DK0912767T3 - Fremgangsmåde til sporing og forstærkning af nukleinsyresekvenser ved anvendelse af modificerede oligonukleotider med foröget targetspecifikt TM - Google Patents

Fremgangsmåde til sporing og forstærkning af nukleinsyresekvenser ved anvendelse af modificerede oligonukleotider med foröget targetspecifikt TM

Info

Publication number
DK0912767T3
DK0912767T3 DK97934169T DK97934169T DK0912767T3 DK 0912767 T3 DK0912767 T3 DK 0912767T3 DK 97934169 T DK97934169 T DK 97934169T DK 97934169 T DK97934169 T DK 97934169T DK 0912767 T3 DK0912767 T3 DK 0912767T3
Authority
DK
Denmark
Prior art keywords
oligonucleotides
modified
modified oligonucleotides
tracking
nucleic acid
Prior art date
Application number
DK97934169T
Other languages
English (en)
Inventor
Mehrdad Majlessi
Michael Mcclellan Becker
Original Assignee
Gen Probe Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gen Probe Inc filed Critical Gen Probe Inc
Application granted granted Critical
Publication of DK0912767T3 publication Critical patent/DK0912767T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6832Enhancement of hybridisation reaction
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/686Polymerase chain reaction [PCR]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/6865Promoter-based amplification, e.g. nucleic acid sequence amplification [NASBA], self-sustained sequence replication [3SR] or transcription-based amplification system [TAS]
DK97934169T 1996-07-16 1997-07-15 Fremgangsmåde til sporing og forstærkning af nukleinsyresekvenser ved anvendelse af modificerede oligonukleotider med foröget targetspecifikt TM DK0912767T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2181896P 1996-07-16 1996-07-16

Publications (1)

Publication Number Publication Date
DK0912767T3 true DK0912767T3 (da) 2006-10-30

Family

ID=21806324

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97934169T DK0912767T3 (da) 1996-07-16 1997-07-15 Fremgangsmåde til sporing og forstærkning af nukleinsyresekvenser ved anvendelse af modificerede oligonukleotider med foröget targetspecifikt TM

Country Status (11)

Country Link
US (3) US6130038A (da)
EP (1) EP0912767B1 (da)
JP (2) JP2000514307A (da)
KR (1) KR20000023814A (da)
AT (1) ATE339514T1 (da)
AU (1) AU726821B2 (da)
CA (1) CA2260749A1 (da)
DE (1) DE69736667T2 (da)
DK (1) DK0912767T3 (da)
ES (1) ES2270467T3 (da)
WO (1) WO1998002582A2 (da)

