DOP2012000224A - Compuesto heterociclico - Google Patents

Compuesto heterociclico

Info

Publication number: DOP2012000224A
Authority: DO; Dominican Republic
Prior art keywords: heterociclical; compound; heterociclical compound
Prior art date: 2010-02-17

Application number

DO2012000224A

Other languages

English (en)

Inventor

Yuya Oguro

Misaki Homma

Toru Miyazaki

Osamu Kurasawa

Original Assignee

Takeda Pharmaceutical

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2010-02-17

Filing date

2012-08-15

Publication date

2013-01-31

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44482985&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DOP2012000224(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2012-08-15 Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical

2013-01-31 Publication of DOP2012000224A publication Critical patent/DOP2012000224A/es

Links

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/20—Spiro-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Hematology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

DO2012000224A 2010-02-17 2012-08-15 Compuesto heterociclico DOP2012000224A (es)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP2010031899		2010-02-17
JP2010131950		2010-06-09

Publications (1)

Publication Number	Publication Date
DOP2012000224A true DOP2012000224A (es)	2013-01-31

Family

ID=44482985

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DO2012000224A DOP2012000224A (es)	2010-02-17	2012-08-15	Compuesto heterociclico

Country Status (35)

Country	Link
US (6)	US8722660B2 (es)
EP (2)	EP3533797B1 (es)
JP (1)	JP5689454B2 (es)
KR (1)	KR101735868B1 (es)
CN (1)	CN102844320B (es)
AU (1)	AU2011216404B2 (es)
BR (1)	BR112012020311B1 (es)
CA (1)	CA2790284C (es)
CL (1)	CL2012002250A1 (es)
CO (1)	CO6592104A2 (es)
CR (1)	CR20120448A (es)
CY (1)	CY1121792T1 (es)
DK (1)	DK2540728T3 (es)
DO (1)	DOP2012000224A (es)
EA (1)	EA020724B1 (es)
EC (1)	ECSP12012160A (es)
ES (1)	ES2733221T3 (es)
GE (1)	GEP20146202B (es)
HR (1)	HRP20190947T1 (es)
HU (1)	HUE043514T2 (es)
IL (1)	IL221442A0 (es)
LT (1)	LT2540728T (es)
MA (1)	MA34064B1 (es)
ME (1)	ME03410B (es)
MX (1)	MX353500B (es)
MY (1)	MY164776A (es)
NZ (1)	NZ602089A (es)
PE (1)	PE20130184A1 (es)
PL (1)	PL2540728T3 (es)
PT (1)	PT2540728T (es)
RS (1)	RS58796B1 (es)
SG (1)	SG183304A1 (es)
SI (1)	SI2540728T1 (es)
TN (1)	TN2012000401A1 (es)
WO (1)	WO2011102399A1 (es)

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TW201620879A (zh)	2014-04-28	2016-06-16	杜邦股份有限公司	除草性經取代之３－苯基－４－氟基苯甲醯基吡唑
US10174032B2 (en) *	2014-05-05	2019-01-08	Signalrx Pharmaceuticals, Inc.	Heterocyclic compound classes for signaling modulation
CA3090392C (en)	2015-12-07	2021-06-01	Zymergen Inc.	Microbial strain improvement by a htp genomic engineering platform
WO2017112777A1 (en)	2015-12-22	2017-06-29	SHY Therapeutics LLC	Compounds for the treatment of cancer and inflammatory disease
ES2884398T3 (es) *	2016-03-28	2021-12-10	Takeda Pharmaceuticals Co	Formas cristalinas de 2-[(2s)-1-azabiciclo[2.2.2]oct-2-il]-6-(3-metil-1H-pirazol-4-il)tieno[3,2-d]pirimidin-4(3H)-ona hemihidrato
EA035560B1 (ru) *	2016-07-28	2020-07-07	Такеда Фармасьютикал Компани Лимитед	Кристаллические формы гемигидрата 2-[(2s)-1-азабицикло[2.2.2]окт-2-ил]-6-(3-метил-1h-пиразол-4-ил)тиено[3,2- d]пиримидин-4(3h)-она
ES2877140T3 (es)	2016-11-08	2021-11-16	Cancer Research Tech Ltd	Derivados de pirimidinona como inhibidores de Cdc7
JP2020508675A (ja) *	2017-03-01	2020-03-26	武田薬品工業株式会社	Ｃｄｃ７阻害剤の効果を予測する方法
JP6825163B2 (ja) *	2017-05-21	2021-02-03	ゼンジリサーチラボラトリーズＺｅｎｊｉＲｅｓｅａｒｃｈＬａｂｏｒａｔｏｒｉｅｓ	抗癌剤としての置換［５，６］シクロ−４（３ｈ）−ピリミジノン
KR20200041294A (ko)	2017-06-21	2020-04-21	샤이 테라퓨틱스 엘엘씨	암, 염증성 질환, 신경발달질환 및 섬유증 질환의 치료를 위하여 Ras 수퍼패밀리와 상호작용하는 화합물
WO2019194319A1 (en) *	2018-04-02	2019-10-10	Takeda Pharmaceutical Company Limited	Process for the synthesis of 2-[(2s)-1-azabicyclo[2.2.2]oct-2-yl]-6- (3-methyl-1 h-pyrazol-4-yl)thieno[3,2-d]pyrimidin-4(3h)-one
JP7334194B2 (ja)	2018-06-19	2023-08-28	武田薬品工業株式会社	Ｔｐ５３突然変異状態及び高頻度突然変異状態に基づくがん治療法
KR20210033483A (ko) *	2018-07-19	2021-03-26	다케다 야쿠힌 고교 가부시키가이샤	Cdc7 억제제를 갖는 약제학적 조성물
EP3978501A4 (en) *	2019-05-30	2023-05-24	Chia Tai Tianqing Pharmaceutical Group Co., Ltd.	TETRACYCLIC COMPOUNDS AS CDC7 INHIBITORS
US20220323443A1 (en) *	2019-07-19	2022-10-13	Takeda Pharmaceutical Company Limited	Combination therapy for cancer treatment
CN114127077B (zh) *	2019-08-20	2023-08-01	正大天晴药业集团股份有限公司	用作Cdc7抑制剂的四并环类化合物
EP4069369A4 (en) *	2019-12-06	2024-02-14	Schrödinger, Inc.	CYCLIC COMPOUNDS AND METHODS OF USE THEREOF
WO2022055963A1 (en) *	2020-09-10	2022-03-17	Schrödinger, Inc.	Heterocyclic pericondensed cdc7 kinase inhibitors for the treatment of cancer
US20240025920A1 (en) *	2020-11-30	2024-01-25	Chia Tai Tianqing Pharmaceutical Group Co., Ltd.	Salt form used as cdc7 inhibitor and crystal form thereof
CN112661770B (zh) *	2020-12-24	2022-11-08	南京正济医药研究有限公司	一种化合物及利用其制备取代的[5,6]环-4(3h)-嘧啶酮化合物的方法
WO2022167999A1 (en)	2021-02-08	2022-08-11	Takeda Pharmaceutical Company Limited	Combination therapy for cancer treatment
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2011
