DK1406907T3 - Antitumorderivater af ET-743 - Google Patents

Antitumorderivater af ET-743

Info

Publication number
DK1406907T3
DK1406907T3 DK02747577T DK02747577T DK1406907T3 DK 1406907 T3 DK1406907 T3 DK 1406907T3 DK 02747577 T DK02747577 T DK 02747577T DK 02747577 T DK02747577 T DK 02747577T DK 1406907 T3 DK1406907 T3 DK 1406907T3
Authority
DK
Denmark
Prior art keywords
substituted
unsubstituted
alkenyl
alkyl
alkynyl
Prior art date
Application number
DK02747577T
Other languages
English (en)
Inventor
Valentin Martinez
Maria Flores
Pilar Gallego
Carmen Cuevas
Simon Munt
Ignacio Manzanares
Original Assignee
Pharma Mar Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharma Mar Sa filed Critical Pharma Mar Sa
Application granted granted Critical
Publication of DK1406907T3 publication Critical patent/DK1406907T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Saccharide Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK02747577T 2001-07-17 2002-07-17 Antitumorderivater af ET-743 DK1406907T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0117402.8A GB0117402D0 (en) 2001-07-17 2001-07-17 New antitumoral derivatives of et-743
PCT/GB2002/003288 WO2003008423A1 (en) 2001-07-17 2002-07-17 New antitumoral derivatives of et-743

Publications (1)

Publication Number Publication Date
DK1406907T3 true DK1406907T3 (da) 2008-02-04

Family

ID=9918658

Family Applications (3)

Application Number Title Priority Date Filing Date
DK10180049.8T DK2298780T3 (da) 2001-07-17 2002-07-17 Tumorhæmmende derivater af Ecteinascidin ET-743
DK07011446.7T DK1854800T3 (da) 2001-07-17 2002-07-17 Tumorhæmmende derivater af ecteinascidin ET-743
DK02747577T DK1406907T3 (da) 2001-07-17 2002-07-17 Antitumorderivater af ET-743

Family Applications Before (2)

Application Number Title Priority Date Filing Date
DK10180049.8T DK2298780T3 (da) 2001-07-17 2002-07-17 Tumorhæmmende derivater af Ecteinascidin ET-743
DK07011446.7T DK1854800T3 (da) 2001-07-17 2002-07-17 Tumorhæmmende derivater af ecteinascidin ET-743

Country Status (16)

