EA200501434A1 - Производные фталазинона - Google Patents
Производные фталазинонаInfo
- Publication number
- EA200501434A1 EA200501434A1 EA200501434A EA200501434A EA200501434A1 EA 200501434 A1 EA200501434 A1 EA 200501434A1 EA 200501434 A EA200501434 A EA 200501434A EA 200501434 A EA200501434 A EA 200501434A EA 200501434 A1 EA200501434 A1 EA 200501434A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- group
- crr
- substitution
- possibly containing
- heterocyclyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
- C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Abstract
Соединения формулы (I)где A и B совместно представляют собой конденсированное ароматическое ядро, возможно содержащее замещение, X может представлять собой NRили CRR, если X = NR, то n представляет собой 1 или 2, а если X = CRR, то n представляет собой 1, Rвыбирают из группы, включающей H, возможно содержащий замещение Cалкил, Cарил, Cгетероциклил, амид, тиоамид, группы сложного эфира, ацил и сульфонильные группы, Rвыбирают из группы, включающей H, гидроксил, амин, или Rи Rмогут совместно образовывать спиро-Cциклоалкильную или гетероциклильную группу, Rи Rпредставляют собой водород, или, если X представляет собой CRR, R, R, Rи Rсовместно с атомами углерода, к которым они присоединены, могут образовывать конденсированное ароматическое ядро, возможно содержащее замещение, а Rвыбирают из группы, включающей H и галоген.Международная заявка была опубликована вместе с отчетом о международном поиске.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0305681.9A GB0305681D0 (en) | 2003-03-12 | 2003-03-12 | Phthalazinone derivatives |
US45499503P | 2003-03-14 | 2003-03-14 | |
US49339903P | 2003-08-06 | 2003-08-06 | |
US52624403P | 2003-12-01 | 2003-12-01 | |
PCT/GB2004/001059 WO2004080976A1 (en) | 2003-03-12 | 2004-03-12 | Phthalazinone derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200501434A1 true EA200501434A1 (ru) | 2006-02-24 |
EA009469B1 EA009469B1 (ru) | 2007-12-28 |
Family
ID=32996122
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200501434A EA009469B1 (ru) | 2003-03-12 | 2004-03-12 | Производные фталазинона |
Country Status (22)
Country | Link |
---|---|
EP (1) | EP1633724B1 (ru) |
JP (3) | JP4027406B2 (ru) |
KR (1) | KR101146806B1 (ru) |
AU (1) | AU2004220321B2 (ru) |
BR (1) | BRPI0408284B8 (ru) |
CA (1) | CA2517629C (ru) |
CO (1) | CO5650256A2 (ru) |
CY (1) | CY1111597T1 (ru) |
EA (1) | EA009469B1 (ru) |
EC (1) | ECSP056094A (ru) |
GB (1) | GB2415430B (ru) |
HK (1) | HK1079530A1 (ru) |
HR (1) | HRP20050895B1 (ru) |
IS (1) | IS2813B (ru) |
LT (1) | LTC1633724I2 (ru) |
MA (1) | MA27758A1 (ru) |
MX (1) | MXPA05009661A (ru) |
NO (2) | NO331807B1 (ru) |
NZ (1) | NZ542680A (ru) |
PL (1) | PL1633724T3 (ru) |
TN (1) | TNSN05212A1 (ru) |
WO (1) | WO2004080976A1 (ru) |
Families Citing this family (144)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2357057T3 (es) | 2002-04-30 | 2011-04-15 | Kudos Pharmaceuticals Limited | Derivados de ftalazinona. |
US7449464B2 (en) | 2003-03-12 | 2008-11-11 | Kudos Pharmaceuticals Limited | Phthalazinone derivatives |
GB0305681D0 (en) | 2003-03-12 | 2003-04-16 | Kudos Pharm Ltd | Phthalazinone derivatives |