- 2011-02-16 EP EP19168244.2A patent/EP3533797B1/en active Active
- 2011-02-16 ME MEP-2019-152A patent/ME03410B/me unknown
- 2011-02-16 HU HUE11744685A patent/HUE043514T2/hu unknown
- 2011-02-16 JP JP2012500632A patent/JP5689454B2/ja active Active
- 2011-02-16 NZ NZ602089A patent/NZ602089A/en unknown
- 2011-02-16 WO PCT/JP2011/053303 patent/WO2011102399A1/ja active Application Filing
- 2011-02-16 ES ES11744685T patent/ES2733221T3/es active Active
- 2011-02-16 GE GEAP201112855A patent/GEP20146202B/en unknown
- 2011-02-16 PE PE2012001253A patent/PE20130184A1/es active IP Right Grant
- 2011-02-16 PL PL11744685T patent/PL2540728T3/pl unknown
- 2011-02-16 MX MX2012009602A patent/MX353500B/es active IP Right Grant
- 2011-02-16 BR BR112012020311-8A patent/BR112012020311B1/pt active IP Right Grant
- 2011-02-16 RS RS20190639A patent/RS58796B1/sr unknown
- 2011-02-16 LT LTEP11744685.6T patent/LT2540728T/lt unknown
- 2011-02-16 MY MYPI2012003715A patent/MY164776A/en unknown
- 2011-02-16 AU AU2011216404A patent/AU2011216404B2/en active Active
- 2011-02-16 DK DK11744685.6T patent/DK2540728T3/da active
- 2011-02-16 US US13/578,959 patent/US8722660B2/en active Active
- 2011-02-16 EP EP11744685.6A patent/EP2540728B1/en active Active
- 2011-02-16 CN CN201180019478.3A patent/CN102844320B/zh active Active
- 2011-02-16 KR KR1020127024086A patent/KR101735868B1/ko active IP Right Grant
- 2011-02-16 EA EA201290800A patent/EA020724B1/ru unknown
- 2011-02-16 SG SG2012059994A patent/SG183304A1/en unknown
- 2011-02-16 MA MA35205A patent/MA34064B1/fr unknown
- 2011-02-16 SI SI201131722T patent/SI2540728T1/sl unknown
- 2011-02-16 CA CA2790284A patent/CA2790284C/en active Active
- 2011-02-16 PT PT11744685T patent/PT2540728T/pt unknown
2012
- 2012-08-09 TN TNP2012000401A patent/TN2012000401A1/en unknown
- 2012-08-14 CL CL2012002250A patent/CL2012002250A1/es unknown
- 2012-08-14 IL IL221442A patent/IL221442A0/en active IP Right Grant
- 2012-08-15 DO DO2012000224A patent/DOP2012000224A/es unknown
- 2012-08-29 CR CR20120448A patent/CR20120448A/es unknown
- 2012-09-13 CO CO12158066A patent/CO6592104A2/es active IP Right Grant
- 2012-09-17 EC ECSP12012160 patent/ECSP12012160A/es unknown
2014
- 2014-03-24 US US14/223,259 patent/US8921354B2/en active Active
- 2014-03-24 US US14/223,329 patent/US8933069B2/en active Active
- 2014-12-10 US US14/566,157 patent/US9388195B2/en active Active
2016
- 2016-06-08 US US15/176,893 patent/US9655900B2/en active Active
2017
- 2017-04-11 US US15/484,755 patent/US20170209452A1/en not_active Abandoned
2019
- 2019-05-23 HR HRP20190947TT patent/HRP20190947T1/hr unknown
- 2019-07-09 CY CY20191100721T patent/CY1121792T1/el unknown

