PT2124903T - Composição farmacêutica sólida compreendendo um derivado de benzimidazole-7-carboxilato e um agente de controlo de ph - Google Patents

Composição farmacêutica sólida compreendendo um derivado de benzimidazole-7-carboxilato e um agente de controlo de ph

Info

Publication number
PT2124903T
PT2124903T PT08739635T PT08739635T PT2124903T PT 2124903 T PT2124903 T PT 2124903T PT 08739635 T PT08739635 T PT 08739635T PT 08739635 T PT08739635 T PT 08739635T PT 2124903 T PT2124903 T PT 2124903T
Authority
PT
Portugal
Prior art keywords
benzimidazole
pharmaceutical composition
control agent
solid pharmaceutical
carboxylate derivative
Prior art date
Application number
PT08739635T
Other languages
English (en)
Inventor
Yoneyama Shuji
Tanoue Yutaka
Original Assignee
Takeda Pharmaceuticals Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39590787&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT2124903(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Pharmaceuticals Co filed Critical Takeda Pharmaceuticals Co
Publication of PT2124903T publication Critical patent/PT2124903T/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PT08739635T 2007-03-28 2008-03-26 Composição farmacêutica sólida compreendendo um derivado de benzimidazole-7-carboxilato e um agente de controlo de ph PT2124903T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US90851507P 2007-03-28 2007-03-28

Publications (1)

Publication Number Publication Date
PT2124903T true PT2124903T (pt) 2019-09-26

Family

ID=39590787

Family Applications (1)

Application Number Title Priority Date Filing Date
PT08739635T PT2124903T (pt) 2007-03-28 2008-03-26 Composição farmacêutica sólida compreendendo um derivado de benzimidazole-7-carboxilato e um agente de controlo de ph

Country Status (19)

Country Link
US (1) US9066936B2 (pt)
EP (1) EP2124903B1 (pt)
JP (1) JP5283632B2 (pt)
KR (1) KR20090125846A (pt)
CN (1) CN101677961B (pt)
AR (1) AR065850A1 (pt)
AU (1) AU2008235790B2 (pt)
BR (1) BRPI0809522A2 (pt)
CA (1) CA2681143C (pt)
CL (1) CL2008000868A1 (pt)
EA (1) EA016593B1 (pt)
ES (1) ES2743784T3 (pt)
IL (1) IL201188A0 (pt)
MX (1) MX2009010167A (pt)
NZ (1) NZ579851A (pt)
PE (2) PE20130210A1 (pt)
PT (1) PT2124903T (pt)
TW (1) TWI415634B (pt)
WO (1) WO2008123536A1 (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA201170273A1 (ru) 2008-07-31 2011-08-30 Такеда Фармасьютикал Компани Лимитед Твердая фармацевтическая композиция
UY32126A (es) * 2008-09-25 2010-04-30 Takeda Pharmaceutical Composición farmacéutica sólida
WO2012159552A1 (zh) * 2011-05-23 2012-11-29 江苏恒瑞医药股份有限公司 包含苯并咪唑衍生物的固体药物组合物
CN102351853B (zh) * 2011-08-29 2014-03-12 石药集团欧意药业有限公司 一种阿齐沙坦酯化合物、制备方法及其药物组合物
BR112015005489B1 (pt) 2012-09-19 2022-07-12 Taiho Pharmaceutical Co., Ltd. Composição farmacêutica para administração oral com dissolução e/ou absorção aperfeiçoadas
EP2928468A4 (en) 2012-12-05 2016-07-27 Sawai Seiyaku Kk PREPARATION CONTAINING CANDÉSARTAN CILEXÉTIL
WO2014102628A1 (en) 2012-12-31 2014-07-03 Ranbaxy Laboratories Limited Stable pharmaceutical composition comprising azilsartan medoxomil
WO2014119667A1 (ja) 2013-01-30 2014-08-07 沢井製薬株式会社 カンデサルタンシレキセチル含有医薬組成物
CN105079815A (zh) * 2014-04-30 2015-11-25 广东东阳光药业有限公司 一种阿齐沙坦酯钾组合物及其制备方法
WO2019130277A1 (en) 2017-12-30 2019-07-04 Lupin Limited Pharmaceutical formulations of azilsartan medoxomil
IN202021028444A (pt) * 2020-07-03 2022-01-28
CN117122570B (zh) * 2022-05-19 2024-04-09 北京阳光诺和药物研究股份有限公司 一种提高稳定性的美阿沙坦钾片及其制备方法
CN118059247A (zh) * 2022-11-24 2024-05-24 上海云晟研新生物科技有限公司 包含美阿沙坦钾与钙通道阻滞剂的药物组合物，及其制备方法及应用

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5250554A (en) * 1989-10-24 1993-10-05 Takeda Chemical Industries, Ltd. Benzimidazole derivatives useful as angiotensin II inhibitors
US5196444A (en) * 1990-04-27 1993-03-23 Takeda Chemical Industries, Ltd. 1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate and compositions and methods of pharmaceutical use thereof
US6004989A (en) * 1990-04-27 1999-12-21 Takeda Chemical Industries, Ltd. Benzimidazole derivatives, their production and use
US5703110A (en) * 1990-04-27 1997-12-30 Takeda Chemical Industries, Ltd. Benzimidazole derivatives, their production and use
IL102183A (en) * 1991-06-27 1999-11-30 Takeda Chemical Industries Ltd The heterocyclic compounds are converted into biphenyl groups, their production and the pharmaceutical compositions containing them
TW284688B (pt) * 1991-11-20 1996-09-01 Takeda Pharm Industry Co Ltd
US5605919A (en) * 1993-02-26 1997-02-25 Takeda Chemical Industries, Ltd. Treatment for viral diseases
CA2115985A1 (en) * 1993-02-25 1994-08-26 Kohei Nishikawa Vascular hypertrophy suppressor
JP3810020B2 (ja) * 1993-04-22 2006-08-16 武田薬品工業株式会社 腎疾患の予防または治療剤
US5721263A (en) * 1993-06-07 1998-02-24 Takeda Chemical Industries, Ltd. Pharmaceutical composition for angiotensin II-mediated diseases
CZ154994A3 (en) * 1993-07-02 1995-09-13 Senju Pharma Co Visual hypotensive agent
WO1997037688A2 (en) * 1996-04-05 1997-10-16 Takeda Chemical Industries, Ltd. Pharmaceutical combination containing a compound having angiotensin ii and antagonistic activity
AU2745199A (en) * 1998-03-04 1999-09-20 Takeda Chemical Industries Ltd. Sustained-release preparation for aii antagonist, production and use thereof
CA2363792C (en) * 1999-02-19 2009-10-27 Takeda Chemical Industries, Ltd. Percutaneous absorption preparation of compound having angiotensin ii antagonistic activity
BR0010084A (pt) * 1999-04-28 2002-01-15 Takeda Chemical Industries Ltd Composição farmacêutica, processos para prevenir, tratar ou inibir o desenvolvimento de retinopatia simples ou retinopatia proliferativa, e para aumentar potencial retiniano ou edema retiniano de mamìfero, e, uso de um composto
WO2001005428A1 (fr) * 1999-07-21 2001-01-25 Takeda Chemical Industries, Ltd. Methodes preventives contre la recurrence d'une insuffisance cerebrovasculaire, et agents destines a ameliorer des troubles causes par une insuffisance cerebrovasculaire et a inhiber leur evolution
US6833381B2 (en) * 2000-02-18 2004-12-21 Takeda Chemical Industries, Ltd. TNF-α inhibitors
JP2001316296A (ja) * 2000-02-21 2001-11-13 Takeda Chem Ind Ltd 水に難溶性の生理活性化合物の徐放性製剤、その製造法および用途
AU2001232348A1 (en) * 2000-02-21 2001-08-27 Takeda Chemical Industries Ltd. Sustained release preparations of physiologically active compound hardly solublein water and production process and use of the same
US7812044B2 (en) * 2001-11-13 2010-10-12 Takeda Pharmaceutical Company Limited Anticancer agents
EP1452176A4 (en) * 2001-12-03 2009-01-21 Takeda Pharmaceutical MEANS FOR IMPROVING INSULIN RESISTANCE
JP4484427B2 (ja) * 2001-12-03 2010-06-16 武田薬品工業株式会社 インスリン抵抗性改善剤
ATE551056T1 (de) * 2002-12-27 2012-04-15 Takeda Pharmaceutical Mittel zur hemmung der körpergewichtszunahme
US20060177506A1 (en) * 2003-03-17 2006-08-10 Shigeo Yanai Release control compositions
US7157584B2 (en) * 2004-02-25 2007-01-02 Takeda Pharmaceutical Company Limited Benzimidazole derivative and use thereof
US7588779B2 (en) * 2004-05-28 2009-09-15 Andrx Labs, Llc Pharmaceutical formulation containing a biguanide and an angiotensin antagonist
CN100558359C (zh) * 2004-09-06 2009-11-11 兴和株式会社 肾小球病治疗剂
US20060159747A1 (en) * 2004-12-17 2006-07-20 Boehringer Ingelheim International Gmbh Telmisartan and hydrochlorothiazide combination therapy
EP1885694A2 (en) 2005-05-13 2008-02-13 Microbia, Inc. 4-biarylyl-1-phenylazetidin-2-ones
KR20130135994A (ko) 2005-06-27 2013-12-11 다이이찌 산쿄 가부시키가이샤 안지오텐신 ⅱ 수용체 길항제 및 칼슘 채널 차단제를 함유한 약학 제제
DE102005031577A1 (de) 2005-07-06 2007-01-11 Bayer Healthcare Ag Pharmazeutische Darreichungsformen enthaltend eine Wirkstoffkombination von Nifedipin und/oder Nisoldipin und einem Angiotensin-II Antagonisten
TWI494134B (zh) * 2006-06-20 2015-08-01 Siegfried Generics Int Ag 含有坎地沙坦酯的組成物、錠劑和顆粒及該錠劑的製造方法
WO2008045006A1 (en) * 2006-10-11 2008-04-17 Fako Ilaclari A. S. Formulations of candesartan
WO2008068217A2 (en) * 2006-12-04 2008-06-12 Boehringer Ingelheim International Gmbh Pharmaceutical composition comprising a coated hmg-coa reductase inhibitor and an inhibitor of the renin-angiotensin system
US9387249B2 (en) * 2008-12-23 2016-07-12 Takeda Pharmaceutical Company Limited Methods of treating hypertension with at least one angiotensin II receptor blocker and chlorthalidone

