BRPI0709690B8 - 5-amido pirimidinas substituídas e composição farmacêutica que as compreende - Google Patents
5-amido pirimidinas substituídas e composição farmacêutica que as compreendeInfo
- Publication number
- BRPI0709690B8 BRPI0709690B8 BRPI0709690A BRPI0709690A BRPI0709690B8 BR PI0709690 B8 BRPI0709690 B8 BR PI0709690B8 BR PI0709690 A BRPI0709690 A BR PI0709690A BR PI0709690 A BRPI0709690 A BR PI0709690A BR PI0709690 B8 BRPI0709690 B8 BR PI0709690B8
- Authority
- BR
- Brazil
- Prior art keywords
- pharmaceutical composition
- substituted pyrimidines
- starch substituted
- starch
- hiv
- Prior art date
Links
- 239000008194 pharmaceutical composition Chemical class 0.000 title abstract 3
- 150000003230 pyrimidines Chemical class 0.000 title abstract 3
- 229920002472 Starch Polymers 0.000 title abstract 2
- 239000008107 starch Substances 0.000 title abstract 2
- 230000002401 inhibitory effect Effects 0.000 abstract 2
- 241000725303 Human immunodeficiency virus Species 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 abstract 1
- 230000010076 replication Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
5-amido pirimidinas substituídas inibidoras de hiv e composição farmacêutica. a presente invenção refere-se aos derivados de pirimidina de fórmula (i) tendo propriedades de inibição de replicação de hiv (vírus de imunodeficiência humana), a preparação desses e composições farmacêuticas compreendendo esses compostos.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06112044.0 | 2006-03-30 | ||
EP06112044 | 2006-03-30 | ||
PCT/EP2007/053111 WO2007113254A1 (en) | 2006-03-30 | 2007-03-30 | Hiv inhibiting 5-amido substituted pyrimidines |
Publications (3)
Publication Number | Publication Date |
---|---|
BRPI0709690A2 BRPI0709690A2 (pt) | 2011-07-19 |
BRPI0709690B1 BRPI0709690B1 (pt) | 2020-09-29 |
BRPI0709690B8 true BRPI0709690B8 (pt) | 2021-05-25 |
Family
ID=36791649
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0709690A BRPI0709690B8 (pt) | 2006-03-30 | 2007-03-30 | 5-amido pirimidinas substituídas e composição farmacêutica que as compreende |
Country Status (14)
Country | Link |
---|---|
US (2) | US8933089B2 (pt) |
EP (1) | EP2004632B1 (pt) |
JP (1) | JP5078986B2 (pt) |
KR (1) | KR20080114741A (pt) |
CN (1) | CN101405283B (pt) |
AU (1) | AU2007233737B2 (pt) |
BR (1) | BRPI0709690B8 (pt) |
CA (1) | CA2645958C (pt) |
DK (1) | DK2004632T3 (pt) |
ES (1) | ES2465666T3 (pt) |
IL (1) | IL193610A (pt) |
MX (1) | MX2008012576A (pt) |
RU (1) | RU2480464C2 (pt) |
WO (1) | WO2007113254A1 (pt) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2005288864B2 (en) | 2004-09-30 | 2012-08-23 | Janssen Sciences Ireland Uc | HIV inhibiting 5-heterocyclyl pyrimidines |
WO2006035069A1 (en) | 2004-09-30 | 2006-04-06 | Tibotec Pharmaceuticals Ltd. | Hiv inhibiting 5-substituted pyrimidines |
WO2006087387A1 (en) * | 2005-02-18 | 2006-08-24 | Tibotec Pharmaceuticals Ltd. | Hiv inhibiting 2-(4-cyanophenylamino) pyrimidine oxide derivatives |
US8933089B2 (en) | 2006-03-30 | 2015-01-13 | Janssen R & D Ireland | HIV inhibiting 5-amido substituted pyrimidines |
AU2007341228B2 (en) | 2006-12-29 | 2013-04-18 | Janssen Sciences Ireland Uc | HIV inhibiting 5,6-substituted pyrimidines |
CN101573343B (zh) | 2006-12-29 | 2016-02-24 | 爱尔兰詹森科学公司 | 抑制人免疫缺陷病毒的6-取代的嘧啶 |
