EA201101566A1 - Производные имидазола и их применение в качестве модуляторов циклинзависимых киназ - Google Patents

Производные имидазола и их применение в качестве модуляторов циклинзависимых киназ

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EA201101566A1
EA201101566A1 EA201101566A EA201101566A EA201101566A1 EA 201101566 A1 EA201101566 A1 EA 201101566A1 EA 201101566 A EA201101566 A EA 201101566A EA 201101566 A EA201101566 A EA 201101566A EA 201101566 A1 EA201101566 A1 EA 201101566A1
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compounds
hydrogen
formula
kinaz
cylin
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EA201101566A
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EA020017B1 (ru
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Стивен Хауард
Пол Нил Мортенсон
Стивен Дуглас Хискок
Элисон Джоу-Энн Вулфорд
Эндрью Джеймс Вудхед
Джанни Кессари
Марк О'Рейли
Майлз Стьюарт Конгрив
Клаудио Дагостин
Ён Шин Чо
Фань Ян
Кристин Сютун Чэнь
Кристофер Томас Брейн
Бхарат Лагу
Япин Ван
Сункю Ким
Джон Гриалдес
Майкл Джозеф Луццио
Лоренс Блас Перес
Ипинь Лу
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Новартис Аг
Астекс Терапьютикс Лимитед
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Publication of EA201101566A1 publication Critical patent/EA201101566A1/ru
Publication of EA020017B1 publication Critical patent/EA020017B1/ru

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Abstract

Настоящее изобретение относится к соединениям формулы (I) и его солям, таутомерам, сольватам и N-оксидам; где Q обозначает СН или N; Х обозначает N, N-Oили CR; Y обозначает N, N-Oили CR; Rи Rнезависимо выбраны из группы, включающей водород и различные заместители, определенные в формуле изобретения; или Rи Rвместе с атомами, к которым они присоединены, связываются с образованием необязательно замещенного карбоциклического или гетероциклического ароматического или неароматического кольца, содержащего от 4 до 7 элементов; Rвыбран из группы, включающей водород и различные заместители; и Rвыбран из группы, включающей водород и v различные заместители, определенные в формуле изобретения. Настоящее изобретение также относится к фармацевтическим композициям, содержащим соединения формулы (I), способам получения соединений и применению соединений в медицине. Соединения формулы (I) обладают активностью в качестве ингибиторов киназ CDK и применимы для лечения, в частности пролиферативных заболеваний, таких как раковые заболевания.
EA201101566A 2009-04-30 2010-04-30 Производные имидазола и их применение в качестве модуляторов циклинзависимых киназ EA020017B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17429309P 2009-04-30 2009-04-30
PCT/GB2010/050725 WO2010125402A1 (en) 2009-04-30 2010-04-30 Imidazole derivatives and their use as modulators of cyclin dependent kinases

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EA201101566A1 true EA201101566A1 (ru) 2012-05-30
EA020017B1 EA020017B1 (ru) 2014-08-29

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US (1) US8598217B2 (ru)
EP (1) EP2424843B1 (ru)
JP (1) JP2012525367A (ru)
KR (1) KR20120004542A (ru)
CN (1) CN102803225A (ru)
AU (1) AU2010243353B2 (ru)
BR (1) BRPI1016190A2 (ru)
CA (1) CA2759083A1 (ru)
EA (1) EA020017B1 (ru)
ES (1) ES2458872T3 (ru)
MX (1) MX2011011516A (ru)
PL (1) PL2424843T3 (ru)
PT (1) PT2424843E (ru)
WO (1) WO2010125402A1 (ru)

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US10124003B2 (en) 2013-07-18 2018-11-13 Taiho Pharmaceutical Co., Ltd. Therapeutic agent for FGFR inhibitor-resistant cancer
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RU2664118C2 (ru) * 2013-07-18 2018-08-15 Тайхо Фармасьютикал Ко., Лтд. Противоопухолевое лекарственное средство для прерывистого введения ингибитора fgfr
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PT2424843E (pt) 2014-06-02
AU2010243353A1 (en) 2011-11-10
CN102803225A (zh) 2012-11-28
CA2759083A1 (en) 2010-11-04
JP2012525367A (ja) 2012-10-22
PL2424843T3 (pl) 2014-07-31
AU2010243353B2 (en) 2014-09-11
US20120101064A1 (en) 2012-04-26
EP2424843A1 (en) 2012-03-07
ES2458872T3 (es) 2014-05-07
US8598217B2 (en) 2013-12-03
EP2424843B1 (en) 2014-03-26
MX2011011516A (es) 2011-11-18
WO2010125402A1 (en) 2010-11-04
BRPI1016190A2 (pt) 2017-03-28
KR20120004542A (ko) 2012-01-12
EA020017B1 (ru) 2014-08-29

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