EA201490300A1 - 4-имидазопиридазин-1-ил-бензамиды и 4-имидазотриазин-1-ил-бензамиды в качестве btk-ингибиторов - Google Patents

4-имидазопиридазин-1-ил-бензамиды и 4-имидазотриазин-1-ил-бензамиды в качестве btk-ингибиторов

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Publication number
EA201490300A1
EA201490300A1 EA201490300A EA201490300A EA201490300A1 EA 201490300 A1 EA201490300 A1 EA 201490300A1 EA 201490300 A EA201490300 A EA 201490300A EA 201490300 A EA201490300 A EA 201490300A EA 201490300 A1 EA201490300 A1 EA 201490300A1
Authority
EA
Eurasian Patent Office
Prior art keywords
btk
imidazotriazin
imidazopyridazin
benzamides
benzamide
Prior art date
Application number
EA201490300A
Other languages
English (en)
Other versions
EA034558B1 (ru
Inventor
Тьерд А. Барф
Христиан Герардус Йоханнес Мария Янс
де Адрианус Петрус Антониус Ман
Артур А. Аубри
Ханс К.А. Раймакерс
Йоханнес Бернардус Мария Ревинкел
Ян-Герард Стерренбург
Якобус К. Х. М. Вейкманс
Original Assignee
Мерк Шарп и Доум Б.В.
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47557677&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201490300(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Мерк Шарп и Доум Б.В. filed Critical Мерк Шарп и Доум Б.В.
Publication of EA201490300A1 publication Critical patent/EA201490300A1/ru
Publication of EA034558B1 publication Critical patent/EA034558B1/ru

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Abstract

Настоящее изобретение относится к 6-5-членным конденсированным с пиридиновым кольцом соединениям в соответствии с формулой Iили их фармацевтически приемлемым солям или к фармацевтическим композициям, содержащим эти соединения, и к их применению в терапии. В частности, настоящее изобретение относится к применению 6-5-членных конденсированных с пиридиновым кольцом соединений в соответствии с формулой I для лечения расстройств, опосредованных тирозинкиназой Брутона (Btk).
EA201490300A 2011-07-19 2012-07-11 4-ИМИДАЗО[1,5-a]ПИРИДАЗИН-1-ИЛ-БЕНЗАМИДЫ В КАЧЕСТВЕ Btk-ИНГИБИТОРОВ EA034558B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161509397P 2011-07-19 2011-07-19
EP11174578 2011-07-19
PCT/EP2012/063552 WO2013010868A1 (en) 2011-07-19 2012-07-11 4 - imidazopyridazin- 1 -yl-benzamides and 4 - imidazotriazin- 1 - yl - benzamides as btk- inhibitors

Publications (2)

Publication Number Publication Date
EA201490300A1 true EA201490300A1 (ru) 2014-05-30
EA034558B1 EA034558B1 (ru) 2020-02-20

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ID=47557677

Family Applications (2)

Application Number Title Priority Date Filing Date
EA201490300A EA034558B1 (ru) 2011-07-19 2012-07-11 4-ИМИДАЗО[1,5-a]ПИРИДАЗИН-1-ИЛ-БЕНЗАМИДЫ В КАЧЕСТВЕ Btk-ИНГИБИТОРОВ
EA201992270A EA037644B1 (ru) 2011-07-19 2012-07-11 СПОСОБ ПОЛУЧЕНИЯ Btk-ИНГИБИТОРА

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EA201992270A EA037644B1 (ru) 2011-07-19 2012-07-11 СПОСОБ ПОЛУЧЕНИЯ Btk-ИНГИБИТОРА