Country Link
US (2) US7759345B2 (da)
EP (3) EP1854800B1 (da)
JP (1) JP4653950B2 (da)
AT (1) ATE371661T1 (da)
AU (2) AU2002317967C1 (da)
CA (1) CA2453991C (da)
CY (2) CY1107809T1 (da)
DE (1) DE60222135T2 (da)
DK (3) DK2298780T3 (da)
ES (3) ES2389671T3 (da)
GB (1) GB0117402D0 (da)
MX (1) MXPA04000506A (da)
NO (2) NO335262B1 (da)
PT (3) PT1406907E (da)
SI (2) SI2298780T1 (da)
WO (1) WO2003008423A1 (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA02011319A (es) 2000-05-15 2003-06-06 Pharma Mar Sa Analogos antitumorales de ecteinascidina 743.
GB0202544D0 (en) * 2002-02-04 2002-03-20 Pharma Mar Sa The synthesis of naturally occuring ecteinascidins and related compounds
WO2006035244A2 (en) * 2004-09-29 2006-04-06 Pharma Mar S.A., Sociedad Unipersonal Ecteinascidin compounds as anti -inflammatory agents
GB0521536D0 (en) * 2005-10-22 2005-11-30 Invibio Ltd Fiducial marker
JP6037337B2 (ja) 2010-05-25 2016-12-07 ファルマ、マール、ソシエダード、アノニマＰｈａｒｍａ Ｍｒｓ，Ｓ．Ａ． エクチナサイジン化合物の製造のための合成方法
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59225189A (ja) 1983-06-03 1984-12-18 Shionogi & Co Ltd キノナミン誘導体およびその製造法
JPS6084288A (ja) 1983-10-13 1985-05-13 Shionogi & Co Ltd シアノキノナミンアセテ−ト類およびその製造法
US5149804A (en) * 1990-11-30 1992-09-22 The Board Of Trustees Of The University Of Illinois Ecteinascidins 736 and 722
US5089273A (en) 1986-06-09 1992-02-18 Board Of Trustees Of The University Of Illinois Ecteinascidins 729, 743, 745, 759A, 759B and 770
ATE69234T1 (de) * 1986-06-09 1991-11-15 Univ Illinois Ekteinascidine 729, 743, 745, 759a, 759b and 770.
US5256663A (en) 1986-06-09 1993-10-26 The Board Of Trustees Of The University Of Illinois Compositions comprising ecteinascidins and a method of treating herpes simplex virus infections therewith
US5478932A (en) 1993-12-02 1995-12-26 The Board Of Trustees Of The University Of Illinois Ecteinascidins
US20040059112A1 (en) 1994-02-18 2004-03-25 Rinehart Kenneth L. Ecteinascidins
US5721362A (en) 1996-09-18 1998-02-24 President And Fellows Of Harvard College Process for producing ecteinascidin compounds
US5985876A (en) 1997-04-15 1999-11-16 Univ Illinois Nucleophile substituted ecteinascidins and N-oxide ecteinascidins
CA2327468C (en) 1998-04-06 2008-05-06 The Board Of Trustees Of The University Of Illinois Semi-synthetic ecteinascidins
ATE303057T1 (de) 1998-05-05 2005-09-15 Pharma Mar Sa Kultivierung von sessilen meerestieren
US6316214B1 (en) 1998-05-11 2001-11-13 The Board Of Trustees Of The University Of Illinois ETM-775 metabolite of ecteinascidin 743
US6124292A (en) 1998-09-30 2000-09-26 President And Fellows Of Harvard College Synthetic analogs of ecteinascidin-743
MY164077A (en) 1999-05-13 2017-11-30 Pharma Mar Sa Compositions and uses of et743 for treating cancer
MY130271A (en) 1999-05-14 2007-06-29 Pharma Mar Sa Hemisynthetic method and new compounds
WO2001053299A1 (en) 2000-01-19 2001-07-26 The Trustees Of Columbia University In The City Of New York Compounds of the saframycin-ecteinascidin series, uses, and synthesis thereof
US6815544B2 (en) 2000-02-11 2004-11-09 President And Fellows Of Harvard College Synthetic process for an intermediate for ecteinascidin and phthalascidin compounds
US6569859B1 (en) 2000-02-22 2003-05-27 President And Fellows Of Harvard College Synthetic analogs of ecteinascidin-743
US7919493B2 (en) 2000-04-12 2011-04-05 Pharma Mar, S.A. Anititumoral ecteinascidin derivatives
PT1280809E (pt) 2000-04-12 2005-11-30 Pharma Mar Sa Derivados antitumorais de ecteinascidina
MXPA02011319A (es) 2000-05-15 2003-06-06 Pharma Mar Sa Analogos antitumorales de ecteinascidina 743.
US7420051B2 (en) 2000-05-15 2008-09-02 Pharma Mar, S.A. Synthetic process for the manufacture of an ecteinaschidin compound
NZ525730A (en) 2000-11-06 2004-12-24 Pharma Mar S Compositions for antitumour treatments containing Ecteinascidin 743
BR0213424A (pt) 2001-10-19 2004-12-14 Pharma Mar Sa Uso aperfeiçoado de composto antitumoral na terapia contra câncer
GB0202544D0 (en) 2002-02-04 2002-03-20 Pharma Mar Sa The synthesis of naturally occuring ecteinascidins and related compounds
GB0218813D0 (en) 2002-08-13 2002-09-18 Pharma Mar Sa DNA sequences from an endosymbiont and their uses
GB0229793D0 (en) 2002-12-20 2003-01-29 Pharma Mar Sa The gene cluster involved in safracin biosynthesis and its uses for genetic engineering
GB0312407D0 (en) 2003-05-29 2003-07-02 Pharma Mar Sau Treatment
GB0324201D0 (en) 2003-10-15 2003-11-19 Pharma Mar Sau Improved antitumoral combinations
PT1689404E (pt) 2003-11-13 2008-12-15 Pharma Mar Sau Combinação de et-743 com pró-fármacos de fluorouracil para o tratamento do cancro
AU2004291037A1 (en) 2003-11-14 2005-06-02 Pharma Mar, S.A. Combination therapy comprising the use of ET-743 and paclitaxel for treating cancer
GB0326486D0 (en) 2003-11-14 2003-12-17 Pharma Mar Sau Combination treatment
EP1768671A2 (en) 2004-07-09 2007-04-04 Pharma Mar, S.A. Use of ecteinascidin in the treatment of cancer in patients with low level of brca1
WO2006035244A2 (en) 2004-09-29 2006-04-06 Pharma Mar S.A., Sociedad Unipersonal Ecteinascidin compounds as anti -inflammatory agents
CN101119750B (zh) 2004-10-26 2013-03-06 法马马私人股份有限公司 抗癌治疗
PL1658848T3 (pl) 2004-10-29 2007-12-31 Pharma Mar Sa Preparaty zawierające ekteinascydynę i disacharyd
GB0522082D0 (en) 2005-10-31 2005-12-07 Pharma Mar Sa Formulations
WO2007062413A2 (en) 2005-11-25 2007-05-31 University Of Medicine And Dentistry Of New Jersey Use of parp-1 inhibitors
JP2009536956A (ja) 2006-05-12 2009-10-22 ファルマ・マール・ソシエダード・アノニマ 抗癌治療法
US20100267732A1 (en) 2007-10-19 2010-10-21 Pharma Mar, S.A. Prognostic Molecular Markers for ET-743 Treatment
CN102065865B (zh) 2008-05-16 2013-03-20 马尔药品公司 多发性骨髓瘤治疗
RU2010151602A (ru) 2008-05-16 2012-06-27 Фарма Мар, С.А. (Es) Комбинированная терапия с помощью рм00104 и другого противоопухолевого средства