GB2415430B (en) * | 2003-03-12 | 2006-07-12 | Kudos Pharm Ltd | Phthalazinone derivatives |
GB0317466D0 (en) * | 2003-07-25 | 2003-08-27 | Univ Sheffield | Use |
CA2533901A1 (en) | 2003-07-30 | 2005-02-10 | Xenon Pharmaceuticals Inc. | Piperazine derivatives and their use as therapeutic agents |
EP3431464A3 (en) | 2003-08-06 | 2019-07-31 | Senomyx Inc. | Novel flavors, flavor modifiers, tastants, taste enhancers, umami or sweet tastants, and/or enhancers and use thereof |
GB0324159D0 (en) | 2003-10-15 | 2003-11-19 | Glaxo Group Ltd | Novel compounds |
SG150548A1 (en) * | 2003-12-01 | 2009-03-30 | Kudos Pharm Ltd | Dna damage repair inhibitors for treatment of cancer |
JP2008510783A (ja) * | 2004-08-26 | 2008-04-10 | クドス ファーマシューティカルズ リミテッド | 4−ヘテロアリールメチル置換フタラジノン誘導体 |
EP1645556A1 (en) * | 2004-10-07 | 2006-04-12 | Boehringer Ingelheim International GmbH | Arylpiperazine-benzoylamide derivatives useful as pharmaceutical agents |
JP4734346B2 (ja) | 2005-02-04 | 2011-07-27 | セノミックス インコーポレイテッド | 連結ヘテロアリール部分を含む化合物、ならびに食用組成物のための新規なうまみフレーバー改変剤、味物質および味覚増強剤としての使用 |
GB0510142D0 (en) * | 2005-05-18 | 2005-06-22 | Addex Pharmaceuticals Sa | Novel compounds A1 |
AR055329A1 (es) | 2005-06-15 | 2007-08-15 | Senomyx Inc | Amidas bis-aromaticas y sus usos como modificadores de sabor dulce, saborizantes, y realzadores de sabor |
DE602005018972D1 (de) | 2005-09-23 | 2010-03-04 | Equispharm Co Ltd | 5,6-dimethylthienoä2,3-diüpyrimidinderivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzung für die bekämpfung von viren |
GB0521373D0 (en) | 2005-10-20 | 2005-11-30 | Kudos Pharm Ltd | Pthalazinone derivatives |
DK3235811T3 (en) | 2006-04-21 | 2018-11-12 | Senomyx Inc | PROCEDURE FOR THE PREPARATION OF OXALAMIDS |
GB0610680D0 (en) * | 2006-05-31 | 2006-07-12 | Istituto Di Ricerche D Biolog | Therapeutic compounds |
EP2032140A1 (en) | 2006-05-31 | 2009-03-11 | Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. | Pyrrolo[1,2-a]pyrazin-1(2h)-one and pyrrolo[1,2-d][1,2,4]triazin-1(2h)-one derivatives as inhibitors of poly(adp-ribose)polymerase(parp) |
WO2007144637A1 (en) * | 2006-06-15 | 2007-12-21 | Kudos Pharmaceuticals Limited | 2 -oxyheteroarylamide derivatives as parp inhibitors |
WO2008020180A2 (en) * | 2006-08-17 | 2008-02-21 | Kudos Pharmaceuticals Limited | Methods of increasing the sensitivity of cancer cells to dna damage |
AU2013201880B2 (en) * | 2006-10-17 | 2015-06-25 | Kudos Pharmaceuticals Limited | Polymorphic form of 4-[3-(4-cyclopropanecarbonyl-piperazine-1-carbonyl)-4-fluorobenzyl]-2H-phthalazin-1-one |
UY30639A1 (es) | 2006-10-17 | 2008-05-31 | Kudos Pharm Ltd | Derivados sustituidos de 2h-ftalazin-1-ona, sus formas cristalinas, proceso de preparacion y aplicaciones |
PE20081229A1 (es) * | 2006-12-01 | 2008-08-28 | Merck & Co Inc | Antagonistas de receptor de orexina de diazepam sustituido |
HUE027641T2 (en) | 2006-12-28 | 2016-11-28 | Abbvie Inc | Poly (ADP-ribose) polymerase inhibitors |
JP2010527981A (ja) * | 2007-05-25 | 2010-08-19 | アストラゼネカ・アクチエボラーグ | 癌処置用のchk阻害剤およびparp阻害剤の組み合わせ剤 |
EP2155689B1 (en) | 2007-05-31 | 2015-07-08 | Boehringer Ingelheim International GmbH | Ccr2 receptor antagonists and uses thereof |
US20090023727A1 (en) * | 2007-07-05 | 2009-01-22 | Muhammad Hashim Javaid | Phthalazinone derivatives |