US8138339B2 (en) | 2008-04-16 | 2012-03-20 | Portola Pharmaceuticals, Inc. | Inhibitors of protein kinases |
MX2010011463A (es) | 2008-04-16 | 2011-06-03 | Portola Pharm Inc | 2,6-diamino-pirimidin-5-il-carboxamidas como inhibidores de syk o jak quinasas. |
US9273077B2 (en) | 2008-05-21 | 2016-03-01 | Ariad Pharmaceuticals, Inc. | Phosphorus derivatives as kinase inhibitors |
SI2300013T1 (en) | 2008-05-21 | 2018-03-30 | Adriad Pharmacaceuticals, Inc. | Phosphorus derivatives as kinase inhibitors |
US8338439B2 (en) | 2008-06-27 | 2012-12-25 | Celgene Avilomics Research, Inc. | 2,4-disubstituted pyrimidines useful as kinase inhibitors |
US11351168B1 (en) | 2008-06-27 | 2022-06-07 | Celgene Car Llc | 2,4-disubstituted pyrimidines useful as kinase inhibitors |
DK2361248T3 (en) | 2008-06-27 | 2019-01-14 | Celgene Car Llc | Heteroberl compounds and uses thereof |
ES2659725T3 (es) | 2009-05-05 | 2018-03-19 | Dana-Farber Cancer Institute, Inc. | Inhibidores de EGFR y procedimiento de tratamiento de trastornos |
EP2571361A4 (en) | 2010-05-19 | 2013-11-13 | Univ North Carolina | PYRAZOLOPYRIMIDINE COMPOUNDS FOR CANCER TREATMENT |
EP3144298A1 (en) | 2010-08-10 | 2017-03-22 | Celgene Avilomics Research, Inc. | Besylate salt of a btk inhibitor |
JP5956999B2 (ja) | 2010-11-01 | 2016-07-27 | セルジーン アヴィロミクス リサーチ, インコーポレイテッド | ヘテロアリール化合物およびその使用 |
MX2013004894A (es) | 2010-11-01 | 2013-10-17 | Celgene Avilomics Res Inc | Compuestos heterociclicos y usos de los mismos. |
US8796255B2 (en) | 2010-11-10 | 2014-08-05 | Celgene Avilomics Research, Inc | Mutant-selective EGFR inhibitors and uses thereof |
JP5999177B2 (ja) | 2011-05-04 | 2016-09-28 | アリアド・ファーマシューティカルズ・インコーポレイテッド | Egfr発動性がんの細胞増殖阻害用化合物 |
US9273056B2 (en) | 2011-10-03 | 2016-03-01 | The University Of North Carolina At Chapel Hill | Pyrrolopyrimidine compounds for the treatment of cancer |
AR088570A1 (es) | 2011-10-28 | 2014-06-18 | Celgene Avilomics Res Inc | Metodos para tratar una enfermedad o trastorno relacionado con la tirosina quinasa de bruton |
AU2012340555B2 (en) | 2011-11-23 | 2016-10-20 | Portola Pharmaceuticals, Inc. | Pyrazine kinase inhibitors |
MX356179B (es) | 2012-03-15 | 2018-05-17 | Celgene Avilomics Res Inc | Sales de un inhibidor de cinasa del receptor del factor de crecimiento epidermico. |
JP6317319B2 (ja) | 2012-03-15 | 2018-04-25 | セルジーン シーエーアール エルエルシー | 上皮成長因子受容体キナーゼ阻害剤の固体形態 |
JP6469567B2 (ja) | 2012-05-05 | 2019-02-13 | アリアド・ファーマシューティカルズ・インコーポレイテッド | Egfr発動性がんの細胞増殖阻害用化合物 |
JP2015517574A (ja) * | 2012-05-22 | 2015-06-22 | ザ・ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル | がん治療のためのピリミジン化合物 |
AU2012382373A1 (en) | 2012-06-12 | 2014-12-11 | Abbvie Inc. | Pyridinone and pyridazinone derivatives |
US9562047B2 (en) | 2012-10-17 | 2017-02-07 | The University Of North Carolina At Chapel Hill | Pyrazolopyrimidine compounds for the treatment of cancer |
SG11201503395TA (en) * | 2012-11-08 | 2015-05-28 | Bristol Myers Squibb Co | ALKYL AMIDE-SUBSTITUTED PYRIMIDINE COMPOUNDS USEFUL IN THE MODULATION OF IL-12, IL-23 AND/OR IFNα |
WO2014085225A1 (en) | 2012-11-27 | 2014-06-05 | The University Of North Carolina At Chapel Hill | Pyrimidine compounds for the treatment of cancer |