Families Citing this family (96)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5714380A (en) 1986-10-23 1998-02-03 Amoco Corporation Closed vessel for isolating target molecules and for performing amplification
US7070925B1 (en) * 1996-07-16 2006-07-04 Gen-Probe Incorporated Method for determining the presence of an RNA analyte in a sample using a modified oligonucleotide probe
DE69736667T2 (de) * 1996-07-16 2007-09-06 Gen-Probe Inc., San Diego Verfahren zum nachweis und amplifikation von nukleinsäuresequenzen unter verbrauch von modifizierten oligonukleotiden mit erhöhter zielschmelztemperatur (tm)
WO1998045420A1 (en) 1997-04-10 1998-10-15 Diagnocure Inc. Pca3, pca3 genes, and methods of use
DE69941333D1 (de) 1998-07-02 2009-10-08 Gen Probe Inc Molekulare fackeln
AU759915B2 (en) 1998-07-31 2003-05-01 Gen-Probe Incorporated Reversible inhibiting probes
US6087112A (en) 1998-12-30 2000-07-11 Oligos Etc. Inc. Arrays with modified oligonucleotide and polynucleotide compositions
WO2000070093A1 (en) * 1999-05-13 2000-11-23 Oligos Etc. Inc. Arrays with modified oligonucleotide and polynucleotide compositions
US6844151B1 (en) 1999-09-29 2005-01-18 Oligos Etc. Inc. Methods for production of arrays with modified oligonucleotide and polynucleotide compositions
PT1222266E (pt) 1999-09-29 2006-07-31 Diagnocure Inc Arn mensageiro de pca3 em tecidos benignos e malignos da prostata
WO2001023620A2 (en) * 1999-09-29 2001-04-05 Oligos Etc. Inc. Arrays with modified oligonucleotide and polynucleotide compositions
GB2355791B (en) * 1999-10-28 2004-10-20 Molecular Light Tech Res Ltd Detection of mRNA expression using chemiluminescent labelled probes
US6924108B2 (en) * 1999-12-21 2005-08-02 Ingeneus Corporation Nucleic acid binding enhancement by conjugation with nucleotides, nucleosides, bases and/or their analogues
US7833715B1 (en) * 2000-01-11 2010-11-16 Nanogen Recognomics Gmbh Biomolecules having multiple attachment moieties for binding to a substrate surface
DK1294751T3 (da) 2000-03-31 2014-03-24 Merial Ltd Gaba-afhængige chloridkanaler fra dermacentor variabilis
JP4950414B2 (ja) * 2000-08-03 2012-06-13 独立行政法人産業技術総合研究所 核酸の測定方法、それに用いる核酸プローブ及びその方法によって得られるデータを解析する方法
ATE414794T1 (de) 2000-09-01 2008-12-15 Gen Probe Inc Amplifizierung von hiv-1 sequenzen zur detektion von sequenzen, die mit wirkstoff-resistenz mutationen einhergehen
JP2004527221A (ja) * 2000-09-12 2004-09-09 ジェン−プロウブ インコーポレイテッド 試験サンプル中のCryptosporidium生物の存在を決定するための組成物、方法およびキット
ES2254306T3 (es) 2000-10-25 2006-06-16 F. Hoffmann-La Roche Ag Amplificacion usando cebadores modificados.
EP1251183A3 (en) * 2001-04-18 2003-12-10 Exiqon A/S Improved helper probes for detection of a target sequence by a capture oligonucleotide
EP1588139A4 (en) 2001-05-31 2006-10-04 Merck & Co Inc RHESUS MONKEY MELANIN CONCENTRATION HORMONE TYPE 2 RECEPTOR, DOG AND FURET
WO2002100250A2 (en) * 2001-06-12 2002-12-19 The Regents Of The University Of California Wit 3.0, a novel gene to control soft tissue wound healing
