B2 (en) | 2008-05-21 | 2016-03-01 | Ariad Pharmaceuticals, Inc. | Phosphorus derivatives as kinase inhibitors |
| CA2986640C (en) | 2008-06-27 | 2019-03-26 | Celgene Avilomics Research, Inc. | Heteroaryl compounds and uses thereof |
| US8338439B2 (en) | 2008-06-27 | 2012-12-25 | Celgene Avilomics Research, Inc. | 2,4-disubstituted pyrimidines useful as kinase inhibitors |
| US11351168B1 (en) | 2008-06-27 | 2022-06-07 | Celgene Car Llc | 2,4-disubstituted pyrimidines useful as kinase inhibitors |
| CA2760794C (en) | 2009-05-05 | 2017-07-25 | Dana Farber Cancer Institute | Egfr inhibitors and methods of treating disorders |
| WO2011146313A1 (en) | 2010-05-19 | 2011-11-24 | The University Of North Carolina At Chapel Hill | Pyrazolopyrimidine compounds for the treatment of cancer |
| KR20130099040A (ko) | 2010-08-10 | 2013-09-05 | 셀진 아빌로믹스 리서치, 인코포레이티드 | Ｂｔｋ 억제제의 베실레이트 염 |
| US8975249B2 (en) | 2010-11-01 | 2015-03-10 | Celgene Avilomics Research, Inc. | Heterocyclic compounds and uses thereof |
| EP2635285B1 (en) | 2010-11-01 | 2017-05-03 | Celgene Avilomics Research, Inc. | Heteroaryl compounds and uses thereof |
| US8796255B2 (en) | 2010-11-10 | 2014-08-05 | Celgene Avilomics Research, Inc | Mutant-selective EGFR inhibitors and uses thereof |
| BR112013027734A2 (pt) | 2011-05-04 | 2017-08-08 | Ariad Pharma Inc | compostos para a inibição de proliferação celular em cânceres impulsionados pelo egfr, método e composição farmacêutica |
| AU2012318896B2 (en) | 2011-10-03 | 2017-03-02 | The University Of North Carolina At Chapel Hill | Pyrrolopyrimidine compounds for the treatment of cancer |
| CA2853498A1 (en) | 2011-10-28 | 2013-05-02 | Celgene Avilomics Research, Inc. | Methods of treating a bruton's tyrosine kinase disease or disorder |
| KR102019530B1 (ko) | 2011-11-23 | 2019-09-06 | 포톨라 파마슈티컬스, 인코포레이티드 | 피라진 키나아제 저해제 |
| EP2825041B1 (en) | 2012-03-15 | 2021-04-21 | Celgene CAR LLC | Solid forms of an epidermal growth factor receptor kinase inhibitor |
| RS57901B1 (sr) | 2012-03-15 | 2019-01-31 | Celgene Car Llc | Soli inhibitora kinaze receptora epidermalnog faktora rasta |
| JP6469567B2 (ja) | 2012-05-05 | 2019-02-13 | アリアド・ファーマシューティカルズ・インコーポレイテッド | Ｅｇｆｒ発動性がんの細胞増殖阻害用化合物 |
| AU2013266438B2 (en) * | 2012-05-22 | 2017-09-07 | The University Of North Carolina At Chapel Hill | Pyrimidine compounds for the treatment of cancer |
| CN104718201A (zh) | 2012-06-12 | 2015-06-17 | 艾伯维公司 | 吡啶酮和哒嗪酮衍生物 |
| WO2014062774A1 (en) | 2012-10-17 | 2014-04-24 | The University Of North Carolina At Chapel Hill | Pyrazolopyrimidine compounds for the treatment of cancer |
| CA2890935A1 (en) * | 2012-11-08 | 2014-05-15 | Bristol-Myers Squibb Company | Alkyl amide-substituted pyrimidine compounds useful in the modulation of il-12, il-23 and/or ifn.alpha. |
| EP2925752A4 (en) | 2012-11-27 | 2016-06-01 | Univ North Carolina | PYRIMIDINE COMPOUNDS FOR CANCER TREATMENT |
| EP2935226A4 (en) | 2012-12-21 | 2016-11-02 | Celgene Avilomics Res Inc | HETEROARYL COMPOUNDS AND USES THEREOF |
| PE20151274A1 (es) | 2013-02-08 | 2015-09-12 | Celgene Avilomics Res Inc | Inhibidores de erk y sus usos |
| US9611283B1 (en) | 2013-04-10 | 2017-04-04 | Ariad Pharmaceuticals, Inc. | Methods for inhibiting cell proliferation in ALK-driven cancers |
| US9492471B2 (en) | 2013-08-27 | 2016-11-15 | Celgene Avilomics Research, Inc. | Methods of treating a disease or disorder associated with Bruton'S Tyrosine Kinase |
| CN103483272B (zh) * | 2013-09-29 | 2015-10-21 | 山东大学 | 间二芳烃-多取代嘧啶类衍生物及其制备方法与应用 |