GB0716532D0 (en) * | 2007-08-24 | 2007-10-03 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
RU2485122C2 (ru) | 2007-10-03 | 2013-06-20 | Эйсэй Инк. | Соединения и композиции, ингибирующие parp, и способы их применения |
MX2010004028A (es) * | 2007-10-17 | 2010-04-30 | Kudos Pharm Ltd | 4-[3-(4-ciclopropancarbonil-piperacin-1-carbonil)-4-fluoro-bencil ]-2h-ftalacin-1-ona. |
RU2490265C2 (ru) * | 2007-11-15 | 2013-08-20 | Институто Ди Ричерке Ди Биолоджиа Молеколаре П. Анджелетти С.П.А. | Пиридазиноновые производные в качестве ингибиторов parp |
CL2008003553A1 (es) * | 2007-12-05 | 2009-11-27 | Grindeks Jsc | Proceso para preparar atipamezol o clorhidrato de 5-(2-etil-2,3-dihidro-1h-inden-2-il)-1h-imidazol: y loa compuestos intermediarios considerados en el proceso |
US8569282B2 (en) | 2007-12-11 | 2013-10-29 | Cytopathfinder, Inc. | Carboxamide compounds and their use |
UY31603A1 (es) * | 2008-01-23 | 2009-08-31 | Derivados de ftalazinona | |
SG193842A1 (en) | 2008-08-06 | 2013-10-30 | Biomarin Pharm Inc | Dihydropyridophthalazinone inhibitors of poly(adp-ribose)polymerase (parp) |
CN102238945B (zh) | 2008-10-07 | 2014-10-29 | 阿斯利康(英国)有限公司 | 药物制剂514 |
MA33085B1 (fr) | 2008-12-19 | 2012-03-01 | Boehringer Ingelheim Int | Pyrimidine-4 carboxamides cycliques en tant qu'antagonistes du recepteur ccr2 pour le traitement d'inflammations, de l'asthme et des broncho-pneumopathies chroniques obstructives |
TW201114756A (en) * | 2009-07-15 | 2011-05-01 | Astrazeneca Ab | Phthalazinone compound |
WO2011030139A1 (en) | 2009-09-11 | 2011-03-17 | Astrazeneca Ab | 4- (pyrimidin-2-yl) -piperazine and 4- (pyrimidin-2-yl) -piperidine derivatives as gpr119 modulators |
EP2322658A1 (en) | 2009-11-13 | 2011-05-18 | Centre National de la Recherche Scientifique (CNRS) | Signature for the diagnosis of breast cancer aggressiveness and genetic instability |
WO2011058367A2 (en) | 2009-11-13 | 2011-05-19 | Astrazeneca Ab | Diagnostic test for predicting responsiveness to treatment with poly(adp-ribose) polymerase (parp) inhibitor |
JP5632014B2 (ja) | 2009-12-17 | 2014-11-26 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規ccr2受容体アンタゴニスト及びこれらの使用 |
JP5883397B2 (ja) | 2010-02-03 | 2016-03-15 | ビオマリン プハルマセウトイカル インコーポレイテッド | Pten欠損に関連した疾患の治療におけるポリ(adpリボース)ポリメラーゼ(parp)のジヒドロピリドフタラジノン阻害剤の使用 |
KR101826652B1 (ko) | 2010-02-08 | 2018-02-07 | 메디베이션 테크놀로지즈, 인크. | 디히드로피리도프탈라지논 유도체의 합성 방법 |
WO2011141474A1 (en) | 2010-05-12 | 2011-11-17 | Boehringer Ingelheim International Gmbh | Novel ccr2 receptor antagonists, method for producing the same, and use thereof as medicaments |
WO2011141477A1 (en) | 2010-05-12 | 2011-11-17 | Boehringer Ingelheim International Gmbh | New ccr2 receptor antagonists, method for producing the same, and use thereof as medicaments |
WO2011144501A1 (en) | 2010-05-17 | 2011-11-24 | Boehringer Ingelheim International Gmbh | Ccr2 antagonists and uses thereof |
US9018212B2 (en) | 2010-05-25 | 2015-04-28 | Boehringer Ingelheim International Gmbh | Pyridazine carboxamides as CCR2 receptor antagonists |
WO2011151251A1 (en) | 2010-06-01 | 2011-12-08 | Boehringer Ingelheim International Gmbh | New ccr2 antagonists |