US20030165859A1 (en) * 2001-10-23 2003-09-04 Invitrogen Corporation Primers and methods for the detection and discrimination of nucleic acids
US20040009506A1 (en) * 2002-03-29 2004-01-15 Genentech, Inc. Methods and compositions for detection and quantitation of nucleic acid analytes
US7211382B2 (en) * 2002-04-09 2007-05-01 Orchid Cellmark Inc. Primer extension using modified nucleotides
US7199107B2 (en) 2002-05-23 2007-04-03 Isis Pharmaceuticals, Inc. Antisense modulation of kinesin-like 1 expression
US20030235827A1 (en) * 2002-06-25 2003-12-25 Orchid Biosciences, Inc. Methods and compositions for monitoring primer extension and polymorphism detection reactions
CA2491117A1 (en) * 2002-06-28 2004-01-08 Orchid Biosciences, Inc. Methods and compositions for analyzing compromised samples using single nucleotide polymorphism panels
EP1576174A4 (en) * 2002-08-02 2007-07-25 Orchid Cellmark Inc METHOD AND COMPOSITIONS FOR GENOTYPING
US7192700B2 (en) * 2002-12-20 2007-03-20 Orchid Cellmark Inc. Methods and compositions for conducting primer extension and polymorphism detection reactions
US7319041B2 (en) * 2002-09-27 2008-01-15 Siemens Medical Solutions Diagnostic Applications of acridinium compounds and derivatives in homogeneous assays
WO2004067726A2 (en) * 2003-01-29 2004-08-12 Keck Graduate Institute Isothermal reactions for the amplification of oligonucleotides
US20050282170A1 (en) 2003-02-07 2005-12-22 Diagnocure Inc. Method to detect prostate cancer in a sample
EP1633893B1 (en) 2003-05-19 2012-01-25 Gen-Probe Incorporated Compositions, methods and kits for determining the presence of trichomonas vaginalis in a test sample
US20080176220A1 (en) * 2004-02-26 2008-07-24 Thomsen Bioscience Method, Kit and System for Enhanced Nested Pcr
DE602005020943D1 (de) 2004-07-01 2010-06-10 Gen Probe Inc Verfahren und zusammensetzungen zum nachweis von nukleinsäuren in einer biologischen probe
AU2005280162B2 (en) * 2004-08-27 2012-04-26 Gen-Probe Incorporated Single-primer nucleic acid amplification methods
US7713697B2 (en) * 2004-08-27 2010-05-11 Gen-Probe Incorporated Methods and kits for amplifying DNA
CA2491067A1 (en) 2004-12-24 2006-06-24 Stichting Katholieke Universiteit Mrna rations in urinary sediments and/or urine as a prognostic marker for prostate cancer
JP5187847B2 (ja) 2005-05-06 2013-04-24 ジェン−プローブ・インコーポレーテッド 核酸標的の捕獲方法
CA2609206A1 (en) 2005-06-06 2006-12-14 Gen-Probe Incorporated Compositions, methods and kits for determining the presence of chlamydophila pneumoniae in a test sample
PL2017356T3 (pl) 2006-06-06 2012-03-30 Gen Probe Inc Znakowane oligonukleotydy i ich zastosowanie w sposobach amplifikacji kwasu nukleinowego
CA2658105C (en) * 2006-08-01 2016-07-05 Gen-Probe Incorporated Methods of nonspecific target capture of nucleic acids
US8586006B2 (en) 2006-08-09 2013-11-19 Institute For Systems Biology Organ-specific proteins and methods of their use
US8183359B2 (en) * 2007-03-01 2012-05-22 Gen-Probe Incorporated Kits for amplifying DNA
EP1978111B1 (en) 2007-04-02 2013-03-27 Gen-Probe Incorporated Compositions, kits and related methods for the detection and/or monitoring of Pseudomonas aeruginosa
