EA200300663A1 - Антагонисты cxcr3 - Google Patents

Антагонисты cxcr3

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Publication number
EA200300663A1
EA200300663A1 EA200300663A EA200300663A EA200300663A1 EA 200300663 A1 EA200300663 A1 EA 200300663A1 EA 200300663 A EA200300663 A EA 200300663A EA 200300663 A EA200300663 A EA 200300663A EA 200300663 A1 EA200300663 A1 EA 200300663A1
Authority
EA
Eurasian Patent Office
Prior art keywords
inflammatory
diseases
applicable
treatment
compounds
Prior art date
Application number
EA200300663A
Other languages
English (en)
Other versions
EA007538B1 (ru
Inventor
Джулио К. Медина
Майкл Дж. Джонсон
Ан-Ронг Ли
Дживен Лиу
Алан Кси Хуанг
Лиушенг Жу
Эндрю П. Маркус
Original Assignee
Туларик Инк.
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Publication date
Application filed by Туларик Инк. filed Critical Туларик Инк.
Publication of EA200300663A1 publication Critical patent/EA200300663A1/ru
Publication of EA007538B1 publication Critical patent/EA007538B1/ru

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
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    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
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    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2

Abstract

Предложены соединения, композиции и способы, которые применимы при лечении воспалительных и иммунных состояний и заболеваний. В частности, изобретение относится к соединениям, которые модулируют экспрессию и/или функцию рецептора хемокина. Предложенные способы применимы для лечения воспалительных и иммунорегуляторных расстройств и заболеваний, таких как рассеянный склероз, ревматоидный артрит и диабет типа I.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200300663A 2000-12-11 2001-12-11 Антагонисты cxcr3 EA007538B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25524100P 2000-12-11 2000-12-11
US29649901P 2001-06-06 2001-06-06
PCT/US2001/047850 WO2002083143A1 (en) 2000-12-11 2001-12-11 Cxcr3 antagonists

Publications (2)

Publication Number Publication Date
EA200300663A1 true EA200300663A1 (ru) 2004-06-24
EA007538B1 EA007538B1 (ru) 2006-10-27

Family

ID=26944548

Family Applications (1)

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EA200300663A EA007538B1 (ru) 2000-12-11 2001-12-11 Антагонисты cxcr3

Country Status (19)

Country Link
US (3) US6964967B2 (ru)
EP (1) EP1343505A1 (ru)
JP (1) JP4259877B2 (ru)
KR (1) KR100883184B1 (ru)
CN (1) CN1575177A (ru)
AU (1) AU2001297717B2 (ru)
BR (1) BR0116096A (ru)
CA (1) CA2431553A1 (ru)
CZ (1) CZ20031910A3 (ru)
EA (1) EA007538B1 (ru)
HU (1) HUP0500880A2 (ru)
IL (2) IL156304A0 (ru)
MX (1) MXPA03005152A (ru)
NO (1) NO325450B1 (ru)
NZ (1) NZ526622A (ru)
PL (1) PL366311A1 (ru)
SK (1) SK8752003A3 (ru)
WO (1) WO2002083143A1 (ru)
ZA (1) ZA200304342B (ru)

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CZ20031910A3 (cs) 2003-12-17
CN1575177A (zh) 2005-02-02
ZA200304342B (en) 2005-08-31
NO20032612D0 (no) 2003-06-10
US7053215B2 (en) 2006-05-30
US20030055054A1 (en) 2003-03-20
JP2004536796A (ja) 2004-12-09

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