UA99617C2 - Производные пирролконденсированного азотсодержащего гетероцикла, их получение и фармацевтическое применение - Google Patents

Производные пирролконденсированного азотсодержащего гетероцикла, их получение и фармацевтическое применение

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Publication number
UA99617C2
UA99617C2 UAA200911632A UAA200911632A UA99617C2 UA 99617 C2 UA99617 C2 UA 99617C2 UA A200911632 A UAA200911632 A UA A200911632A UA A200911632 A UAA200911632 A UA A200911632A UA 99617 C2 UA99617 C2 UA 99617C2
Authority
UA
Ukraine
Prior art keywords
preparation
pyrrolo
nitrogenous heterocyclic
heterocyclic derivatives
pharmaceutical use
Prior art date
Application number
UAA200911632A
Other languages
English (en)
Ukrainian (uk)
Inventor
Пенг Чо Танг
Идонг Су
Яли Ли
Лей Жанг
Фуквянг Жао
Джялянг Янг
Инг Жоу
Пингян Би
Гуангтао Квян
Мингганг Джу
Original Assignee
Шанхай Хенгруй Фармасьютикал Ко. Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Шанхай Хенгруй Фармасьютикал Ко. Лтд. filed Critical Шанхай Хенгруй Фармасьютикал Ко. Лтд.
Publication of UA99617C2 publication Critical patent/UA99617C2/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

Изобретение касается новых производных пирролконденсированного азотсодержащего гетероцикла, представленных формулой (I), или их солей, способов их получения, фармацевтических композиций, содержащих такие производные, и применения таких производных в качестве терапевтических средств, в частности в качестве ингибиторов протеинкиназы, где каждый заместитель в формуле (I) имеет такие же значения, как определено в описании.(I)
UAA200911632A 2007-05-14 2008-05-14 Производные пирролконденсированного азотсодержащего гетероцикла, их получение и фармацевтическое применение UA99617C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN200710107463 2007-05-14

Publications (1)

Publication Number Publication Date
UA99617C2 true UA99617C2 (ru) 2012-09-10

Family

ID=40001668

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200911632A UA99617C2 (ru) 2007-05-14 2008-05-14 Производные пирролконденсированного азотсодержащего гетероцикла, их получение и фармацевтическое применение

Country Status (13)

Country Link
US (2) US8329682B2 (ru)
EP (1) EP2157093A4 (ru)
JP (1) JP5342547B2 (ru)
KR (1) KR20100022003A (ru)
CN (2) CN101307052B (ru)
AU (1) AU2008250895B2 (ru)
BR (1) BRPI0811865A2 (ru)
CA (1) CA2685757A1 (ru)
HK (2) HK1121757A1 (ru)
MX (1) MX2009011964A (ru)
TW (1) TWI409263B (ru)
UA (1) UA99617C2 (ru)
WO (1) WO2008138184A1 (ru)

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WO2011056985A2 (en) * 2009-11-04 2011-05-12 Gilead Sciences, Inc. Substituted heterocyclic compounds
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IN2014DN06869A (ru) 2012-01-26 2015-05-22 Angion Biomedica Corp
EP2882757B1 (en) * 2012-08-07 2016-10-05 Janssen Pharmaceutica, N.V. Process for the preparation of heterocyclic ester derivatives
CN104119321B (zh) * 2013-04-28 2017-09-08 齐鲁制药有限公司 二氢吲哚酮衍生物的二马来酸盐及其多晶型物
PL3322706T3 (pl) 2015-07-16 2021-07-19 Array Biopharma, Inc. Podstawione związki pirazolo[1,5-a]pirydynowe jako inhibitory kinazy ret
AU2017205749B2 (en) * 2016-01-08 2021-12-23 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Use of quinoline derivatives for treating oesophageal cancer and treatment method, pharmaceutical composition and kit thereof
TWI704148B (zh) 2016-10-10 2020-09-11 美商亞雷生物製藥股份有限公司 作為ｒｅｔ激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物
JOP20190077A1 (ar) 2016-10-10 2019-04-09 Array Biopharma Inc مركبات بيرازولو [1، 5-a]بيريدين بها استبدال كمثبطات كيناز ret
WO2018136663A1 (en) 2017-01-18 2018-07-26 Array Biopharma, Inc. Ret inhibitors
WO2018136661A1 (en) 2017-01-18 2018-07-26 Andrews Steven W SUBSTITUTED PYRAZOLO[1,5-a]PYRAZINE COMPOUNDS AS RET KINASE INHIBITORS
JOP20190213A1 (ar) 2017-03-16 2019-09-16 Array Biopharma Inc مركبات حلقية ضخمة كمثبطات لكيناز ros1
US11168082B2 (en) * 2017-05-15 2021-11-09 The Regents Of The University Of Michigan Pyrrolo[2,3-C]pyridines and related analogs as LSD-1 inhibitors
TWI812649B (zh) 2017-10-10 2023-08-21 美商絡速藥業公司 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之調配物
TWI791053B (zh) 2017-10-10 2023-02-01 美商亞雷生物製藥股份有限公司 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之結晶形式及其醫藥組合物
WO2019097112A1 (en) 2017-11-17 2019-05-23 Fermion Oy Synthesis of a 2-indolinone derivative known as intermediate for preparing nintedanib
TWI802635B (zh) 2018-01-18 2023-05-21 美商亞雷生物製藥股份有限公司 作為ｒｅｔ激酶抑制劑之經取代吡咯并[2,3-d]嘧啶化合物
TW201932464A (zh) 2018-01-18 2019-08-16 美商亞雷生物製藥股份有限公司 作為ret激酶抑制劑之經取代吡唑基[4,3-c]吡啶化合物
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ES2922314T3 (es) 2018-09-10 2022-09-13 Array Biopharma Inc Compuestos heterocíclicos condensados como inhibidores de cinasa RET
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Also Published As

Publication number Publication date
JP2010526838A (ja) 2010-08-05
HK1121757A1 (en) 2009-04-30
HK1137027A1 (en) 2010-07-16
JP5342547B2 (ja) 2013-11-13
MX2009011964A (es) 2009-12-01
TW200946530A (en) 2009-11-16
KR20100022003A (ko) 2010-02-26
AU2008250895A1 (en) 2008-11-20
AU2008250895B2 (en) 2012-08-02
US20100075952A1 (en) 2010-03-25
RU2009141799A (ru) 2011-06-20
CN101675061B (zh) 2012-07-04
CN101307052B (zh) 2011-08-17
CN101307052A (zh) 2008-11-19
CN101675061A (zh) 2010-03-17
CA2685757A1 (en) 2008-11-20
US20130303518A1 (en) 2013-11-14
BRPI0811865A2 (pt) 2014-11-18
TWI409263B (zh) 2013-09-21
WO2008138184A1 (fr) 2008-11-20
US8329682B2 (en) 2012-12-11
EP2157093A4 (en) 2012-03-07
EP2157093A1 (en) 2010-02-24

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