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JP (6) JP5826931B2 (ru)
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DO (1) DOP2014000008A (ru)
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EP2548877A1 (en) 2011-07-19 2013-01-23 MSD Oss B.V. 4-(5-Membered fused pyridinyl)benzamides as BTK-inhibitors
ES2950569T3 (es) * 2011-07-19 2023-10-11 Merck Sharp & Dohme (S)-4-(8-amino-3-(1-(but-2-inoil)pirrolidin-2-il)imidazo[1,5-a]pirazin-1-il)-2-metoxi-n-(piridin-2-il)benzamida como inhibidor de la Btk
KR20150032340A (ko) 2012-07-24 2015-03-25 파마시클릭스, 인코포레이티드 브루톤 티로신 키나제(btk)의 억제제에 대한 내성과 관련된 돌연변이
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CN104822663B (zh) * 2012-10-04 2017-03-08 犹他大学研究基金会 作为酪氨酸受体激酶btk抑制剂的取代的n‑(3‑(嘧啶‑4‑基)苯基)丙烯酰胺类似物
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EP3495368B1 (en) 2023-05-31
EP2734522A1 (en) 2014-05-28
US9290504B2 (en) 2016-03-22
CO6940411A2 (es) 2014-05-09
ES2708224T3 (es) 2019-04-09
IN2014CN00408A (ru) 2015-04-03
PL2734522T3 (pl) 2019-04-30
PL3689878T3 (pl) 2022-02-14
JP2022088618A (ja) 2022-06-14
CN106243113A (zh) 2016-12-21
WO2013010868A1 (en) 2013-01-24
US20190276456A1 (en) 2019-09-12
IL230511A0 (en) 2014-03-31
CN103889987A (zh) 2014-06-25
BR112014001255A2 (pt) 2017-02-21
KR20160117642A (ko) 2016-10-10
NZ716110A (en) 2017-07-28
RS62760B1 (sr) 2022-01-31
ECSP14013217A (es) 2015-03-31
EA037644B1 (ru) 2021-04-26
US20210230166A1 (en) 2021-07-29
MX2014000746A (es) 2014-05-07
KR20140036324A (ko) 2014-03-25
IL266894A (en) 2019-07-31
KR101802689B1 (ko) 2017-11-28
JP2020189865A (ja) 2020-11-26
JP2019108395A (ja) 2019-07-04
SI2734522T1 (sl) 2019-03-29
JP6749444B2 (ja) 2020-09-02
JP7054721B2 (ja) 2022-04-14
PH12017500166A1 (en) 2017-09-04
EA201992270A2 (ru) 2020-01-16
SG10201605913VA (en) 2016-09-29
JP5826931B2 (ja) 2015-12-02
KR101702727B1 (ko) 2017-02-06
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GT201400009A (es) 2017-09-28
ES2950569T3 (es) 2023-10-11
AU2017279778A1 (en) 2018-01-25
US20140155385A1 (en) 2014-06-05
AU2012285987B2 (en) 2016-03-10
US20160151364A1 (en) 2016-06-02
AU2012285987A1 (en) 2014-02-06
HUS2100012I1 (hu) 2021-05-28
HRP20212021T1 (hr) 2022-04-01
ES2904707T3 (es) 2022-04-05
RS58177B1 (sr) 2019-03-29
CN103889987B (zh) 2016-09-14
US9758524B2 (en) 2017-09-12
LT2734522T (lt) 2019-02-11
EA201992270A3 (ru) 2020-03-31
BR112014001255B1 (pt) 2019-07-02
NZ620085A (en) 2016-05-27
MX342983B (es) 2016-10-19
MY192354A (en) 2022-08-17
PT3689878T (pt) 2022-01-05
AU2019275591A1 (en) 2020-01-02
CN106243113B (zh) 2018-12-18
HUE041987T2 (hu) 2019-06-28
JP6251220B2 (ja) 2017-12-20
EP3495368A1 (en) 2019-06-12
HRP20190135T1 (hr) 2019-03-22
IL291489A (en) 2022-05-01
PE20141681A1 (es) 2014-11-14
AU2016203837B2 (en) 2018-01-25
US20160159810A1 (en) 2016-06-09
AU2017279778B2 (en) 2019-09-19
US9790226B2 (en) 2017-10-17
CA2841886A1 (en) 2013-01-24
DOP2014000008A (es) 2014-04-30
AU2016203837A1 (en) 2016-06-30
JP6617130B2 (ja) 2019-12-11
AU2012285987C1 (en) 2016-09-08
US10239883B2 (en) 2019-03-26
SI3689878T1 (sl) 2021-12-31

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