EA201100030A1 - Пиразольные соединения 436 - Google Patents
Пиразольные соединения 436Info
- Publication number
- EA201100030A1 EA201100030A1 EA201100030A EA201100030A EA201100030A1 EA 201100030 A1 EA201100030 A1 EA 201100030A1 EA 201100030 A EA201100030 A EA 201100030A EA 201100030 A EA201100030 A EA 201100030A EA 201100030 A1 EA201100030 A1 EA 201100030A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- pyrazol compounds
- compounds
- pyrazol
- therapy
- contain
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
Обеспечиваются новые соединения формулы (Ia) или (Ib)или их фармацевтические соли, способы их получения, фармацевтические композиции, которые их содержат, и их применение в терапии.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7388308P | 2008-06-19 | 2008-06-19 | |
PCT/GB2009/050684 WO2009153592A1 (en) | 2008-06-19 | 2009-06-17 | Pyrazole compounds 436 |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201100030A1 true EA201100030A1 (ru) | 2011-08-30 |
Family
ID=40935715
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201100030A EA201100030A1 (ru) | 2008-06-19 | 2009-06-17 | Пиразольные соединения 436 |
Country Status (23)
Country | Link |
---|---|
US (1) | US20090318468A1 (ru) |
EP (1) | EP2328872A1 (ru) |
JP (1) | JP2011524888A (ru) |
KR (1) | KR20110020904A (ru) |
CN (1) | CN102123989A (ru) |
AR (1) | AR072261A1 (ru) |
AU (1) | AU2009261683A1 (ru) |
BR (1) | BRPI0914233A2 (ru) |
CA (1) | CA2728063A1 (ru) |
CL (1) | CL2010001470A1 (ru) |
CO (1) | CO6351726A2 (ru) |
CR (1) | CR11857A (ru) |
DO (1) | DOP2010000387A (ru) |
EA (1) | EA201100030A1 (ru) |
EC (1) | ECSP10010693A (ru) |
IL (1) | IL210082A0 (ru) |
MX (1) | MX2010014234A (ru) |
PE (1) | PE20110062A1 (ru) |
SV (1) | SV2010003767A (ru) |
TW (1) | TW201002693A (ru) |
UY (1) | UY31918A (ru) |
WO (1) | WO2009153592A1 (ru) |
ZA (1) | ZA201100471B (ru) |
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US8754114B2 (en) | 2010-12-22 | 2014-06-17 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3 |
AR090161A1 (es) | 2012-02-28 | 2014-10-22 | Astellas Pharma Inc | Derivados heterociclicos nitrogenados con accion sobre el cancer de vejiga |
EP3822273B1 (en) | 2012-06-13 | 2024-04-10 | Incyte Holdings Corporation | Substituted tricyclic compounds as fgfr inhibitors |
WO2014026125A1 (en) | 2012-08-10 | 2014-02-13 | Incyte Corporation | Pyrazine derivatives as fgfr inhibitors |
US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
AR094812A1 (es) | 2013-02-20 | 2015-08-26 | Eisai R&D Man Co Ltd | Derivado de piridina monocíclico como inhibidor del fgfr |
PL403149A1 (pl) * | 2013-03-14 | 2014-09-15 | Celon Pharma Spółka Akcyjna | Nowe związki pochodne pirazolilobenzo[d]imidazolu |
US20160052926A1 (en) * | 2013-03-15 | 2016-02-25 | Hutchison Medipharma Limited | Novel pyrimidine and pyridine compounds and usage thereof |
SG10201708520YA (en) | 2013-04-19 | 2017-12-28 | Incyte Corp | Bicyclic heterocycles as fgfr inhibitors |
AU2014291161B2 (en) | 2013-07-18 | 2018-04-26 | Taiho Pharmaceutical Co., Ltd. | Antitumor drug for intermittent administration of FGFR inhibitor |
WO2015008844A1 (ja) | 2013-07-18 | 2015-01-22 | 大鵬薬品工業株式会社 | Fgfr阻害剤耐性癌の治療薬 |
KR102344105B1 (ko) | 2014-08-18 | 2021-12-29 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 모노시클릭 피리딘 유도체의 염 및 이의 결정 |
US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
WO2016134294A1 (en) | 2015-02-20 | 2016-08-25 | Incyte Corporation | Bicyclic heterocycles as fgfr4 inhibitors |
MX2017010673A (es) | 2015-02-20 | 2018-03-21 | Incyte Corp | Heterociclos biciclicos como inhibidores de receptores del factor de crecimiento fibroblastico (fgfr). |
PL3279202T3 (pl) | 2015-03-31 | 2020-12-28 | Taiho Pharmaceutical Co., Ltd. | Kryształ 3,5-dipodstawionego związku benzenoalkinylowego |
US11883404B2 (en) | 2016-03-04 | 2024-01-30 | Taiho Pharmaceuticals Co., Ltd. | Preparation and composition for treatment of malignant tumors |
KR20220110859A (ko) * | 2016-03-04 | 2022-08-09 | 다이호야쿠힌고교 가부시키가이샤 | 악성 종양 치료용 제제 및 조성물 |
AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
JP7341122B2 (ja) | 2017-08-15 | 2023-09-08 | 石薬集団中奇制薬技術(石家庄)有限公司 | Fgfr阻害剤及びその医薬品の用途 |
US11833151B2 (en) | 2018-03-19 | 2023-12-05 | Taiho Pharmaceutical Co., Ltd. | Pharmaceutical composition including sodium alkyl sulfate |
