DK2414362T3 - Pyrimidinsubstituerede purinforbindelser som kinaseinhibitorer - Google Patents
Pyrimidinsubstituerede purinforbindelser som kinaseinhibitorerInfo
- Publication number
- DK2414362T3 DK2414362T3 DK09788615.4T DK09788615T DK2414362T3 DK 2414362 T3 DK2414362 T3 DK 2414362T3 DK 09788615 T DK09788615 T DK 09788615T DK 2414362 T3 DK2414362 T3 DK 2414362T3
- Authority
- DK
- Denmark
- Prior art keywords
- pyrimidine
- kinase inhibitors
- substituted purine
- purine compounds
- compounds
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A—HUMAN NECESSITIES
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/01—Phosphotransferases with an alcohol group as acceptor (2.7.1)
- C12Y207/01137—Phosphatidylinositol 3-kinase (2.7.1.137)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/11—Protein-serine/threonine kinases (2.7.11)
- C12Y207/11001—Non-specific serine/threonine protein kinase (2.7.11.1), i.e. casein kinase or checkpoint kinase
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/SG2009/000124 WO2010114484A1 (en) | 2009-04-03 | 2009-04-03 | Pyrimidine substituted purine compounds as kinase (s) inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2414362T3 true DK2414362T3 (da) | 2014-09-22 |
Family
ID=41136924
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK09788615.4T DK2414362T3 (da) | 2009-04-03 | 2009-04-03 | Pyrimidinsubstituerede purinforbindelser som kinaseinhibitorer |
Country Status (13)
Country | Link |
---|---|
US (4) | US8754080B2 (da) |
EP (1) | EP2414362B1 (da) |
JP (1) | JP5465318B2 (da) |
CN (1) | CN102428085B (da) |
BR (1) | BRPI0925059A2 (da) |
CA (2) | CA2757485C (da) |
DK (1) | DK2414362T3 (da) |
ES (1) | ES2500643T3 (da) |
HK (2) | HK1168088A1 (da) |
MX (1) | MX2011010332A (da) |
RU (1) | RU2506264C2 (da) |
TW (1) | TWI474822B (da) |
WO (1) | WO2010114484A1 (da) |
Families Citing this family (31)
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EP2209786B1 (en) | 2007-10-05 | 2013-02-27 | Verastem, Inc. | Pyrimidine substituted purine derivatives |
AU2009251291B2 (en) * | 2008-05-30 | 2013-05-02 | F. Hoffmann-La Roche Ag | Purine PI3K inhibitor compounds and methods of use |
CA2730271A1 (en) * | 2008-07-07 | 2010-01-14 | Xcovery Holding Company Llc | Pi3k isoform selective inhibitors |
WO2010114484A1 (en) | 2009-04-03 | 2010-10-07 | S*Bio Pte Ltd | Pyrimidine substituted purine compounds as kinase (s) inhibitors |
TWI579274B (zh) * | 2012-04-20 | 2017-04-21 | 龍馬躍公司 | 製備1-芳基-5-烷基吡唑化合物的改良方法 |
US20150258127A1 (en) * | 2012-10-31 | 2015-09-17 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for preventing antiphospholipid syndrome (aps) |
WO2015055071A1 (zh) * | 2013-10-16 | 2015-04-23 | 上海璎黎药业有限公司 | 稠合杂环化合物、其制备方法、药物组合物和用途 |
CA2929181A1 (en) | 2013-11-13 | 2015-05-21 | Novartis Ag | Mtor inhibitors for enhancing the immune response |
WO2015090230A1 (en) | 2013-12-19 | 2015-06-25 | Novartis Ag | Human mesothelin chimeric antigen receptors and uses thereof |
EP3593812A3 (en) | 2014-03-15 | 2020-05-27 | Novartis AG | Treatment of cancer using chimeric antigen receptor |
IL293603B2 (en) | 2014-04-07 | 2024-03-01 | Novartis Ag | Cancer treatment using chimeric antigen receptor (CAR) against CD19 |
JP2017528433A (ja) | 2014-07-21 | 2017-09-28 | ノバルティス アーゲー | 低い免疫増強用量のmTOR阻害剤とCARの組み合わせ |
US9777061B2 (en) | 2014-07-21 | 2017-10-03 | Novartis Ag | Treatment of cancer using a CD33 chimeric antigen receptor |
WO2016014553A1 (en) | 2014-07-21 | 2016-01-28 | Novartis Ag | Sortase synthesized chimeric antigen receptors |
ES2781175T3 (es) | 2014-07-31 | 2020-08-31 | Novartis Ag | Subconjunto optimizado de células T que contienen un receptor de antígeno quimérico |
AU2015301460B2 (en) | 2014-08-14 | 2021-04-08 | Novartis Ag | Treatment of cancer using GFR alpha-4 chimeric antigen receptor |
JP7084138B2 (ja) | 2014-08-19 | 2022-06-14 | ノバルティス アーゲー | 癌処置に使用するための抗cd123キメラ抗原受容体(car) |
CA2961636A1 (en) | 2014-09-17 | 2016-03-24 | Boris ENGELS | Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy |
CA2963935A1 (en) | 2014-10-08 | 2016-04-14 | Novartis Ag | Biomarkers predictive of therapeutic responsiveness to chimeric antigen receptor therapy and uses thereof |