| US9415049B2 (en) | 2013-12-20 | 2016-08-16 | Celgene Avilomics Research, Inc. | Heteroaryl compounds and uses thereof |
| EP3129379A4 (en) | 2014-04-11 | 2017-09-13 | The University of North Carolina at Chapel Hill | Mertk-specific pyrrolopyrimidine compounds |
| AU2015301891B2 (en) | 2014-08-11 | 2019-12-05 | Angion Biomedica Corporation | Cytochrome P450 inhibitors and uses thereof |
| ES2741785T3 (es) | 2014-08-13 | 2020-02-12 | Celgene Car Llc | Formas y composiciones de un inhibidor de ERK |
| AU2015374231B2 (en) | 2014-12-31 | 2020-07-23 | Angion Biomedica Corp. | Methods and agents for treating disease |
| US10709708B2 (en) | 2016-03-17 | 2020-07-14 | The University Of North Carolina At Chapel Hill | Method of treating cancer with a combination of MER tyrosine kinase inhibitor and an epidermal growth factor receptor (EGFR) inhibitor |
| CN106967047A (zh) * | 2017-03-29 | 2017-07-21 | 山东大学 | 一种取代二芳基烟酰胺类衍生物及其制备方法与应用 |
| US20240101548A1 (en) * | 2020-12-02 | 2024-03-28 | Shenzhen Chipscreen Biosciences Co., Ltd. | Hydroxamate compound, preparation method therefor and application thereof |
| WO2023231996A1 (zh) * | 2022-06-01 | 2023-12-07 | 深圳微芯生物科技股份有限公司 | 羟肟酸酯化合物及其盐的结晶形式与制备方法 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3459731A (en) | 1966-12-16 | 1969-08-05 | Corn Products Co | Cyclodextrin polyethers and their production |
| HUP9900730A3 (en) | 1995-11-23 | 2001-04-28 | Janssen Pharmaceutica Nv | Solid mixtures of cyclodextrins prepared via melt-extrusion |
| NO311614B1 (no) | 1996-10-01 | 2001-12-17 | Janssen Pharmaceutica Nv | Substituerte diamino-1,3,5-triazinderivater |
| EP0945447A1 (en) | 1998-03-27 | 1999-09-29 | Janssen Pharmaceutica N.V. | Trisubstituted 1,3,5-triazine derivatives for treatment of HIV infections |
| DE69905306T2 (de) * | 1998-03-27 | 2003-11-27 | Janssen Pharmaceutica Nv | HIV hemmende Pyrimidin Derivate |
| US6459731B1 (en) * | 1998-08-28 | 2002-10-01 | Lucent Technologies Inc. | Technique for video communications using a coding-matched filter arrangement |
| NZ511116A (en) | 1998-11-10 | 2003-08-29 | Janssen Pharmaceutica Nv | HIV replication inhibiting pyrimidines |
| GB9828511D0 (en) | 1998-12-24 | 1999-02-17 | Zeneca Ltd | Chemical compounds |
| WO2001085700A2 (en) | 2000-05-08 | 2001-11-15 | Janssen Pharmaceutica N.V. | Hiv replication inhibiting pyrimidines and triazines |
| NZ526469A (en) | 2000-12-21 | 2005-10-28 | Vertex Pharma | Pyrazole compounds useful as protein kinase inhibitors |
| JO3429B1 (ar) | 2001-08-13 | 2019-10-20 | Janssen Pharmaceutica Nv | مشتقات برميدينات مثبطة فيروس الايدز |
| TWI329105B (en) | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
| TW200400034A (en) | 2002-05-20 | 2004-01-01 | Bristol Myers Squibb Co | Pyrazolo-pyrimidine aniline compounds useful as kinase inhibitors |
| JP2006508145A (ja) | 2002-11-15 | 2006-03-09 | テイボテク・フアーマシユーチカルズ・リミテツド | 抗感染化合物としての置換インドールピリジニウム |
| GB0305929D0 (en) * | 2003-03-14 | 2003-04-23 | Novartis Ag | Organic compounds |
| US7504396B2 (en) | 2003-06-24 | 2009-03-17 | Amgen Inc. | Substituted heterocyclic compounds and methods of use |
| AU2005288866B2 (en) * | 2004-09-30 | 2012-07-26 | Janssen Sciences Ireland Uc | HIV inhibiting 5-substituted pyrimidines |
| MX2007003798A (es) | 2004-09-30 | 2007-04-23 | Tibotec Pharm Ltd | Pirimidinas 5-sustituidas con carbociclos o heterociclos inhibidoras del vih. |
| CN101031558B (zh) | 2004-09-30 | 2011-10-05 | 泰博特克药品有限公司 | 抑制人类免疫缺陷病毒的5-杂环基嘧啶 |
| MX2008012576A (es) | 2006-03-30 | 2008-10-10 | Tibotec Pharm Ltd | Pirimidinas 5-amido sustituidas inhibidoras del virus de inmunodeficiencia humana. |
| DK2114901T3 (da) | 2006-12-29 | 2014-06-30 | Janssen R & D Ireland | Hiv-inhiberende 6-substituerede pyrimidiner |
| JP5283633B2 (ja) | 2006-12-29 | 2013-09-04 | テイボテク・フアーマシユーチカルズ | Ｈｉｖ阻害性５，６−置換ピリミジン |
-
2007
- 2007-03-30 MX MX2008012576A patent/MX2008012576A/es active IP Right Grant
- 2007-03-30 BR BRPI0709690A patent/BRPI0709690B8/pt not_active IP Right Cessation
- 2007-03-30 DK DK07727583T patent/DK2004632T3/da active
- 2007-03-30 US US12/294,692 patent/US8933089B2/en active Active
- 2007-03-30 AU AU2007233737A patent/AU2007233737B2/en not_active Ceased
- 2007-03-30 WO PCT/EP2007/053111 patent/WO2007113254A1/en active Application Filing
- 2007-03-30 RU RU2008143001/04A patent/RU2480464C2/ru active
- 2007-03-30 CA CA2645958A patent/CA2645958C/en active Active
- 2007-03-30 KR KR1020087022769A patent/KR20080114741A/ko not_active Application Discontinuation
- 2007-03-30 CN CN200780010280.2A patent/CN101405283B/zh active Active
- 2007-03-30 ES ES07727583T patent/ES2465666T3/es active Active
- 2007-03-30 JP JP2009502113A patent/JP5078986B2/ja active Active
- 2007-03-30 EP EP20070727583 patent/EP2004632B1/en active Active
-
2008
- 2008-08-21 IL IL19361008A patent/IL193610A/en active IP Right Grant
-
2014
- 2014-12-10 US US14/566,400 patent/US9573942B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP2004632A1 (en) | 2008-12-24 |
| AU2007233737B2 (en) | 2012-11-29 |
| IL193610A0 (en) | 2009-05-04 |
| US8933089B2 (en) | 2015-01-13 |
| RU2008143001A (ru) | 2010-05-10 |
| JP2009531394A (ja) | 2009-09-03 |
| CA2645958C (en) | 2014-11-04 |
| JP5078986B2 (ja) | 2012-11-21 |
| AU2007233737A1 (en) | 2007-10-11 |
| KR20080114741A (ko) | 2008-12-31 |
| WO2007113254A1 (en) | 2007-10-11 |
| CN101405283B (zh) | 2014-06-18 |
| CA2645958A1 (en) | 2007-10-11 |
| BRPI0709690A2 (pt) | 2011-07-19 |
| BRPI0709690B1 (pt) | 2020-09-29 |
| ES2465666T3 (es) | 2014-06-06 |
| US20150099749A1 (en) | 2015-04-09 |
| IL193610A (en) | 2014-01-30 |
| BRPI0709690B8 (pt) | 2021-05-25 |
| EP2004632B1 (en) | 2014-03-12 |
| MX2008012576A (es) | 2008-10-10 |
| RU2480464C2 (ru) | 2013-04-27 |
| CN101405283A (zh) | 2009-04-08 |
| US9573942B2 (en) | 2017-02-21 |
| US20100168104A1 (en) | 2010-07-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK2004632T3 (da) | Hiv-inhiberende 5-amidosubstituerede pyrimidiner | |
| DK2114901T3 (da) | Hiv-inhiberende 6-substituerede pyrimidiner | |
| DK2154967T3 (da) | Pyrimidinderivater | |
| DE602006019782D1 (de) | Kapselperforationsmodul | |
| DE602007000258D1 (de) | Kassetteneinspannmechanismus | |
| DE602007006947D1 (de) | Pyridopyrimidinonderivate | |
| DE602006020192D1 (de) | Riemenscheibenanorndung | |
| DE602007001280D1 (de) | Getränkeextraktor | |
| DE602006019150D1 (de) | Riemenscheibenanorndung | |
| ATE546437T1 (de) | Aminomethyl-4-imidazole | |
| DE502007002453D1 (de) | Kunstoffverdichtergehäuse | |
| DE602007000501D1 (de) | Breitbandrichtkoppler | |
| BRPI0811115A2 (pt) | Compostos de heteroarilamida pirimidona | |
| DE602006005328D1 (de) | Differentialgehäuse | |
| DE602006016174D1 (de) | Blisterverpackungsverfahren | |
| DE502007000361D1 (de) | Stanznieteinheit | |
| DE502007001629D1 (de) | Rfahren | |
| DE602007000333D1 (de) | Napfbefestigungsvorrichtung | |
| BRPI0811094A2 (pt) | Derivados de heteroarilamida pirimidona | |
| DE102006045567A8 (de) | Crimpstabilisierung | |
| DE602007001098D1 (de) | Spindelmäheinheit | |
| BRPI0814725A2 (pt) | Composição antiviral | |
| DE502007001652D1 (de) | Notöltank | |
| DE502007005975D1 (de) | Wischblatt | |
| DE602006015328D1 (de) | Abtastfehlerkompensation |