GT200800251A - Nitrilos espirociclicos como inhibidores de proteasa - Google Patents

Nitrilos espirociclicos como inhibidores de proteasa

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Publication number
GT200800251A
GT200800251A GT200800251A GT200800251A GT200800251A GT 200800251 A GT200800251 A GT 200800251A GT 200800251 A GT200800251 A GT 200800251A GT 200800251 A GT200800251 A GT 200800251A GT 200800251 A GT200800251 A GT 200800251A
Authority
GT
Guatemala
Prior art keywords
siprociclic
nitrils
proteasa
inhibitors
proteasa inhibitors
Prior art date
Application number
GT200800251A
Other languages
English (en)
Inventor
Schudok Manfred
Wagner Michael
Bauer Armin
Kohlmann Anna
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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Publication of GT200800251A publication Critical patent/GT200800251A/es

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    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Abstract

LA INVENCIÓN SE REFIERE A COMPUESTOS ESPIRÀNICOS HETEROCÌCLICOS SUSTITUIDOS DE LA FÓRMULA (I), QUE INHIBEN CATEPSINAS, A PROCEDIMIENTOS PARA SU PREPARACIÓN Y A SU USO COMO MEDICAMENTOS. T2008
GT200800251A 2006-06-01 2008-11-21 Nitrilos espirociclicos como inhibidores de proteasa GT200800251A (es)

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KR102510588B1 (ko) * 2014-09-12 2023-03-17 베링거 인겔하임 인터내셔날 게엠베하 카텝신 c의 스피로사이클릭 억제제
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EP2032535A1 (de) 2009-03-11
DOP2007000107A (es) 2007-12-15
UA107583C2 (ru) 2015-01-26
MY156425A (en) 2016-02-26
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ES2392675T3 (es) 2012-12-12
TWI396691B (zh) 2013-05-21
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KR101426317B1 (ko) 2014-08-06
US8609681B2 (en) 2013-12-17
PT2032535E (pt) 2012-11-13
CY1113320T1 (el) 2016-04-13
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AU2007267470A1 (en) 2007-12-06
CA2653662A1 (en) 2007-12-06
HK1133255A1 (en) 2010-03-19
RU2621695C2 (ru) 2017-06-07
ECSP088925A (es) 2008-12-30
JP5702834B2 (ja) 2015-04-15
MA30435B1 (fr) 2009-05-04
NO20085107L (no) 2008-12-08
US20140073662A1 (en) 2014-03-13
AU2007267470B2 (en) 2012-09-20
HN2008001723A (es) 2010-12-27
RS52464B (en) 2013-02-28
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