WO2016109426A1 (en) * | 2014-12-29 | 2016-07-07 | Verastem, Inc. | Oral dosing regimen of a dual mtor and pi3 inhibitor |
WO2016164580A1 (en) | 2015-04-07 | 2016-10-13 | Novartis Ag | Combination of chimeric antigen receptor therapy and amino pyrimidine derivatives |
WO2016168595A1 (en) | 2015-04-17 | 2016-10-20 | Barrett David Maxwell | Methods for improving the efficacy and expansion of chimeric antigen receptor-expressing cells |
WO2016172583A1 (en) | 2015-04-23 | 2016-10-27 | Novartis Ag | Treatment of cancer using chimeric antigen receptor and protein kinase a blocker |
WO2018017708A1 (en) | 2016-07-20 | 2018-01-25 | University Of Utah Research Foundation | Cd229 car t cells and methods of use thereof |
WO2018067992A1 (en) | 2016-10-07 | 2018-04-12 | Novartis Ag | Chimeric antigen receptors for the treatment of cancer |
EP3615055A1 (en) | 2017-04-28 | 2020-03-04 | Novartis AG | Cells expressing a bcma-targeting chimeric antigen receptor, and combination therapy with a gamma secretase inhibitor |
WO2019157516A1 (en) | 2018-02-12 | 2019-08-15 | resTORbio, Inc. | Combination therapies |
EP3784351A1 (en) | 2018-04-27 | 2021-03-03 | Novartis AG | Car t cell therapies with enhanced efficacy |
EP3788369A1 (en) | 2018-05-01 | 2021-03-10 | Novartis Ag | Biomarkers for evaluating car-t cells to predict clinical outcome |
WO2019241789A1 (en) | 2018-06-15 | 2019-12-19 | Navitor Pharmaceuticals, Inc. | Rapamycin analogs and uses thereof |
AU2020397938A1 (en) | 2019-12-05 | 2022-06-23 | Janssen Pharmaceutica Nv | Rapamycin analogs and uses thereof |
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WO2010114484A1 (en) * | 2009-04-03 | 2010-10-07 | S*Bio Pte Ltd | Pyrimidine substituted purine compounds as kinase (s) inhibitors |
-
2009
- 2009-04-03 WO PCT/SG2009/000124 patent/WO2010114484A1/en active Application Filing
- 2009-04-03 JP JP2012503377A patent/JP5465318B2/ja not_active Expired - Fee Related
- 2009-04-03 CA CA2757485A patent/CA2757485C/en not_active Expired - Fee Related
- 2009-04-03 MX MX2011010332A patent/MX2011010332A/es active IP Right Grant
- 2009-04-03 DK DK09788615.4T patent/DK2414362T3/da active
- 2009-04-03 EP EP09788615.4A patent/EP2414362B1/en not_active Not-in-force
- 2009-04-03 CN CN200980159441.3A patent/CN102428085B/zh not_active Expired - Fee Related
- 2009-04-03 BR BRPI0925059-0A patent/BRPI0925059A2/pt not_active Application Discontinuation
- 2009-04-03 CA CA2950529A patent/CA2950529C/en not_active Expired - Fee Related
- 2009-04-03 ES ES09788615.4T patent/ES2500643T3/es active Active
- 2009-04-03 US US13/262,544 patent/US8754080B2/en not_active Expired - Fee Related
- 2009-04-03 RU RU2011141792/04A patent/RU2506264C2/ru not_active IP Right Cessation
-
2010
- 2010-04-02 TW TW099110426A patent/TWI474822B/zh not_active IP Right Cessation
-
2012
- 2012-07-17 HK HK12106992.1A patent/HK1168088A1/xx not_active IP Right Cessation
-
2014
- 2014-05-07 US US14/271,486 patent/US9138437B2/en not_active Expired - Fee Related
-
2015
- 2015-08-18 US US14/828,886 patent/US20160207927A1/en not_active Abandoned
-
2016
- 2016-04-28 HK HK16104906.7A patent/HK1217017A1/zh not_active IP Right Cessation
-
2017
- 2017-01-09 US US15/401,690 patent/US20170121332A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CN102428085A (zh) | 2012-04-25 |
WO2010114484A1 (en) | 2010-10-07 |
US20160207927A1 (en) | 2016-07-21 |
CN102428085B (zh) | 2015-07-15 |
JP5465318B2 (ja) | 2014-04-09 |
JP2012522769A (ja) | 2012-09-27 |
BRPI0925059A2 (pt) | 2015-07-28 |
CA2757485C (en) | 2017-01-17 |
US20150105382A1 (en) | 2015-04-16 |
RU2011141792A (ru) | 2013-05-10 |
CA2950529A1 (en) | 2010-10-07 |
US9138437B2 (en) | 2015-09-22 |
US20120142683A1 (en) | 2012-06-07 |
EP2414362A1 (en) | 2012-02-08 |
US20170121332A1 (en) | 2017-05-04 |
TWI474822B (zh) | 2015-03-01 |
TW201039828A (en) | 2010-11-16 |
MX2011010332A (es) | 2011-11-29 |
EP2414362B1 (en) | 2014-06-11 |
HK1217017A1 (zh) | 2016-12-16 |
ES2500643T3 (es) | 2014-09-30 |
CA2757485A1 (en) | 2010-10-07 |
HK1168088A1 (en) | 2012-12-21 |
RU2506264C2 (ru) | 2014-02-10 |
US8754080B2 (en) | 2014-06-17 |
CA2950529C (en) | 2019-04-30 |
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