ECSP12012160A - Compuesto heterociclico - Google Patents
Compuesto heterociclicoInfo
- Publication number
- ECSP12012160A ECSP12012160A ECSP12012160A ECSP12012160A EC SP12012160 A ECSP12012160 A EC SP12012160A EC SP12012160 A ECSP12012160 A EC SP12012160A EC SP12012160 A ECSP12012160 A EC SP12012160A
- Authority
- EC
- Ecuador
- Prior art keywords
- compound
- heterociclical
- salt
- useful
- cancer
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/20—Spiro-condensed systems
Abstract
Se proporciona un compuesto útil como un agente profiláctico o terapéutico para cáncer. Se describe específicamente un compuesto representado por la fórmula (I) (en donde cada símbolo es como se define en la descripción) o una sal del mismo, o un promedicamento del compuesto o la sal del mismo, el cual es útil para la prevención o tratamiento de cáncer.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2010031899 | 2010-02-17 | ||
JP2010131950 | 2010-06-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP12012160A true ECSP12012160A (es) | 2013-03-28 |
Family
ID=44482985
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ECSP12012160 ECSP12012160A (es) | 2010-02-17 | 2012-09-17 | Compuesto heterociclico |
Country Status (35)
Country | Link |
---|---|
US (6) | US8722660B2 (es) |
EP (2) | EP3533797B1 (es) |
JP (1) | JP5689454B2 (es) |
KR (1) | KR101735868B1 (es) |
CN (1) | CN102844320B (es) |
AU (1) | AU2011216404B2 (es) |
BR (1) | BR112012020311B1 (es) |
CA (1) | CA2790284C (es) |
CL (1) | CL2012002250A1 (es) |
CO (1) | CO6592104A2 (es) |
CR (1) | CR20120448A (es) |
CY (1) | CY1121792T1 (es) |
DK (1) | DK2540728T3 (es) |
DO (1) | DOP2012000224A (es) |
EA (1) | EA020724B1 (es) |
EC (1) | ECSP12012160A (es) |
ES (1) | ES2733221T3 (es) |
GE (1) | GEP20146202B (es) |
HR (1) | HRP20190947T1 (es) |
HU (1) | HUE043514T2 (es) |
IL (1) | IL221442A0 (es) |
LT (1) | LT2540728T (es) |
MA (1) | MA34064B1 (es) |
ME (1) | ME03410B (es) |
MX (1) | MX353500B (es) |
MY (1) | MY164776A (es) |
NZ (1) | NZ602089A (es) |
PE (1) | PE20130184A1 (es) |
PL (1) | PL2540728T3 (es) |
PT (1) | PT2540728T (es) |
RS (1) | RS58796B1 (es) |
SG (1) | SG183304A1 (es) |
SI (1) | SI2540728T1 (es) |
TN (1) | TN2012000401A1 (es) |
WO (1) | WO2011102399A1 (es) |
Families Citing this family (25)
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MA34797B1 (fr) * | 2010-08-11 | 2014-01-02 | Millennium Pharm Inc | Hétéroaryles et leurs utilisations |
EP3100742B1 (en) | 2014-01-31 | 2020-05-20 | Carna Biosciences Inc. | Anticancer agent composition comprising a cdc7 inhibitor and a wee1 inhibitor |
TW201620879A (zh) | 2014-04-28 | 2016-06-16 | 杜邦股份有限公司 | 除草性經取代之3-苯基-4-氟基苯甲醯基吡唑 |
US10174032B2 (en) * | 2014-05-05 | 2019-01-08 | Signalrx Pharmaceuticals, Inc. | Heterocyclic compound classes for signaling modulation |
KR20190090081A (ko) | 2015-12-07 | 2019-07-31 | 지머젠 인코포레이티드 | Htp 게놈 공학 플랫폼에 의한 미생물 균주 개량 |
SG11201804901WA (en) | 2015-12-22 | 2018-07-30 | SHY Therapeutics LLC | Compounds for the treatment of cancer and inflammatory disease |
WO2017172565A1 (en) | 2016-03-28 | 2017-10-05 | Takeda Pharmaceutical Company Limited | Crystalline forms of 2-[(2s)-1-azabicyclo[2.2.2]oct-2-yl]-6-(3-methyl-1h- pyrazol-4-yl)thieno[3,2-d]pyrimidin-4(3h)-one hemihydrate |
EA035560B1 (ru) * | 2016-07-28 | 2020-07-07 | Такеда Фармасьютикал Компани Лимитед | Кристаллические формы гемигидрата 2-[(2s)-1-азабицикло[2.2.2]окт-2-ил]-6-(3-метил-1h-пиразол-4-ил)тиено[3,2- d]пиримидин-4(3h)-она |
AU2017359561B2 (en) | 2016-11-08 | 2022-02-03 | Cancer Research Technology Limited | Pyrimidinone derivatives as Cdc7 inhibitors |
WO2018158898A1 (en) | 2017-03-01 | 2018-09-07 | Takeda Pharmaceutical Company Limited | Method of predicting effects of cdc7 inhibitor |
WO2018217439A1 (en) * | 2017-05-21 | 2018-11-29 | Zhang Hai Jun | Substituted [5,6]cyclic-4(3h)-pyrimidinones as anticancer agents |
EA201992780A1 (ru) | 2017-06-21 | 2020-06-02 | ШАЙ ТЕРАПЬЮТИКС ЭлЭлСи | Соединения, которые взаимодействуют с суперсемейством ras, для лечения рака, воспалительных заболеваний, ras-опатий и фиброзного заболевания |
WO2019194319A1 (en) | 2018-04-02 | 2019-10-10 | Takeda Pharmaceutical Company Limited | Process for the synthesis of 2-[(2s)-1-azabicyclo[2.2.2]oct-2-yl]-6- (3-methyl-1 h-pyrazol-4-yl)thieno[3,2-d]pyrimidin-4(3h)-one |
TW202016316A (zh) | 2018-06-19 | 2020-05-01 | 日商武田藥品工業股份有限公司 | 癌症治療方法 |
US20210308061A1 (en) | 2018-07-19 | 2021-10-07 | Taked Pharmaceutical Company Limited | Pharmaceutical compositions with a cdc7 inhibitor |
CA3142202A1 (en) * | 2019-05-30 | 2020-12-03 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Tetracyclic compounds as cdc7 inhibitors |
WO2021015294A2 (en) | 2019-07-19 | 2021-01-28 | Takeda Pharmaceutical Company Limited | Combination therapy for cancer treatment |
WO2021032170A1 (zh) * | 2019-08-20 | 2021-02-25 | 南京明德新药研发有限公司 | 用作Cdc7抑制剂的四并环类化合物 |
EP4069369A4 (en) * | 2019-12-06 | 2024-02-14 | Schroedinger Inc | CYCLIC COMPOUNDS AND METHODS OF USE THEREOF |
WO2022055963A1 (en) * | 2020-09-10 | 2022-03-17 | Schrödinger, Inc. | Heterocyclic pericondensed cdc7 kinase inhibitors for the treatment of cancer |
CN116472046A (zh) * | 2020-11-30 | 2023-07-21 | 正大天晴药业集团股份有限公司 | 作为Cdc7抑制剂的盐型及其晶型 |
CN112661770B (zh) * | 2020-12-24 | 2022-11-08 | 南京正济医药研究有限公司 | 一种化合物及利用其制备取代的[5,6]环-4(3h)-嘧啶酮化合物的方法 |
WO2022167999A1 (en) | 2021-02-08 | 2022-08-11 | Takeda Pharmaceutical Company Limited | Combination therapy for cancer treatment |
TW202300150A (zh) * | 2021-03-18 | 2023-01-01 | 美商薛定諤公司 | 環狀化合物及其使用方法 |
TW202330552A (zh) * | 2021-10-13 | 2023-08-01 | 美商雷密克斯醫療公司 | 調節剪接之化合物及方法 |
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AUPO721997A0 (en) | 1997-06-06 | 1997-07-03 | Queensland Institute Of Medical Research, The | Anticancer compounds |
JP2002105081A (ja) | 2000-07-28 | 2002-04-10 | Nikken Chem Co Ltd | 新規チオフェンニ環化合物 |
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2011
- 2011-02-16 EP EP19168244.2A patent/EP3533797B1/en active Active
- 2011-02-16 NZ NZ602089A patent/NZ602089A/en unknown
- 2011-02-16 ME MEP-2019-152A patent/ME03410B/me unknown
- 2011-02-16 MA MA35205A patent/MA34064B1/fr unknown
- 2011-02-16 SI SI201131722T patent/SI2540728T1/sl unknown
- 2011-02-16 KR KR1020127024086A patent/KR101735868B1/ko active IP Right Grant
- 2011-02-16 JP JP2012500632A patent/JP5689454B2/ja active Active
- 2011-02-16 CA CA2790284A patent/CA2790284C/en active Active
- 2011-02-16 PL PL11744685T patent/PL2540728T3/pl unknown
- 2011-02-16 WO PCT/JP2011/053303 patent/WO2011102399A1/ja active Application Filing
- 2011-02-16 EP EP11744685.6A patent/EP2540728B1/en active Active
- 2011-02-16 LT LTEP11744685.6T patent/LT2540728T/lt unknown
- 2011-02-16 GE GEAP201112855A patent/GEP20146202B/en unknown
- 2011-02-16 ES ES11744685T patent/ES2733221T3/es active Active
- 2011-02-16 BR BR112012020311-8A patent/BR112012020311B1/pt active IP Right Grant
- 2011-02-16 MX MX2012009602A patent/MX353500B/es active IP Right Grant
- 2011-02-16 AU AU2011216404A patent/AU2011216404B2/en active Active
- 2011-02-16 MY MYPI2012003715A patent/MY164776A/en unknown
- 2011-02-16 CN CN201180019478.3A patent/CN102844320B/zh active Active
- 2011-02-16 PT PT11744685T patent/PT2540728T/pt unknown
- 2011-02-16 DK DK11744685.6T patent/DK2540728T3/da active
- 2011-02-16 RS RS20190639A patent/RS58796B1/sr unknown
- 2011-02-16 EA EA201290800A patent/EA020724B1/ru unknown
- 2011-02-16 SG SG2012059994A patent/SG183304A1/en unknown
- 2011-02-16 PE PE2012001253A patent/PE20130184A1/es active IP Right Grant
- 2011-02-16 US US13/578,959 patent/US8722660B2/en active Active
- 2011-02-16 HU HUE11744685A patent/HUE043514T2/hu unknown
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2012
- 2012-08-09 TN TNP2012000401A patent/TN2012000401A1/en unknown
- 2012-08-14 CL CL2012002250A patent/CL2012002250A1/es unknown
- 2012-08-14 IL IL221442A patent/IL221442A0/en active IP Right Grant
- 2012-08-15 DO DO2012000224A patent/DOP2012000224A/es unknown
- 2012-08-29 CR CR20120448A patent/CR20120448A/es unknown
- 2012-09-13 CO CO12158066A patent/CO6592104A2/es active IP Right Grant
- 2012-09-17 EC ECSP12012160 patent/ECSP12012160A/es unknown
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2014
- 2014-03-24 US US14/223,259 patent/US8921354B2/en active Active
- 2014-03-24 US US14/223,329 patent/US8933069B2/en active Active
- 2014-12-10 US US14/566,157 patent/US9388195B2/en active Active
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2016
- 2016-06-08 US US15/176,893 patent/US9655900B2/en active Active
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2017
- 2017-04-11 US US15/484,755 patent/US20170209452A1/en not_active Abandoned
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2019
- 2019-05-23 HR HRP20190947TT patent/HRP20190947T1/hr unknown
- 2019-07-09 CY CY20191100721T patent/CY1121792T1/el unknown
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