US9689031B2 (en) 2007-07-14 2017-06-27 Ionian Technologies, Inc. Nicking and extension amplification reaction for the exponential amplification of nucleic acids
CA2709519A1 (en) 2007-12-21 2009-07-09 Gen-Probe Incorporated Detection of antibiotic-resistant microorganisms
US20090215050A1 (en) * 2008-02-22 2009-08-27 Robert Delmar Jenison Systems and methods for point-of-care amplification and detection of polynucleotides
US8911948B2 (en) * 2008-04-30 2014-12-16 Integrated Dna Technologies, Inc. RNase H-based assays utilizing modified RNA monomers
US9434988B2 (en) * 2008-04-30 2016-09-06 Integrated Dna Technologies, Inc. RNase H-based assays utilizing modified RNA monomers
EP2644709B1 (en) 2008-04-30 2014-12-17 Integrated Dna Technologies, Inc. RNase-H-based assays utilizing modified RNA monomers
EP2806037B1 (en) 2008-05-13 2016-09-21 Gen-Probe Incorporated Inactivatable target capture oligomers for use in the selective hybridization and capture of target nucleic acid sequences
US8703421B2 (en) 2008-05-30 2014-04-22 Gen-Probe Incorporated Compositions, kits and related methods for the detection and/or monitoring of Salmonella
EP2367958B1 (en) 2008-11-25 2017-08-23 Gen-Probe Incorporated Compositions and methods for detecting small rnas, and uses thereof
KR101881596B1 (ko) 2008-12-02 2018-07-24 웨이브 라이프 사이언시스 재팬 인코포레이티드 인 원자 변형된 핵산의 합성 방법
AU2009335053B2 (en) 2008-12-30 2013-08-01 Gen-Probe Incorporated Compositions, kits and related methods for the detection and/or monitoring of Listeria
WO2010126913A1 (en) 2009-04-27 2010-11-04 Gen-Probe Incorporated Methods and kits for use in the selective amplification of target sequences
SG177564A1 (en) 2009-07-06 2012-02-28 Ontorii Inc Novel nucleic acid prodrugs and methods of use thereof
CA2770888C (en) 2009-08-31 2020-04-14 Gen-Probe Incorporated Dengue virus assay
WO2011091330A1 (en) 2010-01-22 2011-07-28 Gen-Probe Incorporated Probes for detecting the presence of trichomonas vaginalis in a sample
WO2012003289A1 (en) 2010-06-30 2012-01-05 Gen-Probe Incorporated Method and apparatus for identifying analyte-containing samples using single-read determination of analyte and process control signals
WO2012039448A1 (ja) 2010-09-24 2012-03-29 株式会社キラルジェン 不斉補助基
EP2734208B1 (en) 2011-07-19 2017-03-01 Wave Life Sciences Ltd. Methods for the synthesis of functionalized nucleic acids
EP2758547B1 (en) 2011-09-21 2015-09-16 Gen-Probe Incorporated Methods for amplifying nucleic acid using tag-mediated displacement
US9352312B2 (en) 2011-09-23 2016-05-31 Alere Switzerland Gmbh System and apparatus for reactions
CN114134207A (zh) 2012-04-09 2022-03-04 一龙公司 用于量化样品中核酸序列的组合物和方法
EP3301188B1 (en) * 2012-04-16 2020-10-07 Life Technologies Corporation Methods for the preparation of rna libraries
KR102213609B1 (ko) 2012-07-13 2021-02-08 웨이브 라이프 사이언시스 리미티드 키랄 제어
WO2014010718A1 (ja) 2012-07-13 2014-01-16 株式会社新日本科学 キラル核酸アジュバント
EP2872485B1 (en) 2012-07-13 2020-12-16 Wave Life Sciences Ltd. Asymmetric auxiliary group
