WO2011002988A1
(en)
|
2009-07-01 |
2011-01-06 |
Transposagen Biopharmaceuticals, Inc. |
Genetically modified rat models for severe combined immunodeficiency (scid)
|
US9528124B2
(en)
|
2013-08-27 |
2016-12-27 |
Recombinetics, Inc. |
Efficient non-meiotic allele introgression
|
US10920242B2
(en)
|
2011-02-25 |
2021-02-16 |
Recombinetics, Inc. |
Non-meiotic allele introgression
|
US10323236B2
(en)
|
2011-07-22 |
2019-06-18 |
President And Fellows Of Harvard College |
Evaluation and improvement of nuclease cleavage specificity
|
US11021737B2
(en)
|
2011-12-22 |
2021-06-01 |
President And Fellows Of Harvard College |
Compositions and methods for analyte detection
|
GB201122458D0
(en)
|
2011-12-30 |
2012-02-08 |
Univ Wageningen |
Modified cascade ribonucleoproteins and uses thereof
|
US9737480B2
(en)
|
2012-02-06 |
2017-08-22 |
President And Fellows Of Harvard College |
ARRDC1-mediated microvesicles (ARMMs) and uses thereof
|
US9637739B2
(en)
|
2012-03-20 |
2017-05-02 |
Vilnius University |
RNA-directed DNA cleavage by the Cas9-crRNA complex
|
SG11201406547YA
(en)
|
2012-04-25 |
2014-11-27 |
Regeneron Pharma |
Nuclease-mediated targeting with large targeting vectors
|
EP2841572B1
(en)
|
2012-04-27 |
2019-06-19 |
Duke University |
Genetic correction of mutated genes
|
PT2800811T
(pt)
|
2012-05-25 |
2017-08-17 |
Univ California |
Métodos e composições para modificação de adn alvo dirigida por arn e para modulação dirigida por arn de transcrição
|
EP2861737B1
(en)
|
2012-06-19 |
2019-04-17 |
Regents Of The University Of Minnesota |
Gene targeting in plants using dna viruses
|
US10648001B2
(en)
|
2012-07-11 |
2020-05-12 |
Sangamo Therapeutics, Inc. |
Method of treating mucopolysaccharidosis type I or II
|
ES2813080T3
(es)
|
2012-07-11 |
2021-03-22 |
Sangamo Therapeutics Inc |
Métodos y composiciones para el tratamiento de enfermedades por almacenamiento lisosomal
|
EP2877213B1
(en)
*
|
2012-07-25 |
2020-12-02 |
The Broad Institute, Inc. |
Inducible dna binding proteins and genome perturbation tools and applications thereof
|
CN116064533A
(zh)
|
2012-10-23 |
2023-05-05 |
基因工具股份有限公司 |
用于切割靶dna的组合物及其用途
|
US10968446B2
(en)
|
2012-11-01 |
2021-04-06 |
Massachusetts Institute Of Technology |
Directed evolution of synthetic gene cluster
|
DK3360964T3
(da)
|
2012-12-06 |
2019-10-28 |
Sigma Aldrich Co Llc |
Crispr-baseret genommodifikation og -regulering
|
KR20150105635A
(ko)
*
|
2012-12-12 |
2015-09-17 |
더 브로드 인스티튜트, 인코퍼레이티드 |
서열 조작을 위한 crispr-cas 성분 시스템, 방법 및 조성물
|
EP2896697B1
(en)
|
2012-12-12 |
2015-09-02 |
The Broad Institute, Inc. |
Engineering of systems, methods and optimized guide compositions for sequence manipulation
|
WO2014093709A1
(en)
|
2012-12-12 |
2014-06-19 |
The Broad Institute, Inc. |
Methods, models, systems, and apparatus for identifying target sequences for cas enzymes or crispr-cas systems for target sequences and conveying results thereof
|
PL2931898T3
(pl)
|
2012-12-12 |
2016-09-30 |
Le Cong |
Projektowanie i optymalizacja systemów, sposoby i kompozycje do manipulacji sekwencją z domenami funkcjonalnymi
|
AU2013359212B2
(en)
|
2012-12-12 |
2017-01-19 |
Massachusetts Institute Of Technology |
Engineering and optimization of improved systems, methods and enzyme compositions for sequence manipulation
|
US8697359B1
(en)
|
2012-12-12 |
2014-04-15 |
The Broad Institute, Inc. |
CRISPR-Cas systems and methods for altering expression of gene products
|
MX2015007550A
(es)
|
2012-12-12 |
2017-02-02 |
Broad Inst Inc |
Suministro, modificación y optimización de sistemas, métodos y composiciones para la manipulación de secuencias y aplicaciones terapéuticas.
|
CA2895155C
(en)
*
|
2012-12-17 |
2021-07-06 |
President And Fellows Of Harvard College |
Rna-guided human genome engineering
|
AU2014207618A1
(en)
|
2013-01-16 |
2015-08-06 |
Emory University |
Cas9-nucleic acid complexes and uses related thereto
|
US11135273B2
(en)
|
2013-02-07 |
2021-10-05 |
The Rockefeller University |
Sequence specific antimicrobials
|
US10660943B2
(en)
|
2013-02-07 |
2020-05-26 |
The Rockefeller University |
Sequence specific antimicrobials
|
US10138509B2
(en)
|
2013-03-12 |
2018-11-27 |
President And Fellows Of Harvard College |
Method for generating a three-dimensional nucleic acid containing matrix
|
SG11201507378UA
(en)
|
2013-03-14 |
2015-10-29 |
Caribou Biosciences Inc |
Compositions and methods of nucleic acid-targeting nucleic acids
|
US9234213B2
(en)
|
2013-03-15 |
2016-01-12 |
System Biosciences, Llc |
Compositions and methods directed to CRISPR/Cas genomic engineering systems
|
US20140364333A1
(en)
*
|
2013-03-15 |
2014-12-11 |
President And Fellows Of Harvard College |
Methods for Live Imaging of Cells
|
CN112301024A
(zh)
|
2013-03-15 |
2021-02-02 |
通用医疗公司 |
使用RNA引导的FokI核酸酶(RFN)提高RNA引导的基因组编辑的特异性
|
US10760064B2
(en)
|
2013-03-15 |
2020-09-01 |
The General Hospital Corporation |
RNA-guided targeting of genetic and epigenomic regulatory proteins to specific genomic loci
|
CN115261411A
(zh)
|
2013-04-04 |
2022-11-01 |
哈佛学院校长同事会 |
利用CRISPR/Cas***的基因组编辑的治疗性用途
|
US20140310828A1
(en)
|
2013-04-16 |
2014-10-16 |
Regeneron Pharmaceuticals, Inc. |
Targeted modification of rat genome
|
EP3004349B1
(en)
*
|
2013-05-29 |
2018-03-28 |
Cellectis S.A. |
A method for producing precise dna cleavage using cas9 nickase activity
|
US9873907B2
(en)
|
2013-05-29 |
2018-01-23 |
Agilent Technologies, Inc. |
Method for fragmenting genomic DNA using CAS9
|
MX2015016798A
(es)
*
|
2013-06-04 |
2016-10-26 |
Harvard College |
Regulacion transcripcional guiada por acido ribonucleico.
|
US20140356956A1
(en)
|
2013-06-04 |
2014-12-04 |
President And Fellows Of Harvard College |
RNA-Guided Transcriptional Regulation
|
KR102551324B1
(ko)
|
2013-06-05 |
2023-07-05 |
듀크 유니버시티 |
Rna-가이드 유전자 편집 및 유전자 조절
|
EP3008181B1
(en)
|
2013-06-11 |
2019-11-06 |
The Regents of The University of California |
Methods and compositions for target dna modification
|
WO2014204727A1
(en)
|
2013-06-17 |
2014-12-24 |
The Broad Institute Inc. |
Functional genomics using crispr-cas systems, compositions methods, screens and applications thereof
|
EP3597755A1
(en)
*
|
2013-06-17 |
2020-01-22 |
The Broad Institute, Inc. |
Delivery, use and therapeutic applications of the crispr-cas systems and compositions for targeting disorders and diseases using viral components
|
JP6665088B2
(ja)
|
2013-06-17 |
2020-03-13 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
配列操作のための最適化されたCRISPR−Cas二重ニッカーゼ系、方法および組成物
|
EP3011029B1
(en)
|
2013-06-17 |
2019-12-11 |
The Broad Institute, Inc. |
Delivery, engineering and optimization of tandem guide systems, methods and compositions for sequence manipulation
|
WO2014204726A1
(en)
|
2013-06-17 |
2014-12-24 |
The Broad Institute Inc. |
Delivery and use of the crispr-cas systems, vectors and compositions for hepatic targeting and therapy
|
US10011850B2
(en)
|
2013-06-21 |
2018-07-03 |
The General Hospital Corporation |
Using RNA-guided FokI Nucleases (RFNs) to increase specificity for RNA-Guided Genome Editing
|
JP2016528890A
(ja)
|
2013-07-09 |
2016-09-23 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
CRISPR/Cas系を用いるゲノム編集の治療用の使用
|
US20150044192A1
(en)
|
2013-08-09 |
2015-02-12 |
President And Fellows Of Harvard College |
Methods for identifying a target site of a cas9 nuclease
|
CN105829536A
(zh)
|
2013-08-22 |
2016-08-03 |
纳幕尔杜邦公司 |
用于在不掺入选择性转基因标记的情况下,在植物基因组中产生基因修饰的方法,以及用于这种方法的组合物
|
US9359599B2
(en)
|
2013-08-22 |
2016-06-07 |
President And Fellows Of Harvard College |
Engineered transcription activator-like effector (TALE) domains and uses thereof
|
EP4074330A1
(en)
*
|
2013-09-05 |
2022-10-19 |
Massachusetts Institute of Technology |
Tuning microbial populations with programmable nucleases
|
US9737604B2
(en)
|
2013-09-06 |
2017-08-22 |
President And Fellows Of Harvard College |
Use of cationic lipids to deliver CAS9
|
US9340799B2
(en)
|
2013-09-06 |
2016-05-17 |
President And Fellows Of Harvard College |
MRNA-sensing switchable gRNAs
|
US9388430B2
(en)
|
2013-09-06 |
2016-07-12 |
President And Fellows Of Harvard College |
Cas9-recombinase fusion proteins and uses thereof
|
WO2015040402A1
(en)
*
|
2013-09-18 |
2015-03-26 |
Kymab Limited |
Methods. cells & organisms
|
WO2015054507A1
(en)
|
2013-10-10 |
2015-04-16 |
Pronutria, Inc. |
Nutritive polypeptide production systems, and methods of manufacture and use thereof
|
WO2015065964A1
(en)
|
2013-10-28 |
2015-05-07 |
The Broad Institute Inc. |
Functional genomics using crispr-cas systems, compositions, methods, screens and applications thereof
|
WO2015070062A1
(en)
|
2013-11-07 |
2015-05-14 |
Massachusetts Institute Of Technology |
Cell-based genomic recorded accumulative memory
|
AU2014346559B2
(en)
|
2013-11-07 |
2020-07-09 |
Editas Medicine,Inc. |
CRISPR-related methods and compositions with governing gRNAs
|
CA2933433C
(en)
|
2013-12-11 |
2020-11-17 |
Regeneron Pharmaceuticals, Inc. |
Methods and compositions for the targeted modification of a genome
|
US9994831B2
(en)
|
2013-12-12 |
2018-06-12 |
The Regents Of The University Of California |
Methods and compositions for modifying a single stranded target nucleic acid
|
WO2015089364A1
(en)
|
2013-12-12 |
2015-06-18 |
The Broad Institute Inc. |
Crystal structure of a crispr-cas system, and uses thereof
|
EP3540051B1
(en)
|
2013-12-12 |
2022-08-17 |
The Broad Institute, Inc. |
Delivery, use and therapeutic applications of the crispr-cas systems and compositions for hsv and viral diseases and disorders.
|
US20150166984A1
(en)
|
2013-12-12 |
2015-06-18 |
President And Fellows Of Harvard College |
Methods for correcting alpha-antitrypsin point mutations
|
CN106029880A
(zh)
|
2013-12-12 |
2016-10-12 |
布罗德研究所有限公司 |
核苷酸重复障碍中CRISPR-Cas***的组合物和使用方法
|
WO2015089419A2
(en)
|
2013-12-12 |
2015-06-18 |
The Broad Institute Inc. |
Delivery, use and therapeutic applications of the crispr-cas systems and compositions for targeting disorders and diseases using particle delivery components
|
EP3080259B1
(en)
|
2013-12-12 |
2023-02-01 |
The Broad Institute, Inc. |
Engineering of systems, methods and optimized guide compositions with new architectures for sequence manipulation
|
JP6793547B2
(ja)
|
2013-12-12 |
2020-12-02 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
最適化機能CRISPR−Cas系による配列操作のための系、方法および組成物
|
CN111206032B
(zh)
|
2013-12-12 |
2024-07-19 |
布罗德研究所有限公司 |
用于基因组编辑的crispr-cas***和组合物的递送、用途和治疗应用
|
BR112016013187A2
(pt)
|
2013-12-19 |
2017-09-26 |
Novartis Ag |
receptores de antígenos quiméricos de mesotelina humanos e usos dos mesmos
|
US9963689B2
(en)
|
2013-12-31 |
2018-05-08 |
The Regents Of The University Of California |
Cas9 crystals and methods of use thereof
|
ES2974229T3
(es)
|
2014-02-11 |
2024-06-26 |
Univ Colorado Regents |
Ingeniería del genoma multiplex mediante CRISPR
|
SG11201606819QA
(en)
|
2014-02-18 |
2016-09-29 |
Univ Duke |
Compositions for the inactivation of virus replication and methods of making and using the same
|
CA2940653A1
(en)
|
2014-02-27 |
2015-09-03 |
Vijay Kuchroo |
T cell balance gene expression, compositions of matters and methods of use thereof
|
CA3194412A1
(en)
|
2014-02-27 |
2015-09-03 |
Monsanto Technology Llc |
Compositions and methods for site directed genomic modification
|
EP3957735A1
(en)
|
2014-03-05 |
2022-02-23 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating usher syndrome and retinitis pigmentosa
|
PL3115457T3
(pl)
|
2014-03-05 |
2020-01-31 |
National University Corporation Kobe University |
Sposób modyfikacji sekwencji genomowej do specyficznego przekształcania zasad kwasu nukleinowego docelowej sekwencji dna oraz kompleks molekularny do zastosowania w nim
|
US11339437B2
(en)
|
2014-03-10 |
2022-05-24 |
Editas Medicine, Inc. |
Compositions and methods for treating CEP290-associated disease
|
US9938521B2
(en)
|
2014-03-10 |
2018-04-10 |
Editas Medicine, Inc. |
CRISPR/CAS-related methods and compositions for treating leber's congenital amaurosis 10 (LCA10)
|
US11141493B2
(en)
|
2014-03-10 |
2021-10-12 |
Editas Medicine, Inc. |
Compositions and methods for treating CEP290-associated disease
|
CN106163547A
(zh)
|
2014-03-15 |
2016-11-23 |
诺华股份有限公司 |
使用嵌合抗原受体治疗癌症
|
JP6815986B2
(ja)
|
2014-03-26 |
2021-01-20 |
ユニバーシティ オブ メリーランド, カレッジ パーク |
大型家畜の接合体における標的化ゲノム編集
|
EP3122880B1
(en)
|
2014-03-26 |
2021-05-05 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating sickle cell disease
|
EP3126495A1
(en)
*
|
2014-04-02 |
2017-02-08 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating primary open angle glaucoma
|
IL293603B2
(en)
|
2014-04-07 |
2024-03-01 |
Novartis Ag |
Cancer treatment using chimeric antigen receptor (CAR) against CD19
|
HUE051354T2
(hu)
*
|
2014-04-14 |
2021-03-01 |
Nemesis Bioscience Ltd |
Terapeutikum
|
GB201406970D0
(en)
*
|
2014-04-17 |
2014-06-04 |
Green Biologics Ltd |
Targeted mutations
|
GB201406968D0
(en)
|
2014-04-17 |
2014-06-04 |
Green Biologics Ltd |
Deletion mutants
|
US10280419B2
(en)
|
2014-05-09 |
2019-05-07 |
UNIVERSITé LAVAL |
Reduction of amyloid beta peptide production via modification of the APP gene using the CRISPR/Cas system
|
WO2015177668A1
(en)
|
2014-05-19 |
2015-11-26 |
Pfizer Inc. |
Substituted-6,8-dioxabicyclo[3.2.1]octane-2,3-diol compounds as targeting agents of asgpr
|
AU2015274367B2
(en)
|
2014-06-13 |
2020-11-26 |
Beth Israel Deaconess Medical Center, Inc. |
Products and methods to isolate mitochondria
|
WO2015200378A1
(en)
|
2014-06-23 |
2015-12-30 |
The General Hospital Corporation |
Genomewide unbiased identification of dsbs evaluated by sequencing (guide-seq)
|
BR122023024818A2
(pt)
*
|
2014-07-11 |
2023-12-26 |
Pioneer Hi-Bred International, Inc. |
Rna guia, polinucleotídeo e complexo de ribonucleoproteínas
|
WO2016007347A1
(en)
|
2014-07-11 |
2016-01-14 |
E. I. Du Pont De Nemours And Company |
Compositions and methods for producing plants resistant to glyphosate herbicide
|
EP3169310A1
(en)
|
2014-07-15 |
2017-05-24 |
Life Technologies Corporation |
Compositions with lipid aggregates and methods for efficient delivery of molecules to cells
|
WO2016014553A1
(en)
|
2014-07-21 |
2016-01-28 |
Novartis Ag |
Sortase synthesized chimeric antigen receptors
|
JP2017528433A
(ja)
|
2014-07-21 |
2017-09-28 |
ノバルティス アーゲー |
低い免疫増強用量のmTOR阻害剤とCARの組み合わせ
|
RU2751660C2
(ru)
|
2014-07-21 |
2021-07-15 |
Новартис Аг |
Лечение злокачественного новообразования с использованием гуманизированного химерного антигенного рецептора против всма
|
JP6831777B2
(ja)
|
2014-07-21 |
2021-02-17 |
ノバルティス アーゲー |
Cd33キメラ抗原受容体を使用する癌の処置
|
EP4079847A1
(en)
|
2014-07-30 |
2022-10-26 |
President And Fellows Of Harvard College |
Cas9 proteins including ligand-dependent inteins
|
EP3660042B1
(en)
|
2014-07-31 |
2023-01-11 |
Novartis AG |
Subset-optimized chimeric antigen receptor-containing t-cells
|
US10513711B2
(en)
|
2014-08-13 |
2019-12-24 |
Dupont Us Holding, Llc |
Genetic targeting in non-conventional yeast using an RNA-guided endonuclease
|
CA2958200A1
(en)
|
2014-08-14 |
2016-02-18 |
Novartis Ag |
Treatment of cancer using a gfr alpha-4 chimeric antigen receptor
|
EP3180426B1
(en)
|
2014-08-17 |
2019-12-25 |
The Broad Institute, Inc. |
Genome editing using cas9 nickases
|
PT3183268T
(pt)
|
2014-08-19 |
2020-05-15 |
Novartis Ag |
Recetor de antigénio quimérico (car) anti-cd123 para uso no tratamento de cancro
|
SG11201701245QA
(en)
*
|
2014-08-27 |
2017-03-30 |
Caribou Biosciences Inc |
Methods for increasing cas9-mediated engineering efficiency
|
WO2016033298A1
(en)
|
2014-08-28 |
2016-03-03 |
North Carolina State University |
Novel cas9 proteins and guiding features for dna targeting and genome editing
|
WO2016036754A1
(en)
|
2014-09-02 |
2016-03-10 |
The Regents Of The University Of California |
Methods and compositions for rna-directed target dna modification
|
RU2017112324A
(ru)
|
2014-09-12 |
2018-10-15 |
Пайонир Хай-Бред Интернэшнл, Инк. |
Создание сайтов сайт-специфической интеграции для сложных локусов признаков в кукурузе и сое, а также способы применения
|
CN114621969A
(zh)
|
2014-09-17 |
2022-06-14 |
诺华股份有限公司 |
用于过继免疫疗法的具有嵌合受体的靶向细胞毒性细胞
|
US9616114B1
(en)
|
2014-09-18 |
2017-04-11 |
David Gordon Bermudes |
Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity
|
AU2015320738B2
(en)
|
2014-09-23 |
2021-12-02 |
Acceligen, Inc. |
Materials and methods for producing animals with short hair
|
WO2016049024A2
(en)
*
|
2014-09-24 |
2016-03-31 |
The Broad Institute Inc. |
Delivery, use and therapeutic applications of the crispr-cas systems and compositions for modeling competition of multiple cancer mutations in vivo
|
WO2016049163A2
(en)
|
2014-09-24 |
2016-03-31 |
The Broad Institute Inc. |
Use and production of chd8+/- transgenic animals with behavioral phenotypes characteristic of autism spectrum disorder
|
WO2016049251A1
(en)
|
2014-09-24 |
2016-03-31 |
The Broad Institute Inc. |
Delivery, use and therapeutic applications of the crispr-cas systems and compositions for modeling mutations in leukocytes
|
US10040048B1
(en)
|
2014-09-25 |
2018-08-07 |
Synthego Corporation |
Automated modular system and method for production of biopolymers
|
WO2016049258A2
(en)
|
2014-09-25 |
2016-03-31 |
The Broad Institute Inc. |
Functional screening with optimized functional crispr-cas systems
|
WO2016061073A1
(en)
*
|
2014-10-14 |
2016-04-21 |
Memorial Sloan-Kettering Cancer Center |
Composition and method for in vivo engineering of chromosomal rearrangements
|
CN105602935B
(zh)
*
|
2014-10-20 |
2020-11-13 |
聂凌云 |
一种新型线粒体基因组编辑工具
|
WO2016069591A2
(en)
|
2014-10-27 |
2016-05-06 |
The Broad Institute Inc. |
Compositions, methods and use of synthetic lethal screening
|
US9816080B2
(en)
|
2014-10-31 |
2017-11-14 |
President And Fellows Of Harvard College |
Delivery of CAS9 via ARRDC1-mediated microvesicles (ARMMs)
|
CA2966731C
(en)
|
2014-11-06 |
2023-01-31 |
E. I. Du Pont De Nemours And Company |
Peptide-mediated delivery of rna-guided endonuclease into cells
|
CA2963820A1
(en)
|
2014-11-07 |
2016-05-12 |
Editas Medicine, Inc. |
Methods for improving crispr/cas-mediated genome-editing
|
CA2968440A1
(en)
|
2014-11-21 |
2016-05-26 |
Regeneron Pharmaceuticals, Inc. |
Methods and compositions for targeted genetic modification using paired guide rnas
|
EP3224381B1
(en)
|
2014-11-25 |
2019-09-04 |
The Brigham and Women's Hospital, Inc. |
Method of identifying a person having a predisposition to or afflicted with a cardiometabolic disease
|
WO2016086227A2
(en)
|
2014-11-26 |
2016-06-02 |
The Regents Of The University Of California |
Therapeutic compositions comprising transcription factors and methods of making and using the same
|
GB201421096D0
(en)
|
2014-11-27 |
2015-01-14 |
Imp Innovations Ltd |
Genome editing methods
|
WO2016082135A1
(zh)
*
|
2014-11-27 |
2016-06-02 |
中国农业科学院北京畜牧兽医研究所 |
一种利用定点切割***对猪h11位点定点***的方法
|
EP4400584A2
(en)
|
2014-12-03 |
2024-07-17 |
Agilent Technologies, Inc. |
Guide rna with chemical modifications
|
EP3229586A4
(en)
|
2014-12-10 |
2018-10-24 |
Regents of the University of Minnesota |
Genetically modified cells, tissues, and organs for treating disease
|
WO2016094874A1
(en)
|
2014-12-12 |
2016-06-16 |
The Broad Institute Inc. |
Escorted and functionalized guides for crispr-cas systems
|
WO2016094867A1
(en)
|
2014-12-12 |
2016-06-16 |
The Broad Institute Inc. |
Protected guide rnas (pgrnas)
|
WO2016094880A1
(en)
|
2014-12-12 |
2016-06-16 |
The Broad Institute Inc. |
Delivery, use and therapeutic applications of crispr systems and compositions for genome editing as to hematopoietic stem cells (hscs)
|
EP3230452A1
(en)
|
2014-12-12 |
2017-10-18 |
The Broad Institute Inc. |
Dead guides for crispr transcription factors
|
US20170327834A1
(en)
|
2014-12-15 |
2017-11-16 |
Syngenta Participations Ag |
Pesticidal microrna carriers and use thereof
|
BR112017012837A2
(pt)
*
|
2014-12-16 |
2017-12-26 |
Danisco Us Inc |
sistemas de modificação de genoma fúngico e métodos de uso
|
EP3234117B1
(en)
*
|
2014-12-17 |
2021-03-03 |
DuPont US Holding, LLC |
Compositions and methods for efficient gene editing in e. coli using guide rna/cas endonuclease systems in combination with circular polynucleotide modification templates
|
WO2016098078A2
(en)
|
2014-12-19 |
2016-06-23 |
Novartis Ag |
Dimerization switches and uses thereof
|
WO2016100974A1
(en)
|
2014-12-19 |
2016-06-23 |
The Broad Institute Inc. |
Unbiased identification of double-strand breaks and genomic rearrangement by genome-wide insert capture sequencing
|
US10190106B2
(en)
|
2014-12-22 |
2019-01-29 |
Univesity Of Massachusetts |
Cas9-DNA targeting unit chimeras
|
CA2969151A1
(en)
|
2014-12-23 |
2016-06-30 |
Syngenta Participations Ag |
Methods and compositions for identifying and enriching for cells comprising site specific genomic modifications
|
WO2016106236A1
(en)
|
2014-12-23 |
2016-06-30 |
The Broad Institute Inc. |
Rna-targeting system
|
CA2970370A1
(en)
|
2014-12-24 |
2016-06-30 |
Massachusetts Institute Of Technology |
Crispr having or associated with destabilization domains
|
WO2016108926A1
(en)
|
2014-12-30 |
2016-07-07 |
The Broad Institute Inc. |
Crispr mediated in vivo modeling and genetic screening of tumor growth and metastasis
|
SG11201704272YA
(en)
|
2014-12-31 |
2017-06-29 |
Synthetic Genomics Inc |
Compositions and methods for high efficiency in vivo genome editing
|
US11208638B2
(en)
|
2015-01-12 |
2021-12-28 |
The Regents Of The University Of California |
Heterodimeric Cas9 and methods of use thereof
|
EP3250689B1
(en)
|
2015-01-28 |
2020-11-04 |
The Regents of The University of California |
Methods and compositions for labeling a single-stranded target nucleic acid
|
KR20220159498A
(ko)
|
2015-01-28 |
2022-12-02 |
카리부 바이오사이언시스 인코포레이티드 |
Crispr 하이브리드 dna/rna 폴리뉴클레오티드 및 사용 방법
|
US10676726B2
(en)
|
2015-02-09 |
2020-06-09 |
Duke University |
Compositions and methods for epigenome editing
|
WO2016138488A2
(en)
|
2015-02-26 |
2016-09-01 |
The Broad Institute Inc. |
T cell balance gene expression, compositions of matters and methods of use thereof
|
EP3265560B1
(en)
|
2015-03-02 |
2021-12-08 |
Sinai Health System |
Homologous recombination factors
|
KR102598856B1
(ko)
|
2015-03-03 |
2023-11-07 |
더 제너럴 하스피탈 코포레이션 |
변경된 PAM 특이성을 갖는 조작된 CRISPR-Cas9 뉴클레아제
|
CN104673816A
(zh)
*
|
2015-03-05 |
2015-06-03 |
广东医学院 |
一种pCr-NHEJ载体及其构建方法及其用于细菌基因定点敲除的应用
|
CN107567499A
(zh)
|
2015-03-27 |
2018-01-09 |
纳幕尔杜邦公司 |
大豆u6核小rna基因启动子及其在植物小rna基因的组成型表达中的用途
|
CN114231527A
(zh)
|
2015-04-06 |
2022-03-25 |
里兰斯坦福初级大学理事会 |
用于crispr/cas介导的基因调控的化学修饰的引导rna
|
WO2016168594A1
(en)
*
|
2015-04-16 |
2016-10-20 |
President And Fellows Of Harvard College |
Sensor systems for target ligands and uses thereof
|
GB201506509D0
(en)
|
2015-04-16 |
2015-06-03 |
Univ Wageningen |
Nuclease-mediated genome editing
|
EP3286211A1
(en)
|
2015-04-23 |
2018-02-28 |
Novartis AG |
Treatment of cancer using chimeric antigen receptor and protein kinase a blocker
|
JP2018522249A
(ja)
|
2015-04-24 |
2018-08-09 |
エディタス・メディシン、インコーポレイテッド |
Cas9分子/ガイドrna分子複合体の評価
|
US20180156807A1
(en)
|
2015-04-29 |
2018-06-07 |
New York University |
Method for treating high-grade gliomas
|
CN106191040B
(zh)
*
|
2015-04-30 |
2021-09-14 |
杭州菁因康生物科技有限公司 |
基因打靶方法
|
CN107667173A
(zh)
|
2015-05-06 |
2018-02-06 |
斯尼普技术有限公司 |
改变微生物种群和改善微生物群
|
US10968426B2
(en)
|
2015-05-08 |
2021-04-06 |
President And Fellows Of Harvard College |
Universal donor stem cells and related methods
|
WO2016182893A1
(en)
|
2015-05-08 |
2016-11-17 |
Teh Broad Institute Inc. |
Functional genomics using crispr-cas systems for saturating mutagenesis of non-coding elements, compositions, methods, libraries and applications thereof
|
CA2986310A1
(en)
|
2015-05-11 |
2016-11-17 |
Editas Medicine, Inc. |
Optimized crispr/cas9 systems and methods for gene editing in stem cells
|
WO2016183438A1
(en)
*
|
2015-05-14 |
2016-11-17 |
Massachusetts Institute Of Technology |
Self-targeting genome editing system
|
MX2017014560A
(es)
|
2015-05-15 |
2018-03-01 |
Pioneer Hi Bred Int |
Caracterizacion rapida de sistemas de endonucleasa cas, secuencias pam y elementos arn de guia.
|
WO2016187904A1
(zh)
*
|
2015-05-22 |
2016-12-01 |
深圳市第二人民医院 |
CRISPR-Cas9特异性敲除猪CMAH基因的方法及用于特异性靶向CMAH基因的sgRNA
|
US20180148711A1
(en)
*
|
2015-05-28 |
2018-05-31 |
Coda Biotherapeutics, Inc. |
Genome editing vectors
|
KR20220139447A
(ko)
*
|
2015-05-29 |
2022-10-14 |
노쓰 캐롤라이나 스테이트 유니버시티 |
크리스퍼 핵산을 사용하여 박테리아, 고세균, 조류 및 효모를 스크리닝하는 방법
|
WO2016196655A1
(en)
|
2015-06-03 |
2016-12-08 |
The Regents Of The University Of California |
Cas9 variants and methods of use thereof
|
EP3303585A4
(en)
|
2015-06-03 |
2018-10-31 |
Board of Regents of the University of Nebraska |
Dna editing using single-stranded dna
|
US20180296537A1
(en)
|
2015-06-05 |
2018-10-18 |
Novartis Ag |
Methods and compositions for diagnosing, treating, and monitoring treatment of shank3 deficiency associated disorders
|
CA2986262A1
(en)
|
2015-06-09 |
2016-12-15 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for improving transplantation
|
WO2016198500A1
(en)
*
|
2015-06-10 |
2016-12-15 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods and compositions for rna-guided treatment of human cytomegalovirus (hcmv) infection
|
BR112017026467A2
(pt)
|
2015-06-10 |
2018-09-11 |
Univ Texas |
uso de exossomos para o tratamento de doença
|
US20180187190A1
(en)
*
|
2015-06-12 |
2018-07-05 |
Erasmus University Medical Center Rotterdam |
New crispr assays
|
US11643668B2
(en)
|
2015-06-17 |
2023-05-09 |
The Uab Research Foundation |
CRISPR/Cas9 complex for genomic editing
|
WO2016205728A1
(en)
|
2015-06-17 |
2016-12-22 |
Massachusetts Institute Of Technology |
Crispr mediated recording of cellular events
|
JP2018518181A
(ja)
|
2015-06-17 |
2018-07-12 |
ザ ユーエービー リサーチ ファンデーション |
血液細胞系列の細胞に機能的ポリペプチドを導入するためのCRISPR/Cas9複合体
|
WO2016205749A1
(en)
|
2015-06-18 |
2016-12-22 |
The Broad Institute Inc. |
Novel crispr enzymes and systems
|
WO2016205745A2
(en)
|
2015-06-18 |
2016-12-22 |
The Broad Institute Inc. |
Cell sorting
|
US9790490B2
(en)
|
2015-06-18 |
2017-10-17 |
The Broad Institute Inc. |
CRISPR enzymes and systems
|
EP3129393B1
(en)
*
|
2015-06-18 |
2021-08-04 |
The Broad Institute Inc. |
Crispr enzyme mutations reducing off-target effects
|
AU2016279077A1
(en)
|
2015-06-18 |
2019-03-28 |
Omar O. Abudayyeh |
Novel CRISPR enzymes and systems
|
US10648020B2
(en)
|
2015-06-18 |
2020-05-12 |
The Broad Institute, Inc. |
CRISPR enzymes and systems
|
WO2016205759A1
(en)
|
2015-06-18 |
2016-12-22 |
The Broad Institute Inc. |
Engineering and optimization of systems, methods, enzymes and guide scaffolds of cas9 orthologs and variants for sequence manipulation
|
EP3313989A4
(en)
|
2015-06-29 |
2018-12-05 |
Ionis Pharmaceuticals, Inc. |
Modified crispr rna and modified single crispr rna and uses thereof
|
RU2769873C2
(ru)
|
2015-07-13 |
2022-04-07 |
Пивот Байо, Инк. |
Способы и композиции для улучшения признаков растений
|
JP7044373B2
(ja)
|
2015-07-15 |
2022-03-30 |
ラトガース,ザ ステート ユニバーシティ オブ ニュージャージー |
ヌクレアーゼ非依存的な標的化遺伝子編集プラットフォームおよびその用途
|
WO2017015637A1
(en)
|
2015-07-22 |
2017-01-26 |
Duke University |
High-throughput screening of regulatory element function with epigenome editing technologies
|
IL295616A
(en)
|
2015-07-31 |
2022-10-01 |
Us Health |
Adapted cells and treatment methods
|
US9580727B1
(en)
|
2015-08-07 |
2017-02-28 |
Caribou Biosciences, Inc. |
Compositions and methods of engineered CRISPR-Cas9 systems using split-nexus Cas9-associated polynucleotides
|
WO2017027392A1
(en)
|
2015-08-07 |
2017-02-16 |
Novartis Ag |
Treatment of cancer using chimeric cd3 receptor proteins
|
AU2016309948B2
(en)
|
2015-08-14 |
2021-05-20 |
The University Of Sydney |
Connexin 45 inhibition for therapy
|
EP3337908A4
(en)
|
2015-08-18 |
2019-01-23 |
The Broad Institute, Inc. |
METHOD AND COMPOSITIONS FOR CHANGING THE FUNCTION AND STRUCTURE OF CHROMATIN GRINDING AND / OR DOMAINS
|
IL288662B2
(en)
|
2015-08-25 |
2023-09-01 |
Univ Duke |
Preparations and methods for improving specificity in genomic engineering using RNA-guided endonucleases
|
US9512446B1
(en)
|
2015-08-28 |
2016-12-06 |
The General Hospital Corporation |
Engineered CRISPR-Cas9 nucleases
|
US9926546B2
(en)
|
2015-08-28 |
2018-03-27 |
The General Hospital Corporation |
Engineered CRISPR-Cas9 nucleases
|
EP3341477B1
(en)
|
2015-08-28 |
2022-03-23 |
The General Hospital Corporation |
Engineered crispr-cas9 nucleases
|
CN108271384B
(zh)
|
2015-09-09 |
2022-04-15 |
国立大学法人神户大学 |
用于特异性转变靶向dna序列的核酸碱基的革兰氏阳性菌的基因组序列的转变方法、及其使用的分子复合体
|
IL241462A0
(en)
|
2015-09-10 |
2015-11-30 |
Yeda Res & Dev |
Heterologous engineering of betalain pigments in plants
|
EP3347467B1
(en)
|
2015-09-11 |
2021-06-23 |
The General Hospital Corporation |
Full interrogation of nuclease dsbs and sequencing (find-seq)
|
WO2017053879A1
(en)
|
2015-09-24 |
2017-03-30 |
Editas Medicine, Inc. |
Use of exonucleases to improve crispr/cas-mediated genome editing
|
AU2016331185A1
(en)
|
2015-09-30 |
2018-04-26 |
The General Hospital Corporation |
Comprehensive in vitro reporting of cleavage events by sequencing (CIRCLE-seq)
|
EP3359664A4
(en)
|
2015-10-05 |
2019-03-20 |
Massachusetts Institute Of Technology |
NITROGEN FIXATION WITH REINFORCED NIF CLUSTERS
|
US20190255107A1
(en)
|
2015-10-09 |
2019-08-22 |
The Brigham And Women's Hospital, Inc. |
Modulation of novel immune checkpoint targets
|
EP3362560B1
(en)
|
2015-10-12 |
2022-08-10 |
DuPont US Holding, LLC |
Protected dna templates for gene modification and increased homologous recombination in cells and methods of use
|
EP3362571A4
(en)
|
2015-10-13 |
2019-07-10 |
Duke University |
GENOMIC ENGINEERING WITH TYPE I CRISPRISMS IN EUKARYOTIC CELLS
|
CA3001518A1
(en)
|
2015-10-16 |
2017-04-20 |
Astrazeneca Ab |
Inducible modification of a cell genome
|
US20180273960A1
(en)
|
2015-10-20 |
2018-09-27 |
Pioneer Hi-Bred International, Inc. |
Methods and compositions for marker-free genome modification
|
WO2017068077A1
(en)
|
2015-10-20 |
2017-04-27 |
Institut National De La Sante Et De La Recherche Medicale (Inserm) |
Methods and products for genetic engineering
|
EP3365441A1
(en)
|
2015-10-22 |
2018-08-29 |
The Broad Institute Inc. |
Type vi-b crispr enzymes and systems
|
ES2699848T3
(es)
|
2015-10-23 |
2019-02-13 |
Caribou Biosciences Inc |
Acido nucleico CRISPR clase 2 de tipo cruzado modificado que se dirige a ácidos nucleicos
|
IL294014B2
(en)
|
2015-10-23 |
2024-07-01 |
Harvard College |
Nucleobase editors and their uses
|
EP3368687B1
(en)
|
2015-10-27 |
2021-09-29 |
The Broad Institute, Inc. |
Compositions and methods for targeting cancer-specific sequence variations
|
WO2017075465A1
(en)
|
2015-10-28 |
2017-05-04 |
The Broad Institute Inc. |
Compositions and methods for evaluating and modulating immune responses by detecting and targeting gata3
|
US11092607B2
(en)
|
2015-10-28 |
2021-08-17 |
The Board Institute, Inc. |
Multiplex analysis of single cell constituents
|
WO2017075478A2
(en)
|
2015-10-28 |
2017-05-04 |
The Broad Institute Inc. |
Compositions and methods for evaluating and modulating immune responses by use of immune cell gene signatures
|
WO2017075451A1
(en)
|
2015-10-28 |
2017-05-04 |
The Broad Institute Inc. |
Compositions and methods for evaluating and modulating immune responses by detecting and targeting pou2af1
|
WO2017075294A1
(en)
|
2015-10-28 |
2017-05-04 |
The Board Institute Inc. |
Assays for massively combinatorial perturbation profiling and cellular circuit reconstruction
|
WO2017079406A1
(en)
|
2015-11-03 |
2017-05-11 |
President And Fellows Of Harvard College |
Method and apparatus for volumetric imaging of a three-dimensional nucleic acid containing matrix
|
AU2016349738A1
(en)
*
|
2015-11-06 |
2018-05-24 |
The Jackson Laboratory |
Large genomic DNA knock-in and uses thereof
|
WO2017083368A1
(en)
*
|
2015-11-12 |
2017-05-18 |
Pfizer Inc. |
Tissue-specific genome engineering using crispr-cas9
|
US11306308B2
(en)
|
2015-11-13 |
2022-04-19 |
Massachusetts Institute Of Technology |
High-throughput CRISPR-based library screening
|
EP3374502B1
(en)
|
2015-11-13 |
2021-10-27 |
Avellino Lab USA, Inc. |
Methods for the treatment of corneal dystrophies
|
CA3005633C
(en)
|
2015-11-16 |
2023-11-21 |
Research Institute Of Nationwide Children's Hospital |
Materials and methods for treatment of titin-based myopathies and other titinopathies
|
US11001622B2
(en)
|
2015-11-19 |
2021-05-11 |
The Brigham And Women's Hospital, Inc. |
Method of treating autoimmune disease with lymphocyte antigen CD5-like (CD5L) protein
|
KR102061438B1
(ko)
*
|
2015-11-27 |
2019-12-31 |
고쿠리츠다이가쿠호진 고베다이가쿠 |
표적화 dna 서열 중의 핵산 염기가 특이적으로 전환되어 있는 단자엽식물 게놈 서열을 전환시키는 방법, 및 그것에 사용되는 분자 복합체
|
US11903974B2
(en)
|
2015-11-30 |
2024-02-20 |
Flagship Pioneering Innovations V, Inc. |
Methods and compositions relating to chondrisomes from cultured cells
|
CN105296518A
(zh)
*
|
2015-12-01 |
2016-02-03 |
中国农业大学 |
一种用于CRISPR/Cas9技术的同源臂载体构建方法
|
EP3564371B1
(en)
|
2015-12-04 |
2020-05-27 |
Caribou Biosciences, Inc. |
Engineered nucleic-acid targeting nucleic acids
|
US11208649B2
(en)
|
2015-12-07 |
2021-12-28 |
Zymergen Inc. |
HTP genomic engineering platform
|
BR112018011503A2
(pt)
|
2015-12-07 |
2018-12-04 |
Zymergen Inc |
promotores da corynebacterium glutamicum
|
US9988624B2
(en)
|
2015-12-07 |
2018-06-05 |
Zymergen Inc. |
Microbial strain improvement by a HTP genomic engineering platform
|
US20180362961A1
(en)
|
2015-12-11 |
2018-12-20 |
Danisco Us Inc. |
Methods and compositions for enhanced nuclease-mediated genome modification and reduced off-target site effects
|
EP3390631B1
(en)
|
2015-12-18 |
2020-04-08 |
Danisco US Inc. |
Methods and compositions for t-rna based guide rna expression
|
WO2017112620A1
(en)
|
2015-12-22 |
2017-06-29 |
North Carolina State University |
Methods and compositions for delivery of crispr based antimicrobials
|
CA3009709A1
(en)
|
2015-12-30 |
2017-07-06 |
Novartis Ag |
Immune effector cell therapies with enhanced efficacy
|
AU2017207284B2
(en)
|
2016-01-11 |
2023-01-05 |
The Board Of Trustees Of The Leland Stanford Junior University |
Chimeric proteins and methods of regulating gene expression
|
SG10202112024PA
(en)
|
2016-01-11 |
2021-12-30 |
Univ Leland Stanford Junior |
Chimeric proteins and methods of immunotherapy
|
WO2017132239A1
(en)
|
2016-01-26 |
2017-08-03 |
Pioneer Hi-Bred International, Inc. |
Waxy corn
|
WO2017139309A1
(en)
|
2016-02-12 |
2017-08-17 |
Ceres, Inc. |
Methods and materials for high throughput testing of mutagenized allele combinations
|
EP3881857A1
(en)
|
2016-02-18 |
2021-09-22 |
The Penn State Research Foundation |
Generating gabaergic neurons in brains
|
EP3417061B1
(en)
|
2016-02-18 |
2022-10-26 |
The Regents of the University of California |
Methods and compositions for gene editing in stem cells
|
US20190144942A1
(en)
|
2016-02-22 |
2019-05-16 |
Massachusetts Institute Of Technology |
Methods for identifying and modulating immune phenotypes
|
US10538750B2
(en)
|
2016-02-29 |
2020-01-21 |
Agilent Technologies, Inc. |
Methods and compositions for blocking off-target nucleic acids from cleavage by CRISPR proteins
|
EP3423083A4
(en)
|
2016-03-04 |
2019-10-02 |
Indoor Biotechnologies Inc. |
FEL D 1 INACTIVATIONS AND RELATED COMPOSITIONS AND METHODS BASED ON GENOMIC EDITION OF CRISPR-CAS9
|
WO2017155717A1
(en)
|
2016-03-11 |
2017-09-14 |
Pioneer Hi-Bred International, Inc. |
Novel cas9 systems and methods of use
|
EP3699281A1
(en)
|
2016-03-11 |
2020-08-26 |
Pioneer Hi-Bred International, Inc. |
Novel cas9 systems and methods of use
|
WO2017155715A1
(en)
|
2016-03-11 |
2017-09-14 |
Pioneer Hi-Bred International, Inc. |
Novel cas9 systems and methods of use
|
CN109414414A
(zh)
|
2016-03-16 |
2019-03-01 |
戴维·格拉德斯通研究所 |
用于治疗肥胖症和/或糖尿病以及用于鉴定候选治疗剂的方法和组合物
|
US11427861B2
(en)
|
2016-03-17 |
2022-08-30 |
Massachusetts Institute Of Technology |
Methods for identifying and modulating co-occurant cellular phenotypes
|
EP3219799A1
(en)
|
2016-03-17 |
2017-09-20 |
IMBA-Institut für Molekulare Biotechnologie GmbH |
Conditional crispr sgrna expression
|
AU2017238512B2
(en)
|
2016-03-23 |
2022-12-08 |
Dana-Farber Cancer Institute, Inc. |
Methods for enhancing the efficiency of gene editing
|
EP3433363A1
(en)
|
2016-03-25 |
2019-01-30 |
Editas Medicine, Inc. |
Genome editing systems comprising repair-modulating enzyme molecules and methods of their use
|
EP3433364A1
(en)
|
2016-03-25 |
2019-01-30 |
Editas Medicine, Inc. |
Systems and methods for treating alpha 1-antitrypsin (a1at) deficiency
|
EP3443086B1
(en)
|
2016-04-13 |
2021-11-24 |
Editas Medicine, Inc. |
Cas9 fusion molecules, gene editing systems, and methods of use thereof
|
IL312206A
(en)
|
2016-04-15 |
2024-06-01 |
Novartis Ag |
Preparations and methods for selective protein expression
|
US11286478B2
(en)
|
2016-04-19 |
2022-03-29 |
The Broad Institute, Inc. |
Cpf1 complexes with reduced indel activity
|
CN109641063B
(zh)
|
2016-04-20 |
2022-11-15 |
能源环境和技术研究中心O.A., M.P. |
用于增强pklr的基因表达的组合物和方法
|
CN105861485B
(zh)
*
|
2016-04-20 |
2021-08-17 |
上海伊丽萨生物科技有限公司 |
一种提高基因置换效率的方法
|
WO2017189525A1
(en)
|
2016-04-25 |
2017-11-02 |
President And Fellows Of Harvard College |
Hybridization chain reaction methods for in situ molecular detection
|
US20190203207A1
(en)
*
|
2016-05-20 |
2019-07-04 |
The Trustees Of Columbia University In The City Of New York |
Anabolic Enhancers for Ameliorating Neurodegeneration
|
WO2017205503A1
(en)
|
2016-05-24 |
2017-11-30 |
Indiana University Research And Technology Corporation |
Ku inhibitors and their use
|
GB201609811D0
(en)
|
2016-06-05 |
2016-07-20 |
Snipr Technologies Ltd |
Methods, cells, systems, arrays, RNA and kits
|
US10767175B2
(en)
|
2016-06-08 |
2020-09-08 |
Agilent Technologies, Inc. |
High specificity genome editing using chemically modified guide RNAs
|
AU2017283713B2
(en)
|
2016-06-17 |
2021-04-08 |
Massachusetts Institute Of Technology |
Type VI CRISPR orthologs and systems
|
WO2017223128A1
(en)
|
2016-06-21 |
2017-12-28 |
The Curators Of The University Of Missouri |
Modified dystrophin proteins
|
ES2915562T3
(es)
|
2016-06-24 |
2022-06-23 |
Univ Colorado Regents |
Métodos para generar bibliotecas combinatorias con código de barras
|
EP3474849A4
(en)
|
2016-06-27 |
2020-07-29 |
The Broad Institute, Inc. |
COMPOSITIONS AND METHODS FOR DETECTION AND TREATMENT OF DIABETES
|
WO2018005655A2
(en)
|
2016-06-30 |
2018-01-04 |
Zymergen Inc. |
Methods for generating a bacterial hemoglobin library and uses thereof
|
EP3478845A4
(en)
|
2016-06-30 |
2019-07-31 |
Zymergen, Inc. |
METHODS OF PRODUCING A GLUCOSE PERMEASE BANK AND USES THEREOF
|
US20180004537A1
(en)
|
2016-07-01 |
2018-01-04 |
Microsoft Technology Licensing, Llc |
Molecular State Machines
|
US11359234B2
(en)
*
|
2016-07-01 |
2022-06-14 |
Microsoft Technology Licensing, Llc |
Barcoding sequences for identification of gene expression
|
MA45670A
(fr)
|
2016-07-13 |
2019-05-22 |
Vertex Pharma |
Procédés, compositions et kits pour augmenter l'efficacité d'édition du génome
|
AU2017295886C1
(en)
|
2016-07-15 |
2024-05-16 |
Novartis Ag |
Treatment and prevention of cytokine release syndrome using a chimeric antigen receptor in combination with a kinase inhibitor
|
BR112019001887A2
(pt)
|
2016-08-02 |
2019-07-09 |
Editas Medicine Inc |
composições e métodos para o tratamento de doença associada a cep290
|
AU2017306676B2
(en)
|
2016-08-03 |
2024-02-22 |
President And Fellows Of Harvard College |
Adenosine nucleobase editors and uses thereof
|
US11078481B1
(en)
|
2016-08-03 |
2021-08-03 |
KSQ Therapeutics, Inc. |
Methods for screening for cancer targets
|
EP3497214B1
(en)
|
2016-08-09 |
2023-06-28 |
President and Fellows of Harvard College |
Programmable cas9-recombinase fusion proteins and uses thereof
|
RU2022103870A
(ru)
*
|
2016-08-12 |
2022-03-04 |
Тулджен Инкорпорейтед |
Модифицированный иммунорегуляторный элемент и изменение иммунитета посредством этого элемента
|
KR20180018457A
(ko)
*
|
2016-08-12 |
2018-02-21 |
주식회사 툴젠 |
조작된 면역조절요소 및 이에 의해 변형된 면역 활성
|
EP3500967A1
(en)
|
2016-08-17 |
2019-06-26 |
The Broad Institute, Inc. |
Methods for identifying class 2 crispr-cas systems
|
CN110114461A
(zh)
|
2016-08-17 |
2019-08-09 |
博德研究所 |
新型crispr酶和***
|
WO2018035364A1
(en)
|
2016-08-17 |
2018-02-22 |
The Broad Institute Inc. |
Product and methods useful for modulating and evaluating immune responses
|
KR102594051B1
(ko)
*
|
2016-08-20 |
2023-10-26 |
아벨리노 랩 유에스에이, 인크. |
단일 가이드 RNA, CRISPR/Cas9 시스템, 및 이의 사용방법
|
WO2020225754A1
(en)
|
2019-05-06 |
2020-11-12 |
Mcmullen Tara |
Crispr gene editing for autosomal dominant diseases
|
WO2018039438A1
(en)
|
2016-08-24 |
2018-03-01 |
President And Fellows Of Harvard College |
Incorporation of unnatural amino acids into proteins using base editing
|
US11078483B1
(en)
|
2016-09-02 |
2021-08-03 |
KSQ Therapeutics, Inc. |
Methods for measuring and improving CRISPR reagent function
|
JP7256739B2
(ja)
|
2016-09-07 |
2023-04-12 |
サンガモ セラピューティクス, インコーポレイテッド |
肝臓遺伝子のモジュレーション
|
WO2018049025A2
(en)
|
2016-09-07 |
2018-03-15 |
The Broad Institute Inc. |
Compositions and methods for evaluating and modulating immune responses
|
IL247752A0
(en)
|
2016-09-11 |
2016-11-30 |
Yeda Res & Dev |
Compositions and methods for modulating gene expression for site-directed mutagenesis
|
US20190225974A1
(en)
|
2016-09-23 |
2019-07-25 |
BASF Agricultural Solutions Seed US LLC |
Targeted genome optimization in plants
|
CN109844126A
(zh)
|
2016-09-28 |
2019-06-04 |
诺华股份有限公司 |
基于多孔膜的大分子递送***
|
BR112019006384A2
(pt)
|
2016-09-30 |
2019-06-25 |
Univ California |
enzimas modificadoras de ácido nucleico guiadas por rna e métodos de uso das mesmas
|
EP3518981A4
(en)
|
2016-10-03 |
2020-06-10 |
President and Fellows of Harvard College |
DELIVERING THERAPEUTIC RNAS VIA ARRDC1-MEDIATED MICROVESICLES
|
US10669539B2
(en)
|
2016-10-06 |
2020-06-02 |
Pioneer Biolabs, Llc |
Methods and compositions for generating CRISPR guide RNA libraries
|
US20200016202A1
(en)
|
2016-10-07 |
2020-01-16 |
The Brigham And Women's Hospital, Inc. |
Modulation of novel immune checkpoint targets
|
EP3525578A1
(en)
|
2016-10-13 |
2019-08-21 |
Pioneer Hi-Bred International, Inc. |
Generating northern leaf blight resistant maize
|
JP2019530464A
(ja)
|
2016-10-14 |
2019-10-24 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
核酸塩基エディターのaav送達
|
GB201617559D0
(en)
|
2016-10-17 |
2016-11-30 |
University Court Of The University Of Edinburgh The |
Swine comprising modified cd163 and associated methods
|
GB2573406B
(en)
|
2016-10-18 |
2021-11-10 |
Univ Minnesota |
Tumor infiltrating lymphocytes and methods of therapy
|
JP7157052B2
(ja)
*
|
2016-10-28 |
2022-10-19 |
ジェネトン |
筋緊張性ジストロフィーの治療のための組成物および方法
|
WO2018081531A2
(en)
|
2016-10-28 |
2018-05-03 |
Ariad Pharmaceuticals, Inc. |
Methods for human t-cell activation
|
WO2018076335A1
(en)
|
2016-10-31 |
2018-05-03 |
Institute Of Genetics And Developmental Biology, Chinese Academy Of Sciences |
Compositions and methods for enhancing abiotic stress tolerance
|
WO2018083606A1
(en)
|
2016-11-01 |
2018-05-11 |
Novartis Ag |
Methods and compositions for enhancing gene editing
|
CA3042259A1
(en)
|
2016-11-04 |
2018-05-11 |
Flagship Pioneering Innovations V. Inc. |
Novel plant cells, plants, and seeds
|
EP3541955A1
(en)
|
2016-11-15 |
2019-09-25 |
Genomic Vision |
Method for the monitoring of modified nucleases induced-gene editing events by molecular combing
|
WO2018100431A1
(en)
|
2016-11-29 |
2018-06-07 |
Genomic Vision |
Method for designing a set of polynucleotide sequences for analysis of specific events in a genetic region of interest
|
US9816093B1
(en)
|
2016-12-06 |
2017-11-14 |
Caribou Biosciences, Inc. |
Engineered nucleic acid-targeting nucleic acids
|
US11180535B1
(en)
|
2016-12-07 |
2021-11-23 |
David Gordon Bermudes |
Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
|
US11129906B1
(en)
|
2016-12-07 |
2021-09-28 |
David Gordon Bermudes |
Chimeric protein toxins for expression by therapeutic bacteria
|
US10975388B2
(en)
|
2016-12-14 |
2021-04-13 |
Ligandal, Inc. |
Methods and compositions for nucleic acid and protein payload delivery
|
US10745677B2
(en)
|
2016-12-23 |
2020-08-18 |
President And Fellows Of Harvard College |
Editing of CCR5 receptor gene to protect against HIV infection
|
US20190330658A1
(en)
|
2017-01-05 |
2019-10-31 |
Rutgers, The State University |
Targeted gene editing platform independent of dna double strand break and uses thereof
|
EP3346001A1
(en)
|
2017-01-06 |
2018-07-11 |
TXCell |
Monospecific regulatory t cell population with cytotoxicity for b cells
|
WO2018127585A1
(en)
|
2017-01-06 |
2018-07-12 |
Txcell |
Monospecific regulatory t cell population with cytotoxicity for b cells
|
WO2018129440A1
(en)
|
2017-01-09 |
2018-07-12 |
University Of Massachusetts |
Complexes for gene deletion and editing
|
MX2019008285A
(es)
|
2017-01-12 |
2019-11-11 |
Pivot Bio Inc |
Métodos y composiciones para mejorar atributos de plantas.
|
EP3574005B1
(en)
|
2017-01-26 |
2021-12-15 |
Novartis AG |
Cd28 compositions and methods for chimeric antigen receptor therapy
|
US11624071B2
(en)
|
2017-01-28 |
2023-04-11 |
Inari Agriculture Technology, Inc. |
Method of creating a plurality of targeted insertions in a plant cell
|
EP3577134A1
(en)
|
2017-01-31 |
2019-12-11 |
Novartis AG |
Treatment of cancer using chimeric t cell receptor proteins having multiple specificities
|
TW201839136A
(zh)
|
2017-02-06 |
2018-11-01 |
瑞士商諾華公司 |
治療血色素異常症之組合物及方法
|
KR20190116282A
(ko)
|
2017-02-10 |
2019-10-14 |
지머젠 인코포레이티드 |
복수의 숙주를 위한 다중 dna 구조체의 조립 및 편집을 위한 모듈식 범용 플라스미드 디자인 전략
|
AU2018225180A1
(en)
*
|
2017-02-22 |
2019-09-19 |
Io Biosciences, Inc. |
Nucleic acid constructs comprising gene editing multi-sites and uses thereof
|
US10828330B2
(en)
|
2017-02-22 |
2020-11-10 |
IO Bioscience, Inc. |
Nucleic acid constructs comprising gene editing multi-sites and uses thereof
|
WO2018160731A1
(en)
|
2017-02-28 |
2018-09-07 |
Novartis Ag |
Shp inhibitor compositions and uses for chimeric antigen receptor therapy
|
US11898179B2
(en)
|
2017-03-09 |
2024-02-13 |
President And Fellows Of Harvard College |
Suppression of pain by gene editing
|
US11542496B2
(en)
|
2017-03-10 |
2023-01-03 |
President And Fellows Of Harvard College |
Cytosine to guanine base editor
|
EP3596217A1
(en)
|
2017-03-14 |
2020-01-22 |
Editas Medicine, Inc. |
Systems and methods for the treatment of hemoglobinopathies
|
CN110959039A
(zh)
|
2017-03-15 |
2020-04-03 |
博德研究所 |
新型cas13b直向同源物crispr酶和***
|
WO2018170436A1
(en)
|
2017-03-16 |
2018-09-20 |
Jacobs Farm Del Cabo |
Basil with high tolerance to downy mildew
|
US20200115753A1
(en)
|
2017-03-17 |
2020-04-16 |
Massachusetts Institute Of Technology |
Methods for identifying and modulating co-occurant cellular phenotypes
|
WO2018176009A1
(en)
|
2017-03-23 |
2018-09-27 |
President And Fellows Of Harvard College |
Nucleobase editors comprising nucleic acid programmable dna binding proteins
|
US11963966B2
(en)
|
2017-03-31 |
2024-04-23 |
Dana-Farber Cancer Institute, Inc. |
Compositions and methods for treating ovarian tumors
|
CN110709519B
(zh)
|
2017-03-31 |
2023-09-15 |
先锋国际良种公司 |
表达调控元件及其用途
|
EP3606518A4
(en)
|
2017-04-01 |
2021-04-07 |
The Broad Institute, Inc. |
METHODS AND COMPOSITIONS FOR DETECTION AND MODULATION OF IMMUNOTHERAPY RESISTANCE GENE SIGNATURE IN CANCER
|
AU2018251801A1
(en)
|
2017-04-12 |
2019-11-07 |
Massachusetts Institute Of Technology |
Novel type VI crispr orthologs and systems
|
EP3610266A4
(en)
|
2017-04-12 |
2021-04-21 |
Massachusetts Eye and Ear Infirmary |
TUMOR SIGNATURE OF METASTASIS, COMPOSITIONS OF SUBSTANCES AND USES THEREOF
|
US20210115407A1
(en)
|
2017-04-12 |
2021-04-22 |
The Broad Institute, Inc. |
Respiratory and sweat gland ionocytes
|
US20200405639A1
(en)
|
2017-04-14 |
2020-12-31 |
The Broad Institute, Inc. |
Novel delivery of large payloads
|
MX2019012398A
(es)
|
2017-04-18 |
2020-09-25 |
Broad Inst Inc |
Composiciones para detectar secreciones y metodos de uso.
|
US11834670B2
(en)
|
2017-04-19 |
2023-12-05 |
Global Life Sciences Solutions Usa Llc |
Site-specific DNA modification using a donor DNA repair template having tandem repeat sequences
|
AU2018254619B2
(en)
|
2017-04-21 |
2022-07-21 |
The General Hospital Corporation |
Variants of Cpf1 (CAS12a) with altered PAM specificity
|
WO2018195486A1
(en)
|
2017-04-21 |
2018-10-25 |
The Broad Institute, Inc. |
Targeted delivery to beta cells
|
WO2018201056A1
(en)
|
2017-04-28 |
2018-11-01 |
Novartis Ag |
Cells expressing a bcma-targeting chimeric antigen receptor, and combination therapy with a gamma secretase inhibitor
|
WO2018201086A1
(en)
|
2017-04-28 |
2018-11-01 |
Editas Medicine, Inc. |
Methods and systems for analyzing guide rna molecules
|
EP3615068A1
(en)
|
2017-04-28 |
2020-03-04 |
Novartis AG |
Bcma-targeting agent, and combination therapy with a gamma secretase inhibitor
|
US11591601B2
(en)
|
2017-05-05 |
2023-02-28 |
The Broad Institute, Inc. |
Methods for identification and modification of lncRNA associated with target genotypes and phenotypes
|
WO2018209158A2
(en)
|
2017-05-10 |
2018-11-15 |
Editas Medicine, Inc. |
Crispr/rna-guided nuclease systems and methods
|
US11560566B2
(en)
|
2017-05-12 |
2023-01-24 |
President And Fellows Of Harvard College |
Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation
|
WO2018213708A1
(en)
|
2017-05-18 |
2018-11-22 |
The Broad Institute, Inc. |
Systems, methods, and compositions for targeted nucleic acid editing
|
AU2018273968A1
(en)
|
2017-05-25 |
2019-11-28 |
The General Hospital Corporation |
Using split deaminases to limit unwanted off-target base editor deamination
|
EP3409104A1
(en)
|
2017-05-31 |
2018-12-05 |
Vilmorin et Cie |
Tomato plant resistant to tomato yellow leaf curl virus, powdery mildew, and nematodes
|
EP3409106A1
(en)
|
2017-06-01 |
2018-12-05 |
Vilmorin et Cie |
Tolerance in plants of solanum lycopersicum to the tobamovirus tomato brown rugose fruit virus (tbrfv)
|
WO2020249996A1
(en)
|
2019-06-14 |
2020-12-17 |
Vilmorin & Cie |
Resistance in plants of solanum lycopersicum to the tobamovirus tomato brown rugose fruit virus
|
US20200157570A1
(en)
|
2017-06-05 |
2020-05-21 |
Research Institute At Nationwide Children's Hospital |
Enhanced modified viral capsid proteins
|
CA3102054A1
(en)
|
2017-06-05 |
2018-12-13 |
Fred Hutchinson Cancer Research Center |
Genomic safe harbors for genetic therapies in human stem cells and engineered nanoparticles to provide targeted genetic therapies
|
ES2875579T3
(es)
|
2017-06-06 |
2021-11-10 |
Zymergen Inc |
Plataforma de ingeniería genómica de HTP para mejorar Escherichia coli
|
EP3635112A2
(en)
|
2017-06-06 |
2020-04-15 |
Zymergen, Inc. |
A htp genomic engineering platform for improving fungal strains
