EA201791271A1 - ТИАЗОЛЫ, ЗАМЕЩЕННЫЕ КАРБОКСАМИДОМ ИЛИ СУЛЬФОНАМИДОМ, И РОДСТВЕННЫЕ ПРОИЗВОДНЫЕ В КАЧЕСТВЕ МОДУЛЯТОРОВ ДЛЯ ОРФАННОГО ЯДЕРНОГО РЕЦЕПТОРА RORγ - Google Patents
ТИАЗОЛЫ, ЗАМЕЩЕННЫЕ КАРБОКСАМИДОМ ИЛИ СУЛЬФОНАМИДОМ, И РОДСТВЕННЫЕ ПРОИЗВОДНЫЕ В КАЧЕСТВЕ МОДУЛЯТОРОВ ДЛЯ ОРФАННОГО ЯДЕРНОГО РЕЦЕПТОРА RORγInfo
- Publication number
- EA201791271A1 EA201791271A1 EA201791271A EA201791271A EA201791271A1 EA 201791271 A1 EA201791271 A1 EA 201791271A1 EA 201791271 A EA201791271 A EA 201791271A EA 201791271 A EA201791271 A EA 201791271A EA 201791271 A1 EA201791271 A1 EA 201791271A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- modulators
- rorγ
- carboxamide
- orphanic
- sulphonamide
- Prior art date
Links
- 108091008773 RAR-related orphan receptors γ Proteins 0.000 title abstract 3
- 150000003857 carboxamides Chemical group 0.000 title abstract 2
- 229940124530 sulfonamide Drugs 0.000 title abstract 2
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 title 1
- FDDDEECHVMSUSB-UHFFFAOYSA-N sulfanilamide Chemical group NC1=CC=C(S(N)(=O)=O)C=C1 FDDDEECHVMSUSB-UHFFFAOYSA-N 0.000 title 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 102000001691 Member 3 Group F Nuclear Receptor Subfamily 1 Human genes 0.000 abstract 1
- 108010029279 Member 3 Group F Nuclear Receptor Subfamily 1 Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000001923 cyclic compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 150000003456 sulfonamides Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A61K31/426—1,3-Thiazoles
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Abstract
Настоящее изобретение обеспечивает модуляторы для орфанного ядерного рецептора RORγ и способы лечения заболеваний, опосредуемых RORγ, путем введения этих новых модуляторов RORγ человеку или млекопитающему, нуждающемуся в этом. В частности, настоящее изобретение обеспечивает циклические соединения, содержащие карбоксамид или сульфонамид, формул (1), (1'), (100), (100'), (200) и (200')и энантиомеры, диастереомеры, таутомеры, N-оксиды, сольваты и фармацевтически приемлемые соли таких соединений.
Applications Claiming Priority (2)
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US201261653556P | 2012-05-31 | 2012-05-31 | |
EP12004186 | 2012-05-31 |
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ID=49672489
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EA201491943A EA028330B1 (ru) | 2012-05-31 | 2013-05-29 | ТИАЗОЛЫ, ЗАМЕЩЕННЫЕ КАРБОКСАМИДОМ ИЛИ СУЛЬФОНАМИДОМ, И РОДСТВЕННЫЕ ПРОИЗВОДНЫЕ В КАЧЕСТВЕ МОДУЛЯТОРОВ ДЛЯ ОРФАННОГО ЯДЕРНОГО РЕЦЕПТОРА RORγ |
EA201791271A EA201791271A1 (ru) | 2012-05-31 | 2013-05-29 | ТИАЗОЛЫ, ЗАМЕЩЕННЫЕ КАРБОКСАМИДОМ ИЛИ СУЛЬФОНАМИДОМ, И РОДСТВЕННЫЕ ПРОИЗВОДНЫЕ В КАЧЕСТВЕ МОДУЛЯТОРОВ ДЛЯ ОРФАННОГО ЯДЕРНОГО РЕЦЕПТОРА RORγ |
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EA201491943A EA028330B1 (ru) | 2012-05-31 | 2013-05-29 | ТИАЗОЛЫ, ЗАМЕЩЕННЫЕ КАРБОКСАМИДОМ ИЛИ СУЛЬФОНАМИДОМ, И РОДСТВЕННЫЕ ПРОИЗВОДНЫЕ В КАЧЕСТВЕ МОДУЛЯТОРОВ ДЛЯ ОРФАННОГО ЯДЕРНОГО РЕЦЕПТОРА RORγ |
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CN (2) | CN107007597A (ru) |
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BR (1) | BR112014029868A2 (ru) |
CA (1) | CA2873877C (ru) |
CL (1) | CL2014003277A1 (ru) |
CO (1) | CO7160113A2 (ru) |
CR (1) | CR20150003A (ru) |
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GT (1) | GT201400275A (ru) |
HK (1) | HK1209117A1 (ru) |
IL (1) | IL235626B (ru) |
MX (1) | MX2014014614A (ru) |
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SG (1) | SG11201407919WA (ru) |
TW (1) | TWI511960B (ru) |
UA (1) | UA117913C2 (ru) |
UY (1) | UY34832A (ru) |
WO (1) | WO2013178362A1 (ru) |
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JOP20200117A1 (ar) * | 2014-10-30 | 2017-06-16 | Janssen Pharmaceutica Nv | كحولات ثلاثي فلوروميثيل كمُعدلات للمستقبل النووي جاما تي المرتبط بحمض الريتيونَويك ROR?t |
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EP3419980A4 (en) | 2016-02-26 | 2019-07-03 | The Board of Trustees of the Leland Stanford Junior University | INHIBITORS OF PI-KINASE WITH ANTI-INFECTIOUS ACTIVITY |
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