US8871765B2 (en) | 2010-07-27 | 2014-10-28 | Cadila Healthcare Limited | Substituted 4-(4-fluoro-3-(piperazine-1-carbonyl)benzyl)phthalazin-1(2H)-one derivatives as poly (ADP-ribose) polymerase-1 inhibitors |
CN102372716A (zh) * | 2010-08-09 | 2012-03-14 | 江苏恒瑞医药股份有限公司 | 酞嗪酮类衍生物、其制备方法及其在医药上的应用 |
PT2630146T (pt) * | 2010-10-21 | 2020-07-20 | Medivation Tech Llc | Sal tosilato de (8s,9r)-5-fluoro-8-(4-fluorofenil)-9-(1-metil-1h-1,2,4-triazol-5-il)-8,9-di-hidro-2h-pirido[4,3,2-de]ftalazin-3(7h)-ona cristalino |
US8999985B2 (en) | 2010-12-02 | 2015-04-07 | Shanghai De Novo Pharmatech Co Ltd. | Substituted phthalazin-1(2H)-ones, preparation processes and medical uses thereof |
WO2012125521A1 (en) * | 2011-03-14 | 2012-09-20 | Eternity Bioscience Inc. | Quinazolinediones and their use |
US20140051737A1 (en) * | 2011-05-10 | 2014-02-20 | Universite Laval | Methods for the treatment and diagnostic of pulmonary arterial hypertension |
CN103827314A (zh) | 2011-05-18 | 2014-05-28 | 国家科学研究中心 | 用于诊断癌侵袭性和遗传不稳定性的标记 |
US20140221314A1 (en) * | 2011-05-31 | 2014-08-07 | Newgen Therapeutics, Inc. | Tricyclic inhibitors of poly(adp-ribose)polymerase |
WO2013010839A1 (en) | 2011-07-15 | 2013-01-24 | Boehringer Ingelheim International Gmbh | Novel and selective ccr2 antagonists |
EP2734199B1 (en) | 2011-07-22 | 2022-11-16 | Pacylex Pharmaceuticals Inc. | Synthetic lethality and the treatment of cancer |
CN103130723B (zh) * | 2011-11-30 | 2015-01-14 | 成都地奥制药集团有限公司 | 一种多聚(adp-核糖)聚合酶抑制剂 |
WO2013102680A1 (en) | 2012-01-05 | 2013-07-11 | Centre National De La Recherche Scientifique (Cnrs) | Signature for the diagnosis of lung cancer aggressiveness and genetic instability |
CN102964354B (zh) * | 2012-11-16 | 2014-08-13 | 江苏先声药业有限公司 | 一类噻吩并咪唑衍生物及其应用 |
DK2938598T3 (en) | 2012-12-31 | 2017-02-13 | Cadila Healthcare Ltd | Substituted phthalazine-1 (2H) -one derivatives as selective inhibitors of poly (adp-ribose) polymerase-1 |
JP6545148B2 (ja) | 2013-03-13 | 2019-07-17 | フラットリー ディスカバリー ラブ,エルエルシー | ピリダジノン化合物及び嚢胞性線維症の治療のための方法 |
US9227978B2 (en) | 2013-03-15 | 2016-01-05 | Araxes Pharma Llc | Covalent inhibitors of Kras G12C |
EP2970121B1 (en) * | 2013-03-15 | 2017-12-13 | Araxes Pharma LLC | Covalent inhibitors of kras g12c |
BR112016001645B1 (pt) * | 2013-07-31 | 2023-04-11 | Merck Patent Gmbh | Derivados de oxoquinazolinil-butanamida, seu uso, medicamentos |
EP3030554B1 (en) * | 2013-08-07 | 2018-02-28 | Merck Patent GmbH | Piperidine urea derivatives |
KR101670126B1 (ko) | 2013-09-13 | 2016-10-27 | 일동제약(주) | 신규 프탈라지논 유도체 및 그 제조방법 |
TWI659021B (zh) | 2013-10-10 | 2019-05-11 | 亞瑞克西斯製藥公司 | Kras g12c之抑制劑 |
CN105985294B (zh) * | 2015-02-11 | 2020-12-25 | 四川科伦药物研究院有限公司 | 一种奥拉帕尼的制备方法 |
TW201702232A (zh) | 2015-04-10 | 2017-01-16 | 亞瑞克西斯製藥公司 | 經取代之喹唑啉化合物及其使用方法 |
US10428064B2 (en) | 2015-04-15 | 2019-10-01 | Araxes Pharma Llc | Fused-tricyclic inhibitors of KRAS and methods of use thereof |
CN106146492A (zh) * | 2015-04-17 | 2016-11-23 | 上海汇伦生命科技有限公司 | 杂环并咪唑类化合物、其药物组合物及其制备方法和用途 |
WO2016179558A1 (en) | 2015-05-06 | 2016-11-10 | The Regents Of The University Of California | K-ras modulators |
EP3298005B1 (en) | 2015-05-21 | 2024-01-24 | The Regents of The University of California | Anti-cancer compounds |
