EA200970896A1 - ТВЕРДАЯ ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, ВКЛЮЧАЮЩАЯ ПРОИЗВОДНОЕ БЕНЗИМИДАЗОЛ-7-КАРБОКСИЛАТА И pH РЕГУЛИРУЮЩИЙ АГЕНТ - Google Patents
ТВЕРДАЯ ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, ВКЛЮЧАЮЩАЯ ПРОИЗВОДНОЕ БЕНЗИМИДАЗОЛ-7-КАРБОКСИЛАТА И pH РЕГУЛИРУЮЩИЙ АГЕНТInfo
- Publication number
- EA200970896A1 EA200970896A1 EA200970896A EA200970896A EA200970896A1 EA 200970896 A1 EA200970896 A1 EA 200970896A1 EA 200970896 A EA200970896 A EA 200970896A EA 200970896 A EA200970896 A EA 200970896A EA 200970896 A1 EA200970896 A1 EA 200970896A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- pharmaceutical composition
- solid pharmaceutical
- benzimidazol
- control agent
- composition including
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
- A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Inorganic Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Настоящее изобретение предоставляет твердую фармацевтическую композицию, содержащую соединение (I), обладающее антагонистическим действием по отношению к рецептору ангиотензина II и охарактеризованное в описании, и рН регулирующий агент, состав которого является наилучшим для стабильности и растворимости соединения (I).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US90851507P | 2007-03-28 | 2007-03-28 | |
PCT/JP2008/056522 WO2008123536A1 (en) | 2007-03-28 | 2008-03-26 | Solid pharmaceutical composition comprising a benzimidazole-7-carboxylate derivative and a ph control agent |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200970896A1 true EA200970896A1 (ru) | 2010-04-30 |
EA016593B1 EA016593B1 (ru) | 2012-06-29 |
Family
ID=39590787
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200970896A EA016593B1 (ru) | 2007-03-28 | 2008-03-26 | ТВЕРДАЯ ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, ВКЛЮЧАЮЩАЯ ПРОИЗВОДНОЕ БЕНЗИМИДАЗОЛ-7-КАРБОКСИЛАТА И pH РЕГУЛИРУЮЩИЙ АГЕНТ |
Country Status (19)
Country | Link |
---|---|
US (1) | US9066936B2 (ru) |
EP (1) | EP2124903B1 (ru) |
JP (1) | JP5283632B2 (ru) |
KR (1) | KR20090125846A (ru) |
CN (1) | CN101677961B (ru) |
AR (1) | AR065850A1 (ru) |
AU (1) | AU2008235790B2 (ru) |
BR (1) | BRPI0809522A2 (ru) |
CA (1) | CA2681143C (ru) |
CL (1) | CL2008000868A1 (ru) |
EA (1) | EA016593B1 (ru) |
ES (1) | ES2743784T3 (ru) |
IL (1) | IL201188A0 (ru) |
MX (1) | MX2009010167A (ru) |
NZ (1) | NZ579851A (ru) |
PE (2) | PE20130210A1 (ru) |
PT (1) | PT2124903T (ru) |
TW (1) | TWI415634B (ru) |
WO (1) | WO2008123536A1 (ru) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EA201170273A1 (ru) | 2008-07-31 | 2011-08-30 | Такеда Фармасьютикал Компани Лимитед | Твердая фармацевтическая композиция |
UY32126A (es) * | 2008-09-25 | 2010-04-30 | Takeda Pharmaceutical | Composición farmacéutica sólida |
WO2012159552A1 (zh) * | 2011-05-23 | 2012-11-29 | 江苏恒瑞医药股份有限公司 | 包含苯并咪唑衍生物的固体药物组合物 |
CN102351853B (zh) * | 2011-08-29 | 2014-03-12 | 石药集团欧意药业有限公司 | 一种阿齐沙坦酯化合物、制备方法及其药物组合物 |
BR112015005489B1 (pt) | 2012-09-19 | 2022-07-12 | Taiho Pharmaceutical Co., Ltd. | Composição farmacêutica para administração oral com dissolução e/ou absorção aperfeiçoadas |
EP2928468A4 (en) | 2012-12-05 | 2016-07-27 | Sawai Seiyaku Kk | PREPARATION CONTAINING CANDÉSARTAN CILEXÉTIL |
WO2014102628A1 (en) | 2012-12-31 | 2014-07-03 | Ranbaxy Laboratories Limited | Stable pharmaceutical composition comprising azilsartan medoxomil |
WO2014119667A1 (ja) | 2013-01-30 | 2014-08-07 | 沢井製薬株式会社 | カンデサルタンシレキセチル含有医薬組成物 |
CN105079815A (zh) * | 2014-04-30 | 2015-11-25 | 广东东阳光药业有限公司 | 一种阿齐沙坦酯钾组合物及其制备方法 |
WO2019130277A1 (en) | 2017-12-30 | 2019-07-04 | Lupin Limited | Pharmaceutical formulations of azilsartan medoxomil |
IN202021028444A (ru) * | 2020-07-03 | 2022-01-28 | ||
CN117122570B (zh) * | 2022-05-19 | 2024-04-09 | 北京阳光诺和药物研究股份有限公司 | 一种提高稳定性的美阿沙坦钾片及其制备方法 |
