DK1286998T3 - Oxazolidinonderivater med antibiotisk aktivitet - Google Patents
Oxazolidinonderivater med antibiotisk aktivitetInfo
- Publication number
- DK1286998T3 DK1286998T3 DK01921669T DK01921669T DK1286998T3 DK 1286998 T3 DK1286998 T3 DK 1286998T3 DK 01921669 T DK01921669 T DK 01921669T DK 01921669 T DK01921669 T DK 01921669T DK 1286998 T3 DK1286998 T3 DK 1286998T3
- Authority
- DK
- Denmark
- Prior art keywords
- sup
- alkyl
- optionally substituted
- atom
- het
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0009803.8A GB0009803D0 (en) | 2000-04-25 | 2000-04-25 | Chemical compounds |
PCT/GB2001/001815 WO2001081350A1 (en) | 2000-04-25 | 2001-04-23 | Oxazolidinone derivatives with antibiotic activity |
Publications (2)
Publication Number | Publication Date |
---|---|
DK1286998T3 true DK1286998T3 (da) | 2004-09-06 |
DK1286998T4 DK1286998T4 (da) | 2008-03-10 |
Family
ID=9890314
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK01921669T DK1286998T4 (da) | 2000-04-25 | 2001-04-23 | Oxazolidinonderivater med antibiotisk aktivitet |
Country Status (29)
Country | Link |
---|---|
US (1) | US7141583B2 (da) |
EP (1) | EP1286998B2 (da) |
JP (1) | JP2003531211A (da) |
KR (1) | KR100858771B1 (da) |
CN (1) | CN1277829C (da) |
AT (1) | ATE268778T1 (da) |
AU (1) | AU781784B2 (da) |
BR (1) | BR0110240A (da) |
CA (1) | CA2405349C (da) |
CZ (1) | CZ20023527A3 (da) |
DE (1) | DE60103754T3 (da) |
DK (1) | DK1286998T4 (da) |
EE (1) | EE200200598A (da) |
ES (1) | ES2220759T5 (da) |
GB (1) | GB0009803D0 (da) |
HK (1) | HK1053114A1 (da) |
HU (1) | HUP0300416A2 (da) |
IL (2) | IL152284A0 (da) |
IS (1) | IS6583A (da) |
MX (1) | MXPA02010453A (da) |
NO (1) | NO328549B1 (da) |
NZ (1) | NZ521765A (da) |
PL (1) | PL358326A1 (da) |
PT (1) | PT1286998E (da) |
RU (1) | RU2002131455A (da) |
SI (1) | SI1286998T2 (da) |
TR (1) | TR200402261T4 (da) |
WO (1) | WO2001081350A1 (da) |
ZA (1) | ZA200208187B (da) |
Families Citing this family (54)
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GB0113299D0 (en) * | 2001-06-01 | 2001-07-25 | Astrazeneca Ab | Chemical process & intermediates |
WO2003022824A1 (en) | 2001-09-11 | 2003-03-20 | Astrazeneca Ab | Oxazolidinone and/or isoxazoline as antibacterial agents |
WO2003035073A1 (en) | 2001-10-25 | 2003-05-01 | Astrazeneca Ab | Isoxazoline derivatives useful as antimicrobials |
KR100445437B1 (ko) * | 2002-02-08 | 2004-08-21 | 한국과학기술연구원 | 네오마이신-옥사졸리디논 헤테로 이합체, 그의 제조방법및 그의 용도 |
US7141588B2 (en) | 2002-02-25 | 2006-11-28 | Pfizer, Inc. | N-aryl-2-oxazolidinone-5-carboxamides and their derivatives |
AR038536A1 (es) | 2002-02-25 | 2005-01-19 | Upjohn Co | N-aril-2-oxazolidinona-5- carboxamidas y sus derivados |
IL163688A0 (en) | 2002-02-28 | 2005-12-18 | Astrazeneca Ab | 3-Cyclyl-5-(nitrogen-containing 5-membered ring)methyl-oxazolidinone derivatives and theiruse as antibacterial agents |
