EA200700550A1 - Производные алкилидентетрагидронафталина, способ их получения и их применение в качестве противовоспалительных средств - Google Patents

Производные алкилидентетрагидронафталина, способ их получения и их применение в качестве противовоспалительных средств

Info

Publication number
EA200700550A1
EA200700550A1 EA200700550A EA200700550A EA200700550A1 EA 200700550 A1 EA200700550 A1 EA 200700550A1 EA 200700550 A EA200700550 A EA 200700550A EA 200700550 A EA200700550 A EA 200700550A EA 200700550 A1 EA200700550 A1 EA 200700550A1
Authority
EA
Eurasian Patent Office
Prior art keywords
derivatives
alkylidentetrahydronaptaline
receiving
application
inflammatory means
Prior art date
Application number
EA200700550A
Other languages
English (en)
Inventor
Штефан Бойрле
Маркус Бергер
Штефан Ярох
Конрад Кроликевич
Дуй Нгуйен
Хартмут Ревинкель
Хайке Шэке
Норберт Шмес
Вернер Скубалла
Original Assignee
Байер Шеринг Фарма Акциенгезельшафт
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Байер Шеринг Фарма Акциенгезельшафт filed Critical Байер Шеринг Фарма Акциенгезельшафт
Publication of EA200700550A1 publication Critical patent/EA200700550A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4704—2-Quinolinones, e.g. carbostyril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/734—Ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/84—Nitrogen atoms

Abstract

Изобретение относится к производным алкилидентетрагидронафталина общей формулы (I)способу их получения и их применению в качестве противовоспалительных средств.
EA200700550A 2004-09-09 2005-09-02 Производные алкилидентетрагидронафталина, способ их получения и их применение в качестве противовоспалительных средств EA200700550A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004044680A DE102004044680B3 (de) 2004-09-09 2004-09-09 Alkyliden-Tetrahydronaphthalinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer sowie diese enthaltende pharmazeutische Präparate
PCT/EP2005/009623 WO2006027236A1 (de) 2004-09-09 2005-09-02 Alkyliden-tetrahydronaphthalinderivate, verfahren zu ihrer herstellung und ihre verwendung als entzündungshemmer

Publications (1)

Publication Number Publication Date
EA200700550A1 true EA200700550A1 (ru) 2007-10-26

Family

ID=35517445

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200700550A EA200700550A1 (ru) 2004-09-09 2005-09-02 Производные алкилидентетрагидронафталина, способ их получения и их применение в качестве противовоспалительных средств

Country Status (25)

Country Link
EP (1) EP1786823B1 (ru)
JP (1) JP2008512416A (ru)
KR (1) KR20070050469A (ru)
CN (1) CN101065386A (ru)
AR (1) AR050733A1 (ru)
AT (1) ATE384069T1 (ru)
AU (1) AU2005281859A1 (ru)
BR (1) BRPI0515186A (ru)
CA (1) CA2577861A1 (ru)
DE (2) DE102004044680B3 (ru)
EA (1) EA200700550A1 (ru)
EC (1) ECSP077306A (ru)
ES (1) ES2301056T3 (ru)
GT (1) GT200500241A (ru)
IL (1) IL181832A0 (ru)
MX (1) MX2007002833A (ru)
NO (1) NO20071805L (ru)
PA (1) PA8644701A1 (ru)
PE (1) PE20060596A1 (ru)
RS (1) RS20070095A (ru)
SV (1) SV2006002220A (ru)
TW (1) TW200621703A (ru)
UY (1) UY29109A1 (ru)
WO (1) WO2006027236A1 (ru)
ZA (1) ZA200701399B (ru)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7638515B2 (en) 2003-10-08 2009-12-29 Bayer Schering Pharma Aktiengesellschaft Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents
ES2279454T3 (es) 2003-10-08 2007-08-16 Bayer Schering Pharma Aktiengesellschaft Derivados de tetrahidronaftaleno sustituidos con 1-amino-2-oxi, procedimientos para su preparacion y su utilizacion como anti-inflamatorios.
US7662821B2 (en) 2003-10-08 2010-02-16 Bayer Schering Pharma Ag Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents
US20080153859A1 (en) 2004-04-05 2008-06-26 Hartmut Rehwinkel Multiply-substituted tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents
DE102004063227A1 (de) * 2004-12-22 2006-07-06 Schering Ag Tricylische Aminoalkohole, Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer
EP1834948A1 (de) 2006-03-15 2007-09-19 Bayer Schering Pharma Aktiengesellschaft Tetrahydronaphthalinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer
EP1917963A1 (en) * 2006-10-31 2008-05-07 Bayer Schering Pharma Aktiengesellschaft Cyclic phenyl-substituted indazols, a process for their production and their use as anti-inflammatory agents
EP2129219A4 (en) * 2007-02-16 2012-08-29 Synta Pharmaceuticals Corp SUBSTITUTED FUSED CYCLE COMPOUNDS USED IN CASES OF INFLAMMATION OR IMMUNE DISORDERS
EP2072509A1 (en) 2007-12-18 2009-06-24 Bayer Schering Pharma Aktiengesellschaft 1-Aryl-1H-quinoline-2-ones: process for their production and their use as anti-inflammatory agents

