CR11220A - Derivados de pirimidina 934 - Google Patents

Derivados de pirimidina 934

Info

Publication number
CR11220A
CR11220A CR11220A CR11220A CR11220A CR 11220 A CR11220 A CR 11220A CR 11220 A CR11220 A CR 11220A CR 11220 A CR11220 A CR 11220A CR 11220 A CR11220 A CR 11220A
Authority
CR
Costa Rica
Prior art keywords
pirimidine derivatives
pirimidine
derivatives
ring
condensed
Prior art date
Application number
CR11220A
Other languages
English (en)
Inventor
Berbard Christophe Barlaam
Richard Ducray
Jason Grant Kettle
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of CR11220A publication Critical patent/CR11220A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Un compuesto de formula (i) en la que de A1, A2 o A3 es A3 es N y los otros se relacionan independientemente de CH o N; en anillo B es un anillo carbociclico o heterocicco de 5 o 6 miembros condensado que esta opcialmente sustituido como se define en la memoria descriptiva, y R1; R2, R3, R4 y n son como se define en la memoria decriptiva.
CR11220A 2007-07-16 2010-01-15 Derivados de pirimidina 934 CR11220A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP07301236 2007-07-16

Publications (1)

Publication Number Publication Date
CR11220A true CR11220A (es) 2010-05-20

Family

ID=40260140

Family Applications (1)

Application Number Title Priority Date Filing Date
CR11220A CR11220A (es) 2007-07-16 2010-01-15 Derivados de pirimidina 934

Country Status (18)

Country Link
US (1) US7718653B2 (es)
EP (1) EP2183242A2 (es)
JP (1) JP2010533700A (es)
KR (1) KR20100042272A (es)
CN (1) CN101796046A (es)
AU (1) AU2008277446A1 (es)
BR (1) BRPI0814821A2 (es)
CA (1) CA2693880A1 (es)
CO (1) CO6260075A2 (es)
CR (1) CR11220A (es)
DO (1) DOP2010000022A (es)
EA (1) EA201000101A1 (es)
EC (1) ECSP109958A (es)
MX (1) MX2010000658A (es)
NI (1) NI201000011A (es)
SV (1) SV2010003459A (es)
WO (1) WO2009010789A2 (es)
ZA (1) ZA201000107B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5607241B2 (ja) 2010-05-21 2014-10-15 ケミリア・エービー 新規ピリミジン誘導体
MX2013010898A (es) 2011-03-24 2013-12-06 Chemilia Ab Novedoso derivados de la pirimidina.
LT2699553T (lt) 2011-04-22 2024-02-12 Signal Pharmaceuticals, Llc Pakeistas diaminokarboksamidas ir diaminokarbonitrilo pirimidinai, jų kompozicijos ir gydymo būdai
WO2012150293A1 (de) 2011-05-03 2012-11-08 Scholz Peter-Dominik Anordnung und verfahren zur kontaklosen energieübertragung mit einer kopplungsminimierten matrix aus planaren sendespulen
CN103222842B (zh) 2013-04-18 2015-09-09 安翰光电技术（武汉）有限公司 一种控制胶囊内窥镜在人体消化道运动的装置及方法
NZ715903A (en) 2014-01-30 2017-06-30 Signal Pharm Llc Solid forms of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide, compositions thereof and methods of their use
WO2016100308A1 (en) 2014-12-16 2016-06-23 Signal Pharmaceuticals, Llc Methods for measurement of inhibition of c-jun n-terminal kinase in skin
JP6762940B2 (ja) 2014-12-16 2020-09-30 シグナル ファーマシューティカルズ，エルエルシー ２−（ｔｅｒｔ−ブチルアミノ）−４−（（１Ｒ，３Ｒ，４Ｒ）−３−ヒドロキシ−４−メチルシクロヘキシルアミノ）−ピリミジン−５−カルボキサミドの製剤
WO2016123291A1 (en) 2015-01-29 2016-08-04 Signal Pharmaceuticals, Llc Isotopologues of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide
AU2016297784B2 (en) 2015-07-24 2020-12-24 Celgene Corporation Methods of synthesis of (1R,2R,5R)-5-amino-2-methylcyclohexanol hydrochloride and intermediates useful therein
CN106543089A (zh) * 2016-11-04 2017-03-29 山东铂源药业有限公司 一种达沙替尼中间体的合成方法
EP4163278A1 (en) * 2020-05-29 2023-04-12 Nanjing Chia Tai Tianqing Pharmaceutical Co., Ltd. Pyrimidine compound as axl inhibitor
CN116178433A (zh) * 2021-11-26 2023-05-30 南京正大天晴制药有限公司 Axl激酶抑制剂的盐及其制备方法和用途
CN116178434A (zh) * 2021-11-26 2023-05-30 南京正大天晴制药有限公司 Axl激酶抑制剂的单对甲苯磺酸盐及其晶型