EP2935226A4 (en) | 2012-12-21 | 2016-11-02 | Celgene Avilomics Res Inc | HETEROARYL COMPOUNDS AND USES THEREOF |
CN105188371A (zh) | 2013-02-08 | 2015-12-23 | 西建阿维拉米斯研究公司 | Erk抑制剂及其用途 |
US9611283B1 (en) | 2013-04-10 | 2017-04-04 | Ariad Pharmaceuticals, Inc. | Methods for inhibiting cell proliferation in ALK-driven cancers |
US9492471B2 (en) | 2013-08-27 | 2016-11-15 | Celgene Avilomics Research, Inc. | Methods of treating a disease or disorder associated with Bruton'S Tyrosine Kinase |
CN103483272B (zh) * | 2013-09-29 | 2015-10-21 | 山东大学 | 间二芳烃-多取代嘧啶类衍生物及其制备方法与应用 |
US9415049B2 (en) | 2013-12-20 | 2016-08-16 | Celgene Avilomics Research, Inc. | Heteroaryl compounds and uses thereof |
WO2015157115A1 (en) | 2014-04-11 | 2015-10-15 | The University Of North Carolina At Chapel Hill | Mertk-specific pyrimidine compounds |
US9988374B2 (en) | 2014-08-11 | 2018-06-05 | Angion Biomedica Corp. | Cytochrome P450 inhibitors and uses thereof |
ES2741785T3 (es) | 2014-08-13 | 2020-02-12 | Celgene Car Llc | Formas y composiciones de un inhibidor de ERK |
CN107531631B (zh) | 2014-12-31 | 2021-09-03 | 安吉昂生物医药公司 | 用于治疗疾病的方法和药剂 |
US10709708B2 (en) | 2016-03-17 | 2020-07-14 | The University Of North Carolina At Chapel Hill | Method of treating cancer with a combination of MER tyrosine kinase inhibitor and an epidermal growth factor receptor (EGFR) inhibitor |
CN106967047A (zh) * | 2017-03-29 | 2017-07-21 | 山东大学 | 一种取代二芳基烟酰胺类衍生物及其制备方法与应用 |
WO2022117016A1 (zh) * | 2020-12-02 | 2022-06-09 | 深圳微芯生物科技股份有限公司 | 羟肟酸酯化合物、其制备方法及其应用 |
CN117186070A (zh) * | 2022-06-01 | 2023-12-08 | 深圳微芯生物科技股份有限公司 | 羟肟酸酯化合物及其盐的结晶形式与制备方法 |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3459731A (en) | 1966-12-16 | 1969-08-05 | Corn Products Co | Cyclodextrin polyethers and their production |
TR199800729T2 (xx) | 1995-11-23 | 1998-07-21 | Janssen Pharmaceutica N.V. | Eritmeli ekstr�zyonla haz�rlanan siklodekstrin kat� kar���mlar�. |
NO311614B1 (no) | 1996-10-01 | 2001-12-17 | Janssen Pharmaceutica Nv | Substituerte diamino-1,3,5-triazinderivater |
EP0945443B9 (en) * | 1998-03-27 | 2003-08-13 | Janssen Pharmaceutica N.V. | HIV inhibiting pyrimidine derivatives |
EP0945447A1 (en) | 1998-03-27 | 1999-09-29 | Janssen Pharmaceutica N.V. | Trisubstituted 1,3,5-triazine derivatives for treatment of HIV infections |
US6459731B1 (en) * | 1998-08-28 | 2002-10-01 | Lucent Technologies Inc. | Technique for video communications using a coding-matched filter arrangement |
PL204427B1 (pl) | 1998-11-10 | 2010-01-29 | Janssen Pharmaceutica Nv | Hamująca replikację wirusa HIV pochodna pirymidyny, sposób jej wytwarzania i zastosowanie oraz kompozycja farmaceutyczna |
GB9828511D0 (en) | 1998-12-24 | 1999-02-17 | Zeneca Ltd | Chemical compounds |
WO2001085700A2 (en) * | 2000-05-08 | 2001-11-15 | Janssen Pharmaceutica N.V. | Hiv replication inhibiting pyrimidines and triazines |
ES2265450T3 (es) | 2000-12-21 | 2007-02-16 | Vertex Pharmaceuticals Incorporated | Compuestos de pirazol utiles como inhibidores de la proteina quinasa. |
JO3429B1 (ar) | 2001-08-13 | 2019-10-20 | Janssen Pharmaceutica Nv | مشتقات برميدينات مثبطة فيروس الايدز |
TWI329105B (en) | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
TW200400034A (en) | 2002-05-20 | 2004-01-01 | Bristol Myers Squibb Co | Pyrazolo-pyrimidine aniline compounds useful as kinase inhibitors |
