EA199700223A1 - Бициклические антагонисты тахикининов, их получение и применение в фармацевтической композиции - Google Patents

Бициклические антагонисты тахикининов, их получение и применение в фармацевтической композиции

Info

Publication number
EA199700223A1
EA199700223A1 EA199700223A EA199700223A EA199700223A1 EA 199700223 A1 EA199700223 A1 EA 199700223A1 EA 199700223 A EA199700223 A EA 199700223A EA 199700223 A EA199700223 A EA 199700223A EA 199700223 A1 EA199700223 A1 EA 199700223A1
Authority
EA
Eurasian Patent Office
Prior art keywords
application
tachikinins
bicyclic
antagonists
receiving
Prior art date
Application number
EA199700223A
Other languages
English (en)
Other versions
EA000697B1 (ru
Inventor
Федерико Аркамоне
Карло Альберто Маджи
Лаура Куартара
Данило Джаннотти
Original Assignee
А.Менарини Индустрие Фармасеутике Риюните С.Р.Л.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=11351134&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA199700223(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by А.Менарини Индустрие Фармасеутике Риюните С.Р.Л. filed Critical А.Менарини Индустрие Фармасеутике Риюните С.Р.Л.
Publication of EA199700223A1 publication Critical patent/EA199700223A1/ru
Publication of EA000697B1 publication Critical patent/EA000697B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/22—Tachykinins, e.g. Eledoisins, Substance P; Related peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Virology (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Reproductive Health (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Данное изобретение относится к новым соединениям общей формулы (I) и содержащим их фармацевтическим композициям.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199700223A 1995-03-13 1996-03-11 Бициклические антагонисты тахикининов, их получение и применение в фармацевтической композиции EA000697B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT95FI000044A IT1277835B1 (it) 1995-03-13 1995-03-13 Composti biciclici, loro preparazione ed uso in composizioni farmaceutiche
PCT/EP1996/001028 WO1996028467A1 (en) 1995-03-13 1996-03-11 Bicyclic tachykinins antagonists, preparation thereof and their use in pharmaceutical composition

Publications (2)

Publication Number Publication Date
EA199700223A1 true EA199700223A1 (ru) 1998-04-30
EA000697B1 EA000697B1 (ru) 2000-02-28

Family

ID=11351134

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199700223A EA000697B1 (ru) 1995-03-13 1996-03-11 Бициклические антагонисты тахикининов, их получение и применение в фармацевтической композиции

Country Status (33)

Country Link
US (1) US6150325A (ru)
EP (1) EP0815126B1 (ru)
JP (1) JP4618821B2 (ru)
KR (1) KR100405009B1 (ru)
CN (1) CN1189477C (ru)
AR (1) AR004476A1 (ru)
AT (1) ATE198481T1 (ru)
AU (1) AU696528B2 (ru)
BG (1) BG63208B1 (ru)
BR (1) BR9607348A (ru)
CZ (1) CZ287372B6 (ru)
DE (1) DE69611438T2 (ru)
DK (1) DK0815126T3 (ru)
EA (1) EA000697B1 (ru)
EE (1) EE03618B1 (ru)
ES (1) ES2155187T3 (ru)
GE (1) GEP20002271B (ru)
GR (1) GR3035676T3 (ru)
HR (1) HRP960117B1 (ru)
HU (1) HU222051B1 (ru)
IL (1) IL117395A (ru)
IT (1) IT1277835B1 (ru)
MX (1) MX9706927A (ru)
NO (1) NO319290B1 (ru)
NZ (1) NZ303982A (ru)
PL (1) PL184147B1 (ru)
PT (1) PT815126E (ru)
RO (1) RO118297B1 (ru)
SK (1) SK281899B6 (ru)
TW (1) TW565572B (ru)
UA (1) UA48962C2 (ru)
WO (1) WO1996028467A1 (ru)
ZA (1) ZA961983B (ru)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6017705A (en) * 1995-03-14 2000-01-25 Ludwig Institute For Cancer Research Isolated nucleic acid molecules which are members of the MAGE-B family and uses thereof
IT1291776B1 (it) * 1997-02-07 1999-01-21 Menarini Ricerche Spa Composti monociclici a quattro residui bifunzionali, aventi azione nk-2 antagonista
IT1304888B1 (it) * 1998-08-05 2001-04-05 Menarini Ricerche Spa Composti monociclici ad azione nk-2 antagonista e formulazioni che licontengono
EP1299100B1 (en) * 2000-06-12 2007-07-25 The University Of Rochester Method of treating hot flashes, using tachykinin receptor antagonist
EP1297826A1 (en) * 2001-09-27 2003-04-02 Menarini Ricerche S.p.A. Nasal pharmaceutical compositions containing a NK-2 antagonist
ITFI20020239A1 (it) * 2002-12-06 2004-06-07 Menarini Ricerche Spa Processo per la preparazione di composti peptidici biciclici.
ITFI20040221A1 (it) 2004-10-27 2005-01-27 Guidotti & C Spa Composizioni farmaceutiche a base di nk2 antagonisti per uso pediatrico
ITRM20120331A1 (it) 2012-07-12 2014-01-13 Guidotti & C Spa Labor Composizioni pediatriche orali liquide contenenti nepadutant.

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1262902B (it) * 1992-04-15 1996-07-22 Menarini Farma Ind Composti triciclici antagonisti delle tachichinine, loro preparazione e loro uso in composizioni farmaceutiche.

Also Published As

Publication number Publication date
HU222051B1 (hu) 2003-04-28
CZ286297A3 (cs) 1998-02-18
JP4618821B2 (ja) 2011-01-26
ITFI950044A0 (it) 1995-03-13
GEP20002271B (en) 2000-10-25
ZA961983B (en) 1997-09-29
HUP9801835A2 (hu) 1999-01-28
ITFI950044A1 (it) 1996-09-13
BR9607348A (pt) 1997-12-30
PT815126E (pt) 2001-06-29
DE69611438D1 (de) 2001-02-08
KR19980703011A (ko) 1998-09-05
SK281899B6 (sk) 2001-09-11
AU5105996A (en) 1996-10-02
UA48962C2 (ru) 2002-09-16
HRP960117B1 (en) 2001-06-30
BG63208B1 (bg) 2001-06-29
EE9700230A (et) 1998-04-15
CZ287372B6 (en) 2000-11-15
NZ303982A (en) 1998-04-27
AU696528B2 (en) 1998-09-10
ES2155187T3 (es) 2001-05-01
MX9706927A (es) 1997-11-29
SK121297A3 (en) 1998-02-04
JPH11501643A (ja) 1999-02-09
CN1189477C (zh) 2005-02-16
DE69611438T2 (de) 2001-06-13
NO974057L (no) 1997-11-07
WO1996028467A1 (en) 1996-09-19
NO974057D0 (no) 1997-09-03
IL117395A (en) 1999-12-31
TW565572B (en) 2003-12-11
ATE198481T1 (de) 2001-01-15
NO319290B1 (no) 2005-07-11
EP0815126A1 (en) 1998-01-07
RO118297B1 (ro) 2003-04-30
US6150325A (en) 2000-11-21
KR100405009B1 (ko) 2004-05-20
HUP9801835A3 (en) 2000-05-29
PL184147B1 (pl) 2002-09-30
GR3035676T3 (en) 2001-06-29
DK0815126T3 (da) 2001-05-07
EP0815126B1 (en) 2001-01-03
EE03618B1 (et) 2002-02-15
IL117395A0 (en) 1996-07-23
PL322105A1 (en) 1998-01-05
EA000697B1 (ru) 2000-02-28
HRP960117A2 (en) 1997-08-31
BG101849A (en) 1998-04-30
AR004476A1 (es) 1998-12-16
CN1183786A (zh) 1998-06-03
IT1277835B1 (it) 1997-11-12

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EA200000198A1 (ru) 2-ациламинопропанамины в качестве антагонистов рецепторов тахикининов

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