MX2020008610A (es) | 2018-03-28 | 2020-09-21 | Eisai R&D Man Co Ltd | Agente terapeutico para carcinoma hepatocelular. |
CN110317173B (zh) * | 2018-03-30 | 2022-10-11 | 上海奕拓医药科技有限责任公司 | 用作fgfr不可逆抑制剂的酰胺基吡唑类化合物 |
CN112566912A (zh) | 2018-05-04 | 2021-03-26 | 因赛特公司 | Fgfr抑制剂的盐 |
CN112867716A (zh) | 2018-05-04 | 2021-05-28 | 因赛特公司 | Fgfr抑制剂的固体形式和其制备方法 |
WO2020185532A1 (en) | 2019-03-08 | 2020-09-17 | Incyte Corporation | Methods of treating cancer with an fgfr inhibitor |
AU2020242287A1 (en) | 2019-03-21 | 2021-09-02 | INSERM (Institut National de la Santé et de la Recherche Médicale) | A Dbait molecule in combination with kinase inhibitor for the treatment of cancer |
WO2021007269A1 (en) | 2019-07-09 | 2021-01-14 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
AU2020366006A1 (en) | 2019-10-14 | 2022-04-21 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
US11566028B2 (en) | 2019-10-16 | 2023-01-31 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
WO2021089791A1 (en) | 2019-11-08 | 2021-05-14 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the treatment of cancers that have acquired resistance to kinase inhibitors |
EP4069696A1 (en) | 2019-12-04 | 2022-10-12 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
KR20220131900A (ko) | 2019-12-04 | 2022-09-29 | 인사이트 코포레이션 | Fgfr 억제제의 유도체 |
WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
US11939331B2 (en) | 2021-06-09 | 2024-03-26 | Incyte Corporation | Tricyclic heterocycles as FGFR inhibitors |
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CZ290470B6 (cs) * | 1991-10-18 | 2002-07-17 | Monsanto Technology Llc | 5 či 6 členné aromáty jako fungicidy pro kontrolu stéblolamu rostlin, způsob kontroly a fungicidní směs k provedení tohoto způsobu |
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-
2009
- 2009-06-17 AU AU2009261683A patent/AU2009261683A1/en not_active Abandoned
- 2009-06-17 WO PCT/GB2009/050684 patent/WO2009153592A1/en active Application Filing
- 2009-06-17 BR BRPI0914233A patent/BRPI0914233A2/pt not_active Application Discontinuation
- 2009-06-17 PE PE2010001161A patent/PE20110062A1/es not_active Application Discontinuation
- 2009-06-17 JP JP2011514127A patent/JP2011524888A/ja active Pending
- 2009-06-17 EP EP09766153A patent/EP2328872A1/en not_active Withdrawn
- 2009-06-17 MX MX2010014234A patent/MX2010014234A/es not_active Application Discontinuation
- 2009-06-17 KR KR1020117000437A patent/KR20110020904A/ko not_active Application Discontinuation
- 2009-06-17 EA EA201100030A patent/EA201100030A1/ru unknown
- 2009-06-17 CA CA2728063A patent/CA2728063A1/en not_active Abandoned
- 2009-06-17 CN CN2009801328063A patent/CN102123989A/zh active Pending
- 2009-06-18 TW TW098120493A patent/TW201002693A/zh unknown
- 2009-06-18 UY UY0001031918A patent/UY31918A/es not_active Application Discontinuation
- 2009-06-19 US US12/487,838 patent/US20090318468A1/en not_active Abandoned
- 2009-06-19 AR ARP090102262A patent/AR072261A1/es unknown
-
2010
- 2010-12-16 IL IL210082A patent/IL210082A0/en unknown
- 2010-12-17 DO DO2010000387A patent/DOP2010000387A/es unknown
- 2010-12-17 SV SV2010003767A patent/SV2010003767A/es not_active Application Discontinuation
- 2010-12-17 EC EC2010010693A patent/ECSP10010693A/es unknown
- 2010-12-17 CR CR11857A patent/CR11857A/es not_active Application Discontinuation
- 2010-12-17 CL CL2010001470A patent/CL2010001470A1/es unknown
-
2011
- 2011-01-18 ZA ZA2011/00471A patent/ZA201100471B/en unknown
- 2011-01-19 CO CO11005446A patent/CO6351726A2/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
DOP2010000387A (es) | 2012-09-30 |
AR072261A1 (es) | 2010-08-18 |
TW201002693A (en) | 2010-01-16 |
CR11857A (es) | 2011-02-25 |
WO2009153592A1 (en) | 2009-12-23 |
JP2011524888A (ja) | 2011-09-08 |
BRPI0914233A2 (pt) | 2015-11-03 |
PE20110062A1 (es) | 2011-03-09 |
IL210082A0 (en) | 2011-02-28 |
UY31918A (es) | 2010-01-29 |
ZA201100471B (en) | 2012-06-27 |
ECSP10010693A (es) | 2011-01-31 |
CL2010001470A1 (es) | 2011-05-06 |
MX2010014234A (es) | 2011-03-25 |
EP2328872A1 (en) | 2011-06-08 |
CO6351726A2 (es) | 2011-12-20 |
CN102123989A (zh) | 2011-07-13 |
SV2010003767A (es) | 2011-05-20 |
KR20110020904A (ko) | 2011-03-03 |
AU2009261683A1 (en) | 2009-12-23 |
US20090318468A1 (en) | 2009-12-24 |
CA2728063A1 (en) | 2009-12-23 |
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