AP1927A (en) | 2002-11-15 | 2008-12-10 | Tibotec Pharm Ltd | Substituted indolepyridinium as anti-infective compounds |
GB0305929D0 (en) | 2003-03-14 | 2003-04-23 | Novartis Ag | Organic compounds |
US7504396B2 (en) * | 2003-06-24 | 2009-03-17 | Amgen Inc. | Substituted heterocyclic compounds and methods of use |
WO2006035069A1 (en) * | 2004-09-30 | 2006-04-06 | Tibotec Pharmaceuticals Ltd. | Hiv inhibiting 5-substituted pyrimidines |
AU2005288864B2 (en) | 2004-09-30 | 2012-08-23 | Janssen Sciences Ireland Uc | HIV inhibiting 5-heterocyclyl pyrimidines |
ES2371924T3 (es) | 2004-09-30 | 2012-01-11 | Tibotec Pharmaceuticals | Pirimidinas 5-carbo o heterociclo- sustituidas que inhiben el hiv. |
US8933089B2 (en) | 2006-03-30 | 2015-01-13 | Janssen R & D Ireland | HIV inhibiting 5-amido substituted pyrimidines |
CN101573343B (zh) | 2006-12-29 | 2016-02-24 | 爱尔兰詹森科学公司 | 抑制人免疫缺陷病毒的6-取代的嘧啶 |
AU2007341228B2 (en) | 2006-12-29 | 2013-04-18 | Janssen Sciences Ireland Uc | HIV inhibiting 5,6-substituted pyrimidines |
-
2007
- 2007-03-30 US US12/294,692 patent/US8933089B2/en active Active
- 2007-03-30 WO PCT/EP2007/053111 patent/WO2007113254A1/en active Application Filing
- 2007-03-30 DK DK07727583T patent/DK2004632T3/da active
- 2007-03-30 ES ES07727583T patent/ES2465666T3/es active Active
- 2007-03-30 RU RU2008143001/04A patent/RU2480464C2/ru active
- 2007-03-30 KR KR1020087022769A patent/KR20080114741A/ko not_active Application Discontinuation
- 2007-03-30 MX MX2008012576A patent/MX2008012576A/es active IP Right Grant
- 2007-03-30 EP EP20070727583 patent/EP2004632B1/en active Active
- 2007-03-30 CA CA2645958A patent/CA2645958C/en active Active
- 2007-03-30 BR BRPI0709690A patent/BRPI0709690B8/pt not_active IP Right Cessation
- 2007-03-30 AU AU2007233737A patent/AU2007233737B2/en not_active Ceased
- 2007-03-30 JP JP2009502113A patent/JP5078986B2/ja active Active
- 2007-03-30 CN CN200780010280.2A patent/CN101405283B/zh active Active
-
2008
- 2008-08-21 IL IL19361008A patent/IL193610A/en active IP Right Grant
-
2014
- 2014-12-10 US US14/566,400 patent/US9573942B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
US8933089B2 (en) | 2015-01-13 |
JP5078986B2 (ja) | 2012-11-21 |
KR20080114741A (ko) | 2008-12-31 |
US20100168104A1 (en) | 2010-07-01 |
IL193610A (en) | 2014-01-30 |
EP2004632B1 (en) | 2014-03-12 |
AU2007233737A1 (en) | 2007-10-11 |
JP2009531394A (ja) | 2009-09-03 |
RU2008143001A (ru) | 2010-05-10 |
EP2004632A1 (en) | 2008-12-24 |
MX2008012576A (es) | 2008-10-10 |
CN101405283B (zh) | 2014-06-18 |
IL193610A0 (en) | 2009-05-04 |
WO2007113254A1 (en) | 2007-10-11 |
US20150099749A1 (en) | 2015-04-09 |
AU2007233737B2 (en) | 2012-11-29 |
CN101405283A (zh) | 2009-04-08 |
US9573942B2 (en) | 2017-02-21 |
RU2480464C2 (ru) | 2013-04-27 |
DK2004632T3 (da) | 2014-06-16 |
ES2465666T3 (es) | 2014-06-06 |
BRPI0709690A2 (pt) | 2011-07-19 |
CA2645958A1 (en) | 2007-10-11 |
CA2645958C (en) | 2014-11-04 |
BRPI0709690B1 (pt) | 2020-09-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BRPI0709690B8 (pt) | 5-amido pirimidinas substituídas e composição farmacêutica que as compreende | |
BRPI0709266B8 (pt) | 5-(hidroximetileno e aminometileno) pirimidinas substituídas e composição farmacêutica que as compreende | |