WO2017004537A1 (en) | 2015-07-02 | 2017-01-05 | Centrexion Therapeutics Corporation | (4-((3r,4r)-3-methoxytetrahydro-pyran-4-ylamino)piperidin-1-yl)(5-methyl-6-(((2r,6s)-6-(p-tolyl)tetrahydro-2h-pyran-2-yl)methylamino)pyrimidin-4yl)methanone citrate |
ES2964607T3 (es) | 2015-07-17 | 2024-04-08 | Pacylex Pharmaceuticals Inc | Silenciamiento epigenético de NMT2 |
US10144724B2 (en) | 2015-07-22 | 2018-12-04 | Araxes Pharma Llc | Substituted quinazoline compounds and methods of use thereof |
KR101896567B1 (ko) | 2015-07-23 | 2018-09-07 | 인스티튜트 큐리 | 암 치료를 위한 디베이트 분자와 parp 억제제의 병용 용도 |
US10882847B2 (en) | 2015-09-28 | 2021-01-05 | Araxes Pharma Llc | Inhibitors of KRAS G12C mutant proteins |
WO2017058768A1 (en) | 2015-09-28 | 2017-04-06 | Araxes Pharma Llc | Inhibitors of kras g12c mutant proteins |
WO2017058915A1 (en) | 2015-09-28 | 2017-04-06 | Araxes Pharma Llc | Inhibitors of kras g12c mutant proteins |
WO2017058807A1 (en) | 2015-09-28 | 2017-04-06 | Araxes Pharma Llc | Inhibitors of kras g12c mutant proteins |
EP3356339A1 (en) | 2015-09-28 | 2018-08-08 | Araxes Pharma LLC | Inhibitors of kras g12c mutant proteins |
US10730867B2 (en) | 2015-09-28 | 2020-08-04 | Araxes Pharma Llc | Inhibitors of KRAS G12C mutant proteins |
US10858343B2 (en) | 2015-09-28 | 2020-12-08 | Araxes Pharma Llc | Inhibitors of KRAS G12C mutant proteins |
CN106554316B (zh) * | 2015-09-28 | 2019-03-08 | 上海医药集团股份有限公司 | 一种制备1-[5-[(3,4-二氢-4-氧代-1-酞嗪基)甲基]-2-氟苯甲酰基]哌嗪的方法 |
GB201519573D0 (en) | 2015-11-05 | 2015-12-23 | King S College London | Combination |
JP7015059B2 (ja) | 2015-11-16 | 2022-02-15 | アラクセス ファーマ エルエルシー | 置換複素環式基を含む2-置換キナゾリン化合物およびその使用方法 |
US10857156B2 (en) * | 2015-11-20 | 2020-12-08 | Senhwa Biosciences, Inc. | Combination therapy of tetracyclic quinolone analogs for treating cancer |
CZ201682A3 (cs) | 2016-02-15 | 2017-08-23 | Zentiva, K.S. | Solvatované krystalické formy olaparibu, jejich příprava a použití |
WO2017191562A1 (en) * | 2016-05-04 | 2017-11-09 | Alembic Pharmaceuticals Limited | Process for the preparation of olaparib and polymorphs thereof |
IL263917B (en) | 2016-06-24 | 2022-07-01 | Univ California | Pthalazine derivatives as parp1, parp2 and/or tubulin suppressors for use in cancer therapy |
CZ2016391A3 (cs) | 2016-06-29 | 2018-01-10 | Zentiva, K.S. | Farmaceutická formulace olaparibu |
US10646488B2 (en) | 2016-07-13 | 2020-05-12 | Araxes Pharma Llc | Conjugates of cereblon binding compounds and G12C mutant KRAS, HRAS or NRAS protein modulating compounds and methods of use thereof |
CN109563080B (zh) | 2016-08-24 | 2021-07-30 | 台湾神隆股份有限公司 | 奥拉帕尼的制备方法 |
EP3519402A1 (en) | 2016-09-29 | 2019-08-07 | Araxes Pharma LLC | Inhibitors of kras g12c mutant proteins |
CN110312711A (zh) | 2016-10-07 | 2019-10-08 | 亚瑞克西斯制药公司 | 作为ras抑制剂的杂环化合物及其使用方法 |
CN107955001A (zh) * | 2016-10-14 | 2018-04-24 | 上海汇伦生命科技有限公司 | 抗肿瘤杂环并咪唑类化合物的药用盐 |
WO2018122168A1 (en) | 2016-12-29 | 2018-07-05 | Bayer Pharma Aktiengesellschaft | Combinations of bub1 kinase and parp inhibitors |
WO2018140514A1 (en) | 2017-01-26 | 2018-08-02 | Araxes Pharma Llc | 1-(6-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)azetidin-1-yl)prop-2-en-1-one derivatives and similar compounds as kras g12c inhibitors for the treatment of cancer |
