EA201791271A1 - ТИАЗОЛЫ, ЗАМЕЩЕННЫЕ КАРБОКСАМИДОМ ИЛИ СУЛЬФОНАМИДОМ, И РОДСТВЕННЫЕ ПРОИЗВОДНЫЕ В КАЧЕСТВЕ МОДУЛЯТОРОВ ДЛЯ ОРФАННОГО ЯДЕРНОГО РЕЦЕПТОРА RORγ - Google Patents

ТИАЗОЛЫ, ЗАМЕЩЕННЫЕ КАРБОКСАМИДОМ ИЛИ СУЛЬФОНАМИДОМ, И РОДСТВЕННЫЕ ПРОИЗВОДНЫЕ В КАЧЕСТВЕ МОДУЛЯТОРОВ ДЛЯ ОРФАННОГО ЯДЕРНОГО РЕЦЕПТОРА RORγ

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Publication number
EA201791271A1
EA201791271A1 EA201791271A EA201791271A EA201791271A1 EA 201791271 A1 EA201791271 A1 EA 201791271A1 EA 201791271 A EA201791271 A EA 201791271A EA 201791271 A EA201791271 A EA 201791271A EA 201791271 A1 EA201791271 A1 EA 201791271A1
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EA
Eurasian Patent Office
Prior art keywords
modulators
rorγ
carboxamide
orphanic
sulphonamide
Prior art date
Application number
EA201791271A
Other languages
English (en)
Inventor
Кристиан Геге
Кристоф Штеенек
Олаф КИНЦЕЛЬ
Джеральд Клейманн
Томас ХОФФМАНН
Original Assignee
Фенекс Фармасьютикалз Аг
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Application filed by Фенекс Фармасьютикалз Аг filed Critical Фенекс Фармасьютикалз Аг
Publication of EA201791271A1 publication Critical patent/EA201791271A1/ru

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    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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Abstract

Настоящее изобретение обеспечивает модуляторы для орфанного ядерного рецептора RORγ и способы лечения заболеваний, опосредуемых RORγ, путем введения этих новых модуляторов RORγ человеку или млекопитающему, нуждающемуся в этом. В частности, настоящее изобретение обеспечивает циклические соединения, содержащие карбоксамид или сульфонамид, формул (1), (1'), (100), (100'), (200) и (200')и энантиомеры, диастереомеры, таутомеры, N-оксиды, сольваты и фармацевтически приемлемые соли таких соединений.
EA201791271A 2012-05-31 2013-05-29 ТИАЗОЛЫ, ЗАМЕЩЕННЫЕ КАРБОКСАМИДОМ ИЛИ СУЛЬФОНАМИДОМ, И РОДСТВЕННЫЕ ПРОИЗВОДНЫЕ В КАЧЕСТВЕ МОДУЛЯТОРОВ ДЛЯ ОРФАННОГО ЯДЕРНОГО РЕЦЕПТОРА RORγ EA201791271A1 (ru)

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EA201491943A EA028330B1 (ru) 2012-05-31 2013-05-29 ТИАЗОЛЫ, ЗАМЕЩЕННЫЕ КАРБОКСАМИДОМ ИЛИ СУЛЬФОНАМИДОМ, И РОДСТВЕННЫЕ ПРОИЗВОДНЫЕ В КАЧЕСТВЕ МОДУЛЯТОРОВ ДЛЯ ОРФАННОГО ЯДЕРНОГО РЕЦЕПТОРА RORγ
EA201791271A EA201791271A1 (ru) 2012-05-31 2013-05-29 ТИАЗОЛЫ, ЗАМЕЩЕННЫЕ КАРБОКСАМИДОМ ИЛИ СУЛЬФОНАМИДОМ, И РОДСТВЕННЫЕ ПРОИЗВОДНЫЕ В КАЧЕСТВЕ МОДУЛЯТОРОВ ДЛЯ ОРФАННОГО ЯДЕРНОГО РЕЦЕПТОРА RORγ

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