BRPI0819328A8 (pt) | Compostos inibidores de replicação de vírus da imunodeficiência humana, composição farmacêutica e uso dos ditos compostos | |
BRPI0408347B8 (pt) | derivados de pirimidina, seu uso, e composição e combinação farmacêuticas | |
ECSP067110A (es) | Derivados de 2-carbamida-4-feniltiazol, su preparación y su aplicación en terapéutica | |
BRPI0715579A2 (pt) | "composto, composição farmacêutica e uso de um composto" | |
EA200802209A1 (ru) | Ингибиторы репликации вируса иммунодефицита человека | |
UA117800C2 (uk) | Похідні урацилу або тиміну для лікування гепатиту с | |
NI200800294A (es) | Nueva forma cristalina vi de la agomelatina, su procedimiento de preparacion y las composiciones farmacéuticas que la contienen. | |
BRPI0513901A (pt) | derivados de uréia cìclicos substituìdos, preparação dos mesmos e uso farmacêutico dos mesmos como inibidores de cinase | |
UY29675A1 (es) | Nuevos derivados de 1,1-dióxido de 1,4-benzotiazepina con mejores propiedades, procedimiento para su preparacion, medicamentoss que comprenden este compuestoy su uso. | |
CR10497A (es) | Derivados de piperazinilo utiles en el tratamiento de enfermedades mediadas por el receptor gpr38 | |
UY32648A (es) | Nuevos derivados de pirimidina y su uso en el tratamiento de enfermedades | |
UY30824A1 (es) | Nuevos derivados de idazolil éster o amida, composiciones farmacéuticas conteniéndolas, procesos de preparacion y aplicaciones. | |
WO2008089105A3 (en) | Antiviral nucleoside analogs | |
DOP2011000171A (es) | Compuestos organico | |
BRPI0814065B8 (pt) | derivados de alcoóis de 1-fenil-2-piridinil alquila como inibidores da fosfodiesterase | |
BRPI0512677A2 (pt) | derivados de quinazolina | |
UY29416A1 (es) | Derivados de ácido pirimidincarboxílico y su uso | |
MX2010001338A (es) | Derivados de pirimidina y piridina y su uso y composiciones farmaceuticas. | |
CL2008000959A1 (es) | Compuestos derivados de 1,2,4-tiadiazina o 1,4-tiazina; composiciones farmaceuticas que los contienen; y su uso para la prevencion y/o tratamiento de infecciones producidas por el virus de la hepatitis c. | |
HN2008001393A (es) | Derivados de 1,2,4,5- tetrahidro -3h- benzazepinas, su procedimiento de preparacion y las composiciones farmaceuticas que las contienen | |
BRPI0714553B8 (pt) | derivados de camptotecina, processo para preparação dos mesmos, composição farmacêutica e seu uso | |
BRPI0909055A2 (pt) | composto derivado de piridin-2-il, composição farmacêutica que o contém e uso desse composto. | |
CO6351723A2 (es) | Derivados de pirazolo-[5,1-b]-oxazol como antagonistas de crf1 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B25D | Requested change of name of applicant approved |
Owner name: TIBOTEC PHARMACEUTICALS (IE) |
|
B25D | Requested change of name of applicant approved |
Owner name: JANSSEN R AND D IRELAND (IE) |
|
B25A | Requested transfer of rights approved |
Owner name: JANSSEN SCIENCES IRELAND UC (IE) |
|
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 29/09/2020, OBSERVADAS AS CONDICOES LEGAIS. |
|
B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 30/03/2007 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |
|
B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time |
Free format text: REFERENTE A 17A ANUIDADE. |