MXPA04000506A - Nuevos derivados de et-743 antitumorales. - Google Patents

Nuevos derivados de et-743 antitumorales.

Info

Publication number
MXPA04000506A
MXPA04000506A MXPA04000506A MXPA04000506A MXPA04000506A MX PA04000506 A MXPA04000506 A MX PA04000506A MX PA04000506 A MXPA04000506 A MX PA04000506A MX PA04000506 A MXPA04000506 A MX PA04000506A MX PA04000506 A MXPA04000506 A MX PA04000506A
Authority
MX
Mexico
Prior art keywords
derivatives
new antitumoral
antitumoral derivatives
new
general formula
Prior art date
Application number
MXPA04000506A
Other languages
English (en)
Inventor
Gallego Pilar
Original Assignee
Pharma Mar Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharma Mar Sa filed Critical Pharma Mar Sa
Publication of MXPA04000506A publication Critical patent/MXPA04000506A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Se proporcionan derivados de Et-743 o Et-770 o Et-729. Los derivados son de la formula general (la), en donde los grupos substituyentes toman varios significados permitidos. (ver formula).
MXPA04000506A 2001-07-17 2002-07-17 Nuevos derivados de et-743 antitumorales. MXPA04000506A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0117402.8A GB0117402D0 (en) 2001-07-17 2001-07-17 New antitumoral derivatives of et-743
PCT/GB2002/003288 WO2003008423A1 (en) 2001-07-17 2002-07-17 New antitumoral derivatives of et-743

Publications (1)

Publication Number Publication Date
MXPA04000506A true MXPA04000506A (es) 2004-07-23

Family

ID=9918658

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA04000506A MXPA04000506A (es) 2001-07-17 2002-07-17 Nuevos derivados de et-743 antitumorales.

Country Status (16)

