SG11201704272YA - Compositions and methods for high efficiency in vivo genome editing - Google Patents
Compositions and methods for high efficiency in vivo genome editingInfo
- Publication number
- SG11201704272YA SG11201704272YA SG11201704272YA SG11201704272YA SG11201704272YA SG 11201704272Y A SG11201704272Y A SG 11201704272YA SG 11201704272Y A SG11201704272Y A SG 11201704272YA SG 11201704272Y A SG11201704272Y A SG 11201704272YA SG 11201704272Y A SG11201704272Y A SG 11201704272YA
- Authority
- SG
- Singapore
- Prior art keywords
- compositions
- methods
- high efficiency
- genome editing
- vivo genome
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8201—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation
- C12N15/8213—Targeted insertion of genes into the plant genome by homologous recombination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8201—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation
- C12N15/8209—Selection, visualisation of transformants, reporter constructs, e.g. antibiotic resistance markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
- C12N15/905—Stable introduction of foreign DNA into chromosome using homologous recombination in yeast
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
- C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1241—Nucleotidyltransferases (2.7.7)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases RNAses, DNAses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/07—Nucleotidyltransferases (2.7.7)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Mycology (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462099014P | 2014-12-31 | 2014-12-31 | |
PCT/US2015/068356 WO2016109840A2 (en) | 2014-12-31 | 2015-12-31 | Compositions and methods for high efficiency in vivo genome editing |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201704272YA true SG11201704272YA (en) | 2017-06-29 |
Family
ID=56285162
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201906070XA SG10201906070XA (en) | 2014-12-31 | 2015-12-31 | Compositions and methods for high efficiency in vivo genome editing |
SG11201704272YA SG11201704272YA (en) | 2014-12-31 | 2015-12-31 | Compositions and methods for high efficiency in vivo genome editing |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201906070XA SG10201906070XA (en) | 2014-12-31 | 2015-12-31 | Compositions and methods for high efficiency in vivo genome editing |
Country Status (8)
Country | Link |
---|---|
US (2) | US11339399B2 (en) |
EP (1) | EP3240889A4 (en) |
JP (2) | JP2018500037A (en) |
AU (1) | AU2015373893B2 (en) |
CA (1) | CA2972454A1 (en) |
IL (1) | IL252970B (en) |
SG (2) | SG10201906070XA (en) |
WO (1) | WO2016109840A2 (en) |
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WO2013066438A2 (en) | 2011-07-22 | 2013-05-10 | President And Fellows Of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
US20150044192A1 (en) | 2013-08-09 | 2015-02-12 | President And Fellows Of Harvard College | Methods for identifying a target site of a cas9 nuclease |
US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
US9228207B2 (en) | 2013-09-06 | 2016-01-05 | President And Fellows Of Harvard College | Switchable gRNAs comprising aptamers |
US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
US9322037B2 (en) | 2013-09-06 | 2016-04-26 | President And Fellows Of Harvard College | Cas9-FokI fusion proteins and uses thereof |
US11053481B2 (en) | 2013-12-12 | 2021-07-06 | President And Fellows Of Harvard College | Fusions of Cas9 domains and nucleic acid-editing domains |
AU2015298571B2 (en) | 2014-07-30 | 2020-09-03 | President And Fellows Of Harvard College | Cas9 proteins including ligand-dependent inteins |
PT3322799T (en) | 2015-07-14 | 2021-06-02 | Synthetic Genomics Inc | Microorganisms having increased lipid productivity |
WO2017023803A1 (en) | 2015-07-31 | 2017-02-09 | Regents Of The University Of Minnesota | Modified cells and methods of therapy |
CA2996599A1 (en) * | 2015-09-01 | 2017-03-09 | Dana-Farber Cancer Institute Inc. | Systems and methods for selection of grna targeting strands for cas9 localization |