CN118059247A (zh) * | 2022-11-24 | 2024-05-24 | 上海云晟研新生物科技有限公司 | 包含美阿沙坦钾与钙通道阻滞剂的药物组合物,及其制备方法及应用 |
Family Cites Families (35)
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US5250554A (en) * | 1989-10-24 | 1993-10-05 | Takeda Chemical Industries, Ltd. | Benzimidazole derivatives useful as angiotensin II inhibitors |
US5196444A (en) * | 1990-04-27 | 1993-03-23 | Takeda Chemical Industries, Ltd. | 1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate and compositions and methods of pharmaceutical use thereof |
US6004989A (en) * | 1990-04-27 | 1999-12-21 | Takeda Chemical Industries, Ltd. | Benzimidazole derivatives, their production and use |
US5703110A (en) * | 1990-04-27 | 1997-12-30 | Takeda Chemical Industries, Ltd. | Benzimidazole derivatives, their production and use |
IL102183A (en) * | 1991-06-27 | 1999-11-30 | Takeda Chemical Industries Ltd | The heterocyclic compounds are converted into biphenyl groups, their production and the pharmaceutical compositions containing them |
TW284688B (ru) * | 1991-11-20 | 1996-09-01 | Takeda Pharm Industry Co Ltd | |
US5605919A (en) * | 1993-02-26 | 1997-02-25 | Takeda Chemical Industries, Ltd. | Treatment for viral diseases |
CA2115985A1 (en) * | 1993-02-25 | 1994-08-26 | Kohei Nishikawa | Vascular hypertrophy suppressor |
JP3810020B2 (ja) * | 1993-04-22 | 2006-08-16 | 武田薬品工業株式会社 | 腎疾患の予防または治療剤 |
US5721263A (en) * | 1993-06-07 | 1998-02-24 | Takeda Chemical Industries, Ltd. | Pharmaceutical composition for angiotensin II-mediated diseases |
CZ154994A3 (en) * | 1993-07-02 | 1995-09-13 | Senju Pharma Co | Visual hypotensive agent |
WO1997037688A2 (en) * | 1996-04-05 | 1997-10-16 | Takeda Chemical Industries, Ltd. | Pharmaceutical combination containing a compound having angiotensin ii and antagonistic activity |
AU2745199A (en) * | 1998-03-04 | 1999-09-20 | Takeda Chemical Industries Ltd. | Sustained-release preparation for aii antagonist, production and use thereof |
CA2363792C (en) * | 1999-02-19 | 2009-10-27 | Takeda Chemical Industries, Ltd. | Percutaneous absorption preparation of compound having angiotensin ii antagonistic activity |
BR0010084A (pt) * | 1999-04-28 | 2002-01-15 | Takeda Chemical Industries Ltd | Composição farmacêutica, processos para prevenir, tratar ou inibir o desenvolvimento de retinopatia simples ou retinopatia proliferativa, e para aumentar potencial retiniano ou edema retiniano de mamìfero, e, uso de um composto |
WO2001005428A1 (fr) * | 1999-07-21 | 2001-01-25 | Takeda Chemical Industries, Ltd. | Methodes preventives contre la recurrence d'une insuffisance cerebrovasculaire, et agents destines a ameliorer des troubles causes par une insuffisance cerebrovasculaire et a inhiber leur evolution |
US6833381B2 (en) * | 2000-02-18 | 2004-12-21 | Takeda Chemical Industries, Ltd. | TNF-α inhibitors |
JP2001316296A (ja) * | 2000-02-21 | 2001-11-13 | Takeda Chem Ind Ltd | 水に難溶性の生理活性化合物の徐放性製剤、その製造法および用途 |
AU2001232348A1 (en) * | 2000-02-21 | 2001-08-27 | Takeda Chemical Industries Ltd. | Sustained release preparations of physiologically active compound hardly solublein water and production process and use of the same |
US7812044B2 (en) * | 2001-11-13 | 2010-10-12 | Takeda Pharmaceutical Company Limited | Anticancer agents |
EP1452176A4 (en) * | 2001-12-03 | 2009-01-21 | Takeda Pharmaceutical | MEANS FOR IMPROVING INSULIN RESISTANCE |
JP4484427B2 (ja) * | 2001-12-03 | 2010-06-16 | 武田薬品工業株式会社 | インスリン抵抗性改善剤 |
ATE551056T1 (de) * | 2002-12-27 | 2012-04-15 | Takeda Pharmaceutical | Mittel zur hemmung der körpergewichtszunahme |
US20060177506A1 (en) * | 2003-03-17 | 2006-08-10 | Shigeo Yanai | Release control compositions |
US7157584B2 (en) * | 2004-02-25 | 2007-01-02 | Takeda Pharmaceutical Company Limited | Benzimidazole derivative and use thereof |