Country Link
US (2) US7759345B2 (es)
EP (3) EP1854800B1 (es)
JP (1) JP4653950B2 (es)
AT (1) ATE371661T1 (es)
AU (2) AU2002317967C1 (es)
CA (1) CA2453991C (es)
CY (2) CY1107809T1 (es)
DE (1) DE60222135T2 (es)
DK (3) DK2298780T3 (es)
ES (3) ES2291479T3 (es)
GB (1) GB0117402D0 (es)
MX (1) MXPA04000506A (es)
NO (2) NO335262B1 (es)
PT (3) PT2298780E (es)
SI (2) SI1854800T1 (es)
WO (1) WO2003008423A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA02011319A (es) 2000-05-15 2003-06-06 Pharma Mar Sa Analogos antitumorales de ecteinascidina 743.
GB0202544D0 (en) 2002-02-04 2002-03-20 Pharma Mar Sa The synthesis of naturally occuring ecteinascidins and related compounds
CN101068596A (zh) * 2004-09-29 2007-11-07 法马马私人股份有限公司 艾可特耐思地作抗炎药
GB0521536D0 (en) * 2005-10-22 2005-11-30 Invibio Ltd Fiducial marker
CN107033164A (zh) 2010-05-25 2017-08-11 法马马有限公司 制备海鞘素化合物的合成方法
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59225189A (ja) 1983-06-03 1984-12-18 Shionogi & Co Ltd キノナミン誘導体およびその製造法
JPS6084288A (ja) 1983-10-13 1985-05-13 Shionogi & Co Ltd シアノキノナミンアセテ−ト類およびその製造法
US5089273A (en) 1986-06-09 1992-02-18 Board Of Trustees Of The University Of Illinois Ecteinascidins 729, 743, 745, 759A, 759B and 770
US5256663A (en) * 1986-06-09 1993-10-26 The Board Of Trustees Of The University Of Illinois Compositions comprising ecteinascidins and a method of treating herpes simplex virus infections therewith
WO1987007610A2 (en) * 1986-06-09 1987-12-17 University Of Illinois Ecteinascidins 729, 743, 745, 759a, 759b and 770
US5149804A (en) * 1990-11-30 1992-09-22 The Board Of Trustees Of The University Of Illinois Ecteinascidins 736 and 722
US5478932A (en) 1993-12-02 1995-12-26 The Board Of Trustees Of The University Of Illinois Ecteinascidins
US20040059112A1 (en) 1994-02-18 2004-03-25 Rinehart Kenneth L. Ecteinascidins
US5721362A (en) 1996-09-18 1998-02-24 President And Fellows Of Harvard College Process for producing ecteinascidin compounds
US5985876A (en) * 1997-04-15 1999-11-16 Univ Illinois Nucleophile substituted ecteinascidins and N-oxide ecteinascidins
NZ507350A (en) * 1998-04-06 2003-03-28 Univ Illinois Semi-synthetic ecteinascidins and use in treatment of tumors
TR200003257T2 (tr) * 1998-05-05 2001-03-21 Graham Keith Ruffles Yerleşmiş deniz hayvanları kültürü.
NZ508585A (en) * 1998-05-11 2002-11-26 Pharma Mar S Metabolites of ecteinascidin 743
US6124292A (en) * 1998-09-30 2000-09-26 President And Fellows Of Harvard College Synthetic analogs of ecteinascidin-743
MY164077A (en) 1999-05-13 2017-11-30 Pharma Mar Sa Compositions and uses of et743 for treating cancer
AR035842A1 (es) 1999-05-14 2004-07-21 Pharma Mar Sa Metodo de hemisintesis para la formacion de compuestos intermediarios y derivados y de estructuras relacionadas con la ecteinascidina y de tetrahidroisoquinolinfenoles y compuestos intermediarios de aplicacion en dicho metodo
US6686470B2 (en) * 2000-01-19 2004-02-03 The Trustees Of Columbia University In The City Of New York Compounds of the saframycin-ecteinascidin series, uses, and synthesis thereof
US6815544B2 (en) * 2000-02-11 2004-11-09 President And Fellows Of Harvard College Synthetic process for an intermediate for ecteinascidin and phthalascidin compounds
US6569859B1 (en) * 2000-02-22 2003-05-27 President And Fellows Of Harvard College Synthetic analogs of ecteinascidin-743
CN1436191B (zh) 2000-04-12 2011-09-14 法马马有限公司 抗肿瘤海鞘素衍生物
US7919493B2 (en) 2000-04-12 2011-04-05 Pharma Mar, S.A. Anititumoral ecteinascidin derivatives
US7420051B2 (en) 2000-05-15 2008-09-02 Pharma Mar, S.A. Synthetic process for the manufacture of an ecteinaschidin compound
MXPA02011319A (es) * 2000-05-15 2003-06-06 Pharma Mar Sa Analogos antitumorales de ecteinascidina 743.
ATE495793T1 (de) 2000-11-06 2011-02-15 Pharma Mar Sa Antitumorzusammensetzungen welche ecteinascidin 743 enthalten
PL368458A1 (en) 2001-10-19 2005-03-21 Pharmamar S.A. Improved use of antitumoral compound in cancer therapy
GB0202544D0 (en) 2002-02-04 2002-03-20 Pharma Mar Sa The synthesis of naturally occuring ecteinascidins and related compounds
GB0218813D0 (en) * 2002-08-13 2002-09-18 Pharma Mar Sa DNA sequences from an endosymbiont and their uses
GB0229793D0 (en) 2002-12-20 2003-01-29 Pharma Mar Sa The gene cluster involved in safracin biosynthesis and its uses for genetic engineering
GB0312407D0 (en) 2003-05-29 2003-07-02 Pharma Mar Sau Treatment
GB0324201D0 (en) 2003-10-15 2003-11-19 Pharma Mar Sau Improved antitumoral combinations
DE602004016376D1 (de) * 2003-11-13 2008-10-16 Pharma Mar Sau Kombination von et-743 mit 5-fluorouracil pro-drugs zur behandlung von krebs
GB0326486D0 (en) 2003-11-14 2003-12-17 Pharma Mar Sau Combination treatment
EP1691809A1 (en) 2003-11-14 2006-08-23 Pharma Mar, S.A. Combination therapy comprising the use of et-743 and paclitaxel for treating cancer
CA2573072A1 (en) 2004-07-09 2006-01-19 Rafael Rosell Costa Use of ecteinascidin in the treatment of cancer in patients with low level of brca1
CN101068596A (zh) 2004-09-29 2007-11-07 法马马私人股份有限公司 艾可特耐思地作抗炎药
ATE430586T1 (de) 2004-10-26 2009-05-15 Pharma Mar Sa Pegyliertes liposomales doxorubicin in kombination mit ecteinescidin 743
EP1658848B1 (en) 2004-10-29 2007-08-01 Pharma Mar S.A., Sociedad Unipersonal Formulations comprising ecteinascidin and a disaccharide
GB0522082D0 (en) 2005-10-31 2005-12-07 Pharma Mar Sa Formulations
ES2361566T3 (es) 2005-11-25 2011-06-20 Pharma Mar S.A., Sociedad Unipersonal Uso de inhibidores de parp-1.
AU2007249281A1 (en) 2006-05-12 2007-11-22 Pharma Mar, S.A. Anticancer treatments with a combination of docetaxel and ecteinascidin
AU2008313634A1 (en) 2007-10-19 2009-04-23 Pharma Mar, S.A. Prognostic molecular markers for ET-743 treatment
JP2011520921A (ja) 2008-05-16 2011-07-21 ファルマ・マール・ソシエダード・アノニマ 抗腫瘍アルカロイドとの併用療法
NZ589270A (en) 2008-05-16 2011-12-22 Pharma Mar Sa Multiple myeloma treatments