AU2013202793B2 (en) 2012-07-31 2014-09-18 Gen-Probe Incorporated System, method and apparatus for automated incubation
WO2014140165A1 (en) 2013-03-14 2014-09-18 Dsm Ip Assets B.V. Cell wall deconstruction enzymes of paecilomyces byssochlamydoides and uses thereof
WO2014140167A1 (en) 2013-03-14 2014-09-18 Dsm Ip Assets B.V. Cell wall deconstruction enzymes of malbranchea cinnamomea and uses thereof
WO2014152054A1 (en) 2013-03-15 2014-09-25 Bio-Rad Laboratories, Inc. Digital assays for mutation detection
DK3066219T3 (da) * 2013-11-08 2019-03-11 Ionis Pharmaceuticals Inc Fremgangsmåder til påvisning af oligonukleotider
WO2015108047A1 (ja) 2014-01-15 2015-07-23 株式会社新日本科学 免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤
JPWO2015108046A1 (ja) 2014-01-15 2017-03-23 株式会社新日本科学 抗アレルギー作用を有するキラル核酸アジュバンド及び抗アレルギー剤
JPWO2015108048A1 (ja) 2014-01-15 2017-03-23 株式会社新日本科学 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤
AU2015207773B2 (en) 2014-01-16 2021-06-17 Wave Life Sciences Ltd. Chiral design
BR112016024622A2 (pt) 2014-04-22 2017-10-10 Envirologix Inc composições e métodos para melhorar e/ou prever a amplificação de dna
CA2970143A1 (en) 2014-12-08 2016-06-16 Berg Llc Use of markers including filamin a in the diagnosis and treatment of prostate cancer
AU2016252998B2 (en) 2015-04-24 2021-11-04 Atila Biosystems Incorporated Amplification with primers of limited nucleotide composition
US10329601B2 (en) * 2015-12-28 2019-06-25 Ionian Technologies, Inc. Nicking and extension amplification reaction (NEAR) of Streptococcus species
EP3841223A1 (en) 2018-08-08 2021-06-30 Gen-Probe Incorporated Compositions, methods and kits for detecting mycoplasma genitalium
EP3914732A1 (en) 2019-01-25 2021-12-01 Gen-Probe Incorporated Detection of drug-resistant mycoplasma genitalium
SG11202111824UA (en) 2019-04-30 2021-11-29 Larimar Therapeutics Inc Frataxin-sensitive markers for determining effectiveness of frataxin replacement therapy
CN114096683A (zh) 2019-07-03 2022-02-25 简·探针公司 用于确定样品中***毛滴虫的存在的寡核苷酸
AU2020335996A1 (en) 2019-08-23 2022-03-31 Gen-Probe Incorporated Compositions, methods and kits for detecting Treponema pallidum
AU2021308095A1 (en) 2020-07-17 2023-03-09 Gen-Probe Incorporated Detection of macrolide-resistant mycoplasma genitalium
WO2022047359A1 (en) 2020-08-31 2022-03-03 Berg Llc Protein biomarkers for pancreatic cancer
IL307531A (en) 2021-04-06 2023-12-01 Bpgbio Inc Protein markers for estrogen receptor (ER)-like and estrogen receptor (ER)-negative breast cancer
CA3214819A1 (en) 2021-04-06 2022-10-13 Guisong WANG Protein markers for estrogen receptor (er)-positive luminal a(la)-like and luminal b1 (lb1)-like breast cancer
IL307528A (en) 2021-04-06 2023-12-01 Bpgbio Inc Protein markers for the prognosis of breast cancer progression
US20230357851A1 (en) 2022-04-06 2023-11-09 Larimar Therapeutics, Inc. Frataxin-sensitive markers for monitoring frataxin-replacement therapy
WO2023240201A1 (en) 2022-06-08 2023-12-14 Larimar Therapeutics, Inc. Frataxin-sensitive markers for monitoring progression and treatment of leigh syndrome

