LT2734522T - 4-imidazopiridazin-1-il-benzamidai ir 4-imidazotriazin-1-il-benzamidai kaip btk-inhibitoriai - Google Patents

4-imidazopiridazin-1-il-benzamidai ir 4-imidazotriazin-1-il-benzamidai kaip btk-inhibitoriai

Info

Publication number
LT2734522T
LT2734522T LTEP12733505.7T LT12733505T LT2734522T LT 2734522 T LT2734522 T LT 2734522T LT 12733505 T LT12733505 T LT 12733505T LT 2734522 T LT2734522 T LT 2734522T
Authority
LT
Lithuania
Prior art keywords
benzamides
imidazotriazin
imidazopyridazin
btk
inhibitors
Prior art date
Application number
LTEP12733505.7T
Other languages
English (en)
Inventor
Tjeerd A. Barf
Christiaan Jans
de Adrianus MAN
Arthur A. Oubrie
Hans C.A. Raaijmakers
Johannes Rewinkel
Jan-Gerard Sterrenburg
Jacobus C.H.M. Wijkmans
Original Assignee
Merck Sharp & Dohme B.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47557677&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LT2734522(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Sharp & Dohme B.V. filed Critical Merck Sharp & Dohme B.V.
Publication of LT2734522T publication Critical patent/LT2734522T/lt

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    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
LTEP12733505.7T 2011-07-19 2012-07-11 4-imidazopiridazin-1-il-benzamidai ir 4-imidazotriazin-1-il-benzamidai kaip btk-inhibitoriai LT2734522T (lt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161509397P 2011-07-19 2011-07-19
EP11174578 2011-07-19
PCT/EP2012/063552 WO2013010868A1 (en) 2011-07-19 2012-07-11 4 - imidazopyridazin- 1 -yl-benzamides and 4 - imidazotriazin- 1 - yl - benzamides as btk- inhibitors

Publications (1)

Publication Number Publication Date
LT2734522T true LT2734522T (lt) 2019-02-11

Family

ID=47557677

Family Applications (1)

Application Number Title Priority Date Filing Date
LTEP12733505.7T LT2734522T (lt) 2011-07-19 2012-07-11 4-imidazopiridazin-1-il-benzamidai ir 4-imidazotriazin-1-il-benzamidai kaip btk-inhibitoriai

Country Status (35)

Country Link
US (7) US9290504B2 (lt)
EP (4) EP3495368B1 (lt)
JP (6) JP5826931B2 (lt)
KR (2) KR101702727B1 (lt)
CN (2) CN103889987B (lt)
AU (4) AU2012285987C1 (lt)
BR (1) BR112014001255B1 (lt)
CA (1) CA2841886C (lt)
CL (1) CL2014000130A1 (lt)
CO (1) CO6940411A2 (lt)
CR (1) CR20140030A (lt)
DK (2) DK3689878T3 (lt)
DO (1) DOP2014000008A (lt)
EA (2) EA037644B1 (lt)
EC (1) ECSP14013217A (lt)
ES (3) ES2904707T3 (lt)
GT (1) GT201400009A (lt)
HR (2) HRP20212021T1 (lt)
HU (3) HUE041987T2 (lt)
IL (3) IL230511B (lt)
IN (1) IN2014CN00408A (lt)
LT (1) LT2734522T (lt)
MA (1) MA35348B1 (lt)
MX (1) MX342983B (lt)
MY (1) MY192354A (lt)
PE (1) PE20141681A1 (lt)
PH (1) PH12017500166B1 (lt)
PL (2) PL3689878T3 (lt)
PT (1) PT3689878T (lt)
RS (2) RS58177B1 (lt)
SG (1) SG10201605913VA (lt)
SI (2) SI2734522T1 (lt)
TN (1) TN2014000027A1 (lt)
UA (1) UA115312C2 (lt)
WO (1) WO2013010868A1 (lt)

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EP2548877A1 (en) 2011-07-19 2013-01-23 MSD Oss B.V. 4-(5-Membered fused pyridinyl)benzamides as BTK-inhibitors
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BR112015001690A2 (pt) 2012-07-24 2017-11-07 Pharmacyclics Inc mutações associadas com a resistência a inibidores da tirosina quinase de bruton (btk)
PT2892900T (pt) 2012-09-10 2017-11-06 Principia Biopharma Inc Compostos de pirazolopirimidina como inibidores de cinase
CN104995192A (zh) * 2012-09-26 2015-10-21 加利福尼亚大学董事会 Ire1的调节
JP6313772B2 (ja) * 2012-10-04 2018-04-18 ユニヴァーシティー オブ ユタ リサーチ ファウンデーション チロシン受容体キナーゼｂｔｋ阻害剤である置換ｎ−（３−（ピリミジン−４−イル）フェニル）アクリルアミド類似体
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JP2022088618A (ja) 2022-06-14
DOP2014000008A (es) 2014-04-30
US20160151364A1 (en) 2016-06-02
ECSP14013217A (es) 2015-03-31
IL266894A (en) 2019-07-31
SI3689878T1 (sl) 2021-12-31
SI2734522T1 (sl) 2019-03-29
IN2014CN00408A (lt) 2015-04-03
MX342983B (es) 2016-10-19
US20190276456A1 (en) 2019-09-12
JP2019108395A (ja) 2019-07-04
EA034558B1 (ru) 2020-02-20
EA201992270A3 (ru) 2020-03-31
CN103889987B (zh) 2016-09-14
RS62760B1 (sr) 2022-01-31
EP2734522B1 (en) 2018-10-31
JP2020189865A (ja) 2020-11-26
KR101802689B1 (ko) 2017-11-28
PT3689878T (pt) 2022-01-05
HRP20190135T1 (hr) 2019-03-22
AU2016203837B2 (en) 2018-01-25
AU2019275591A1 (en) 2020-01-02
CA2841886C (en) 2016-08-16
AU2012285987C1 (en) 2016-09-08
NZ620085A (en) 2016-05-27
RS58177B1 (sr) 2019-03-29
EP4249076A3 (en) 2023-11-01

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