JP7109784B2 (en) | 2015-10-23 | 2022-08-01 | プレジデント アンド フェローズ オブ ハーバード カレッジ | Evolved Cas9 protein for gene editing |
US10041079B2 (en) | 2015-11-30 | 2018-08-07 | Synthetic Genomics, Inc. | Compositions and methods for expressing genes in algae |
CA3007635A1 (en) | 2015-12-07 | 2017-06-15 | Zymergen Inc. | Promoters from corynebacterium glutamicum |
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US9988624B2 (en) | 2015-12-07 | 2018-06-05 | Zymergen Inc. | Microbial strain improvement by a HTP genomic engineering platform |
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WO2018005793A1 (en) | 2016-06-30 | 2018-01-04 | Zymergen Inc. | Methods for generating a glucose permease library and uses thereof |
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US11466269B2 (en) | 2016-07-13 | 2022-10-11 | Dsm Ip Assets B.V. | CRISPR-Cas system for an algal host cell |
CN110214183A (en) | 2016-08-03 | 2019-09-06 | 哈佛大学的校长及成员们 | Adenosine nucleobase editing machine and application thereof |
US11661590B2 (en) | 2016-08-09 | 2023-05-30 | President And Fellows Of Harvard College | Programmable CAS9-recombinase fusion proteins and uses thereof |
WO2018039438A1 (en) | 2016-08-24 | 2018-03-01 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
JP6829761B2 (en) | 2016-09-29 | 2021-02-10 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | Methods for analyzing and optimizing gene editing modules and gene delivery approaches |
SG11201903089RA (en) | 2016-10-14 | 2019-05-30 | Harvard College | Aav delivery of nucleobase editors |
JP7181862B2 (en) | 2016-10-18 | 2022-12-01 | リージェンツ オブ ザ ユニバーシティ オブ ミネソタ | Tumor-infiltrating lymphocytes and methods of treatment |
GB201618414D0 (en) * | 2016-11-01 | 2016-12-14 | Patterson James | Regulated cell lines and methods of use thereof |
GB201618507D0 (en) * | 2016-11-02 | 2016-12-14 | Stichting Voor De Technische Wetenschappen And Wageningen Univ | Microbial genome editing |
US10745677B2 (en) | 2016-12-23 | 2020-08-18 | President And Fellows Of Harvard College | Editing of CCR5 receptor gene to protect against HIV infection |
EP3592853A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Suppression of pain by gene editing |
JP2020510439A (en) | 2017-03-10 | 2020-04-09 | プレジデント アンド フェローズ オブ ハーバード カレッジ | Base-editing factor from cytosine to guanine |
IL306092A (en) | 2017-03-23 | 2023-11-01 | Harvard College | Nucleobase editors comprising nucleic acid programmable dna binding proteins |
WO2018209320A1 (en) | 2017-05-12 | 2018-11-15 | President And Fellows Of Harvard College | Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation |
US20200109408A1 (en) * | 2017-05-31 | 2020-04-09 | Tropic Biosciences UK Limited | Methods of selecting cells comprising genome editing events |
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EP3658573A1 (en) | 2017-07-28 | 2020-06-03 | President and Fellows of Harvard College | Methods and compositions for evolving base editors using phage-assisted continuous evolution (pace) |
EP3676376A2 (en) | 2017-08-30 | 2020-07-08 | President and Fellows of Harvard College | High efficiency base editors comprising gam |
CN111757937A (en) | 2017-10-16 | 2020-10-09 | 布罗德研究所股份有限公司 | Use of adenosine base editor |
BR112020011350A2 (en) | 2017-12-08 | 2020-11-17 | Synthetic Genomics, Inc. | improvement of lipid productivity of algae through genetic modification of a protein that contains the tpr domain |
AU2018395264B2 (en) | 2017-12-29 | 2023-06-22 | Synthetic Genomics, Inc. | Genetic modulation of photosynthetic organisms for improved growth |
WO2019222545A1 (en) * | 2018-05-16 | 2019-11-21 | Synthego Corporation | Methods and systems for guide rna design and use |
US11046979B2 (en) * | 2018-07-23 | 2021-06-29 | Synthetic Genomics, Inc. | Recombinant algal microorganisms having increased lipid production, and methods of making and using the same |
EP3862430A4 (en) * | 2018-10-04 | 2022-06-15 | Kaneka Corporation | Dna construct to be used in genome editing of plant |
JP7460643B2 (en) * | 2018-10-16 | 2024-04-02 | ブルーアレル, エルエルシー | Methods for targeted insertion of DNA into genes |
CN113166774A (en) * | 2018-12-19 | 2021-07-23 | 合成基因组股份有限公司 | Inducible expression of algal genes |
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US20220177923A1 (en) * | 2019-04-05 | 2022-06-09 | Danisco Us Inc | Methods for integrating a donor DNA sequence into the genome of bacillus using linear recombinant DNA constructs and compositions thereof |
CN110331169A (en) * | 2019-07-05 | 2019-10-15 | 亢庆铮 | It is a kind of efficiently quickly in screening-gene regulatory region functional site method and application |
JP7428459B2 (en) * | 2019-07-08 | 2024-02-06 | 株式会社ユーグレナ | Euglena genome modification method and Euglena breeding method |
WO2021085580A1 (en) * | 2019-10-31 | 2021-05-06 | 国立研究開発法人理化学研究所 | Polynucleotide and use for same |
CA3177481A1 (en) | 2020-05-08 | 2021-11-11 | David R. Liu | Methods and compositions for simultaneous editing of both strands of a target double-stranded nucleotide sequence |
JPWO2022080234A1 (en) * | 2020-10-12 | 2022-04-21 | ||
AU2023211606A1 (en) * | 2022-01-27 | 2024-07-11 | Asklepios Biopharmaceutical, Inc. | Compositions for treating neurological disease |
WO2023225358A1 (en) * | 2022-05-20 | 2023-11-23 | The Board Of Trustees Of The Leland Stanford Junior University | Generation and tracking of cells with precise edits |
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GB9304200D0 (en) | 1993-03-02 | 1993-04-21 | Sandoz Ltd | Improvements in or relating to organic compounds |
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AU2013359262C1 (en) | 2012-12-12 | 2021-05-13 | Massachusetts Institute Of Technology | CRISPR-Cas component systems, methods and compositions for sequence manipulation |
EP2931899A1 (en) * | 2012-12-12 | 2015-10-21 | The Broad Institute, Inc. | Functional genomics using crispr-cas systems, compositions, methods, knock out libraries and applications thereof |
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EP4389903A2 (en) * | 2013-06-05 | 2024-06-26 | Duke University | Rna-guided gene editing and gene regulation |
DK3011029T3 (en) * | 2013-06-17 | 2020-03-16 | Broad Inst Inc | ADMINISTRATION, MODIFICATION AND OPTIMIZATION OF TANDEM GUIDE SYSTEMS, PROCEDURES AND COMPOSITIONS FOR SEQUENCE MANIPULATION |
WO2015051342A2 (en) | 2013-10-04 | 2015-04-09 | Synthetic Genomics, Inc. | Compositions and methods for modulating biomass productivity |
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CN105814190A (en) | 2013-12-31 | 2016-07-27 | 合成基因组股份有限公司 | Biomass productivity regulator |
US10968259B2 (en) * | 2016-12-30 | 2021-04-06 | Synthetic Genomics, Inc. | High productivity algal mutants having reduced photosynthetic antenna |
-
2015
- 2015-12-31 AU AU2015373893A patent/AU2015373893B2/en active Active
- 2015-12-31 WO PCT/US2015/068356 patent/WO2016109840A2/en active Application Filing
- 2015-12-31 JP JP2017534947A patent/JP2018500037A/en active Pending
- 2015-12-31 US US14/986,492 patent/US11339399B2/en active Active
- 2015-12-31 EP EP15876386.2A patent/EP3240889A4/en active Pending
- 2015-12-31 CA CA2972454A patent/CA2972454A1/en active Pending
- 2015-12-31 SG SG10201906070XA patent/SG10201906070XA/en unknown
- 2015-12-31 SG SG11201704272YA patent/SG11201704272YA/en unknown
-
2017
- 2017-06-18 IL IL252970A patent/IL252970B/en unknown
-
2020
- 2020-09-29 JP JP2020162773A patent/JP7046139B2/en active Active
- 2020-09-30 US US17/039,839 patent/US12043836B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
JP2021036866A (en) | 2021-03-11 |
EP3240889A4 (en) | 2018-06-20 |
WO2016109840A3 (en) | 2016-10-13 |
IL252970A0 (en) | 2017-08-31 |
US20210017530A1 (en) | 2021-01-21 |
JP2018500037A (en) | 2018-01-11 |
WO2016109840A9 (en) | 2016-11-17 |
CA2972454A1 (en) | 2016-07-07 |
EP3240889A2 (en) | 2017-11-08 |
JP7046139B2 (en) | 2022-04-01 |
US11339399B2 (en) | 2022-05-24 |
AU2015373893B2 (en) | 2021-07-29 |
AU2015373893A1 (en) | 2017-06-15 |
US20170073695A1 (en) | 2017-03-16 |
SG10201906070XA (en) | 2019-08-27 |
US12043836B2 (en) | 2024-07-23 |
WO2016109840A2 (en) | 2016-07-07 |
IL252970B (en) | 2021-07-29 |
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