|
CN117778466A
(zh)
*
|
2017-06-08 |
2024-03-29 |
国立大学法人大阪大学 |
Dna经编辑的真核细胞制造方法和用于该方法的试剂盒
|
AU2018279829B2
(en)
|
2017-06-09 |
2024-01-04 |
Editas Medicine, Inc. |
Engineered Cas9 nucleases
|
MA52134A
(fr)
|
2017-06-09 |
2020-04-15 |
Vilmorin & Cie |
Compositions et procédés pour l'édition génomique
|
JP2020524993A
(ja)
|
2017-06-13 |
2020-08-27 |
フラッグシップ パイオニアリング イノベーションズ ブイ, インコーポレイテッド |
クロンを含む組成物及びその使用
|
US11897953B2
(en)
|
2017-06-14 |
2024-02-13 |
The Broad Institute, Inc. |
Compositions and methods targeting complement component 3 for inhibiting tumor growth
|
CN111344020A
(zh)
|
2017-06-15 |
2020-06-26 |
加利福尼亚大学董事会 |
靶向非病毒dna***
|
US10011849B1
(en)
|
2017-06-23 |
2018-07-03 |
Inscripta, Inc. |
Nucleic acid-guided nucleases
|
US9982279B1
(en)
|
2017-06-23 |
2018-05-29 |
Inscripta, Inc. |
Nucleic acid-guided nucleases
|
JP7454494B2
(ja)
|
2017-06-26 |
2024-03-22 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
標的化された核酸編集のためのcrispr/cas-アデニンデアミナーゼ系の組成物、系及び方法
|
WO2019003193A1
(en)
|
2017-06-30 |
2019-01-03 |
Novartis Ag |
METHODS FOR TREATING DISEASES USING GENE EDITING SYSTEMS
|
US11168322B2
(en)
|
2017-06-30 |
2021-11-09 |
Arbor Biotechnologies, Inc. |
CRISPR RNA targeting enzymes and systems and uses thereof
|
WO2019006418A2
(en)
|
2017-06-30 |
2019-01-03 |
Intima Bioscience, Inc. |
ADENO-ASSOCIATED VIRAL VECTORS FOR GENE THERAPY
|
WO2019014564A1
(en)
|
2017-07-14 |
2019-01-17 |
Editas Medicine, Inc. |
SYSTEMS AND METHODS OF TARGETED INTEGRATION AND GENOME EDITING AND DETECTION THEREOF WITH INTEGRATED PRIMING SITES
|
US10510743B2
(en)
*
|
2017-07-18 |
2019-12-17 |
Hong Kong Applied Science and Technology Research Institute Company, Limited |
Step fin field-effect-transistor (FinFET) with slim top of fin and thick bottom of fin for electro-static-discharge (ESD) or electrical over-stress (EOS) protection
|
CA3067124A1
(en)
*
|
2017-07-18 |
2019-01-24 |
Genovie Ab |
A two-component vector library system for rapid assembly and diversification of full-length t-cell receptor open reading frames
|
WO2019023291A2
(en)
|
2017-07-25 |
2019-01-31 |
Dana-Farber Cancer Institute, Inc. |
COMPOSITIONS AND METHODS FOR PRODUCTION AND DECODING OF GUIDE RNA LIBRARIES AND USES THEREOF
|
EP3658573A1
(en)
|
2017-07-28 |
2020-06-03 |
President and Fellows of Harvard College |
Methods and compositions for evolving base editors using phage-assisted continuous evolution (pace)
|
US11384383B2
(en)
|
2017-08-08 |
2022-07-12 |
Depixus |
In vitro isolation and enrichment of nucleic acids using site-specific nucleases
|
US10476825B2
(en)
|
2017-08-22 |
2019-11-12 |
Salk Institue for Biological Studies |
RNA targeting methods and compositions
|
US11970720B2
(en)
|
2017-08-22 |
2024-04-30 |
Salk Institute For Biological Studies |
RNA targeting methods and compositions
|
WO2019040650A1
(en)
|
2017-08-23 |
2019-02-28 |
The General Hospital Corporation |
GENETICALLY MODIFIED CRISPR-CAS9 NUCLEASES HAVING MODIFIED PAM SPECIFICITY
|
SG11202001008RA
(en)
*
|
2017-08-25 |
2020-03-30 |
Codiak Biosciences Inc |
Preparation of therapeutic exosomes using membrane proteins
|
WO2019139645A2
(en)
|
2017-08-30 |
2019-07-18 |
President And Fellows Of Harvard College |
High efficiency base editors comprising gam
|
AR113064A1
(es)
|
2017-09-15 |
2020-01-22 |
Covercress Inc |
Composición que comprende harina de carraspique con bajo contenido de fibras y métodos para su elaboración
|
JP7317023B2
(ja)
|
2017-09-20 |
2023-07-28 |
ザ・ユニバーシティ・オブ・ブリティッシュ・コロンビア |
新規抗hla-a2抗体、およびその使用
|
CN109517820B
(zh)
|
2017-09-20 |
2021-09-24 |
北京宇繁生物科技有限公司 |
一种靶向HPK1的gRNA以及HPK1基因编辑方法
|
US11534471B2
(en)
|
2017-09-21 |
2022-12-27 |
Dana-Farber Cancer Institute, Inc. |
Isolation, preservation, compositions and uses of extracts from justicia plants
|
KR102338449B1
(ko)
|
2017-09-21 |
2021-12-10 |
더 브로드 인스티튜트, 인코퍼레이티드 |
표적화된 핵산 편집을 위한 시스템, 방법, 및 조성물
|
US11252928B2
(en)
|
2017-09-21 |
2022-02-22 |
The Condard-Pyle Company |
Miniature rose plant named ‘Meibenbino’
|
US11917978B2
(en)
|
2017-09-21 |
2024-03-05 |
The Conard Pyle Company |
Miniature rose plant named ‘meibenbino’
|
EP3692152A4
(en)
|
2017-10-04 |
2021-12-01 |
The Broad Institute, Inc. |
PROCESSES AND COMPOSITIONS FOR MODIFYING THE FUNCTION AND STRUCTURE OF CHROMATIN LOOPS AND / OR DOMAINS
|
EP3694993A4
(en)
|
2017-10-11 |
2021-10-13 |
The General Hospital Corporation |
METHOD OF DETECTING A SITE-SPECIFIC AND UNDESIRED GENOMIC DESAMINATION INDUCED BY BASE EDITING TECHNOLOGIES
|
WO2019079362A1
(en)
|
2017-10-16 |
2019-04-25 |
Massachusetts Institute Of Technology |
HOST-PATHOGENIC INTERACTION OF MYCOBACTERIUM TUBERCULOSIS
|
AU2018352583A1
(en)
|
2017-10-16 |
2020-04-09 |
Centro de Investigaciones Energeticas, Medioambientales Y Tecnologicas, O.A., M.P. |
Lentiviral vectors for delivery of PKLR to treat pyruvate kinase deficiency
|
AU2018352592A1
(en)
|
2017-10-16 |
2020-06-04 |
Beam Therapeutics, Inc. |
Uses of adenosine base editors
|
JP7383607B2
(ja)
|
2017-10-20 |
2023-11-20 |
フレッド ハッチンソン キャンサー センター |
選択された抗体を発現するように遺伝子改変されたb細胞を産生するシステム及び方法
|
MX2020004343A
(es)
|
2017-10-25 |
2021-01-08 |
Pivot Bio Inc |
Métodos y composiciones para mejorar microbios modificados que fijan nitrógeno.
|
KR102503130B1
(ko)
|
2017-10-27 |
2023-02-24 |
더 리전트 오브 더 유니버시티 오브 캘리포니아 |
내인성 t 세포 수용체의 표적화된 대체
|
US20210179709A1
(en)
|
2017-10-31 |
2021-06-17 |
Novartis Ag |
Anti-car compositions and methods
|
WO2019089803A1
(en)
|
2017-10-31 |
2019-05-09 |
The Broad Institute, Inc. |
Methods and compositions for studying cell evolution
|
US20210180053A1
(en)
|
2017-11-01 |
2021-06-17 |
Novartis Ag |
Synthetic rnas and methods of use
|
SG11202003863VA
(en)
|
2017-11-01 |
2020-05-28 |
Univ California |
Casz compositions and methods of use
|
WO2019090174A1
(en)
|
2017-11-02 |
2019-05-09 |
Arbor Biotechnologies, Inc. |
Novel crispr-associated transposon systems and components
|
US12018080B2
(en)
|
2017-11-13 |
2024-06-25 |
The Broad Institute, Inc. |
Methods and compositions for treating cancer by targeting the CLEC2D-KLRB1 pathway
|
AU2018368786A1
(en)
|
2017-11-17 |
2020-06-18 |
Iovance Biotherapeutics, Inc. |
TIL expansion from fine needle aspirates and small biopsies
|
EP3714041A1
(en)
|
2017-11-22 |
2020-09-30 |
Iovance Biotherapeutics, Inc. |
Expansion of peripheral blood lymphocytes (pbls) from peripheral blood
|
CN111433219A
(zh)
*
|
2017-12-05 |
2020-07-17 |
合成基因组股份有限公司 |
通过基因修饰信号传导蛋白提高藻类脂质生产力
|
US11332736B2
(en)
|
2017-12-07 |
2022-05-17 |
The Broad Institute, Inc. |
Methods and compositions for multiplexing single cell and single nuclei sequencing
|
US11124798B2
(en)
|
2017-12-08 |
2021-09-21 |
Synthetic Genomics, Inc. |
Algal lipid productivity via genetic modification of a TPR domain containing protein
|
EP3724216A1
(en)
|
2017-12-15 |
2020-10-21 |
Dana Farber Cancer Institute, Inc. |
Stabilized peptide-mediated targeted protein degradation
|
EP3707253A1
(en)
|
2017-12-15 |
2020-09-16 |
Danisco US Inc. |
Cas9 variants and methods of use
|
EA202091134A1
(ru)
|
2017-12-28 |
2020-11-20 |
Кодиак Байосайенсес, Инк. |
Экзосомы для иммуноонкологической и противовоспалительной терапии
|
WO2019133881A1
(en)
|
2017-12-29 |
2019-07-04 |
Rubius Therapeutics, Inc. |
Gene editing and targeted transcriptional modulation for enginerering erythroid cells
|
US11994512B2
(en)
|
2018-01-04 |
2024-05-28 |
Massachusetts Institute Of Technology |
Single-cell genomic methods to generate ex vivo cell systems that recapitulate in vivo biology with improved fidelity
|
EP3737690A1
(en)
|
2018-01-12 |
2020-11-18 |
Basf Se |
Gene underlying the number of spikelets per spike qtl in wheat on chromosome 7a
|
MA51616A
(fr)
|
2018-01-17 |
2020-11-25 |
Vertex Pharma |
Inhibiteurs d'adn-pk
|
CA3088791A1
(en)
|
2018-01-17 |
2019-07-25 |
Vertex Pharmaceuticals Incorporated |
Quinoxalinone compounds, compositions, methods, and kits for increasing genome editing efficiency
|
US12005127B2
(en)
|
2018-01-17 |
2024-06-11 |
Vertex Pharmaceuticals Incorporated |
DNA-PK inhibitors
|
US20190233816A1
(en)
|
2018-01-26 |
2019-08-01 |
Massachusetts Institute Of Technology |
Structure-guided chemical modification of guide rna and its applications
|
US11926835B1
(en)
|
2018-01-29 |
2024-03-12 |
Inari Agriculture Technology, Inc. |
Methods for efficient tomato genome editing
|
KR102136132B1
(ko)
*
|
2018-01-31 |
2020-07-22 |
서울대학교 산학협력단 |
CRISPR/Cas9 시스템을 통한 닭 백혈병 바이러스(Avian Leukosis Virus, ALV) 저항성 조류의 제조방법
|
CA3087715A1
(en)
|
2018-02-08 |
2019-08-15 |
Zymergen Inc. |
Genome editing using crispr in corynebacterium
|
US10767193B2
(en)
*
|
2018-02-15 |
2020-09-08 |
Sigma-Aldrich Co. Llc |
Engineered CAS9 systems for eukaryotic genome modification
|
WO2019173125A1
(en)
|
2018-03-09 |
2019-09-12 |
Pioneer Hi-Bred International, Inc. |
Compositions and methods for modification of fatty acids in soybean
|
FI3765616T3
(fi)
|
2018-03-14 |
2023-08-29 |
Arbor Biotechnologies Inc |
Uusia CRISPR-DNA- ja RNA-kohdennusentsyymejä ja -järjestelmiä
|
KR20200132924A
(ko)
|
2018-03-14 |
2020-11-25 |
에디타스 메디신, 인코포레이티드 |
혈색소병증 치료를 위한 시스템 및 방법
|
DK3765615T3
(da)
|
2018-03-14 |
2023-08-21 |
Arbor Biotechnologies Inc |
Nye enzymer og systemer til målretning af crispr dna
|
US10760075B2
(en)
|
2018-04-30 |
2020-09-01 |
Snipr Biome Aps |
Treating and preventing microbial infections
|
EP3772928A4
(en)
|
2018-04-06 |
2021-12-29 |
Children's Medical Center Corporation |
Compositions and methods for somatic cell reprogramming and modulating imprinting
|
BR112020020919A2
(pt)
|
2018-04-13 |
2021-04-06 |
Sangamo Therapeutics France |
Receptor de antígeno quimérico específico para receptor de interleucina-23
|
WO2019204378A1
(en)
|
2018-04-17 |
2019-10-24 |
The General Hospital Corporation |
Sensitive in vitro assays for substrate preferences and sites of nucleic acid binding, modifying, and cleaving agents
|
WO2019204766A1
(en)
|
2018-04-19 |
2019-10-24 |
The Regents Of The University Of California |
Compositions and methods for gene editing
|
US20210071240A1
(en)
|
2018-04-19 |
2021-03-11 |
Massachusetts Institute Of Technology |
Single-stranded break detection in double-stranded dna
|
ES2922902T3
(es)
|
2018-04-24 |
2022-09-21 |
Kws Saat Se & Co Kgaa |
Plantas con digestibilidad mejorada y haplotipos marcadores
|
US11957695B2
(en)
|
2018-04-26 |
2024-04-16 |
The Broad Institute, Inc. |
Methods and compositions targeting glucocorticoid signaling for modulating immune responses
|
KR20210005932A
(ko)
|
2018-04-27 |
2021-01-15 |
진에딧 인코포레이티드 |
양이온성 폴리머 및 생분자 전달을 위한 이용
|
WO2019210131A1
(en)
|
2018-04-27 |
2019-10-31 |
Iovance Biotherapeutics, Inc. |
Closed process for expansion and gene editing of tumor infiltrating lymphocytes and uses of same in immunotherapy
|
EP3784351A1
(en)
|
2018-04-27 |
2021-03-03 |
Novartis AG |
Car t cell therapies with enhanced efficacy
|
US20210147831A1
(en)
|
2018-04-27 |
2021-05-20 |
The Broad Institute, Inc. |
Sequencing-based proteomics
|
US20210386829A1
(en)
|
2018-05-04 |
2021-12-16 |
The Broad Institute, Inc. |
Compositions and methods for modulating cgrp signaling to regulate innate lymphoid cell inflammatory responses
|
WO2019222555A1
(en)
|
2018-05-16 |
2019-11-21 |
Arbor Biotechnologies, Inc. |
Novel crispr-associated systems and components
|
EP3794130A4
(en)
|
2018-05-16 |
2022-07-27 |
Synthego Corporation |
METHODS AND SYSTEMS FOR DESIGN AND USE OF GUIDE RNA
|
CA3096859A1
(en)
|
2018-05-25 |
2019-11-28 |
Pioneer Hi-Bred International, Inc. |
Systems and methods for improved breeding by modulating recombination rates
|
CN108707628B
(zh)
*
|
2018-05-28 |
2021-11-23 |
上海海洋大学 |
斑马鱼notch2基因突变体的制备方法
|
WO2019232542A2
(en)
|
2018-06-01 |
2019-12-05 |
Massachusetts Institute Of Technology |
Methods and compositions for detecting and modulating microenvironment gene signatures from the csf of metastasis patients
|
US11866719B1
(en)
|
2018-06-04 |
2024-01-09 |
Inari Agriculture Technology, Inc. |
Heterologous integration of regulatory elements to alter gene expression in wheat cells and wheat plants
|
EP3578658A1
(en)
*
|
2018-06-08 |
2019-12-11 |
Johann Wolfgang Goethe-Universität Frankfurt |
Method for generating a gene editing vector with fixed guide rna pairs
|
US20220403001A1
(en)
|
2018-06-12 |
2022-12-22 |
Obsidian Therapeutics, Inc. |
Pde5 derived regulatory constructs and methods of use in immunotherapy
|
SG11202011830SA
(en)
|
2018-06-13 |
2020-12-30 |
Novartis Ag |
Bcma chimeric antigen receptors and uses thereof
|
US12036240B2
(en)
|
2018-06-14 |
2024-07-16 |
The Broad Institute, Inc. |
Compositions and methods targeting complement component 3 for inhibiting tumor growth
|
CA3102264A1
(en)
*
|
2018-06-19 |
2019-12-26 |
Lunella Biotech, Inc. |
"energetic" cancer stem cells (e-cscs): a new hyper-metabolic and proliferative tumor cell phenotype, driven by mitochondrial energy
|
MX2020013836A
(es)
|
2018-06-26 |
2021-05-27 |
Massachusetts Inst Technology |
Métodos, sistemas y diagnósticos de amplificación basados en el sistema efector crispr.
|
JP2021528975A
(ja)
|
2018-06-26 |
2021-10-28 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
Crispr/cas及びトランスポザーゼを利用した増幅用の組成物、システム、及び方法
|
MX2020013875A
(es)
|
2018-06-27 |
2021-08-11 |
Pivot Bio Inc |
Composiciones agricolas que comprenden microbios remodelados de fijacion de nitrogeno.
|
EP3814369A1
(en)
|
2018-06-29 |
2021-05-05 |
Stichting Het Nederlands Kanker Instituut- Antoni van Leeuwenhoek Ziekenhuis |
Tweak-receptor agonists for use in combination with immunotherapy of a cancer
|
WO2020014528A1
(en)
|
2018-07-13 |
2020-01-16 |
The Regents Of The University Of California |
Retrotransposon-based delivery vehicle and methods of use thereof
|
WO2020018142A1
(en)
|
2018-07-16 |
2020-01-23 |
Arbor Biotechnologies, Inc. |
Novel crispr dna targeting enzymes and systems
|
KR20210053898A
(ko)
|
2018-07-31 |
2021-05-12 |
더 브로드 인스티튜트, 인코퍼레이티드 |
신규 crispr 효소 및 시스템
|
WO2020028729A1
(en)
|
2018-08-01 |
2020-02-06 |
Mammoth Biosciences, Inc. |
Programmable nuclease compositions and methods of use thereof
|
AU2019318079A1
(en)
|
2018-08-07 |
2021-01-28 |
Massachusetts Institute Of Technology |
Novel Cas12b enzymes and systems
|
CN112888481A
(zh)
|
2018-08-10 |
2021-06-01 |
桑格摩生物治疗法国公司 |
包含tnfr2结构域的新型car构建体
|
EP3607819A1
(en)
|
2018-08-10 |
2020-02-12 |
Vilmorin et Cie |
Resistance to xanthomonas campestris pv. campestris (xcc) in cauliflower
|
KR20210044795A
(ko)
|
2018-08-15 |
2021-04-23 |
지머젠 인코포레이티드 |
고 처리량 대사 공학에서 CRISPRi의 응용
|
WO2020041387A1
(en)
|
2018-08-20 |
2020-02-27 |
The Brigham And Women's Hospital, Inc. |
Degradation domain modifications for spatio-temporal control of rna-guided nucleases
|
US20210317429A1
(en)
|
2018-08-20 |
2021-10-14 |
The Broad Institute, Inc. |
Methods and compositions for optochemical control of crispr-cas9
|
EP3841204A4
(en)
|
2018-08-23 |
2022-05-18 |
Sangamo Therapeutics, Inc. |
CHANGED TARGET SPECIFIC BASE EDITORS
|
US11459551B1
(en)
|
2018-08-31 |
2022-10-04 |
Inari Agriculture Technology, Inc. |
Compositions, systems, and methods for genome editing
|
EP3847650A1
(en)
|
2018-09-06 |
2021-07-14 |
The Broad Institute, Inc. |
Nucleic acid assemblies for use in targeted delivery
|
EP3849565A4
(en)
|
2018-09-12 |
2022-12-28 |
Fred Hutchinson Cancer Research Center |
REDUCING CD33 EXPRESSION FOR SELECTIVE PROTECTION OF THERAPEUTIC CELLS
|
WO2020061229A2
(en)
|
2018-09-18 |
2020-03-26 |
Vnv Newco Inc. |
Arc-based capsids and uses thereof
|
CN109265562B
(zh)
*
|
2018-09-26 |
2021-03-30 |
北京市农林科学院 |
一种切刻酶及其在基因组碱基替换中的应用
|
GB201815820D0
(en)
|
2018-09-28 |
2018-11-14 |
Univ Wageningen |
Off-target activity inhibitors for guided endonucleases
|
US10711267B2
(en)
|
2018-10-01 |
2020-07-14 |
North Carolina State University |
Recombinant type I CRISPR-Cas system
|
WO2020077236A1
(en)
|
2018-10-12 |
2020-04-16 |
The Broad Institute, Inc. |
Method for extracting nuclei or whole cells from formalin-fixed paraffin-embedded tissues
|
US11851663B2
(en)
|
2018-10-14 |
2023-12-26 |
Snipr Biome Aps |
Single-vector type I vectors
|
US20210379057A1
(en)
|
2018-10-16 |
2021-12-09 |
Massachusetts Institute Of Technology |
Nutlin-3a for use in treating a mycobacterium tuberculosis infection
|
WO2020086910A1
(en)
|
2018-10-24 |
2020-04-30 |
Genedit Inc. |
Cationic polymer with alkyl side chains and use for biomolecule delivery
|
WO2020086742A1
(en)
|
2018-10-24 |
2020-04-30 |
Obsidian Therapeutics, Inc. |
Er tunable protein regulation
|
US11407995B1
(en)
|
2018-10-26 |
2022-08-09 |
Inari Agriculture Technology, Inc. |
RNA-guided nucleases and DNA binding proteins
|
BR112021007994A2
(pt)
*
|
2018-10-29 |
2021-10-26 |
China Agricultural University |
Sistema e enzima crispr/cas12f
|
US11066663B2
(en)
|
2018-10-31 |
2021-07-20 |
Zymergen Inc. |
Multiplexed deterministic assembly of DNA libraries
|
EP3874049A1
(en)
|
2018-10-31 |
2021-09-08 |
Pioneer Hi-Bred International Inc. |
<smallcaps/>? ? ?ochrobactrum? ? ? ? ?compositions and methods for-mediated gene editing
|
US11970733B2
(en)
|
2018-11-01 |
2024-04-30 |
Synthego Corporation |
Methods for analyzing nucleic acid sequences
|
US11434477B1
(en)
|
2018-11-02 |
2022-09-06 |
Inari Agriculture Technology, Inc. |
RNA-guided nucleases and DNA binding proteins
|
KR20210091212A
(ko)
|
2018-11-05 |
2021-07-21 |
이오반스 바이오테라퓨틱스, 인크. |
항-pd-1 항체에 불응성인 nsclc 환자의 치료
|
MX2021004775A
(es)
|
2018-11-05 |
2021-06-08 |
Iovance Biotherapeutics Inc |
Expansion de linfocitos infiltrantes de tumores (tils) usando inhibidores de la via de proteina cinasa b (akt).
|
CA3118616A1
(en)
|
2018-11-05 |
2020-05-14 |
Iovance Biotherapeutics, Inc. |
Selection of improved tumor reactive t-cells
|
SG11202104615VA
(en)
|
2018-11-05 |
2021-06-29 |
Iovance Biotherapeutics Inc |
Processes for production of tumor infiltrating lymphocytes and uses of the same in immunotherapy
|
WO2020102659A1
(en)
|
2018-11-15 |
2020-05-22 |
The Broad Institute, Inc. |
G-to-t base editors and uses thereof
|
US11166996B2
(en)
|
2018-12-12 |
2021-11-09 |
Flagship Pioneering Innovations V, Inc. |
Anellovirus compositions and methods of use
|
AU2019398351A1
(en)
|
2018-12-14 |
2021-06-03 |
Pioneer Hi-Bred International, Inc. |
Novel CRISPR-Cas systems for genome editing
|
US20220062394A1
(en)
|
2018-12-17 |
2022-03-03 |
The Broad Institute, Inc. |
Methods for identifying neoantigens
|
WO2020131862A1
(en)
|
2018-12-17 |
2020-06-25 |
The Broad Institute, Inc. |
Crispr-associated transposase systems and methods of use thereof
|
WO2020128618A2
(en)
|
2018-12-18 |
2020-06-25 |
Braskem S.A. |
Co-production pathway for 3-hp and acetyl-coa derivatives from malonate semialdehyde
|
US20220193131A1
(en)
|
2018-12-19 |
2022-06-23 |
Iovance Biotherapeutics, Inc. |
Methods of Expanding Tumor Infiltrating Lymphocytes Using Engineered Cytokine Receptor Pairs and Uses Thereof
|
CN113825393A
(zh)
|
2018-12-21 |
2021-12-21 |
皮沃特生物股份有限公司 |
改善植物性状的方法、组合物和培养基
|
BR112021012231A2
(pt)
|
2018-12-28 |
2021-09-28 |
Braskem S.A. |
Modulação do fluxo de carbono através das vias de meg e c3 para a produção melhorada de monoetileno glicol e compostos c3
|
CN113574386A
(zh)
|
2019-01-03 |
2021-10-29 |
国家医疗保健研究所 |
用于增强癌症患者的cd8+t细胞依赖性免疫应答的方法和药物组合物
|
EP3931313A2
(en)
|
2019-01-04 |
2022-01-05 |
Mammoth Biosciences, Inc. |
Programmable nuclease improvements and compositions and methods for nucleic acid amplification and detection
|
US11739156B2
(en)
|
2019-01-06 |
2023-08-29 |
The Broad Institute, Inc. Massachusetts Institute of Technology |
Methods and compositions for overcoming immunosuppression
|
US20220106584A1
(en)
|
2019-01-14 |
2022-04-07 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods and kits for generating and selecting a variant of a binding protein with increased binding affinity and/or specificity
|
US11946040B2
(en)
|
2019-02-04 |
2024-04-02 |
The General Hospital Corporation |
Adenine DNA base editor variants with reduced off-target RNA editing
|
AU2020219078A1
(en)
|
2019-02-06 |
2021-08-26 |
Fred Hutchinson Cancer Center |
Minicircle producing bacteria engineered to differentially methylate nucleic acid molecules therein
|
US20220145330A1
(en)
|
2019-02-10 |
2022-05-12 |
The J. David Gladstone Institutes, a testamentary trust established under the Will of J. David Glads |
Modified mitochondrion and methods of use thereof
|
CN110177061B
(zh)
*
|
2019-03-01 |
2023-04-07 |
致讯科技(天津)有限公司 |
一种异构网络中信号干扰的协调方法
|
MX2021010288A
(es)
|
2019-03-01 |
2021-09-23 |
Iovance Biotherapeutics Inc |
Expansion de linfocitos infiltrantes de tumores a partir de tumores liquidos y usos terapeuticos de los mismos.
|
BR112021016818A2
(pt)
|
2019-03-01 |
2021-11-16 |
Braskem Sa |
Método para síntese in vivo de 4-hidroximetilfurfural e derivados do mesmo
|
WO2020181193A1
(en)
|
2019-03-06 |
2020-09-10 |
The Broad Institute, Inc. |
T:a to a:t base editing through adenosine methylation
|
WO2020181180A1
(en)
|
2019-03-06 |
2020-09-10 |
The Broad Institute, Inc. |
A:t to c:g base editors and uses thereof
|
WO2020181195A1
(en)
|
2019-03-06 |
2020-09-10 |
The Broad Institute, Inc. |
T:a to a:t base editing through adenine excision
|
WO2020181202A1
(en)
|
2019-03-06 |
2020-09-10 |
The Broad Institute, Inc. |
A:t to t:a base editing through adenine deamination and oxidation
|
WO2020181178A1
(en)
|
2019-03-06 |
2020-09-10 |
The Broad Institute, Inc. |
T:a to a:t base editing through thymine alkylation
|
EP4219700A1
(en)
|
2019-03-07 |
2023-08-02 |
The Regents of the University of California |
Crispr-cas effector polypeptides and methods of use thereof
|
BR112021017744A2
(pt)
|
2019-03-08 |
2021-11-16 |
Obsidian Therapeutics Inc |
Composições e métodos de cd40l para regulação ajustável
|
KR20210136997A
(ko)
|
2019-03-08 |
2021-11-17 |
지머젠 인코포레이티드 |
미생물에서 반복적 게놈 편집
|
US11053515B2
(en)
|
2019-03-08 |
2021-07-06 |
Zymergen Inc. |
Pooled genome editing in microbes
|
EP3769090B1
(en)
|
2019-03-18 |
2023-11-15 |
Regeneron Pharmaceuticals, Inc. |
Crispr/cas dropout screening platform to reveal genetic vulnerabilities associated with tau aggregation
|
IL312893A
(en)
|
2019-03-18 |
2024-07-01 |
Regeneron Pharma |
A CRISPR/CAS scanning platform for the identification of genetic modifiers for tau seeding or aggregation
|
EP3942040A1
(en)
|
2019-03-19 |
2022-01-26 |
The Broad Institute, Inc. |
Methods and compositions for editing nucleotide sequences
|
US20220162649A1
(en)
|
2019-04-01 |
2022-05-26 |
The Broad Institute, Inc. |
Novel nucleic acid modifiers
|
RU2710731C1
(ru)
*
|
2019-04-02 |
2020-01-10 |
Общество с ограниченной ответственностью "Зеленые линии" |
Система редактирования генома дрожжей debaryomyces hansenii на основе crispr/cas9
|
JP2022528894A
(ja)
|
2019-04-04 |
2022-06-16 |
ブラスケム エス.エー. |
第二世代の糖から化学物質を生成するためのキシロースおよびグルコースの同時消費のための代謝工学
|
EP3956349A1
(en)
|
2019-04-17 |
2022-02-23 |
The Broad Institute, Inc. |
Adenine base editors with reduced off-target effects
|
JP2022530224A
(ja)
|
2019-04-23 |
2022-06-28 |
ジーンエディット インコーポレイテッド |
アルキル側鎖を有するカチオン性ポリマー
|
AU2020261427A1
(en)
|
2019-04-24 |
2021-11-11 |
Pivot Bio, Inc. |
Gene targets for nitrogen fixation targeting for improving plant traits
|
US20220251152A1
(en)
|
2019-04-24 |
2022-08-11 |
Novartis Ag |
Compositions and methods for selective protein degradation
|
CN113825838A
(zh)
|
2019-05-10 |
2021-12-21 |
巴斯夫欧洲公司 |
增强植物中基因表达的调节性核酸分子
|
CN114096684A
(zh)
|
2019-05-13 |
2022-02-25 |
科沃施种子欧洲股份两合公司 |
玉米的耐旱性
|
WO2020232029A1
(en)
|
2019-05-13 |
2020-11-19 |
Iovance Biotherapeutics, Inc. |
Methods and compositions for selecting tumor infiltrating lymphocytes and uses of the same in immunotherapy
|
EP3973054A1
(en)
|
2019-05-20 |
2022-03-30 |
The Broad Institute Inc. |
Aav delivery of nucleobase editors
|
US20220235340A1
(en)
|
2019-05-20 |
2022-07-28 |
The Broad Institute, Inc. |
Novel crispr-cas systems and uses thereof
|
US20220220469A1
(en)
|
2019-05-20 |
2022-07-14 |
The Broad Institute, Inc. |
Non-class i multi-component nucleic acid targeting systems
|
AR118995A1
(es)
|
2019-05-25 |
2021-11-17 |
Kws Saat Se & Co Kgaa |
Mejorador de la inducción de haploides
|
CA3142035A1
(en)
|
2019-05-28 |
2020-12-03 |
Genedit Inc. |
Polymer comprising multiple functionalized sidechains for biomolecule delivery
|
US20220243178A1
(en)
|
2019-05-31 |
2022-08-04 |
The Broad Institute, Inc. |
Methods for treating metabolic disorders by targeting adcy5
|
EP3976073A4
(en)
*
|
2019-06-01 |
2023-08-02 |
Sivec Biotechnologies, LLC |
BACTERIAL PLATFORM FOR DELIVERING GENE EDITING SYSTEMS TO EUKARYOT CELLS
|
WO2020244759A1
(en)
|
2019-06-05 |
2020-12-10 |
Klemm & Sohn Gmbh & Co. Kg |
New plants having a white foliage phenotype
|
KR20220024053A
(ko)
|
2019-06-14 |
2022-03-03 |
리제너론 파마슈티칼스 인코포레이티드 |
타우병증의 모델
|
WO2020254850A1
(en)
|
2019-06-21 |
2020-12-24 |
Vilmorin & Cie |
Improvement of quality and permanence of green color of peppers at maturity and over-maturity
|
WO2020263825A1
(en)
|
2019-06-24 |
2020-12-30 |
Promega Corporation |
Modified polyamine polymers for delivery of biomolecules into cells
|
US11041172B2
(en)
|
2019-06-25 |
2021-06-22 |
Inari Agriculture, Inc. |
Homology dependent repair genome editing
|
SG11202111943UA
(en)
|
2019-07-02 |
2021-11-29 |
Hutchinson Fred Cancer Res |
Recombinant ad35 vectors and related gene therapy improvements
|
GB201909597D0
(en)
|
2019-07-03 |
2019-08-14 |
Univ Wageningen |
Crispr type v-u1 system from mycobacterium mucogenicum and uses thereof
|
JP2022540083A
(ja)
|
2019-07-08 |
2022-09-14 |
リサーチ インスティチュート アット ネイションワイド チルドレンズ ホスピタル |
バイオフィルムを破壊するための抗体組成物
|
CN110452966A
(zh)
*
|
2019-07-17 |
2019-11-15 |
浙江善测禾骑士生物科技有限公司 |
一种利用raa-crispr蛋白酶***快速检测方法
|
WO2021009299A1
(en)
|
2019-07-17 |
2021-01-21 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Bcl-xl:fkbp12 fusion proteins suitable for screening agents capable of slowing down the aging process
|
CN110387405A
(zh)
*
|
2019-07-17 |
2019-10-29 |
浙江善测禾骑士生物科技有限公司 |
一种快速检测核酸的(rt)raa-crispr***
|
WO2021019272A1
(en)
|
2019-07-31 |
2021-02-04 |
Vilmorin & Cie |
Tolerance to tolcndv in cucumber
|
EP3772542A1
(en)
|
2019-08-07 |
2021-02-10 |
KWS SAAT SE & Co. KGaA |
Modifying genetic variation in crops by modulating the pachytene checkpoint protein 2
|
WO2021028359A1
(en)
|
2019-08-09 |
2021-02-18 |
Sangamo Therapeutics France |
Controlled expression of chimeric antigen receptors in t cells
|
WO2021030666A1
(en)
|
2019-08-15 |
2021-02-18 |
The Broad Institute, Inc. |
Base editing by transglycosylation
|
EP4013859A4
(en)
*
|
2019-08-15 |
2023-10-11 |
The Rockefeller University |
CRISPR-BASED GENOME EDITING WITH CELL SURFACE DISPLAY TO PRODUCE HOMOZYGOTICLY ENGINEERED EUKARYOTIC CELLS
|
WO2021041922A1
(en)
|
2019-08-30 |
2021-03-04 |
The Broad Institute, Inc. |
Crispr-associated mu transposase systems
|
WO2021046451A1
(en)
|
2019-09-06 |
2021-03-11 |
Obsidian Therapeutics, Inc. |
Compositions and methods for dhfr tunable protein regulation
|
AU2020344905A1
(en)
|
2019-09-12 |
2022-04-28 |
Basf Se |
Regulatory nucleic acid molecules for enhancing gene expression in plants
|
WO2021055874A1
(en)
|
2019-09-20 |
2021-03-25 |
The Broad Institute, Inc. |
Novel type vi crispr enzymes and systems
|
CN110541001A
(zh)
*
|
2019-09-20 |
2019-12-06 |
福建上源生物科学技术有限公司 |
精确大片段基因删除结合终止密码子***的基因敲除法
|
WO2021061815A1
(en)
|
2019-09-23 |
2021-04-01 |
Omega Therapeutics, Inc. |
COMPOSITIONS AND METHODS FOR MODULATING HEPATOCYTE NUCLEAR FACTOR 4-ALPHA (HNF4α) GENE EXPRESSION
|
EP4048807A1
(en)
|
2019-09-23 |
2022-08-31 |
Omega Therapeutics, Inc. |
Compositions and methods for modulating apolipoprotein b (apob) gene expression
|
US11981922B2
(en)
|
2019-10-03 |
2024-05-14 |
Dana-Farber Cancer Institute, Inc. |
Methods and compositions for the modulation of cell interactions and signaling in the tumor microenvironment
|
WO2021069387A1
(en)
|
2019-10-07 |
2021-04-15 |
Basf Se |
Regulatory nucleic acid molecules for enhancing gene expression in plants
|
EP3808766A1
(en)
|
2019-10-15 |
2021-04-21 |
Sangamo Therapeutics France |
Chimeric antigen receptor specific for interleukin-23 receptor
|
WO2021074367A1
(en)
|
2019-10-17 |
2021-04-22 |
KWS SAAT SE & Co. KGaA |
Enhanced disease resistance of crops by downregulation of repressor genes
|
US20220389381A1
(en)
|
2019-10-25 |
2022-12-08 |
Iovance Biotherapeutics, Inc. |
Gene editing of tumor infiltrating lymphocytes and uses of same in immunotherapy
|
EP4057802A1
(en)
|
2019-11-14 |
2022-09-21 |
Vilmorin & Cie |
Resistance to acidovorax valerianellae in corn salad
|
JP2023503899A
(ja)
|
2019-11-22 |
2023-02-01 |
プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ |
薬物送達のためのイオン液体
|
US20230086199A1
(en)
|
2019-11-26 |
2023-03-23 |
The Broad Institute, Inc. |
Systems and methods for evaluating cas9-independent off-target editing of nucleic acids
|
BR112022006229A2
(pt)
|
2019-11-29 |
2022-06-21 |
Basf Se |
Métodos para conferir ou aumentar a resistência a fungos, controlar um fungo e cultivar uma planta, construção de vetor recombinante, vetor de expressão recombinante, planta geneticamente modificada, planta de cultivo, métodos para a produção de uma planta e para a produção de um produto, uso de uma proteína, parte colhível de uma planta, produto derivado de uma planta e método de avaliação de uma planta
|
AU2020394910A1
(en)
*
|
2019-12-02 |
2022-06-23 |
Council Of Scientific & Industrial Research |
Method and kit for detection of polynucleotide
|
CA3159805A1
(en)
|
2019-12-03 |
2021-06-10 |
Frank Meulewaeter |
Regulatory nucleic acid molecules for enhancing gene expression in plants
|
US20230220341A1
(en)
|
2019-12-11 |
2023-07-13 |
lovance Biotherapeutics, Inc. |
Processes for the production of tumor infiltrating lymphocytes (tils) and methods of using the same
|
US20230000063A1
(en)
|
2019-12-13 |
2023-01-05 |
Chugai Seiyaku Kabushiki Kaisha |
System for detecting extracellular purinergic receptor ligand, and non-human animal having the system introduced thereinto
|
CA3161898A1
(en)
|
2019-12-19 |
2021-06-24 |
Basf Se |
Increasing space-time-yield, carbon-conversion-efficiency and carbon substrate flexibility in the production of fine chemicals
|
MX2022007714A
(es)
|
2019-12-20 |
2022-07-19 |
Basf Se |
Disminucion de la toxicidad de terpenos y aumento de la posible produccion en microorganismos.
|
WO2021221690A1
(en)
|
2020-05-01 |
2021-11-04 |
Pivot Bio, Inc. |
Modified bacterial strains for improved fixation of nitrogen
|
CN116234906A
(zh)
|
2020-01-13 |
2023-06-06 |
萨那生物技术股份有限公司 |
血型抗原的修饰
|
CA3165346A1
(en)
|
2020-01-23 |
2021-07-29 |
George Q. Daley |
Stroma-free t cell differentiation from human pluripotent stem cells
|
US20230235309A1
(en)
|
2020-02-05 |
2023-07-27 |
The Broad Institute, Inc. |
Adenine base editors and uses thereof
|
EP3872190A1
(en)
|
2020-02-26 |
2021-09-01 |
Antibodies-Online GmbH |
A method of using cut&run or cut&tag to validate crispr-cas targeting
|
JP2023517326A
(ja)
|
2020-03-11 |
2023-04-25 |
オメガ セラピューティクス, インコーポレイテッド |
フォークヘッドボックスp3(foxp3)遺伝子発現をモジュレートするための組成物および方法
|
AU2021237790A1
(en)
|
2020-03-20 |
2022-10-13 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Chimeric antigen receptor specific for human CD45RC and uses thereof
|
US20210319851A1
(en)
|
2020-04-03 |
2021-10-14 |
Creyon Bio, Inc. |
Oligonucleotide-based machine learning
|
WO2021216623A1
(en)
|
2020-04-21 |
2021-10-28 |
Aspen Neuroscience, Inc. |
Gene editing of lrrk2 in stem cells and method of use of cells differentiated therefrom
|
WO2021216622A1
(en)
|
2020-04-21 |
2021-10-28 |
Aspen Neuroscience, Inc. |
Gene editing of gba1 in stem cells and method of use of cells differentiated therefrom
|
EP4143211A2
(en)
|
2020-05-01 |
2023-03-08 |
Pivot Bio, Inc. |
Modified bacterial strains for improved fixation of nitrogen
|
WO2021221689A1
(en)
|
2020-05-01 |
2021-11-04 |
Pivot Bio, Inc. |
Measurement of nitrogen fixation and incorporation
|
CA3176826A1
(en)
|
2020-05-04 |
2021-11-11 |
Iovance Biotherapeutics, Inc. |
Processes for production of tumor infiltrating lymphocytes and uses of the same in immunotherapy
|
US20230193212A1
(en)
|
2020-05-06 |
2023-06-22 |
Orchard Therapeutics (Europe) Limited |
Treatment for neurodegenerative diseases
|
MX2022014008A
(es)
|
2020-05-08 |
2023-02-09 |
Broad Inst Inc |
Métodos y composiciones para la edición simultánea de ambas cadenas de una secuencia de nucleótidos de doble cadena objetivo.
|
WO2021231449A2
(en)
|
2020-05-13 |
2021-11-18 |
Pivot Bio, Inc. |
De-repression of nitrogen fixation in gram-positive microorganisms
|
GB202007943D0
(en)
|
2020-05-27 |
2020-07-08 |
Snipr Biome Aps |
Products & methods
|
WO2021239986A1
(en)
|
2020-05-29 |
2021-12-02 |
KWS SAAT SE & Co. KGaA |
Plant haploid induction
|
WO2021245435A1
(en)
|
2020-06-03 |
2021-12-09 |
Vilmorin & Cie |
Melon plants resistant to scab disease, aphids and powdery mildew
|
CA3186284A1
(en)
|
2020-06-05 |
2021-12-09 |
Vilmorin & Cie |
Resistance in plants of solanum lycopersicum to the tobrfv
|
JP2023530234A
(ja)
|
2020-06-05 |
2023-07-14 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
新生物を治療するための組成物および方法
|
AU2021288224A1
(en)
|
2020-06-11 |
2023-01-05 |
Novartis Ag |
ZBTB32 inhibitors and uses thereof
|
US20230235315A1
(en)
|
2020-07-10 |
2023-07-27 |
Horizon Discovery Limited |
Method for producing genetically modified cells
|
US20230323299A1
(en)
|
2020-08-03 |
2023-10-12 |
Inserm (Institut National De La Santé Et De La Recherch Médicale) |
Population of treg cells functionally committed to exert a regulatory activity and their use for adoptive therapy
|
WO2022034474A1
(en)
|
2020-08-10 |
2022-02-17 |
Novartis Ag |
Treatments for retinal degenerative diseases
|
CN116134143A
(zh)
|
2020-08-18 |
2023-05-16 |
先锋国际良种公司 |
多种抗病基因及其基因组堆叠件
|
EP4097486A4
(en)
|
2020-08-20 |
2023-09-06 |
A2 Biotherapeutics, Inc. |
COMPOSITIONS AND METHODS OF TREATMENT OF POSITIVE CANCERS AT CEACAM
|
KR20230051677A
(ko)
|
2020-08-20 |
2023-04-18 |
에이투 바이오쎄라퓨틱스, 인크. |
메소텔린 양성 암을 치료하기 위한 조성물 및 방법
|
AU2021328478A1
(en)
|
2020-08-20 |
2023-04-20 |
A2 Biotherapeutics, Inc. |
Compositions and methods for treating egfr positive cancers
|
CN112080587A
(zh)
*
|
2020-08-31 |
2020-12-15 |
上海海关动植物与食品检验检疫技术中心 |
用于高效检测新型冠状病毒的raa-crispr扩增引物组、试剂盒及方法
|
KR102424351B1
(ko)
*
|
2020-09-21 |
2022-08-05 |
한국과학기술원 |
파브알부민 유전자 발현 억제용 CRISPR/Cas9 시스템 및 이의 용도
|
US11944063B2
(en)
|
2020-09-30 |
2024-04-02 |
Spring Meadow Nursery, Inc. |
Hydrangea ‘SMNHPH’
|
WO2022068912A1
(en)
|
2020-09-30 |
2022-04-07 |
Huigene Therapeutics Co., Ltd. |
Engineered crispr/cas13 system and uses thereof
|
WO2022188039A1
(en)
|
2021-03-09 |
2022-09-15 |
Huigene Therapeutics Co., Ltd. |
Engineered crispr/cas13 system and uses thereof
|
US20230363337A1
(en)
|
2020-10-02 |
2023-11-16 |
Vilmorin & Cie |
Melon with extended shelf life
|
US20230372397A1
(en)
|
2020-10-06 |
2023-11-23 |
Iovance Biotherapeutics, Inc. |
Treatment of nsclc patients with tumor infiltrating lymphocyte therapies
|
WO2022076606A1
(en)
|
2020-10-06 |
2022-04-14 |
Iovance Biotherapeutics, Inc. |
Treatment of nsclc patients with tumor infiltrating lymphocyte therapies
|
EP3984355B1
(en)
|
2020-10-16 |
2024-05-15 |
Klemm & Sohn GmbH & Co. KG |
Double-flowering dwarf calibrachoa
|
US11155884B1
(en)
|
2020-10-16 |
2021-10-26 |
Klemm & Sohn Gmbh & Co. Kg |
Double-flowering dwarf Calibrachoa
|
US20230147779A1
(en)
|
2020-10-28 |
2023-05-11 |
GeneEdit, Inc. |
Polymer with cationic and hydrophobic side chains
|
WO2022093977A1
(en)
|
2020-10-30 |
2022-05-05 |
Fortiphyte, Inc. |
Pathogen resistance in plants
|
WO2022104061A1
(en)
|
2020-11-13 |
2022-05-19 |
Novartis Ag |
Combination therapies with chimeric antigen receptor (car)-expressing cells
|
EP4001429A1
(en)
|
2020-11-16 |
2022-05-25 |
Antibodies-Online GmbH |
Analysis of crispr-cas binding and cleavage sites followed by high-throughput sequencing (abc-seq)
|
CA3203609A1
(en)
|
2020-12-03 |
2022-06-09 |
Vilmorin & Cie |
Tomato plants resistant to tobrfv, tmv, tomv and tommv and corresponding resistance genes
|
EP4262827A1
(en)
|
2020-12-17 |
2023-10-25 |
Iovance Biotherapeutics, Inc. |
Treatment of cancers with tumor infiltrating lymphocytes
|
WO2022133140A1
(en)
|
2020-12-17 |
2022-06-23 |
Iovance Biotherapeutics, Inc. |
Treatment with tumor infiltrating lymphocyte therapies in combination with ctla-4 and pd-1 inhibitors
|
TW202235622A
(zh)
|
2020-12-23 |
2022-09-16 |
美商旗艦先鋒創新公司 |
包裹rna之指環病毒(anellovirus)蛋白殼之活體外組裝
|
WO2022148955A1
(en)
|
2021-01-05 |
2022-07-14 |
Horizon Discovery Limited |
Method for producing genetically modified cells
|
WO2022150776A1
(en)
*
|
2021-01-11 |
2022-07-14 |
Vedere Bio Ii, Inc. |
OPTOGENETIC COMPOSITIONS COMPRISING A CBh PROMOTER SEQUENCE AND METHODS FOR USE
|
JP2024502630A
(ja)
|
2021-01-12 |
2024-01-22 |
マーチ セラピューティクス, インコーポレイテッド |
コンテキスト依存性二本鎖dna特異的デアミナーゼ及びその使用
|
TW202241508A
(zh)
|
2021-01-29 |
2022-11-01 |
美商艾歐凡斯生物治療公司 |
細胞介素相關之腫瘤浸潤性淋巴球組合物及方法
|
WO2022177979A1
(en)
|
2021-02-16 |
2022-08-25 |
A2 Biotherapeutics, Inc. |
Compositions and methods for treating her2 positive cancers
|
EP4305157A1
(en)
|
2021-03-09 |
2024-01-17 |
Huidagene Therapeutics (Singapore) Pte. Ltd. |
Engineered crispr/cas13 system and uses thereof
|
CA3212439A1
(en)
|
2021-03-19 |
2022-09-22 |
Michelle SIMPSON-ABELSON |
Methods for tumor infiltrating lymphocyte (til) expansion related to cd39/cd69 selection and gene knockout in tils
|
JP2024519601A
(ja)
|
2021-03-31 |
2024-05-20 |
エントラーダ セラピューティクス,インコーポレイティド |
環状細胞透過性ペプチド
|
WO2022208489A1
(en)
|
2021-04-02 |
2022-10-06 |
Vilmorin & Cie |
Semi-determinate or determinate growth habit trait in cucurbita
|
EP4323501A1
(en)
|
2021-04-16 |
2024-02-21 |
Beam Therapeutics Inc. |
Genetic modification of hepatocytes
|
KR20240037185A
(ko)
|
2021-04-19 |
2024-03-21 |
이오반스 바이오테라퓨틱스, 인크. |
키메라 공동자극 수용체, 케모카인 수용체, 및 세포 면역치료에서의 이의 용도
|
WO2022235929A1
(en)
|
2021-05-05 |
2022-11-10 |
Radius Pharmaceuticals, Inc. |
Animal model having homologous recombination of mouse pth1 receptor
|
WO2022241408A1
(en)
|
2021-05-10 |
2022-11-17 |
Entrada Therapeutics, Inc. |
Compositions and methods for modulating tissue distribution of intracellular therapeutics
|
WO2022240760A2
(en)
|
2021-05-10 |
2022-11-17 |
Entrada Therapeutics, Inc. |
COMPOSITIONS AND METHODS FOR MODULATING mRNA SPLICING
|
EP4337263A1
(en)
|
2021-05-10 |
2024-03-20 |
Entrada Therapeutics, Inc. |
Compositions and methods for modulating interferon regulatory factor-5 (irf-5) activity
|
EP4337770A1
(en)
|
2021-05-13 |
2024-03-20 |
The United States of America, as represented by the Secretary, Department of Health and Human Services |
Compositions and methods for treating sickle cell diseases
|
CA3219148A1
(en)
|
2021-05-17 |
2022-11-24 |
Frederick G. Vogt |
Pd-1 gene-edited tumor infiltrating lymphocytes and uses of same in immunotherapy
|
US20230023791A1
(en)
|
2021-06-01 |
2023-01-26 |
Arbor Biotechnologies, Inc. |
Gene editing systems comprising a crispr nuclease and uses thereof
|
EP4352131A1
(en)
|
2021-06-11 |
2024-04-17 |
Genedit Inc. |
Biodegradable polymer comprising side chains with polyamine and polyalkylene oxide groups
|
WO2022261509A1
(en)
|
2021-06-11 |
2022-12-15 |
The Broad Institute, Inc. |
Improved cytosine to guanine base editors
|
WO2022266105A1
(en)
*
|
2021-06-14 |
2022-12-22 |
The University Of Chicago |
Characterization and treatment of asthma
|
EP4359006A1
(en)
|
2021-06-23 |
2024-05-01 |
Entrada Therapeutics, Inc. |
Antisense compounds and methods for targeting cug repeats
|
EP4362661A1
(en)
|
2021-07-02 |
2024-05-08 |
Pivot Bio, Inc. |
Genetically-engineered bacterial strains for improved fixation of nitrogen
|
EP4367242A2
(en)
|
2021-07-07 |
2024-05-15 |
Omega Therapeutics, Inc. |
Compositions and methods for modulating secreted frizzled receptor protein 1 (sfrp1) gene expression
|
CA3226111A1
(en)
|
2021-07-22 |
2023-01-26 |
Iovance Biotherapeutics, Inc. |
Method for cryopreservation of solid tumor fragments
|
WO2023009716A1
(en)
|
2021-07-28 |
2023-02-02 |
Iovance Biotherapeutics, Inc. |
Treatment of cancer patients with tumor infiltrating lymphocyte therapies in combination with kras inhibitors
|
CA3187918A1
(en)
|
2021-07-30 |
2023-01-30 |
Helaina, Inc. |
Methods and compositions for protein synthesis and secretion
|
EP4376596A1
(en)
|
2021-07-30 |
2024-06-05 |
KWS SAAT SE & Co. KGaA |
Plants with improved digestibility and marker haplotypes
|
WO2023012325A1
(en)
|
2021-08-06 |
2023-02-09 |
Vilmorin & Cie |
Resistance to leveillula taurica in pepper
|
WO2023031885A1
(en)
|
2021-09-02 |
2023-03-09 |
SESVanderHave NV |
Methods and compositions for ppo herbicide tolerance
|
WO2023039586A1
(en)
|
2021-09-10 |
2023-03-16 |
Agilent Technologies, Inc. |
Guide rnas with chemical modification for prime editing
|
WO2023056367A1
(en)
|
2021-09-30 |
2023-04-06 |
The Board Of Regents Of The Universityof Texas System |
Slc13a5 gene therapy vectors and uses thereof
|
WO2023059846A1
(en)
|
2021-10-08 |
2023-04-13 |
President And Fellows Of Harvard College |
Ionic liquids for drug delivery
|
AU2022366987A1
(en)
|
2021-10-14 |
2024-05-16 |
Arsenal Biosciences, Inc. |
Immune cells having co-expressed shrnas and logic gate systems
|
AR127482A1
(es)
|
2021-10-27 |
2024-01-31 |
Iovance Biotherapeutics Inc |
Sistemas y métodos para coordinar la fabricación de células para inmunoterapia específica de paciente
|
CA3237300A1
(en)
|
2021-11-01 |
2023-05-04 |
Tome Biosciences, Inc. |
Single construct platform for simultaneous delivery of gene editing machinery and nucleic acid cargo
|
WO2023081756A1
(en)
|
2021-11-03 |
2023-05-11 |
The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone |
Precise genome editing using retrons
|
WO2023081762A2
(en)
*
|
2021-11-03 |
2023-05-11 |
The Regents Of The University Of California |
Serine recombinases
|
CA3237410A1
(en)
|
2021-11-10 |
2023-05-19 |
Friedrich Graf Finck VON FINCKENSTEIN |
Methods of expansion treatment utilizing cd8 tumor infiltrating lymphocytes
|
WO2023092153A2
(en)
*
|
2021-11-22 |
2023-05-25 |
The Texas A&M University System |
Methods and compositions targeting nucleus accumbens-associated protein-1 for treatment of autoimmune disorders and cancers
|
WO2023096996A2
(en)
|
2021-11-24 |
2023-06-01 |
Research Institute At Nationwide Children's Hospital |
Chimeric hsv expressing hil21 to boost anti-tumor immune activity
|
WO2023093862A1
(en)
|
2021-11-26 |
2023-06-01 |
Epigenic Therapeutics Inc. |
Method of modulating pcsk9 and uses thereof
|
WO2023102406A1
(en)
|
2021-12-01 |
2023-06-08 |
The Board Of Regents Of The Univesity Of Texas System |
Vector genome design to express optimized cln7 transgene
|
WO2023102518A1
(en)
|
2021-12-03 |
2023-06-08 |
The Board Of Regents Of The University Of Texas System |
Gnao1 gene therapy vectors and uses thereof
|
GB202118058D0
(en)
|
2021-12-14 |
2022-01-26 |
Univ Warwick |
Methods to increase yields in crops
|
US20230279442A1
(en)
|
2021-12-15 |
2023-09-07 |
Versitech Limited |
Engineered cas9-nucleases and method of use thereof
|
TW202342498A
(zh)
|
2021-12-17 |
2023-11-01 |
美商薩那生物科技公司 |
經修飾副黏液病毒科融合醣蛋白
|
TW202342757A
(zh)
|
2021-12-17 |
2023-11-01 |
美商薩那生物科技公司 |
經修飾副黏液病毒科附著醣蛋白
|
WO2023122805A1
(en)
|
2021-12-20 |
2023-06-29 |
Vestaron Corporation |
Sorbitol driven selection pressure method
|
AU2022420615A1
(en)
|
2021-12-22 |
2024-07-04 |
Tome Biosciences, Inc. |
Co-delivery of a gene editor construct and a donor template
|
WO2023122800A1
(en)
|
2021-12-23 |
2023-06-29 |
University Of Massachusetts |
Therapeutic treatment for fragile x-associated disorder
|
WO2023133595A2
(en)
|
2022-01-10 |
2023-07-13 |
Sana Biotechnology, Inc. |
Methods of ex vivo dosing and administration of lipid particles or viral vectors and related systems and uses
|
WO2023141602A2
(en)
|
2022-01-21 |
2023-07-27 |
Renagade Therapeutics Management Inc. |
Engineered retrons and methods of use
|
WO2023147476A1
(en)
|
2022-01-28 |
2023-08-03 |
The Board Of Regents Of The University Of Texas System |
Transgene casette designed to express the human codon-optimized gene fmr1
|
WO2023147488A1
(en)
|
2022-01-28 |
2023-08-03 |
Iovance Biotherapeutics, Inc. |
Cytokine associated tumor infiltrating lymphocytes compositions and methods
|
WO2023150518A1
(en)
|
2022-02-01 |
2023-08-10 |
Sana Biotechnology, Inc. |
Cd3-targeted lentiviral vectors and uses thereof
|
WO2023150647A1
(en)
|
2022-02-02 |
2023-08-10 |
Sana Biotechnology, Inc. |
Methods of repeat dosing and administration of lipid particles or viral vectors and related systems and uses
|
WO2023156587A1
(en)
|
2022-02-18 |
2023-08-24 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Use of tcr-deficient car-tregs in combination with anti-tcr complex monoclonal antibodies for inducing durable tolerance
|
WO2023196802A1
(en)
|
2022-04-04 |
2023-10-12 |
The Broad Institute, Inc. |
Cas9 variants having non-canonical pam specificities and uses thereof
|
EP4256950A1
(en)
|
2022-04-06 |
2023-10-11 |
Vilmorin et Cie |
Tolerance to cgmmv in cucumber
|
WO2023196877A1
(en)
|
2022-04-06 |
2023-10-12 |
Iovance Biotherapeutics, Inc. |
Treatment of nsclc patients with tumor infiltrating lymphocyte therapies
|
WO2023201369A1
(en)
|
2022-04-15 |
2023-10-19 |
Iovance Biotherapeutics, Inc. |
Til expansion processes using specific cytokine combinations and/or akti treatment
|
WO2023205744A1
(en)
|
2022-04-20 |
2023-10-26 |
Tome Biosciences, Inc. |
Programmable gene insertion compositions
|
WO2023212715A1
(en)
|
2022-04-28 |
2023-11-02 |
The Broad Institute, Inc. |
Aav vectors encoding base editors and uses thereof
|
WO2023215831A1
(en)
|
2022-05-04 |
2023-11-09 |
Tome Biosciences, Inc. |
Guide rna compositions for programmable gene insertion
|
WO2023219933A1
(en)
|
2022-05-09 |
2023-11-16 |
Entrada Therapeutics, Inc. |
Compositions and methods for delivery of nucleic acid therapeutics
|
WO2023220040A1
(en)
|
2022-05-09 |
2023-11-16 |
Synteny Therapeutics, Inc. |
Erythroparvovirus with a modified capsid for gene therapy
|
WO2023220035A1
(en)
|
2022-05-09 |
2023-11-16 |
Synteny Therapeutics, Inc. |
Erythroparvovirus compositions and methods for gene therapy
|
WO2023220043A1
(en)
|
2022-05-09 |
2023-11-16 |
Synteny Therapeutics, Inc. |
Erythroparvovirus with a modified genome for gene therapy
|
WO2023220608A1
(en)
|
2022-05-10 |
2023-11-16 |
Iovance Biotherapeutics, Inc. |
Treatment of cancer patients with tumor infiltrating lymphocyte therapies in combination with an il-15r agonist
|
WO2023225670A2
(en)
|
2022-05-20 |
2023-11-23 |
Tome Biosciences, Inc. |
Ex vivo programmable gene insertion
|
WO2023230549A2
(en)
|
2022-05-25 |
2023-11-30 |
Flagship Pioneering Innovations Vii, Llc |
Compositions and methods for modulation of tumor suppressors and oncogenes
|
WO2023230578A2
(en)
|
2022-05-25 |
2023-11-30 |
Flagship Pioneering Innovations Vii, Llc |
Compositions and methods for modulating circulating factors
|
WO2023230573A2
(en)
|
2022-05-25 |
2023-11-30 |
Flagship Pioneering Innovations Vii, Llc |
Compositions and methods for modulation of immune responses
|
WO2023230566A2
(en)
|
2022-05-25 |
2023-11-30 |
Flagship Pioneering Innovations Vii, Llc |
Compositions and methods for modulating cytokines
|
WO2023230570A2
(en)
|
2022-05-25 |
2023-11-30 |
Flagship Pioneering Innovations Vii, Llc |
Compositions and methods for modulating genetic drivers
|
EP4299733A1
(en)
|
2022-06-30 |
2024-01-03 |
Inari Agriculture Technology, Inc. |
Compositions, systems, and methods for genome editing
|
WO2024005864A1
(en)
|
2022-06-30 |
2024-01-04 |
Inari Agriculture Technology, Inc. |
Compositions, systems, and methods for genome editing
|
WO2024005863A1
(en)
|
2022-06-30 |
2024-01-04 |
Inari Agriculture Technology, Inc. |
Compositions, systems, and methods for genome editing
|
WO2024006802A1
(en)
|
2022-06-30 |
2024-01-04 |
Pioneer Hi-Bred International, Inc. |
Artificial intelligence-mediated methods and systems for genome editing
|
GB2621813A
(en)
|
2022-06-30 |
2024-02-28 |
Univ Newcastle |
Preventing disease recurrence in Mitochondrial replacement therapy
|
EP4299739A1
(en)
|
2022-06-30 |
2024-01-03 |
Inari Agriculture Technology, Inc. |
Compositions, systems, and methods for genome editing
|
WO2024020346A2
(en)
|
2022-07-18 |
2024-01-25 |
Renagade Therapeutics Management Inc. |
Gene editing components, systems, and methods of use
|
WO2024020587A2
(en)
|
2022-07-22 |
2024-01-25 |
Tome Biosciences, Inc. |
Pleiopluripotent stem cell programmable gene insertion
|
WO2024023578A1
(en)
|
2022-07-28 |
2024-02-01 |
Institut Pasteur |
Hsc70-4 in host-induced and spray-induced gene silencing
|
WO2024026406A2
(en)
|
2022-07-29 |
2024-02-01 |
Vestaron Corporation |
Next Generation ACTX Peptides
|
WO2024036190A2
(en)
|
2022-08-09 |
2024-02-15 |
Pioneer Hi-Bred International, Inc. |
Guide polynucleotide multiplexing
|
WO2024040083A1
(en)
|
2022-08-16 |
2024-02-22 |
The Broad Institute, Inc. |
Evolved cytosine deaminases and methods of editing dna using same
|
WO2024040222A1
(en)
|
2022-08-19 |
2024-02-22 |
Generation Bio Co. |
Cleavable closed-ended dna (cedna) and methods of use thereof
|
WO2024044655A1
(en)
|
2022-08-24 |
2024-02-29 |
Sana Biotechnology, Inc. |
Delivery of heterologous proteins
|
WO2024044723A1
(en)
|
2022-08-25 |
2024-02-29 |
Renagade Therapeutics Management Inc. |
Engineered retrons and methods of use
|
WO2024042199A1
(en)
|
2022-08-26 |
2024-02-29 |
KWS SAAT SE & Co. KGaA |
Use of paired genes in hybrid breeding
|
WO2024047605A1
(en)
|
2022-09-01 |
2024-03-07 |
SESVanderHave NV |
Methods and compositions for ppo herbicide tolerance
|
WO2024050544A2
(en)
|
2022-09-01 |
2024-03-07 |
J.R. Simplot Company |
Enhanced targeted knock-in frequency in host genomes through crispr exonuclease processing
|
WO2024052318A1
(en)
|
2022-09-06 |
2024-03-14 |
Institut National de la Santé et de la Recherche Médicale |
Novel dual split car-t cells for the treatment of cd38-positive hematological malignancies
|
WO2024064824A2
(en)
|
2022-09-21 |
2024-03-28 |
Yale University |
Compositions and methods for identification of membrane targets for enhancement of nk cell therapy
|
WO2024064838A1
(en)
|
2022-09-21 |
2024-03-28 |
Sana Biotechnology, Inc. |
Lipid particles comprising variant paramyxovirus attachment glycoproteins and uses thereof
|
WO2024081820A1
(en)
|
2022-10-13 |
2024-04-18 |
Sana Biotechnology, Inc. |
Viral particles targeting hematopoietic stem cells
|
WO2024083579A1
(en)
|
2022-10-20 |
2024-04-25 |
Basf Se |
Regulatory nucleic acid molecules for enhancing gene expression in plants
|
WO2024098027A1
(en)
|
2022-11-04 |
2024-05-10 |
Iovance Biotherapeutics, Inc. |
Methods for tumor infiltrating lymphocyte (til) expansion related to cd39/cd103 selection
|
WO2024098024A1
(en)
|
2022-11-04 |
2024-05-10 |
Iovance Biotherapeutics, Inc. |
Expansion of tumor infiltrating lymphocytes from liquid tumors and therapeutic uses thereof
|
WO2024102434A1
(en)
|
2022-11-10 |
2024-05-16 |
Senda Biosciences, Inc. |
Rna compositions comprising lipid nanoparticles or lipid reconstructed natural messenger packs
|
WO2024112571A2
(en)
|
2022-11-21 |
2024-05-30 |
Iovance Biotherapeutics, Inc. |
Two-dimensional processes for the expansion of tumor infiltrating lymphocytes and therapies therefrom
|
WO2024118836A1
(en)
|
2022-11-30 |
2024-06-06 |
Iovance Biotherapeutics, Inc. |
Processes for production of tumor infiltrating lymphocytes with shortened rep step
|
WO2024119157A1
(en)
|
2022-12-02 |
2024-06-06 |
Sana Biotechnology, Inc. |
Lipid particles with cofusogens and methods of producing and using the same
|
WO2024123786A1
(en)
|
2022-12-06 |
2024-06-13 |
Pioneer Hi-Bred International, Inc. |
Methods and compositions for co-delivery of t-dnas expressing multiple guide polynucleotides into plants
|
WO2024138194A1
(en)
|
2022-12-22 |
2024-06-27 |
Tome Biosciences, Inc. |
Platforms, compositions, and methods for in vivo programmable gene insertion
|
WO2024137259A1
(en)
|
2022-12-23 |
2024-06-27 |
Pivot Bio, Inc. |
Combination of various nitrogen fixing bacteria with various biological products to achieve synergistic effects
|
WO2024141599A1
(en)
|
2022-12-29 |
2024-07-04 |
Vilmorin & Cie |
Tomato plants resistant to resistance-breaking tswv strains and corresponding resistance genes
|