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0301117A3 (en) * 2000-02-17 2004-01-28 Amgen Inc Thousand Oaks Imidazole derivatives kinase inhibitors, their use, process for their preparation and pharmaceutical compositions containing them
PT1487818E (pt) 2002-03-05 2007-07-18 Astrazeneca Ab Sais de alquilamónio de omeprazole e esomeprazole
GB0305929D0 (en) * 2003-03-14 2003-04-23 Novartis Ag Organic compounds
EP1660458B1 (en) * 2003-08-15 2012-01-25 Novartis AG 2, 4-pyrimidinediamines useful in the treatment of neoplastic diseases, inflammatory and immune system disorders
US7521457B2 (en) 2004-08-20 2009-04-21 Boehringer Ingelheim International Gmbh Pyrimidines as PLK inhibitors
GB0419161D0 (en) * 2004-08-27 2004-09-29 Novartis Ag Organic compounds
AU2006227628A1 (en) 2005-03-16 2006-09-28 Targegen, Inc. Pyrimidine compounds and methods of use
WO2006129100A1 (en) * 2005-06-03 2006-12-07 Glaxo Group Limited Novel compounds
PE20070362A1 (es) 2005-07-15 2007-04-23 Glaxo Group Ltd COMPUESTOS DERIVADOS DE INDAZOL-4-IL-2,4-PIRIMIDINDIAMINA COMO INHIBIDORES DE TIROSINA QUINASA (QUINASA Syk)
WO2007028445A1 (en) * 2005-07-15 2007-03-15 Glaxo Group Limited 6-indolyl-4-yl-amino-5-halogeno-2-pyrimidinyl-amino derivatives
EP1934200A1 (en) 2005-09-15 2008-06-25 Merck & Co., Inc. Tyrosine kinase inhibitors
NZ592990A (en) * 2005-11-01 2013-01-25 Targegen Inc Bi-aryl meta-pyrimidine inhibitors of kinases
TW200736232A (en) 2006-01-26 2007-10-01 Astrazeneca Ab Pyrimidine derivatives
WO2007085540A1 (en) 2006-01-27 2007-08-02 Glaxo Group Limited 1h-indaz0l-4-yl-2 , 4-pyrimidinediamine derivatives
TW200840581A (en) 2007-02-28 2008-10-16 Astrazeneca Ab Novel pyrimidine derivatives
US7947698B2 (en) * 2007-03-23 2011-05-24 Rigel Pharmaceuticals, Inc. Compositions and methods for inhibition of the JAK pathway
JP2010525047A (ja) 2007-04-27 2010-07-22 アストラゼネカ アクチボラグ 増殖状態の処置のためのＥｐｈＢ４キナーゼ阻害剤としてのＮ’−（フェニル）−Ｎ−（モルホリン−４−イル−ピリジン−２−イル）−ピリミジン−２，４−ジアミン誘導体

Also Published As

Publication number Publication date
CN101796046A (zh) 2010-08-04
SV2010003459A (es) 2010-04-30
MX2010000658A (es) 2010-03-26
WO2009010789A3 (en) 2009-05-07
US20090023719A1 (en) 2009-01-22
EP2183242A2 (en) 2010-05-12
AU2008277446A1 (en) 2009-01-22
ECSP109958A (es) 2010-03-31
US7718653B2 (en) 2010-05-18
NI201000011A (es) 2010-12-07
CO6260075A2 (es) 2011-03-22
JP2010533700A (ja) 2010-10-28
ZA201000107B (en) 2010-09-29
DOP2010000022A (es) 2010-02-15
EA201000101A1 (ru) 2010-08-30
CA2693880A1 (en) 2009-01-22
WO2009010789A2 (en) 2009-01-22
BRPI0814821A2 (pt) 2015-02-03
KR20100042272A (ko) 2010-04-23

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Legal Events

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FA Abandonment or withdrawal (granting procedure)