EA200700143A1 - Производные замещенного пропенилпиперазина в качестве новых ингибиторов гистондеацетилазы - Google Patents

Производные замещенного пропенилпиперазина в качестве новых ингибиторов гистондеацетилазы

Info

Publication number
EA200700143A1
EA200700143A1 EA200700143A EA200700143A EA200700143A1 EA 200700143 A1 EA200700143 A1 EA 200700143A1 EA 200700143 A EA200700143 A EA 200700143A EA 200700143 A EA200700143 A EA 200700143A EA 200700143 A1 EA200700143 A1 EA 200700143A1
Authority
EA
Eurasian Patent Office
Prior art keywords
propenylpiperasine
dedeacetylase
histone
derivatives
substituted
Prior art date
Application number
EA200700143A
Other languages
English (en)
Other versions
EA011932B1 (ru
Inventor
Свен Францискус Анна Ван Брандт
Кристоф Ван Эмелен
Патрик Рене Анжибо
Лоранс Франсуаз Бернадетт Марконне-Декран
Янине Артс
Original Assignee
Янссен Фармацевтика Н.В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39294123&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA200700143(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Янссен Фармацевтика Н.В. filed Critical Янссен Фармацевтика Н.В.
Publication of EA200700143A1 publication Critical patent/EA200700143A1/ru
Publication of EA011932B1 publication Critical patent/EA011932B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Abstract

Изобретение относится к новым соединениям формулы (I), где R, R, R, Rи Х имеют определенные значения, обладающим ферментативной активностью, ингибирующей гистондеацетилазу; их получению, композициям, содержащим указанные соединения, и к их применению в качестве лекарственного средства.
EA200700143A 2004-07-28 2005-07-25 Производные замещенного пропенилпиперазина в качестве новых ингибиторов гистондеацетилазы EA011932B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP04077171 2004-07-28
US59235704P 2004-07-29 2004-07-29
PCT/EP2005/053611 WO2006010749A2 (en) 2004-07-28 2005-07-25 Substituted propenyl piperazine derivatives as novel inhibitors of histone deacetylase

Publications (2)

Publication Number Publication Date
EA200700143A1 true EA200700143A1 (ru) 2007-06-29
EA011932B1 EA011932B1 (ru) 2009-06-30

Family

ID=39294123

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200700143A EA011932B1 (ru) 2004-07-28 2005-07-25 Производные замещенного пропенилпиперазина в качестве новых ингибиторов гистондеацетилазы

Country Status (26)