Also Published As

Publication number Publication date
PT1854800E (pt) 2012-09-25
ES2394772T3 (es) 2013-02-05
NO340213B1 (no) 2017-03-20
EP1406907B1 (en) 2007-08-29
NO335262B1 (no) 2014-10-27
DE60222135D1 (de) 2007-10-11
ES2291479T3 (es) 2008-03-01
WO2003008423A1 (en) 2003-01-30
EP1854800B1 (en) 2012-06-27
EP1406907A1 (en) 2004-04-14
JP4653950B2 (ja) 2011-03-16
EP1854800A1 (en) 2007-11-14
ES2389671T3 (es) 2012-10-30
US20060106021A1 (en) 2006-05-18
CY1113359T1 (el) 2016-06-22
CY1107809T1 (el) 2013-06-19
GB0117402D0 (en) 2001-09-05
AU2002317967C1 (en) 2009-01-22
CA2453991A1 (en) 2003-01-30
MXPA04000506A (es) 2004-07-23
EP2298780A1 (en) 2011-03-23
NO20040189L (no) 2004-03-16
EP2298780B1 (en) 2012-09-12
SI2298780T1 (sl) 2013-01-31
NO20140711L (no) 2004-03-16
US8076337B2 (en) 2011-12-13
JP2004536132A (ja) 2004-12-02
US7759345B2 (en) 2010-07-20
SI1854800T1 (sl) 2012-11-30
AU2008207381B2 (en) 2011-07-14
AU2002317967B2 (en) 2008-06-05
DK2298780T3 (da) 2013-01-07
AU2008207381A1 (en) 2008-09-11
DK1854800T3 (da) 2012-10-01
PT1406907E (pt) 2007-12-10
DE60222135T2 (de) 2008-05-21
US20100197695A1 (en) 2010-08-05
ATE371661T1 (de) 2007-09-15
CA2453991C (en) 2011-12-20
PT2298780E (pt) 2012-12-17

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