EP3573964A1 (en) | 2017-01-26 | 2019-12-04 | Araxes Pharma LLC | Benzothiophene and benzothiazole compounds and methods of use thereof |
US11059819B2 (en) | 2017-01-26 | 2021-07-13 | Janssen Biotech, Inc. | Fused hetero-hetero bicyclic compounds and methods of use thereof |
WO2018140513A1 (en) | 2017-01-26 | 2018-08-02 | Araxes Pharma Llc | 1-(3-(6-(3-hydroxynaphthalen-1-yl)benzofuran-2-yl)azetidin-1yl)prop-2-en-1-one derivatives and similar compounds as kras g12c modulators for treating cancer |
US11274093B2 (en) | 2017-01-26 | 2022-03-15 | Araxes Pharma Llc | Fused bicyclic benzoheteroaromatic compounds and methods of use thereof |
WO2018162439A1 (en) | 2017-03-08 | 2018-09-13 | Onxeo | New predictive biomarker for the sensitivity to a treatment of cancer with a dbait molecule |
CA3059943A1 (en) | 2017-04-20 | 2018-10-25 | The Regents Of The University Of California | K-ras modulators |
WO2018218071A1 (en) | 2017-05-25 | 2018-11-29 | Araxes Pharma Llc | Compounds and methods of use thereof for treatment of cancer |
CA3063440A1 (en) | 2017-05-25 | 2018-11-29 | Araxes Pharma Llc | Covalent inhibitors of kras |
US11639346B2 (en) | 2017-05-25 | 2023-05-02 | Araxes Pharma Llc | Quinazoline derivatives as modulators of mutant KRAS, HRAS or NRAS |
CA3031777A1 (en) | 2018-01-31 | 2019-07-31 | Apotex Inc. | Crystalline form of olaparib |
CA3088998A1 (en) | 2018-02-15 | 2019-09-06 | Senhwa Biosciences, Inc. | Quinolone analogs and their salts, compositions, and method for their use |
CA3129516A1 (en) * | 2018-02-28 | 2019-09-06 | The Trustees Of The University Of Pennsylvania | Low affinity poly(ad-ribose) polymerase 1 dependent cytotoxic agents |
EP3765613A1 (en) | 2018-03-13 | 2021-01-20 | Onxeo | A dbait molecule against acquired resistance in the treatment of cancer |
GB201804924D0 (en) * | 2018-03-27 | 2018-05-09 | Univ Oxford Innovation Ltd | Radiolabelled compound |
KR102548191B1 (ko) * | 2018-04-09 | 2023-06-28 | 상하이테크 유니버시티 | 표적 단백질 분해 화합물, 이의 항종양 응용, 이의 중간체 및 중간체의 응용 |
CN112566666A (zh) * | 2018-05-14 | 2021-03-26 | 努瓦申生物公司 | 靶向抗癌核激素受体的化合物 |
CN108558773A (zh) * | 2018-05-17 | 2018-09-21 | 苏州莱克施德药业有限公司 | 一种奥拉帕尼药物中间体的制备方法 |
JP2022532342A (ja) | 2019-05-14 | 2022-07-14 | ニューベイション・バイオ・インコーポレイテッド | 抗がん核内ホルモン受容体標的化化合物 |
CA3145644A1 (en) | 2019-07-19 | 2021-01-28 | Astrazeneca Ab | Parp1 inhibitors |
WO2021097046A1 (en) | 2019-11-13 | 2021-05-20 | Nuvation Bio Inc. | Anti-cancer nuclear hormone receptor-targeting compounds |
BR112022013492A2 (pt) | 2020-01-09 | 2022-09-13 | Astrazeneca Ab | Terapia de combinação para tratar câncer |
WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
CA3176219A1 (en) | 2020-04-21 | 2021-10-28 | Kunhee LEE | Crystalline forms of phthalazinone compound |
IL297537A (en) | 2020-04-28 | 2022-12-01 | Rhizen Pharmaceuticals Ag | New compounds useful as poly (adp-ribose) polymerase (parp) inhibitors |
CN111592522B (zh) * | 2020-06-17 | 2022-09-09 | 郑州大学 | 一种精氨酸甲基化转移酶5小分子抑制剂及其制备方法和用途 |
US11795158B2 (en) | 2020-06-25 | 2023-10-24 | Astrazeneca Ab | Chemical compounds |
WO2022058785A1 (en) | 2020-09-16 | 2022-03-24 | Nuformix Technologies Limited | Olaparib oxalic acid cocrystals and their pharmaceutical use |
BR112023006337A2 (pt) | 2020-10-09 | 2023-05-09 | Astrazeneca Uk Ltd | Produto farmacêutico, uso de um conjugado anticorpo anti-her2-fármaco ou um inibidor seletivo de parp1, e, método de tratamento do câncer |
WO2022090938A1 (en) | 2020-10-31 | 2022-05-05 | Rhizen Pharmaceuticals Ag | Phthalazinone derivatives useful as parp inhibitors |
CN112500379B (zh) * | 2020-12-23 | 2024-01-23 | 南京方生和医药科技有限公司 | 一种奥拉帕利中间体及奥拉帕利的制备方法 |
IL306010A (en) | 2021-03-23 | 2023-11-01 | Nuvation Bio Inc | Anticancer compounds against the nuclear hormone receptor |
CN113024516B (zh) * | 2021-03-29 | 2022-05-17 | 中国药科大学 | 双靶点parp/ezh2抑制剂、制备方法及用途 |
AU2022255809A1 (en) | 2021-04-08 | 2023-10-26 | Incozen Therapeutics Pvt. Ltd. | Inhibitors of poly(adp-ribose) polymerase |
CA3219248A1 (en) | 2021-05-18 | 2022-11-24 | Hyun Ju Cha | Parp inhibitor-resistant cancer therapeutic agent |
WO2022253800A1 (en) | 2021-06-02 | 2022-12-08 | Astrazeneca Ab | Methods of treating breast cancer |
KR102645122B1 (ko) | 2021-08-25 | 2024-03-07 | 주식회사 보령 | 올라파립의 제조방법 |
US20230183185A1 (en) | 2021-11-10 | 2023-06-15 | Nufromix Technologies Limited | Olaparib hydroxybenzoic acid cocrystals and their pharmaceutical use |
TW202329936A (zh) | 2021-11-18 | 2023-08-01 | 英商阿斯特捷利康英國股份有限公司 | 抗體-藥物結合物與parp1選擇性抑制劑之組合 |
WO2023118085A1 (en) | 2021-12-21 | 2023-06-29 | Astrazeneca Ab | Methods of treating brain tumours and neuroblastomas |
KR20230114646A (ko) * | 2022-01-25 | 2023-08-01 | 재단법인 한국파스퇴르연구소 | 벤조다이옥세인 유도체 화합물 및 이의 의약 용도 |
WO2023156357A1 (en) | 2022-02-15 | 2023-08-24 | Astrazeneca Ab | Methods of treating prostate cancer |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL155645A0 (en) * | 2000-10-30 | 2003-11-23 | Kudos Pharm Ltd | Phthalazinone derivatives |
US6664269B2 (en) * | 2001-05-08 | 2003-12-16 | Maybridge Plc | Isoquinolinone derivatives |
ES2357057T3 (es) * | 2002-04-30 | 2011-04-15 | Kudos Pharmaceuticals Limited | Derivados de ftalazinona. |
GB2415430B (en) * | 2003-03-12 | 2006-07-12 | Kudos Pharm Ltd | Phthalazinone derivatives |
-
2004
- 2004-03-12 GB GB0520754A patent/GB2415430B/en not_active Expired - Lifetime
- 2004-03-12 WO PCT/GB2004/001059 patent/WO2004080976A1/en active Application Filing
- 2004-03-12 JP JP2006505955A patent/JP4027406B2/ja not_active Expired - Lifetime
- 2004-03-12 KR KR1020057016883A patent/KR101146806B1/ko active Protection Beyond IP Right Term
- 2004-03-12 EA EA200501434A patent/EA009469B1/ru active Protection Beyond IP Right Term
- 2004-03-12 EP EP04720068A patent/EP1633724B1/en not_active Expired - Lifetime
- 2004-03-12 BR BRPI0408284A patent/BRPI0408284B8/pt active IP Right Grant
- 2004-03-12 MX MXPA05009661A patent/MXPA05009661A/es active IP Right Grant
- 2004-03-12 CA CA2517629A patent/CA2517629C/en not_active Expired - Lifetime
- 2004-03-12 NZ NZ542680A patent/NZ542680A/en not_active IP Right Cessation
- 2004-03-12 AU AU2004220321A patent/AU2004220321B2/en active Active
- 2004-03-12 PL PL04720068T patent/PL1633724T3/pl unknown
-
2005
- 2005-08-31 TN TNP2005000212A patent/TNSN05212A1/en unknown
- 2005-09-28 IS IS8052A patent/IS2813B/is unknown
- 2005-10-03 MA MA28536A patent/MA27758A1/fr unknown
- 2005-10-07 NO NO20054625A patent/NO331807B1/no active Protection Beyond IP Right Term
- 2005-10-12 EC EC2005006094A patent/ECSP056094A/es unknown