Country Link
EP (1) EP1776358B1 (ru)
JP (1) JP5279268B2 (ru)
KR (1) KR101282833B1 (ru)
CN (1) CN1993356B (ru)
AR (1) AR050189A1 (ru)
AT (1) ATE432274T1 (ru)
AU (1) AU2005266311B2 (ru)
BR (1) BRPI0513891B8 (ru)
CA (1) CA2572971C (ru)
CY (1) CY1110358T1 (ru)
DE (1) DE602005014646D1 (ru)
DK (1) DK1776358T3 (ru)
EA (1) EA011932B1 (ru)
ES (1) ES2327253T3 (ru)
HK (1) HK1106236A1 (ru)
HR (1) HRP20090439T1 (ru)
IL (1) IL180961A0 (ru)
MX (1) MX2007001119A (ru)
MY (1) MY142831A (ru)
NO (1) NO20071117L (ru)
NZ (1) NZ552758A (ru)
PL (1) PL1776358T3 (ru)
PT (1) PT1776358E (ru)
SI (1) SI1776358T1 (ru)
TW (1) TWI394752B (ru)
WO (1) WO2006010749A2 (ru)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4725944B2 (ja) 2002-03-13 2011-07-13 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ヒストンデアセチラーゼの阻害剤
DE60321667D1 (en) 2002-03-13 2008-07-31 Janssen Pharmaceutica Nv Piperazinyl-, piperidinyl- und morpholinylderivate als neue inhibitoren von histon-deacetylase
NZ534771A (en) 2002-03-13 2006-04-28 Janssen Pharmaceutica Nv Sulfonylamino-derivatives as novel inhibitors of histone deacetylase
MX2007001120A (es) 2004-07-28 2007-03-15 Janssen Pharmaceutica Nv Derivados de indolil alquil sustituidos como nuevos inhibidores de la histona desacetilasa.
US8138198B2 (en) 2005-05-18 2012-03-20 Angibaud Patrick Rene Substituted aminopropenyl piperidine or morpholine derivatives as novel inhibitors of histone deacetylase
WO2007049262A1 (en) * 2005-10-27 2007-05-03 Berand Limited Methods and compositions for the promotion of neuronal growth and the treatment of asociality and affective disorders
JP5137848B2 (ja) * 2006-01-19 2013-02-06 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ヒストンデアセチラーゼのインヒビターとしてのピリジン及びピリミジン誘導体
AU2007206950B2 (en) 2006-01-19 2012-02-02 Janssen Pharmaceutica N.V. Substituted indolyl-alkyl-amino-derivatives as inhibitors of histone deacetylase
EP1979326B1 (en) 2006-01-19 2012-10-03 Janssen Pharmaceutica N.V. Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase
JP5225104B2 (ja) 2006-01-19 2013-07-03 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 新しい、ヒストンデアセチラーゼのインヒビターとしてのアミノフェニル誘導体
EP1839656A1 (en) * 2006-03-31 2007-10-03 TopoTarget Germany AG Use of valproic acid for the topical treatment of mild to moderate acne vulgaris
CN101918389A (zh) * 2007-11-02 2010-12-15 梅特希尔基因公司 组蛋白脱乙酰酶抑制剂
CN101723896B (zh) * 2009-11-03 2012-10-31 山东大学 酪氨酸衍生物类组蛋白去乙酰化酶抑制剂及其应用
WO2012117421A1 (en) 2011-03-02 2012-09-07 Orchid Research Laboratories Ltd Histone deacetylase inhibitors
KR101419836B1 (ko) * 2012-05-10 2014-07-16 서울대학교산학협력단 Δ5-2-옥소피페라진 유도체를 포함하는 중간엽 줄기세포의 연골세포로의 분화 유도용 조성물
KR101586045B1 (ko) 2013-07-30 2016-01-15 충북대학교 산학협력단 신규 페닐티아졸 기반 히드록삼산 및 이를 유효성분으로 포함하는 항암용 조성물
KR102132078B1 (ko) 2018-09-20 2020-07-08 원광대학교산학협력단 방향족 화합물, 아민 및 친핵체를 이용한 3가지 성분 반응으로 1-에틸-4-페닐피페라진 유도체를 제조하는 방법
KR20230155311A (ko) 2022-05-03 2023-11-10 충북대학교 산학협력단 신규한 n-히드록시프로펜아미드 화합물 및 이를 유효성분으로 포함하는 암 예방 또는 치료용 약학적 조성물
KR20230155310A (ko) 2022-05-03 2023-11-10 충북대학교 산학협력단 신규한 n-히드록시프로펜아미드 화합물 및 이를 유효성분으로 포함하는 암 예방 또는 치료용 약학적 조성물

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH17194A (en) * 1980-03-06 1984-06-19 Otsuka Pharma Co Ltd Novel carbostyril derivatives,and pharmaceutical composition containing the same
JP4725944B2 (ja) * 2002-03-13 2011-07-13 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ヒストンデアセチラーゼの阻害剤
DE60321667D1 (en) * 2002-03-13 2008-07-31 Janssen Pharmaceutica Nv Piperazinyl-, piperidinyl- und morpholinylderivate als neue inhibitoren von histon-deacetylase
EP1492534B1 (en) * 2002-04-03 2008-06-25 TopoTarget UK Limited Carbamic acid compounds comprising a piperazine linkage as hdac inhibitors

Also Published As

Publication number Publication date
SI1776358T1 (sl) 2009-10-31
PT1776358E (pt) 2009-08-13
HRP20090439T1 (hr) 2009-09-30
NO20071117L (no) 2007-02-27
CY1110358T1 (el) 2015-04-29
AU2005266311B2 (en) 2011-08-11
DE602005014646D1 (de) 2009-07-09
NZ552758A (en) 2009-08-28
JP2008508234A (ja) 2008-03-21
CA2572971C (en) 2013-01-15
ATE432274T1 (de) 2009-06-15
TW200616998A (en) 2006-06-01
AU2005266311A1 (en) 2006-02-02
AR050189A1 (es) 2006-10-04
PL1776358T3 (pl) 2009-10-30
TWI394752B (zh) 2013-05-01
IL180961A0 (en) 2007-07-04
WO2006010749A3 (en) 2006-06-08
JP5279268B2 (ja) 2013-09-04
EP1776358A2 (en) 2007-04-25
MX2007001119A (es) 2007-03-15
HK1106236A1 (en) 2008-03-07
ES2327253T3 (es) 2009-10-27
BRPI0513891A (pt) 2008-05-20
BRPI0513891B8 (pt) 2021-05-25
BRPI0513891B1 (pt) 2020-09-29
KR20070043978A (ko) 2007-04-26
CN1993356A (zh) 2007-07-04
EP1776358B1 (en) 2009-05-27
CA2572971A1 (en) 2006-02-02
WO2006010749A2 (en) 2006-02-02
EA011932B1 (ru) 2009-06-30
KR101282833B1 (ko) 2013-07-08
MY142831A (en) 2011-01-14
DK1776358T3 (da) 2009-09-07
CN1993356B (zh) 2010-10-27

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