Also Published As

Publication number Publication date
CA2681143C (en) 2017-01-03
WO2008123536A1 (en) 2008-10-16
US20100121071A1 (en) 2010-05-13
JP2010522692A (ja) 2010-07-08
TWI415634B (zh) 2013-11-21
CA2681143A1 (en) 2008-10-16
PE20090550A1 (es) 2009-06-01
BRPI0809522A2 (pt) 2014-10-14
IL201188A0 (en) 2010-05-17
CN101677961A (zh) 2010-03-24
ES2743784T3 (es) 2020-02-20
KR20090125846A (ko) 2009-12-07
JP5283632B2 (ja) 2013-09-04
TW200902089A (en) 2009-01-16
EP2124903A1 (en) 2009-12-02
CL2008000868A1 (es) 2008-10-10
AU2008235790B2 (en) 2013-06-06
CN101677961B (zh) 2012-10-17
EA200970896A1 (ru) 2010-04-30
EP2124903B1 (en) 2019-06-12
MX2009010167A (es) 2009-10-12
US9066936B2 (en) 2015-06-30
AR065850A1 (es) 2009-07-08
PE20130210A1 (es) 2013-03-11
NZ579851A (en) 2012-02-24
EA016593B1 (ru) 2012-06-29
AU2008235790A1 (en) 2008-10-16

Similar Documents

Publication Publication Date Title
IL201188A0 (en) Solid pharmaceutical composition comprising a benzimidazole-7-carboxylate derivative and a ph control agent
EP2177519A4 (en) OXIME TETRAZOYL DERIVATIVE AND PLANT ANTIPARASITIC AGENT
EP2025337A4 (en) EXTERNAL PHARMACEUTICAL COMPOSITION
EP2005959A4 (en) EXTERNAL PHARMACEUTICAL COMPOSITION
PL2005958T3 (pl) Kompozycja farmaceutyczna do stosowania zewnętrznego
EP2074142A4 (en) COMPOUNDS FOR STIMULATING THE FUNCTION OF P-GLYCOPROTEIN AND APPLICATIONS THEREOF
EP2056835A4 (en) PHARMACEUTICAL COMPOSITIONS AND USES THEREOF
ZA200910116B (en) Pharmaceutical composition comprising amlodipine and losartan
IL197093A0 (en) Pharmaceutical composition comprising candesartan cilexetil
SI2154966T1 (sl) Benzimidazoli in njihovi farmacevtski sestavki
ZA201002547B (en) Heterocyclic compound and pharmaceutical composition thereof
GB0614586D0 (en) Pharmaceutical Formulation
IL197107A0 (en) Pharmaceutical compositions including vitamin d and corticosteriod
EP2119442A4 (en) PHARMACEUTICAL COMPOSITION WITH TACROLIMUS MAINTAINED RELEASE
EP2202226A4 (en) 3-ALKOXY-1-PHENYLPYRAZOLE DERIVATIVE AND PESTICIDES
IL193211A (en) Derivatives of Indzol-Troaril and pharmaceutical preparations containing them
EP1980237A4 (en) GELIFYING AGENT
PT2193795E (pt) Composição farmacêutica aquosa contendo latanoprost
EP2070919A4 (en) SPIROCHINONE COMPOUND AND PHARMACEUTICAL COMPOSITION
EP2025667A4 (en) 9, 10-SECOPREGNANDERIVAT AND MEDICINAL PRODUCTS
EP2124959A4 (en) PHARMACEUTICAL COMPOSITION
IL198160A0 (en) Pharmaceutical formulations
EP2097074A4 (en) TOPICAL PHARMACEUTICAL COMPOSITION
GB0600168D0 (en) A therapeutic composition
EP2114404A4 (en) COMPOUND AND PHARMACEUTICAL COMPOSITION