Family Cites Families (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5087558A (en) 1981-09-25 1992-02-11 Webster John A Jr Method for identifying and characterizing organisms
US4766062A (en) * 1984-05-07 1988-08-23 Allied Corporation Displacement polynucleotide assay method and polynucleotide complex reagent therefor
US4820630A (en) * 1984-11-23 1989-04-11 Digene Diagnostics, Incorporated Assay for nucleic acid sequences, particularly genetic lesions, using interactive labels
JPS61243182A (ja) * 1985-04-19 1986-10-29 Nitsukan Kogyo Kk 金属メツキされたチタン酸カリウム繊維およびその製造方法
US4822733A (en) * 1985-05-28 1989-04-18 Amoco Corporation Lifetime-resolved assay procedures
US4797355A (en) * 1985-06-13 1989-01-10 Amgen Inc. Methods for attaching polynucleotides to supports
US4996143A (en) * 1985-12-23 1991-02-26 Syngene, Inc. Fluorescent stokes shift probes for polynucleotide hybridization
ATE88761T1 (de) * 1986-01-10 1993-05-15 Amoco Corp Kompetitiver homogener test.
US4925785A (en) * 1986-03-07 1990-05-15 Biotechnica Diagnostics, Inc. Nucleic acid hybridization assays
US5091519A (en) * 1986-05-01 1992-02-25 Amoco Corporation Nucleotide compositions with linking groups
CA1340843C (en) 1987-07-31 1999-12-07 J. Lawrence Burg Selective amplification of target polynucleotide sequences
US5030557A (en) * 1987-11-24 1991-07-09 Ml Technology Venture Means and method for enhancing nucleic acid hybridization
US5403711A (en) 1987-11-30 1995-04-04 University Of Iowa Research Foundation Nucleic acid hybridization and amplification method for detection of specific sequences in which a complementary labeled nucleic acid probe is cleaved
US5118801A (en) * 1988-09-30 1992-06-02 The Public Health Research Institute Nucleic acid process containing improved molecular switch
CA2008096A1 (en) * 1989-01-19 1990-07-19 Samuel Rose Nucleic acid amplification using single primer
WO1990012116A1 (en) * 1989-04-05 1990-10-18 Gene-Trak Systems Hybridization promotion reagents
IE81145B1 (en) 1989-04-20 2000-05-03 Thomas Gerard Barry Generation of specific probes for target nucleotide sequences
DE69022362T2 (de) * 1989-05-24 1996-05-09 Amoco Corp Nukleinsäuresonden für die detektion von neisseria gonorrhoeae.
US5849504A (en) 1989-08-11 1998-12-15 Amoco Corporation Nucleic acid probes and methods for detecting Pneumocystis carinii
US5134066A (en) * 1989-08-29 1992-07-28 Monsanto Company Improved probes using nucleosides containing 3-dezauracil analogs
CA2025178A1 (en) * 1989-10-02 1991-04-03 William G. Weisburg Nucleic acid probes for the detection of lyme disease spirochetes
US5474911A (en) * 1989-12-01 1995-12-12 The Board Of Trustees Of Leland Stanford Jr. University Promotion of high specificity molecular assembly
US5914396A (en) 1990-01-11 1999-06-22 Isis Pharmaceuticals, Inc. 2'-O-modified nucleosides and phosphoramidites
US5536638A (en) 1990-04-18 1996-07-16 N.V. Innogenetics S.A. Hybridization probes derived from the spacer region between the 16S and 23S rRNA genes for the detection of Neisseria gonorrhoeae
US5811533A (en) 1990-06-11 1998-09-22 Nexstar Pharmaceuticals, Inc. High-affinity oligonucleotide ligands to vascular endothelial growth factor (VEGF)
BR9106702A (pt) * 1990-07-27 1993-06-08 Isis Pharmaceuticals Inc Analogo de oligonucleotideos e processos para modular a producao de uma proteina por um organismo e para tratar um organismo
US5386023A (en) * 1990-07-27 1995-01-31 Isis Pharmaceuticals Backbone modified oligonucleotide analogs and preparation thereof through reductive coupling
US5210015A (en) * 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
KR950013854B1 (ko) * 1990-11-29 1995-11-17 구미아이 가가쿠 고오교오 가부시기가이샤 벤조히드록시모일라졸 유도체와 그의 제조방법 및 그를 함유한 살충제
US5641625A (en) * 1992-05-22 1997-06-24 Isis Pharmaceuticals, Inc. Cleaving double-stranded DNA with peptide nucleic acids
US5435248A (en) * 1991-07-09 1995-07-25 The Ensign-Bickford Company Extended range digital delay detonator
JP3739785B2 (ja) * 1991-11-26 2006-01-25 アイシス ファーマシューティカルズ,インコーポレイティド 修飾されたピリミジンを含有するオリゴマーを使用する増強された三重らせんおよび二重らせんの成形
ATE515510T1 (de) * 1991-12-24 2011-07-15 Isis Pharmaceuticals Inc Durch dna-abschnitte unterbrochene modifizierte oligonukleotide
US5700922A (en) * 1991-12-24 1997-12-23 Isis Pharmaceuticals, Inc. PNA-DNA-PNA chimeric macromolecules
US5652099A (en) * 1992-02-12 1997-07-29 Conrad; Michael J. Probes comprising fluorescent nucleosides and uses thereof
EP0566751B1 (en) * 1992-03-23 1996-01-10 F. Hoffmann-La Roche Ag DNA detection method
