ES8506659A1 - Un procedimiento para la preparacion de nuevos derivados del amino-metil-oxooxazolidinil-benzeno. - Google Patents

Un procedimiento para la preparacion de nuevos derivados del amino-metil-oxooxazolidinil-benzeno.

Info

Publication number
ES8506659A1
ES8506659A1 ES533097A ES533097A ES8506659A1 ES 8506659 A1 ES8506659 A1 ES 8506659A1 ES 533097 A ES533097 A ES 533097A ES 533097 A ES533097 A ES 533097A ES 8506659 A1 ES8506659 A1 ES 8506659A1
Authority
ES
Spain
Prior art keywords
benzene derivatives
antibacterial agents
derivatives useful
aminomethyl oxooxazolidinyl
aminomethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES533097A
Other languages
English (en)
Other versions
ES533097A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
EIDP Inc
Original Assignee
EI Du Pont de Nemours and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EI Du Pont de Nemours and Co filed Critical EI Du Pont de Nemours and Co
Publication of ES533097A0 publication Critical patent/ES533097A0/es
Publication of ES8506659A1 publication Critical patent/ES8506659A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/24—Oxygen atoms attached in position 2 with hydrocarbon radicals, substituted by oxygen atoms, attached to other ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE AMINOMETIL-OXOOXAZOLIDINIL-BENCENO, DE FORMULA GENERAL (I), EN LA QUE A ES EL GRUPO -NO2; B ES EL GRUPO -NH2; E Y ES UN ATOMO DE HIDROGENO, FLUOR O CLORO, Y SUS SALES FARMACEUTICAMENTE ACEPTABLES.COMPRENDE LAS SIGUIENTES OPERACIONES: PRIMERA, SE HACE REACCIONAR UN COMPUESTO DE FORMULA GENERAL (II) CON UN ION AZIDA, PARA PRODUCIR UN COMPUESTO DE FORMULA GENERAL (III); SEGUNDA, EL COMPUESTO OBTENIDO SE REDUCE PARA OBTENER UNA AMINA; Y POR ULTIMO, OPCIONALMENTE, LA AMINA OBTENIDA SE HACE REACCIONAR CON UN CLORURO DE SULFONILO O CON ACIDO CARBOXILICO.DE APLICACION EN LA PREPARACION DE COMPOSICIONES FARMACEUTICAS UTILIZADAS PARA ALIVIAR LAS INFECCIONES BACTERIANAS.
ES533097A 1983-06-07 1984-06-04 Un procedimiento para la preparacion de nuevos derivados del amino-metil-oxooxazolidinil-benzeno. Expired ES8506659A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50189783A 1983-06-07 1983-06-07
US57833284A 1984-02-14 1984-02-14

Publications (2)

Publication Number Publication Date
ES533097A0 ES533097A0 (es) 1985-08-01
ES8506659A1 true ES8506659A1 (es) 1985-08-01

Family

ID=27053956

Family Applications (2)

Application Number Title Priority Date Filing Date
ES533097A Expired ES8506659A1 (es) 1983-06-07 1984-06-04 Un procedimiento para la preparacion de nuevos derivados del amino-metil-oxooxazolidinil-benzeno.
ES540812A Expired ES8802037A1 (es) 1983-06-07 1985-02-28 Un procedimiento para la preparacion de nuevos derivados delaminometil-oxooxazolidinil-benceno

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES540812A Expired ES8802037A1 (es) 1983-06-07 1985-02-28 Un procedimiento para la preparacion de nuevos derivados delaminometil-oxooxazolidinil-benceno

Country Status (16)

Country Link
EP (1) EP0127902B1 (es)
AU (1) AU583250B2 (es)
CA (2) CA1254213A (es)
DE (1) DE3485162D1 (es)
DK (1) DK279584A (es)
ES (2) ES8506659A1 (es)
FI (1) FI83216C (es)
GR (1) GR82361B (es)
HU (1) HU194194B (es)
IE (1) IE57619B1 (es)
IL (1) IL72028A (es)
MX (1) MX169619B (es)
NO (1) NO163451C (es)
NZ (1) NZ208395A (es)
PT (1) PT78703A (es)
SU (2) SU1505442A3 (es)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4705799A (en) * 1983-06-07 1987-11-10 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl benzenes useful as antibacterial agents
CA1260948A (en) * 1984-12-05 1989-09-26 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl benzene derivatives useful as antibacterial agents
CA1323370C (en) * 1986-09-12 1993-10-19 Davis H. Crater Fluorochemical oxazolidinones
US5099026A (en) * 1986-09-12 1992-03-24 Crater Davis H Fluorochemical oxazolidinones
US5036093A (en) * 1987-10-09 1991-07-30 Du Pont Merck Pharmaceutical Aminomethyl oxooxazolidinyl azacycloalkylbenzene derivatives useful as antibacterial agents
US4921869A (en) * 1987-10-09 1990-05-01 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents
US4801600A (en) * 1987-10-09 1989-01-31 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents
US5036092A (en) * 1987-10-09 1991-07-30 Du Pont Merck Pharmaceutical Aminomethyl oxooxazolidinyl azacycloalkylbenzene derivatives useful as antibacterial agents
US4965268A (en) * 1987-10-09 1990-10-23 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents
US5032605A (en) * 1987-10-09 1991-07-16 Du Pont Merck Pharmaceutical Company Aminomethyl oxooxazolidinyl oxa or thia cycloalkylbenzene derivatives useful as antibacterial agents
US4985429A (en) * 1987-10-09 1991-01-15 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents
US5039690A (en) * 1987-10-09 1991-08-13 Du Pont Merck Pharmaceutical Company Aminomethyl oxooxazolidinyl oxa or thia cycloalkylbenzene derivatives useful as antibacterial agents
US4942183A (en) * 1987-10-16 1990-07-17 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl aroylbenzene derivatives useful as antibacterial agents
CA1320730C (en) * 1987-10-16 1993-07-27 The Du Pont Merck Pharmaceutical Company Aminomethyl oxooxazolidinyl aroylbenzene derivatives useful as antibacterial agents
US4977173A (en) * 1987-10-21 1990-12-11 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl ethenylbenzene derivatives useful as antibacterial agents
CA1317594C (en) * 1987-10-21 1993-05-11 Chung-Ho Park Aminomethyloxooxazolidinyl ethenylbenzene derivatives useful as antibacterial agents
US4948801A (en) * 1988-07-29 1990-08-14 E. I. Du Pont De Nemours And Company Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents
US5225565A (en) * 1988-09-15 1993-07-06 The Upjohn Company Antibacterial 3-(fused-ring substituted)phenyl-5β-amidomethyloxazolidin-2-ones
ATE112773T1 (de) * 1988-09-15 1994-10-15 Upjohn Co 5-indolinyl-5-beta-amidomethyloxazolidin-2-one, 3-(substituierte kondensierte)phenyl-5-beta amidomethyloxazolidin-2-one und 3-(nitrogen- substituierte)phenyl-5-beta-amidomethyloxazolid n-2-one.
US5182403A (en) * 1988-09-15 1993-01-26 The Upjohn Company Substituted 3(5'indazolyl) oxazolidin-2-ones
US5231188A (en) * 1989-11-17 1993-07-27 The Upjohn Company Tricyclic [6.5.51]-fused oxazolidinone antibacterial agents
EP0610265B1 (en) * 1991-11-01 1996-12-27 PHARMACIA & UPJOHN COMPANY Substituted aryl- and heteroarylphenyloxazolidinones useful as antibacterial agents
DK0673370T3 (da) * 1992-12-08 1998-09-07 Upjohn Co Troponsubstituerede phenyloxazolidinoner som antibakterielle midler
TW299332B (es) * 1992-12-08 1997-03-01 Upjohn Co
US5688792A (en) * 1994-08-16 1997-11-18 Pharmacia & Upjohn Company Substituted oxazine and thiazine oxazolidinone antimicrobials
MY115155A (en) * 1993-09-09 2003-04-30 Upjohn Co Substituted oxazine and thiazine oxazolidinone antimicrobials.
CZ291847B6 (cs) * 1994-10-26 2003-06-18 Pharmacia Upjohn Company Antimikrobiální fenyloxazolidinony
US5883093A (en) * 1995-09-12 1999-03-16 Pharmacia & Upjohn Company Phenyloxazolidinone antimicrobials
GB9601666D0 (en) * 1996-01-27 1996-03-27 Zeneca Ltd Chemical compounds
GB9702213D0 (en) 1996-02-24 1997-03-26 Zeneca Ltd Chemical compounds
GB9609919D0 (en) * 1996-05-11 1996-07-17 Zeneca Ltd Chemical compounds
ATE293609T1 (de) 1997-05-30 2005-05-15 Upjohn Co Antibakteriell wirksam oxazolidinone mit einer thiocarbonylfunktionalität
US6255304B1 (en) 1997-05-30 2001-07-03 Pharmacia & Upjohn Company Oxazolidinone antibacterial agents having a thiocarbonyl functionality
GB9717804D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
GB9717807D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
AU9001598A (en) * 1997-09-11 1999-03-29 Hokuriku Seiyaku Co. Ltd Thiourea derivatives
GB9725244D0 (en) 1997-11-29 1998-01-28 Zeneca Ltd Chemical compounds
WO1999037630A1 (en) * 1998-01-23 1999-07-29 Versicor, Inc. Oxazolidinone combinatorial libraries, compositions and methods of preparation
GB9821938D0 (en) * 1998-10-09 1998-12-02 Zeneca Ltd Chemical compounds
CN1142162C (zh) 1999-05-27 2004-03-17 法玛西雅厄普约翰美国公司 作为抗菌剂的新的双环噁唑烷酮
US6297242B1 (en) * 1999-08-12 2001-10-02 Ortho-Mcneil Pharmaceutical, Inc. N-substituted amidine and guanidine oxazolidinone antibacterials and methods of use thereof
GB9928568D0 (en) 1999-12-03 2000-02-02 Zeneca Ltd Chemical compounds
US6518285B2 (en) 1999-12-21 2003-02-11 Ortho Mcneil Pharmaceutical, Inc. Piperidinyloxy and pyrrolidinyloxy oxazolidinone antibacterials
DE19962924A1 (de) 1999-12-24 2001-07-05 Bayer Ag Substituierte Oxazolidinone und ihre Verwendung
GB0009803D0 (en) 2000-04-25 2000-06-07 Astrazeneca Ab Chemical compounds
US6833453B2 (en) 2000-10-17 2004-12-21 Pharmacia & Upjohn Company Methods of producing oxazolidinone compounds
DE10129725A1 (de) 2001-06-20 2003-01-02 Bayer Ag Kombinationstherapie substituierter Oxazolidinone
DE10300111A1 (de) 2003-01-07 2004-07-15 Bayer Healthcare Ag Verfahren zur Herstellung von 5-Chlor-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophencarboxamid
DE10355461A1 (de) 2003-11-27 2005-06-23 Bayer Healthcare Ag Verfahren zur Herstellung einer festen, oral applizierbaren pharmazeutischen Zusammensetzung
EP1685841A1 (en) 2005-01-31 2006-08-02 Bayer Health Care Aktiengesellschaft Prevention and treatment of thromboembolic disorders
DE102005045518A1 (de) 2005-09-23 2007-03-29 Bayer Healthcare Ag 2-Aminoethoxyessigsäure-Derivate und ihre Verwendung
DE102005047561A1 (de) 2005-10-04 2007-04-05 Bayer Healthcare Ag Feste, oral applizierbare pharmazeutische Darreichungsformen mit schneller Wirkstofffreisetzung
EP1934208B1 (de) 2005-10-04 2011-03-23 Bayer Schering Pharma Aktiengesellschaft Neue polymorphe form von 5-chlor-n-({ ( 5s )-2-0x0-3-[4-( 3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl} -methyl)-2-thiophencarboxamid
KR101653570B1 (ko) 2011-03-30 2016-09-02 주식회사 레고켐 바이오사이언스 신규한 옥사졸리디논 유도체 및 이를 함유하는 의약 조성물

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GB1222708A (en) * 1968-10-22 1971-02-17 Delalande Sa Novel 5-(n-substituted aminomethyl)-2-oxazolidinones and their process of preparation
US4348393A (en) * 1978-06-09 1982-09-07 Delalande S.A. N-Aryl oxazolidinones, oxazolidinethiones, pyrrolidinones, pyrrolidines and thiazolidinones
US4340606A (en) * 1980-10-23 1982-07-20 E. I. Du Pont De Nemours And Company 3-(p-Alkylsulfonylphenyl)oxazolidinone derivatives as antibacterial agents
FR2500450A1 (fr) * 1981-02-25 1982-08-27 Delalande Sa Nouveaux derives aminomethyl-5 oxazolidiniques, leur procede de preparation et leur application en therapeutique
AU560666B2 (en) * 1981-12-04 1987-04-16 E.I. Du Pont De Nemours And Company P(2-oxo oxazolidinyl)benzene sulphonamides
CA1260948A (en) * 1984-12-05 1989-09-26 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl benzene derivatives useful as antibacterial agents

Also Published As

Publication number Publication date
NO842273L (no) 1984-12-10
FI842273A (fi) 1984-12-08
SU1426451A3 (ru) 1988-09-23
ES533097A0 (es) 1985-08-01
ES8802037A1 (es) 1988-03-16
DE3485162D1 (de) 1991-11-21
MX169619B (es) 1993-07-15
FI842273A0 (fi) 1984-06-06
NO163451C (no) 1990-05-30
IL72028A (en) 1988-05-31
IE57619B1 (en) 1993-02-10
AU2909984A (en) 1984-12-13
SU1505442A3 (ru) 1989-08-30
FI83216B (fi) 1991-02-28
CA1275652C (en) 1990-10-30
ES540812A0 (es) 1988-03-16
IE841407L (en) 1984-12-07
EP0127902A2 (en) 1984-12-12
DK279584A (da) 1984-12-08
EP0127902A3 (en) 1987-09-02
HUT34462A (en) 1985-03-28
NO163451B (no) 1990-02-19
FI83216C (fi) 1991-06-10
DK279584D0 (da) 1984-06-06
IL72028A0 (en) 1984-10-31
AU583250B2 (en) 1989-04-27
PT78703A (en) 1984-07-01
CA1254213A (en) 1989-05-16
HU194194B (en) 1988-01-28
NZ208395A (en) 1987-07-31
EP0127902B1 (en) 1991-10-16
GR82361B (es) 1984-12-13

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