- 2005-10-12 HR HRP20050895AA patent/HRP20050895B1/hr not_active IP Right Cessation
- 2005-10-12 CO CO05104500A patent/CO5650256A2/es active IP Right Grant
-
2006
- 2006-01-27 HK HK06101301A patent/HK1079530A1/xx not_active IP Right Cessation
-
2007
- 2007-08-31 JP JP2007226723A patent/JP4268651B2/ja not_active Expired - Lifetime
-
2008
- 2008-10-07 JP JP2008260806A patent/JP2009079056A/ja active Pending
-
2011
- 2011-06-28 CY CY20111100619T patent/CY1111597T1/el unknown
-
2015
- 2015-03-12 NO NO2015008C patent/NO2015008I1/no unknown
- 2015-04-02 LT LTPA2015016C patent/LTC1633724I2/lt unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EA200501434A1 (ru) | Производные фталазинона | |
AR068054A1 (es) | Compuestos de pirrolopirimidina | |
EA200100755A1 (ru) | 4-оксо-1,4-дигидро-3-хинолинкарбоксамиды как антивирусные агенты | |
NO308599B1 (no) | Piperidinderivater og fremgangsmate for fremstilling derav | |
NO20004090L (no) | Kjemiske forbindelser | |
ATE205515T1 (de) | Versteifte trimethin-cyaninfarbstoffe | |
EA200201071A1 (ru) | Циклопентилзамещенные производные глутарамида в качестве ингибиторов нейтральной эндопептидазы | |
EA200600487A1 (ru) | Соединения инданилпиперазина, способ их получения и содержащие их фармацевтические композиции | |
EA199801006A1 (ru) | Бициклические амины в качестве инсектицидов | |
EA199801013A1 (ru) | Производные дистамицина, способ их получения и применение в качестве противоопухолевых и противовирусных агентов | |
EA199800233A1 (ru) | Производные 2-циклогексан-1,3-дионбензоила | |
ATE312150T1 (de) | Electrochrome lösung, enthaltend eine hydrazonverbindung und mit dieser hergestellte vorrichtung | |
KR830006186A (ko) | 알릴아민 유도체의 제조방법 | |
EA200400323A1 (ru) | Аралкилтетрагидропиридины, их получение и содержащие их фармацевтические композиции | |
DE69311500D1 (de) | 2,3-Diphenyl-5-pyrrolyl-furan Derivate, Verfahren und Zwischenprodukte für ihre Herstellung und ihre Verwendung als entzündungshemmende, antiallergische und blutplättchenaggregationshemmende Mittel | |
EA200400828A1 (ru) | Гетероциклические замещённые фенилсодержащие сульфонамиды широкого спектра действия в качестве ингибиторов протеазы вич | |
CO5011097A1 (es) | Derivados de 8-azabiciclo [3.2.1]octan-3-metanamina . | |
EA200400469A1 (ru) | Замещенные производные алкиламинопиридазинона, способ их получения и содержащие их фармацевтические композиции | |
EA200500212A1 (ru) | Способ получения енамидопроизводных фенилаланина | |
KR970006283A (ko) | 신규 아민고리 화합물 | |
KR960703119A (ko) | 합성적 용도로 사용하기 위한 신규한 중간체 및 아미노피페라진 유도체를 제조하는 방법(Novel intermediate for synthetic use and process for producing amino-piperazine derivative) | |
ES2063177T3 (es) | Antagonistas de calcio. | |
AR016689A1 (es) | Oximas sustituidas. | |
KR960700232A (ko) | 신규시클로프로필유도체, 그 제조방법 및 용도(new cyclopropyl deri vatives, preparation method thereof and applications) | |
DK0381628T3 (da) | Glycocyamidinderivater |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC4A | Registration of transfer of a eurasian patent by assignment | ||
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ KG MD TJ TM |
|
ND4A | Extension of term of a eurasian patent | ||
ND4A | Extension of term of a eurasian patent |