DE69333842T2 (de) * 1992-07-23 2006-04-27 Isis Pharmaceuticals, Inc., Carlsbad Neue 2'-O-Alkyl-Nukleoside und -Phosphoramidite, Verfahren zu ihrer Herstellung und ihre Verwendungen
US5445933A (en) * 1992-09-15 1995-08-29 Boehringer Mannheim Corporation Strand displacement assay and complex useful therefor
EP0601889A2 (en) * 1992-12-10 1994-06-15 Maine Medical Center Research Institute Nucleic acid probes
WO1994019023A1 (en) * 1993-02-19 1994-09-01 Isis Pharmaceuticals, Inc. Cyclobutyl antisense oligonucleotides, methods of making and use thereof
US5514546A (en) * 1993-09-01 1996-05-07 Research Corporation Technologies, Inc. Stem-loop oligonucleotides containing parallel and antiparallel binding domains
US6156501A (en) 1993-10-26 2000-12-05 Affymetrix, Inc. Arrays of modified nucleic acid probes and methods of use
US5925517A (en) * 1993-11-12 1999-07-20 The Public Health Research Institute Of The City Of New York, Inc. Detectably labeled dual conformation oligonucleotide probes, assays and kits
US5538848A (en) * 1994-11-16 1996-07-23 Applied Biosystems Division, Perkin-Elmer Corp. Method for detecting nucleic acid amplification using self-quenching fluorescence probe
US5827648A (en) * 1995-12-13 1998-10-27 Chiron Corporation Differential hybridization for relative quantification of variant populations
SE9400522D0 (sv) * 1994-02-16 1994-02-16 Ulf Landegren Method and reagent for detecting specific nucleotide sequences
EP0760008A1 (en) * 1994-05-19 1997-03-05 Dako A/S Pna probes for detection of neisseria gonorrhoeae and chlamydia trachomatis
ZA956776B (en) * 1994-08-25 1996-03-20 Akzo Nobel Nv A process for making the product of a nucleic acid amplification reaction incapable of being a target for further amplification a diagnostic assay employing said process a kit and a container suitable for carrying out said process for assay
US5656427A (en) * 1994-08-29 1997-08-12 Gen-Probe Incorporated Nucleic acid hybridization assay probes, helper probes and amplification oligonucleotides targeted to Mycoplasma pneumoniae nucleic acid
US5681702A (en) * 1994-08-30 1997-10-28 Chiron Corporation Reduction of nonspecific hybridization by using novel base-pairing schemes
US6001564A (en) * 1994-09-12 1999-12-14 Infectio Diagnostic, Inc. Species specific and universal DNA probes and amplification primers to rapidly detect and identify common bacterial pathogens and associated antibiotic resistance genes from clinical specimens for routine diagnosis in microbiology laboratories
US5514551A (en) * 1994-10-14 1996-05-07 Gen-Probe Incorporated Compositions for the detection of Chlamydia trachomatis
WO1996034983A1 (en) * 1995-05-05 1996-11-07 The Perkin-Elmer Corporation Methods and reagents for combined pcr amplification and hybridization probing assay
US5731148A (en) 1995-06-07 1998-03-24 Gen-Probe Incorporated Adduct protection assay
US5747252A (en) * 1995-06-07 1998-05-05 Gen-Probe Incorporated Nucleic acid probes and amplification oligonucleotides for Neisseria species
DK0833944T3 (da) 1995-06-07 2009-05-11 Gilead Sciences Inc Nucleinsyreligander som binder til og inhiberer DNA-polymeraser
EP0892808B1 (en) * 1996-04-12 2008-05-14 PHRI Properties, Inc. Detection probes, kits and assays
AU710996B2 (en) 1996-05-22 1999-10-07 Gen-Probe Incorporated Compositions and methods for the detection of mycobacterium kansasii
US5898031A (en) * 1996-06-06 1999-04-27 Isis Pharmaceuticals, Inc. Oligoribonucleotides for cleaving RNA
US5866336A (en) * 1996-07-16 1999-02-02 Oncor, Inc. Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon
DE69736667T2 (de) * 1996-07-16 2007-09-06 Gen-Probe Inc., San Diego Verfahren zum nachweis und amplifikation von nukleinsäuresequenzen unter verbrauch von modifizierten oligonukleotiden mit erhöhter zielschmelztemperatur (tm)
US7070925B1 (en) * 1996-07-16 2006-07-04 Gen-Probe Incorporated Method for determining the presence of an RNA analyte in a sample using a modified oligonucleotide probe
US6117635A (en) * 1996-07-16 2000-09-12 Intergen Company Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon
US6747252B2 (en) * 1996-11-15 2004-06-08 Kenneth J. Herzog Multiple head induction sealer apparatus and method
US5846726A (en) * 1997-05-13 1998-12-08 Becton, Dickinson And Company Detection of nucleic acids by fluorescence quenching
US6210015B1 (en) * 1999-10-04 2001-04-03 Kenneth Alan Ross Stand for cakes or pastry