Also Published As

Publication number Publication date
EP2298780A1 (en) 2011-03-23
ES2394772T3 (es) 2013-02-05
DK1406907T3 (da) 2008-02-04
WO2003008423A1 (en) 2003-01-30
EP1406907B1 (en) 2007-08-29
JP4653950B2 (ja) 2011-03-16
NO340213B1 (no) 2017-03-20
EP2298780B1 (en) 2012-09-12
US7759345B2 (en) 2010-07-20
AU2008207381A1 (en) 2008-09-11
EP1406907A1 (en) 2004-04-14
EP1854800A1 (en) 2007-11-14
SI2298780T1 (sl) 2013-01-31
DE60222135D1 (de) 2007-10-11
JP2004536132A (ja) 2004-12-02
PT1406907E (pt) 2007-12-10
AU2002317967C1 (en) 2009-01-22
NO20140711L (no) 2004-03-16
AU2008207381B2 (en) 2011-07-14
GB0117402D0 (en) 2001-09-05
CA2453991A1 (en) 2003-01-30
CY1107809T1 (el) 2013-06-19
EP1854800B1 (en) 2012-06-27
DE60222135T2 (de) 2008-05-21
AU2002317967B2 (en) 2008-06-05
ES2291479T3 (es) 2008-03-01
US8076337B2 (en) 2011-12-13
DK1854800T3 (da) 2012-10-01
ATE371661T1 (de) 2007-09-15
PT1854800E (pt) 2012-09-25
US20060106021A1 (en) 2006-05-18
ES2389671T3 (es) 2012-10-30
DK2298780T3 (da) 2013-01-07
PT2298780E (pt) 2012-12-17
US20100197695A1 (en) 2010-08-05
NO20040189L (no) 2004-03-16
CY1113359T1 (el) 2016-06-22
CA2453991C (en) 2011-12-20
SI1854800T1 (sl) 2012-11-30
NO335262B1 (no) 2014-10-27

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