PL372090A1 (en) | 2002-02-28 | 2005-07-11 | Astrazeneca Ab | Chemical compounds |
JP2005537301A (ja) | 2002-08-12 | 2005-12-08 | ファルマシア・アンド・アップジョン・カンパニー・エルエルシー | N−アリール−2−オキサゾリジノン類及びそれらの誘導体 |
AR043050A1 (es) | 2002-09-26 | 2005-07-13 | Rib X Pharmaceuticals Inc | Compuestos heterociclicos bifuncionales y metodos para preparar y usar los mismos |
US6875784B2 (en) | 2002-10-09 | 2005-04-05 | Pharmacia & Upjohn Company | Antimibicrobial [3.1.0.] bicyclic oxazolidinone derivatives |
AR042086A1 (es) | 2002-11-21 | 2005-06-08 | Upjohn Co | N-aril-2- oxazolidinon -5- carboxamidas y sus derivados, usados como agentes antibacterianos |
KR20050084010A (ko) * | 2002-11-28 | 2005-08-26 | 아스트라제네카 아베 | 항균제로서의 옥사졸리디논 |
GB0227701D0 (en) * | 2002-11-28 | 2003-01-08 | Astrazeneca Ab | Chemical compounds |
GB0229522D0 (en) * | 2002-12-19 | 2003-01-22 | Astrazeneca Ab | Chemical compounds |
US7012088B2 (en) | 2003-02-24 | 2006-03-14 | Pharmacia & Upjohn Company | Indolone oxazolidinones and derivatives thereof |
GB0304723D0 (en) * | 2003-03-01 | 2003-04-02 | Astrazeneca Ab | Chemical compounds |
GB0306357D0 (en) * | 2003-03-20 | 2003-04-23 | Astrazeneca Ab | Chemical compounds |
GB0306358D0 (en) | 2003-03-20 | 2003-04-23 | Astrazeneca Ab | Chemical compounds |
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US6969726B2 (en) | 2003-06-03 | 2005-11-29 | Rib X Pharmaceuticals Inc | Biaryl heterocyclic compounds and methods of making and using the same |
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KR100854211B1 (ko) | 2003-12-18 | 2008-08-26 | 동아제약주식회사 | 신규한 옥사졸리디논 유도체, 그의 제조방법 및 이를유효성분으로 하는 항생제용 약학 조성물 |
EP2716647A3 (en) | 2004-02-27 | 2014-08-20 | Rib-X Pharmaceuticals, Inc. | Macrocyclic compounds and methods of making and using the same |
AU2005247670A1 (en) * | 2004-05-25 | 2005-12-08 | Astrazeneca Ab | 3- {4- (pyridin-3-yl) phenyl} -5- (1H-1, 2, 3-triazol-1-ylmethyl) -1, 3-oxazolidin-2-ones as antibacterial agents |
EP1753754A1 (en) * | 2004-05-25 | 2007-02-21 | AstraZeneca AB | 3- '4- {6-substituted alkanoyl) pyridin-3-yl} -3-phenyl! -5- (1h-1, 2, 3-triazol-1-ylmethyl) -1, 3-oxazolidin-2-ones as antibacterial agents |
CN100360525C (zh) * | 2004-09-16 | 2008-01-09 | 中国科学院上海药物研究所 | 一类新的噁唑烷酮衍生物、其制备方法和用途 |
KR100629327B1 (ko) | 2004-10-20 | 2006-09-29 | 한국과학기술연구원 | 신규 트리아졸릴메틸옥사졸리디논 유도체 |
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CA2751392C (en) * | 2009-02-03 | 2017-03-28 | Trius Therapeutics, Inc. | Crystalline form of r)-3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-5-hydroxymethyl oxazolidin-2-one dihydrogen phosphate |
US8580767B2 (en) * | 2009-05-28 | 2013-11-12 | Trius Therapeutics, Inc. | Oxazolidinone containing dimer compounds, compositions and methods to make and use |
CN101792437B (zh) * | 2010-03-10 | 2012-01-25 | 天津药物研究院 | 一类三氮唑的衍生物、其制备方法和用途 |