Also Published As

Publication number Publication date
US20050106610A1 (en) 2005-05-19
ES2270467T3 (es) 2007-04-01
US6903206B1 (en) 2005-06-07
CA2260749A1 (en) 1998-01-22
JP4527789B2 (ja) 2010-08-18
WO1998002582A3 (en) 1998-07-02
AU3728897A (en) 1998-02-09
KR20000023814A (ko) 2000-04-25
EP0912767A2 (en) 1999-05-06
DE69736667T2 (de) 2007-09-06
DE69736667D1 (de) 2006-10-26
AU726821B2 (en) 2000-11-23
JP2008283973A (ja) 2008-11-27
ATE339514T1 (de) 2006-10-15
JP2000514307A (ja) 2000-10-31
WO1998002582A2 (en) 1998-01-22
US6130038A (en) 2000-10-10
EP0912767B1 (en) 2006-09-13

Similar Documents

Publication Publication Date Title
DK0912767T3 (da) Fremgangsmåde til sporing og forstærkning af nukleinsyresekvenser ved anvendelse af modificerede oligonukleotider med foröget targetspecifikt TM
US5683869A (en) Method of nucleic acid sequencing
US5686242A (en) Determination of oligonucleotides for therapeutics, diagnostics and research reagents
DE60005309D1 (de) Methode zur sequenzierung von polynukleotiden
DE69034177D1 (de) Verfahren zur Amplifikation von Nukleinsäuresequenzen
DE69432419D1 (de) Ein elektrochemiluminescenter nachweis von nukleinsäuren auf basis der selbsttragenden sequenzreplikation
ATE545710T1 (de) Verfahren zur vervielfältigung von nukleinsäuren
PL307341A1 (en) Method of as well as reagent and kit for detecting and amplifying a sequence of nucleic acids
EP1961826A3 (en) A method for direct nucleic acid sequencing
AU7487294A (en) Compositions and methods for detecting target nucleic acid sequences utilizing flanking sequence enzyme molecules
WO1999063112A3 (en) Pcr techniques for detecting microbial and viral contaminants in foodstuffs
WO2003064615A3 (en) Amplifying repetitive nucleic acid sequences
CA2358992A1 (en) Method for controlling the extension of an oligonucleotide
DE60039772D1 (de) Verfahren zur amplifikation von signal-flankierend
WO2001088089A8 (en) Single copy genomic hybridization probes and method of generating same
Murray et al. Synthesis of single-stranded plasmid pT181 DNA in vitro: initiation and termination of DNA replication
WO1996015264A3 (en) Method for identifying nucleic acid sequences from different biological sources through amplification of the same
ATE368751T1 (de) In situ-hybridisation zum nachweis von spezifischen nukleinsäuresequenzen in eukaryontischen proben
ATE211180T1 (de) Verfahren zur nicht-radioaktiven detektion von membran-gebundenen nukleinsäuren und testkit
EP0812921A3 (en) Amplification and detection of chlamydia trachomatis nucleic acids
WO2003019189A1 (fr) Microreseau de genes a phase homogene
WO2002059371A3 (en) Genome-wide location and function of dna binding proteins
TH28996B (th) "โอลิโกนิวคลีโอไทด์จำเพาะสำหรับไวรัสตับอักเสบ c