US7588779B2 (en) * | 2004-05-28 | 2009-09-15 | Andrx Labs, Llc | Pharmaceutical formulation containing a biguanide and an angiotensin antagonist |
CN100558359C (zh) * | 2004-09-06 | 2009-11-11 | 兴和株式会社 | 肾小球病治疗剂 |
US20060159747A1 (en) * | 2004-12-17 | 2006-07-20 | Boehringer Ingelheim International Gmbh | Telmisartan and hydrochlorothiazide combination therapy |
EP1885694A2 (en) | 2005-05-13 | 2008-02-13 | Microbia, Inc. | 4-biarylyl-1-phenylazetidin-2-ones |
KR20130135994A (ko) | 2005-06-27 | 2013-12-11 | 다이이찌 산쿄 가부시키가이샤 | 안지오텐신 ⅱ 수용체 길항제 및 칼슘 채널 차단제를 함유한 약학 제제 |
DE102005031577A1 (de) | 2005-07-06 | 2007-01-11 | Bayer Healthcare Ag | Pharmazeutische Darreichungsformen enthaltend eine Wirkstoffkombination von Nifedipin und/oder Nisoldipin und einem Angiotensin-II Antagonisten |
TWI494134B (zh) * | 2006-06-20 | 2015-08-01 | Siegfried Generics Int Ag | 含有坎地沙坦酯的組成物、錠劑和顆粒及該錠劑的製造方法 |
WO2008045006A1 (en) * | 2006-10-11 | 2008-04-17 | Fako Ilaclari A. S. | Formulations of candesartan |
WO2008068217A2 (en) * | 2006-12-04 | 2008-06-12 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition comprising a coated hmg-coa reductase inhibitor and an inhibitor of the renin-angiotensin system |
US9387249B2 (en) * | 2008-12-23 | 2016-07-12 | Takeda Pharmaceutical Company Limited | Methods of treating hypertension with at least one angiotensin II receptor blocker and chlorthalidone |
-
2008
- 2008-03-26 US US12/450,403 patent/US9066936B2/en active Active
- 2008-03-26 CN CN2008800177926A patent/CN101677961B/zh active Active
- 2008-03-26 CA CA2681143A patent/CA2681143C/en active Active
- 2008-03-26 BR BRPI0809522-1A2A patent/BRPI0809522A2/pt not_active IP Right Cessation
- 2008-03-26 TW TW097110689A patent/TWI415634B/zh not_active IP Right Cessation
- 2008-03-26 NZ NZ579851A patent/NZ579851A/en not_active IP Right Cessation
- 2008-03-26 JP JP2009541656A patent/JP5283632B2/ja active Active
- 2008-03-26 KR KR1020097022475A patent/KR20090125846A/ko not_active Application Discontinuation
- 2008-03-26 AR ARP080101237A patent/AR065850A1/es not_active Application Discontinuation
- 2008-03-26 MX MX2009010167A patent/MX2009010167A/es active IP Right Grant
- 2008-03-26 ES ES08739635T patent/ES2743784T3/es active Active
- 2008-03-26 CL CL200800868A patent/CL2008000868A1/es unknown
- 2008-03-26 PE PE2012001692A patent/PE20130210A1/es not_active Application Discontinuation
- 2008-03-26 EP EP08739635.4A patent/EP2124903B1/en active Active
- 2008-03-26 AU AU2008235790A patent/AU2008235790B2/en not_active Ceased
- 2008-03-26 WO PCT/JP2008/056522 patent/WO2008123536A1/en active Application Filing
- 2008-03-26 PE PE2008000540A patent/PE20090550A1/es not_active Application Discontinuation
- 2008-03-26 PT PT08739635T patent/PT2124903T/pt unknown
- 2008-03-26 EA EA200970896A patent/EA016593B1/ru not_active IP Right Cessation
-
2009
- 2009-09-24 IL IL201188A patent/IL201188A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
CA2681143C (en) | 2017-01-03 |
WO2008123536A1 (en) | 2008-10-16 |
US20100121071A1 (en) | 2010-05-13 |
JP2010522692A (ja) | 2010-07-08 |
TWI415634B (zh) | 2013-11-21 |
CA2681143A1 (en) | 2008-10-16 |
PE20090550A1 (es) | 2009-06-01 |
BRPI0809522A2 (pt) | 2014-10-14 |
IL201188A0 (en) | 2010-05-17 |
CN101677961A (zh) | 2010-03-24 |
ES2743784T3 (es) | 2020-02-20 |
KR20090125846A (ko) | 2009-12-07 |
PT2124903T (pt) | 2019-09-26 |
JP5283632B2 (ja) | 2013-09-04 |
TW200902089A (en) | 2009-01-16 |
EP2124903A1 (en) | 2009-12-02 |
CL2008000868A1 (es) | 2008-10-10 |
AU2008235790B2 (en) | 2013-06-06 |
CN101677961B (zh) | 2012-10-17 |
EP2124903B1 (en) | 2019-06-12 |
MX2009010167A (es) | 2009-10-12 |
US9066936B2 (en) | 2015-06-30 |
AR065850A1 (es) | 2009-07-08 |
PE20130210A1 (es) | 2013-03-11 |
NZ579851A (en) | 2012-02-24 |
EA016593B1 (ru) | 2012-06-29 |
AU2008235790A1 (en) | 2008-10-16 |
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