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0800517A1 (en) * 1994-12-29 1997-10-15 Allergan Acetylenes disubstituted with a 5 or 8 substituted tetrahydronaphthyl or dihydronaphthyl group and with an aryl or heteroaryl groups having retinoid-like biological activity
DE10038639A1 (de) * 2000-07-28 2002-02-21 Schering Ag Nichtsteroidale Entzündungshemmer
EA008830B1 (ru) * 2002-03-26 2007-08-31 Бёрингер Ингельхайм Фармасьютиклз, Инк. Миметики глюкокортикоидов, способы их получения, фармацевтические композиции и их применение
DE10215316C1 (de) * 2002-04-02 2003-12-18 Schering Ag Chinolin- und Isochinolin-Derivate, ein pharmazeutisches Mittel und ihre Verwendung als Entzündungshemmer
ES2279454T3 (es) * 2003-10-08 2007-08-16 Bayer Schering Pharma Aktiengesellschaft Derivados de tetrahidronaftaleno sustituidos con 1-amino-2-oxi, procedimientos para su preparacion y su utilizacion como anti-inflamatorios.

Also Published As

Publication number Publication date
AR050733A1 (es) 2006-11-15
TW200621703A (en) 2006-07-01
EP1786823A1 (de) 2007-05-23
ECSP077306A (es) 2007-04-26
PA8644701A1 (es) 2006-07-03
RS20070095A (en) 2008-11-28
DE102004044680B3 (de) 2006-06-08
IL181832A0 (en) 2007-07-04
DE502005002595D1 (de) 2008-03-06
ATE384069T1 (de) 2008-02-15
CA2577861A1 (en) 2006-03-16
MX2007002833A (es) 2007-07-09
AU2005281859A1 (en) 2006-03-16
UY29109A1 (es) 2006-03-31
WO2006027236A1 (de) 2006-03-16
KR20070050469A (ko) 2007-05-15
SV2006002220A (es) 2006-03-15
ES2301056T3 (es) 2008-06-16
BRPI0515186A (pt) 2008-07-22
PE20060596A1 (es) 2006-07-26
NO20071805L (no) 2007-06-07
CN101065386A (zh) 2007-10-31
JP2008512416A (ja) 2008-04-24
GT200500241A (es) 2006-08-17
ZA200701399B (en) 2008-09-25
EP1786823B1 (de) 2008-01-16

Similar Documents

Publication Publication Date Title
EA200870193A1 (ru) Цитотоксические агенты, включающие новые производные томаймицина, и их терапевтическое применение
EA201000642A1 (ru) 2'-фтор-2'-дезокситетрагидроуридины в качестве ингибиторов цитидиндеаминазы
EA200600621A1 (ru) Производные тетрагидронафталина, способ их получения и их применение в качестве противовоспалительных средств
EA200700096A1 (ru) Производные 2-карбамид-4-фенилтиазола, способ их получения и их применение в терапии
EA200802213A1 (ru) Способы лечения заболеваний крови
NO20062021L (no) Omleirede pentanoler, fremgangsmpte for fremstilling av dette, og deres anvendelse som antiflogistika
EA201200669A1 (ru) ПИРИДОПИРИМИДИНОНОВЫЕ ИНГИБИТОРЫ PI3Kα
BRPI0510177B8 (pt) composto, composição farmacêutica e uso do mesmo
EA200700550A1 (ru) Производные алкилидентетрагидронафталина, способ их получения и их применение в качестве противовоспалительных средств
CY1109998T1 (el) Ενδυναμωτες υποδοχεων γλουταμινικου
EA200800760A1 (ru) ПИРИДОПИРИМИДИНОНОВЫЕ ИНГИБИТОРЫ PI3Kα
EA200702363A1 (ru) Новые лиганды гистамина h-рецептора и их терапевтические применения
EA200601391A1 (ru) Производные хинолина для применения в качестве микобактериальных ингибиторов
ECSP056111A (es) Derivados de 2-acilamino-4-feniltiazol, su preparación y aplicación en terapeutica
EA200500203A1 (ru) Новый способ синтеза и новая кристаллическая форма агомелатина и фармацевтические композиции, которые её содержат
EA200970149A1 (ru) Производные n-(аминогетероарил)-1h-индол-2-карбоксамидов, их получение и их применение в терапии
EA200801608A1 (ru) Производные бензимидазолонкарбоновой кислоты
DK1893587T3 (da) Fremgangsmåde til fremstilling af dihydroquinazoliner
EA201000814A1 (ru) 5-[(3,3,3-трифтор-2-гидрокси-1-арилпропил)амино]-1h-хинолин-2-оны, способ их получения и их применение в качестве противовоспалительных средств
DE502005008057D1 (de) Substituierte cyclopenten-verbindungen
EA200900090A1 (ru) Бензиламины, способ их получения и их применение в качестве противовоспалительных средств
EA201070009A1 (ru) Производные 7-алкинил-1,8-нафтиридонов, их получение и их применение в терапии
EA200970192A1 (ru) Производные 5,6-бисарил-2-пиридин-карбоксамида, их получение и их применение в терапии в качестве антагонистов рецепторов уротензина ii
EA200700400A1 (ru) Производные n-(1h-индолил)-1н-индол-2-карбоксамидов, их получение и их применение в терапии
TW200716564A (en) Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents