DE69909442D1 - Assay für spezifische stämme von mit mehreren krankheiten zusammenhängenden proteinkonformationen - Google Patents

Assay für spezifische stämme von mit mehreren krankheiten zusammenhängenden proteinkonformationen

Info

Publication number
DE69909442D1
DE69909442D1 DE69909442T DE69909442T DE69909442D1 DE 69909442 D1 DE69909442 D1 DE 69909442D1 DE 69909442 T DE69909442 T DE 69909442T DE 69909442 T DE69909442 T DE 69909442T DE 69909442 D1 DE69909442 D1 DE 69909442D1
Authority
DE
Germany
Prior art keywords
protein
amount
determining
sample
assay
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69909442T
Other languages
English (en)
Other versions
DE69909442T2 (de
Inventor
B Prusiner
G Safar
E Cohen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
Original Assignee
University of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California filed Critical University of California
Publication of DE69909442D1 publication Critical patent/DE69909442D1/de
Application granted granted Critical
Publication of DE69909442T2 publication Critical patent/DE69909442T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2828—Prion diseases
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DE69909442T 1998-02-20 1999-02-05 Assay für spezifische stämme von mit mehreren krankheiten zusammenhängenden proteinkonformationen Expired - Fee Related DE69909442T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US26957 1993-03-05
US2695798A 1998-02-20 1998-02-20
US15105798A 1998-09-10 1998-09-10
US151057 1998-09-10
PCT/US1999/002580 WO1999042829A1 (en) 1998-02-20 1999-02-05 Assay for specific strains of multiple disease related conformations of a protein

Publications (2)

Publication Number Publication Date
DE69909442D1 true DE69909442D1 (de) 2003-08-14
DE69909442T2 DE69909442T2 (de) 2004-04-22

Family

ID=26701861

Family Applications (2)

Application Number Title Priority Date Filing Date
DE1057022T Pending DE1057022T1 (de) 1998-02-20 1999-02-05 Assay für spezifische stämme von mit mehreren krankheiten zusammenhängenden proteinkonformationen
DE69909442T Expired - Fee Related DE69909442T2 (de) 1998-02-20 1999-02-05 Assay für spezifische stämme von mit mehreren krankheiten zusammenhängenden proteinkonformationen

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE1057022T Pending DE1057022T1 (de) 1998-02-20 1999-02-05 Assay für spezifische stämme von mit mehreren krankheiten zusammenhängenden proteinkonformationen

Country Status (10)

Country Link
EP (1) EP1057022B1 (de)
JP (1) JP2003519357A (de)
KR (1) KR20010041135A (de)
AT (1) ATE244889T1 (de)
AU (1) AU753331B2 (de)
BR (1) BR9908059A (de)
CA (1) CA2318477A1 (de)
DE (2) DE1057022T1 (de)
ES (1) ES2203073T3 (de)
WO (1) WO1999042829A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6617119B2 (en) 1997-02-21 2003-09-09 The Regents Of The University Of California Assay for specific strains of multiple disease related conformations of a protein
US6221614B1 (en) 1997-02-21 2001-04-24 The Regents Of The University Of California Removal of prions from blood, plasma and other liquids
US6620629B1 (en) 1997-02-21 2003-09-16 The Regents Of The University Of California Method for detecting prions
US7041807B1 (en) 1999-06-23 2006-05-09 Caprion Pharmaceuticals, Inc. Antibodies to a YYX epitope of a mammalian prion protein
KR20010112840A (ko) * 2000-06-15 2001-12-22 김유삼 기능성 단백질의 패턴분석을 이용한 진단 시스템
US6537548B1 (en) 2000-07-27 2003-03-25 The Regents Of The University Of California Antibodies specific for ungulate PrP
US6716589B2 (en) * 2000-11-20 2004-04-06 Alphabeta Ab Discordant helix stabilization for prevention of amyloid formation
AUPR293801A0 (en) 2001-02-07 2001-03-01 Novapharm Research (Australia) Pty Ltd Prion disinfection
GB2376071A (en) * 2001-05-31 2002-12-04 Mini Agriculture & Fisheries Method for typing a TSE strain
EP1436618A4 (de) * 2001-09-20 2006-02-08 Univ California Für einen prionen-assay hergestellte muskelprobe
US7052849B2 (en) * 2001-11-23 2006-05-30 Syn X Pharma, Inc. Protein biopolymer markers predictive of insulin resistance
US20040072236A1 (en) 2002-09-27 2004-04-15 Neil Cashman PrPSc -interacting molecules and uses thereof
WO2006076687A2 (en) * 2005-01-13 2006-07-20 Novartis Vaccines And Diagnostics Inc. Elisa assays using prion-specific peptide reagents
US8293174B2 (en) 2007-10-17 2012-10-23 American Sterilizer Company Prion deactivating composition and methods of using same
JP5747444B2 (ja) * 2010-04-27 2015-07-15 パナソニックヘルスケア株式会社 βアミロイドに関連する病的状態の診断補助方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4806627A (en) * 1987-05-29 1989-02-21 Research Foundation Of Mental Hygiene Inc. Hybrid cell lines producing monoclonal antibodies dircted against scrapie-associated fibril proteins
WO1993023432A1 (en) * 1992-05-15 1993-11-25 New York University Soluble prion polypeptides, and methods for detecting and purifying thereof
US5565186A (en) * 1994-05-13 1996-10-15 The Regents Of The University Of California Method of detecting prions in a sample and transgenic animal used for same
US5757361A (en) * 1996-03-20 1998-05-26 International Business Machines Corporation Method and apparatus in computer systems to selectively map tablet input devices using a virtual boundary
US5891641A (en) * 1997-02-21 1999-04-06 The Regents Of The University Of California Assay for disease related conformation of a protein
US5977324A (en) * 1998-02-20 1999-11-02 The Regents Of The University Of California Process for concentrating protein with disease-related conformation

Also Published As

Publication number Publication date
AU2660299A (en) 1999-09-06
WO1999042829A1 (en) 1999-08-26
AU753331B2 (en) 2002-10-17
CA2318477A1 (en) 1999-08-26
EP1057022B1 (de) 2003-07-09
ATE244889T1 (de) 2003-07-15
JP2003519357A (ja) 2003-06-17
ES2203073T3 (es) 2004-04-01
EP1057022A4 (de) 2001-05-30
KR20010041135A (ko) 2001-05-15
BR9908059A (pt) 2002-01-08
EP1057022A1 (de) 2000-12-06
DE69909442T2 (de) 2004-04-22
DE1057022T1 (de) 2001-10-25

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Legal Events

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8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee