BR112016013187A2 - receptores de antígenos quiméricos de mesotelina humanos e usos dos mesmos - Google Patents
receptores de antígenos quiméricos de mesotelina humanos e usos dos mesmosInfo
- Publication number
- BR112016013187A2 BR112016013187A2 BR112016013187A BR112016013187A BR112016013187A2 BR 112016013187 A2 BR112016013187 A2 BR 112016013187A2 BR 112016013187 A BR112016013187 A BR 112016013187A BR 112016013187 A BR112016013187 A BR 112016013187A BR 112016013187 A2 BR112016013187 A2 BR 112016013187A2
- Authority
- BR
- Brazil
- Prior art keywords
- mesothelin
- chimeric antigen
- antigen receptors
- human mesothelin
- mesothelin chimeric
- Prior art date
Links
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 title 1
- 101000576802 Homo sapiens Mesothelin Proteins 0.000 title 1
- 102000003735 Mesothelin Human genes 0.000 abstract 4
- 108090000015 Mesothelin Proteins 0.000 abstract 4
- 102000006306 Antigen Receptors Human genes 0.000 abstract 1
- 108010083359 Antigen Receptors Proteins 0.000 abstract 1
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 abstract 1
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
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Abstract
proporcionam-se composições e métodos para tratar doenças associadas à expressão da mesotelina. proporcionam-se também um receptor de antígeno quimérico (car) específico para a mesotelina, vetores codificando o mesmo, e células t recombinantes compreendendo o car de mesotelina. proporcionam-se adicionalmente métodos de administrar uma célula t geneticamente modificada expressando um car que compreende um domínio de ligação à mesotelina.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2013089979 | 2013-12-19 | ||
CN2014082610 | 2014-07-21 | ||
CN2014090509 | 2014-11-06 | ||
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B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
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B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements | ||
B350 | Update of information on the portal [chapter 15.35 patent gazette] |