Also Published As

Publication number	Publication date
US20170209452A1 (en)	2017-07-27
US20160310494A1 (en)	2016-10-27
TN2012000401A1 (en)	2014-01-30
AU2011216404A1 (en)	2012-09-20
CR20120448A (es)	2012-11-13
US20140235615A1 (en)	2014-08-21
CN102844320B (zh)	2016-03-23
HUE043514T2 (hu)	2019-08-28
BR112012020311A2 (pt)	2017-03-01
CN102844320A (zh)	2012-12-26
RS58796B1 (sr)	2019-07-31
GEP20146202B (en)	2014-11-25
EP2540728A4 (en)	2013-11-06
NZ602089A (en)	2014-05-30
EA020724B1 (ru)	2015-01-30
SI2540728T1 (sl)	2019-06-28
PL2540728T3 (pl)	2019-09-30
KR101735868B1 (ko)	2017-05-15
CA2790284A1 (en)	2011-08-25
EP2540728A1 (en)	2013-01-02
ME03410B (me)	2020-01-20
PT2540728T (pt)	2019-07-11
CY1121792T1 (el)	2020-07-31
EP2540728B1 (en)	2019-04-10
US9655900B2 (en)	2017-05-23
EP3533797B1 (en)	2023-12-20
LT2540728T (lt)	2019-06-25
ECSP12012160A (es)	2013-03-28
SG183304A1 (en)	2012-09-27
US20140228352A1 (en)	2014-08-14
IL221442A0 (en)	2012-10-31
WO2011102399A1 (ja)	2011-08-25
EA201290800A1 (ru)	2013-03-29
HRP20190947T1 (hr)	2019-07-26
US20130029969A1 (en)	2013-01-31
MY164776A (en)	2018-01-30
AU2011216404B2 (en)	2016-04-07
MX2012009602A (es)	2012-12-17
CO6592104A2 (es)	2013-01-02
US8722660B2 (en)	2014-05-13
EP3533797A1 (en)	2019-09-04
ES2733221T3 (es)	2019-11-28
PE20130184A1 (es)	2013-03-09
BR112012020311B1 (pt)	2019-01-29
MX353500B (es)	2018-01-16
CL2012002250A1 (es)	2013-02-08
US20150158882A1 (en)	2015-06-11
US8921354B2 (en)	2014-12-30
CA2790284C (en)	2019-01-08
KR20130001246A (ko)	2013-01-03
US9388195B2 (en)	2016-07-12
MA34064B1 (fr)	2013-03-05
JPWO2011102399A1 (ja)	2013-06-17
DK2540728T3 (da)	2019-05-13
JP5689454B2 (ja)	2015-03-25
US8933069B2 (en)	2015-01-13

Publication	Publication Date	Title
DOP2012000224A (es)	2013-01-31	Compuesto heterociclico
BR112013009935C8 (pt)	2017-09-19	compostos
BR112013003753A2 (pt)	2016-05-31	compostos
BR112012028556A2 (pt)	2014-04-01	Indóis
DE102011100241A8 (de)	2012-03-01	Nitridhalbleiterbauteil
DK3225404T3 (da)	2020-02-10	Fluidpatron
CR20130111A (es)	2013-05-29	Triazina-oxidiazoles
DE10170954T8 (de)	2013-04-25	Mikrowellendruckgarer
DK2648516T3 (da)	2019-01-02	Substituerede pyridinon-pyridinylforbindelser
DE112011104226A5 (de)	2013-09-26	Käfigmutter
CO6801726A2 (es)	2013-11-29	Compuestos
DE102011117046A8 (de)	2012-12-27	Doppelkupplungswindungsgetriebe
DK2649070T3 (da)	2014-10-13	Triazolpyridinforbindelser
DE112011102080A5 (de)	2013-04-11	Kupplungszentralausrücker
DE112011101226A5 (de)	2013-01-24	Linearwegmesssystem
DK2539163T3 (da)	2015-09-21	Dækventil
DK2442899T3 (da)	2013-10-07	Rotorskive
DE102011002623A8 (de)	2012-02-02	Ventilsteuerzeitversteller
DE112011102711A5 (de)	2013-05-29	Hydrostataktor
DK2448659T3 (da)	2013-07-22	Rotorskive
DK2447426T3 (da)	2013-06-03	Vaske-WC
BR112012026803A2 (pt)	2016-07-12	composto
BR112013014966A2 (pt)	2016-09-13	composto aricíclico contínuo
DE112010005518A5 (de)	2013-04-25	Dichtungsmanchette
DE102010038420A8 (de)	2013-01-10	Reinigungungsvorrichtung