WO2014085413A1 (en) * | 2012-11-28 | 2014-06-05 | Temple University - Of The Commonwealth System Of Higher Education | Disubstituted oxazolidin-2-ones 5-hydroxytryptamine receptor 2b activity modulators |
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WO2020234636A1 (en) * | 2019-05-17 | 2020-11-26 | Cadila Healthcare Limited | Novel compounds for the treatment of mammalian infections |
CN111560014A (zh) * | 2020-05-13 | 2020-08-21 | 河南科技大学第一附属医院 | 一种杀菌消毒所用噁唑链接***类药物分子及其制备方法和应用 |
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-
2000
- 2000-04-25 GB GBGB0009803.8A patent/GB0009803D0/en not_active Ceased
-
2001
- 2001-04-23 ES ES01921669T patent/ES2220759T5/es not_active Expired - Lifetime
- 2001-04-23 US US10/258,355 patent/US7141583B2/en not_active Expired - Fee Related
- 2001-04-23 PL PL01358326A patent/PL358326A1/xx not_active Application Discontinuation
- 2001-04-23 EP EP01921669A patent/EP1286998B2/en not_active Expired - Lifetime
- 2001-04-23 KR KR1020027014321A patent/KR100858771B1/ko not_active IP Right Cessation
- 2001-04-23 NZ NZ521765A patent/NZ521765A/en not_active IP Right Cessation
- 2001-04-23 BR BR0110240-0A patent/BR0110240A/pt not_active Application Discontinuation
- 2001-04-23 PT PT01921669T patent/PT1286998E/pt unknown
- 2001-04-23 CN CNB01811640XA patent/CN1277829C/zh not_active Expired - Fee Related
- 2001-04-23 DK DK01921669T patent/DK1286998T4/da active
- 2001-04-23 CZ CZ20023527A patent/CZ20023527A3/cs unknown
- 2001-04-23 RU RU2002131455/04A patent/RU2002131455A/ru not_active Application Discontinuation
- 2001-04-23 HU HU0300416A patent/HUP0300416A2/hu unknown
- 2001-04-23 TR TR2004/02261T patent/TR200402261T4/xx unknown
- 2001-04-23 MX MXPA02010453A patent/MXPA02010453A/es active IP Right Grant
- 2001-04-23 AU AU48636/01A patent/AU781784B2/en not_active Ceased
- 2001-04-23 DE DE60103754T patent/DE60103754T3/de not_active Expired - Lifetime
- 2001-04-23 SI SI200130129T patent/SI1286998T2/sl unknown
- 2001-04-23 JP JP2001578439A patent/JP2003531211A/ja active Pending
- 2001-04-23 WO PCT/GB2001/001815 patent/WO2001081350A1/en active IP Right Grant
- 2001-04-23 AT AT01921669T patent/ATE268778T1/de active
- 2001-04-23 IL IL15228401A patent/IL152284A0/xx unknown
- 2001-04-23 CA CA2405349A patent/CA2405349C/en not_active Expired - Lifetime
- 2001-04-23 EE EEP200200598A patent/EE200200598A/xx unknown
-
2002
- 2002-10-10 ZA ZA200208187A patent/ZA200208187B/en unknown
- 2002-10-14 IL IL152284A patent/IL152284A/en not_active IP Right Cessation
- 2002-10-16 IS IS6583A patent/IS6583A/is unknown
- 2002-10-23 NO NO20025091A patent/NO328549B1/no not_active IP Right Cessation
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2003
- 2003-07-25 HK HK03105394A patent/HK1053114A1/xx not_active IP Right Cessation
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